Article(id=1319981808645681291, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1319981498787279574, articleNumber=PA20260909_UvGXNDDM, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.16.026, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1759334400000, receivedDateStr=2025-10-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792637787257, onlineDateStr=2026-10-22, pubDate=1787846400000, pubDateStr=2026-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792637787256, onlineIssueDateStr=2026-10-22, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792637787256, creator=admin, updateTime=1792637787256, updator=admin, issue=Issue{id=1319981498787279574, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='16', pageStart='6209', pageEnd='6660', issueExtLink='null', onlineDate='null', pubDate='1787846400000', pubDateStr='2026-08-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792637713380, creator='ztmeta', updateTime=1792637713380, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=6543, endPage=6551, ext={EN=ArticleExt(id=1319981813196501133, articleId=1319981808645681291, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Chemical exploration on origin of “Tong-guan-teng” and analysis of its main components, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To explore the botanical origin of traditional Chinese medicine Tong-guan-teng and establish a semi-quantitative analysis method, and provide a scientific basis for the quality control and criterion improvement of the medicinal material. Methods Reference sample of Tong-guan-teng, market-available materials, and vine samples of two possible origin plants (Marsdenia tenacissima and M. cavaleriei ) were collected. Ultra-high-performance liquid chromatography coupled with charged aerosol detector (UHPLC-CAD) was employed, and an ACQUITY BEH C18 column (100 mm×2.1 mm, 1.7 μm) was used. The mobile phase consisted of 0.1% formic acid aqueous solution and acetonitrile, at a flow rate of 0.5 mL/min, with an injection volume of 2 μL. The similarity of sample chromatograms was analyzed by the “Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine (2012 edition) ”. Based on the chromatographic peak areas of eight main components in the UHPLC-CAD fingerprint, semi-quantitative analysis of relative contents and total relative contents among batches was carried out. Results The established fingerprint was validated by methodology, with demonstrated satisfactory precision, stability and repeatability, which met the requirements of traditional Chinese medicine fingerprint analysis. The similarity of fingerprints among the reference sample and 12 batches of commercial Tong-guan-teng samples ranged from 0.927 to 0.988. Significant differences were observed between the reference fingerprint of Tong-guan-teng and those of M. tenacissima stems, while a high degree of consistency was achieved with M. cavaleriei stems (similarity > 0.85) and the total contents of major components were relatively consistent. The relative contents of the eight major components followed the order: tenacissoside A > marsdenoside H > marsdenoside K > tenacissoside B > tenacissoside H > tenacissoside D > tenacissoside I > tenacissoside E. Conclusion In addition to tenacissoside H (the index component specified in the 2025 edition of the Chinese Pharmacopoeia ), tenacissoside A, marsdenoside H, marsdenoside K and tenacissoside B have relatively high contents, which can serve as potential quality markers and provide a theoretical basis for the botanical origin identification of the traditional Chinese medicine Tong-guan-teng from the perspective of chemical composition., authors=NAN Yi1,2 , SONG Juan1 , LIANG Haizhen1 , SHI Yuhao1,2 , HUANG Changliang1 , YU Dexin1,2 , CHEN Xiaojuan1 , LI Haitao3 , GUO Baolin4 , MA Baiping1,2 , authorsList=NAN Yi, SONG Juan, LIANG Haizhen, SHI Yuhao, HUANG Changliang, YU Dexin, CHEN Xiaojuan, LI Haitao, GUO Baolin, MA Baiping, authorCompany=1 Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China; 目的 探究通关藤的基原，建立其半定量分析方法，为药材质量控制与标准完善提供科学依据。方法 收集通关藤的对照药材、市场销售药材及2种可能基原植物（通光散Masdenia tenacissima 和灵药牛奶菜M. cavaleriei ）的藤茎样品，采用超高效液相色谱-电雾式检测器（UHPLC-CAD）技术，使用ACQUITY BEH C₁₈色谱柱（100 mm×2.1 mm，1.7 μm），以0.1%甲酸水溶液-乙腈作为流动相进行梯度洗脱，体积流量0.5 mL/min，进样量2 μL。通过《中药色谱指纹图谱相似度评价系统（2012版）》分析样品谱图相似度。以UHPLC-CAD指纹图谱中8个主要成分的色谱峰面积为指标，开展相对含量及批次间总相对含量的半定量分析。结果 所建立的UHPLC-CAD指纹图谱分析方法的精密度、稳定性及重复性良好，符合中药指纹图谱分析的方法要求。通关藤对照药材与市场上12批药材指纹图谱的相似度为0.927～0.988，通关藤药材对照指纹图谱与通光散藤茎的指纹图谱差异显著，而与灵药牛奶菜藤茎的指纹谱图一致性良好，相似度均大于0.85，且主成分含量较为一致。8个主要成分的相对含量依次为通关藤苷A＞marsdenoside H＞marsdenoside K＞通关藤苷B＞通关藤苷H＞通关藤苷D＞通关藤苷I＞通关藤苷E。结论 除了《中国药典》2025年版规定的指标成分通关藤苷H外，通关藤苷A、marsdenoside H、marsdenoside K和通关藤苷B的含量较高，可以作为潜在质量标志物，从化学成分角度为中药通关藤的基原鉴定提供理论基础。, authors=南易1,2 , 宋娟1 , 梁海珍1 , 石宇浩1,2 , 黄长亮1 , 于德鑫1,2 , 陈晓娟1 , 李海涛3 , 郭宝林4 , 马百平1,2 , authorsList=南易, 宋娟, 梁海珍, 石宇浩, 黄长亮, 于德鑫, 陈晓娟, 李海涛, 郭宝林, 马百平, authorCompany=1 军事科学院军事医学研究院, 北京 100850; 1 ,,2 ,, address=5 ,6 军事科学院军事医学研究院, 北京 100850, bio=南易: 南易,博士研究生,研究方向是天然药物化学。E-mail:nanyi96@126.com, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])]), Author(id=1319981819492151455, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=宋娟, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981819576037537, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981819492151455, language=CN, stringName=宋娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,, address=5 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)])]), Author(id=1319981819894804642, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=梁海珍, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981820335206564, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981819894804642, language=CN, stringName=梁海珍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,, address=5 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)])]), Author(id=1319981820414898341, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=石宇浩, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981820796580008, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981820414898341, language=CN, stringName=石宇浩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,,2 ,, address=5 ,6 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])]), Author(id=1319981820863688873, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=黄长亮, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981821601886379, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981820863688873, language=CN, stringName=黄长亮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,, address=5 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)])]), Author(id=1319981822012928173, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=于德鑫, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981824135246000, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981822012928173, language=CN, stringName=于德鑫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,,2 ,, address=5 ,6 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])]), Author(id=1319981825355788465, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=陈晓娟, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981825812967603, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981825355788465, language=CN, stringName=陈晓娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,, address=5 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)])]), Author(id=1319981826643439796, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=李海涛, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981828698648759, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981826643439796, language=CN, stringName=李海涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3 , address=3. 中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816153485459, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=3, ext=[AuthorCompanyExt(id=1319981816170262676, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816153485459, language=CN, country=null, province=null, city=null, postcode=null, companyName=中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100, departmentName=null, remark=3. 中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100)])]), Author(id=1319981828832866488, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=9, firstName=null, middleName=null, lastName=null, nameCn=郭宝林, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981829193576634, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981828832866488, language=CN, stringName=郭宝林, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4 , address=4. 中国医学科学院北京协和医学院 药用植物研究所, 北京 100193中国医学科学院北京协和医学院 药用植物研究所, 北京 100193, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816614858901, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=4* , ext=[AuthorCompanyExt(id=1319981816623247510, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816614858901, language=CN, country=null, province=null, city=null, postcode=null, companyName=中国医学科学院北京协和医学院 药用植物研究所, 北京 100193, departmentName=null, remark=4. 中国医学科学院北京协和医学院 药用植物研究所, 北京 100193)])]), Author(id=1319981829596229819, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=10, firstName=null, middleName=null, lastName=null, nameCn=马百平, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981830384758974, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981829596229819, language=CN, stringName=马百平, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,,2 ,, address=5 ,6 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])])], keywords=[Keyword(id=1322633189269549998, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=CN, orderNo=1, keyword=通关藤), Keyword(id=1322633189328270255, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=CN, orderNo=2, keyword=UHPLC-CAD), Keyword(id=1322633189403767728, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=CN, orderNo=3, keyword=指纹图谱), Keyword(id=1322633189466682289, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=CN, orderNo=4, keyword=通光散), Keyword(id=1322633189525402546, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=CN, orderNo=5, keyword=灵药牛奶菜), Keyword(id=1322633189592511411, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=CN, orderNo=6, keyword=相似度评价), Keyword(id=1322633189709951924, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=EN, orderNo=1, keyword=Tong-guan-teng), Keyword(id=1322633189785449397, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=EN, orderNo=2, keyword=UHPLC-CAD), Keyword(id=1322633189869335478, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=EN, orderNo=3, keyword=fingerprint), Keyword(id=1322633189944832951, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=EN, orderNo=4, keyword=Masdenia tenacissima (Roxb.) Wight et Arn.), Keyword(id=1322633190003553208, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=EN, orderNo=5, keyword=Masdenia cavaleriei Lé), Keyword(id=1322633190079050681, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=EN, orderNo=6, keyword=veillé), Keyword(id=1322633190146159546, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, language=EN, orderNo=7, keyword=similarity evaluation)], refs=[Reference(id=1319981838026780880, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=1, rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=贾祎萍, 吴子薇, 李晓波, 等. 通关藤化学成分及其细胞毒活性[J]. 中成药, 2023, 45(9): 2910-2916., articleTitle=null, refAbstract=null), Reference(id=1319981838026780881, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=2, rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=Wang P L, Yang J, Zhu Z F, et al . Marsdenia tenacissima : A review of traditional uses, phytochemistry and pharmacology [J]. Am J Chin Med , 2018: 1-32., articleTitle=null, refAbstract=null), Reference(id=1319981838026780882, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=3, rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=中国药典[S]. 一部. 2025: 317-318., articleTitle=null, refAbstract=null), Reference(id=1319981838026780883, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=4, rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=中国科学院中国植物志编辑委员会. 中国植物志（第63卷）[M]. 北京: 科学出版社, 1977., articleTitle=null, refAbstract=null), Reference(id=1319981838026780884, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=5, rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=William Roxbujgh M D. Plant of the coast of Coromandel: Vol. 3 [M]. London: W. Bulmer and Co., 1819, 35-36., articleTitle=null, refAbstract=null), Reference(id=1319981838030975185, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=6, rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=Flora of China Editorial Committee. Flora of China [M]. Beijing: Science Press, 1995, 16: 245., articleTitle=null, refAbstract=null), Reference(id=1319981838030975186, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=7, rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=李金月, 谭运洪, 李海涛, 等. 基于分子与形态证据的傣药“傣百解” 基原考证[J]. 广西植物, 2023, 43(1): 32-42., articleTitle=null, refAbstract=null), Reference(id=1319981838030975187, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=8, rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=于绍帅, 陈明苍, 李志雄, 等. 通关藤的化学成分与药理活性研究进展[J]. 中国实验方剂学杂志, 2011, 17(21): 279-283., articleTitle=null, refAbstract=null), Reference(id=1319981838030975188, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=9, rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=李双凤, 黄家彦, 韩笑, 等. 通关藤抗肿瘤主要成分及作用机制研究进展[J]. 药物评价研究, 2023, 46(1): 187-197., articleTitle=null, refAbstract=null), Reference(id=1319981838030975189, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=10, rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=李思雨, 张冬月, 韩丽, 等. HPLC-DAD-ELSD法同时测定22个产地通关藤中3种皂苷[J]. 中成药, 2019, 41(5): 1144-1146., articleTitle=null, refAbstract=null), Reference(id=1319981838030975190, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=11, rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=吕磊, 杨伟, 吴于初, 等. HPLC法同时测定不同产地通关藤中通关藤苷GIH的含量[J]. 解放军药学学报, 2017, 33(4): 323-325., articleTitle=null, refAbstract=null), Reference(id=1319981838030975191, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=12, rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=徐凯, 乔佳, 韩丽, 等. HPLC法测定不同产地通关藤中通关藤苷G和I的含量[J]. 药物分析杂志, 2016, 36(4): 607-610., articleTitle=null, refAbstract=null), Reference(id=1319981838030975192, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=13, rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=陈敏, 李媛媛, 李先荣. HPLC测定通关藤药材及消癌平片中通关藤苷A含量[J]. 中国中医药信息杂志, 2013, 20(3): 55-57., articleTitle=null, refAbstract=null), Reference(id=1319981838030975193, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=14, rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=董占军, 安静, 王祁民, 等. UPLC-MS/MS同时检测消癌平注射液中通关藤苷A、I、H的含量[J]. 中国现代应用药学, 2018, 35(3): 396-398., articleTitle=null, refAbstract=null), Reference(id=1319981838030975194, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=15, rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=邹纯才, 鄢海燕. 我国中药色谱指纹图谱相似度评价方法30年(1988—2017年)研究进展与展望[J]. 中国中药杂志, 2018, 43(10): 1969-1977., articleTitle=null, refAbstract=null), Reference(id=1319981838030975195, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=16, rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=Eom H Y, Park S Y, Kim M K, et al . Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins [J]. J Chromatogr A , 2010, 1217(26): 4347-4354., articleTitle=null, refAbstract=null), Reference(id=1319981838030975196, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=17, rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=卢彭信, 李港, 郑伟, 等. 超高效液相色谱-电雾式检测器测定福建产绞股蓝中绞股蓝皂苷XLVI和LVI [J]. 色谱, 2022, 40(9): 833-842., articleTitle=null, refAbstract=null), Reference(id=1319981838030975197, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=18, rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=南易, 郑伟, 马凤霞, 等. HPLC-CAD同时测定知母中芒果苷和知母皂苷B Ⅱ的含量[J]. 药物分析杂志, 2021, 41(1): 111-116., articleTitle=null, refAbstract=null), Reference(id=1319981838030975198, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=19, rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=石宇浩, 南易, 郑伟, 等. 酸枣仁种皮和种仁化学成分的定性及半定量分析[J]. 色谱, 2024, 42(3): 234-244., articleTitle=null, refAbstract=null), Reference(id=1319981838030975199, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=20, rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=李海涛, 康利平, 郭宝林, 等. 常用傣药“傣百解”的基原考证[J]. 中国中药杂志, 2014, 39(8): 781-792., articleTitle=null, refAbstract=null), Reference(id=1319981838030975200, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=21, rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=Pang X, Kang L P, Fang X M, et al . C(21) steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima , and their screening for anti-HIV activity [J]. J Nat Med , 2018, 72(1): 166-180., articleTitle=null, refAbstract=null), Reference(id=1319981838030975201, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=22, rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=Pang X, Kang L P, Fang X, et al . Polyoxypregnane glycosides from the roots of Marsdenia tenacissima and their anti-HIV activities [J]. Planta Med , 2017, 83(1/02): 126-134., articleTitle=null, refAbstract=null), Reference(id=1319981838030975202, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=23, rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=Nan Y, Song J, Liang H Z, et al . Qualitative and quantitative analyses of chemical components in different parts of Marsdenia cavaleriei [J]. J Chromatogr B Analyt Technol Biomed Life Sci , 2025, 1259: 124617., articleTitle=null, refAbstract=null), Reference(id=1319981838030975203, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=24, rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=Li X L, He S H, Liang W, et al . Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the Akt/GSK3β/STAT3 signaling axis [J]. Chin J Nat Med , 2023, 21(2): 113-126., articleTitle=null, refAbstract=null), Reference(id=1319981838030975204, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=25, rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=刘丽, 彭雨晴, 杨晨欣, 等. 消癌平抗肿瘤药理作用及机制研究进展[J]. 药物评价研究, 2025, 48(2): 526-538., articleTitle=null, refAbstract=null)], funds=[Fund(id=1319981837557018831, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, awardId=2097521990509334530, language=CN, fundingSource=国家自然科学基金项目, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1319981815281070223, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=1, ext=[AuthorCompanyExt(id=1319981815289458832, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981815281070223, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=1. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981815729860753, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=2, ext=[AuthorCompanyExt(id=1319981815750832274, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981815729860753, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=2. 天津中医药大学, 天津 301617)]), AuthorCompany(id=1319981816153485459, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=3, ext=[AuthorCompanyExt(id=1319981816170262676, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816153485459, language=CN, country=null, province=null, city=null, postcode=null, companyName=中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100, departmentName=null, remark=3. 中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100)]), AuthorCompany(id=1319981816614858901, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=4* , ext=[AuthorCompanyExt(id=1319981816623247510, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816614858901, language=CN, country=null, province=null, city=null, postcode=null, companyName=中国医学科学院北京协和医学院 药用植物研究所, 北京 100193, departmentName=null, remark=4. 中国医学科学院北京协和医学院 药用植物研究所, 北京 100193)]), AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])], figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.16.026, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.16.026, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.16.026, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.16.026, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1787846400000, fullTextJson=null, articleText=null, reference=贾祎萍, 吴子薇, 李晓波, 等. 通关藤化学成分及其细胞毒活性[J]. 中成药, 2023, 45(9): 2910-2916.et al . Marsdenia tenacissima : A review of traditional uses, phytochemistry and pharmacology [J]. Am J Chin Med , 2018: 1-32.Plant of the coast of Coromandel: Vol. 3 [M]. London: W. Bulmer and Co., 1819, 35-36.Flora of China [M]. Beijing: Science Press, 1995, 16: 245.et al . Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins [J]. J Chromatogr A , 2010, 1217(26): 4347-4354.et al . C(21) steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima , and their screening for anti-HIV activity [J]. J Nat Med , 2018, 72(1): 166-180.et al . Polyoxypregnane glycosides from the roots of Marsdenia tenacissima and their anti-HIV activities [J]. Planta Med , 2017, 83(1/02): 126-134.et al . Qualitative and quantitative analyses of chemical components in different parts of Marsdenia cavaleriei [J]. J Chromatogr B Analyt Technol Biomed Life Sci , 2025, 1259: 124617.et al . Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the Akt/GSK3β/STAT3 signaling axis [J]. Chin J Nat Med , 2023, 21(2): 113-126.
中草药
|药材与资源
2026
, 57
(16) :
6543
-6551
通关藤基原的化学探究及其主要成分分析
全屏
[Author(id=1319981817453719707, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=南易, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981817537605790, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981817453719707, language=CN, stringName=南易, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,,2 ,, address=5 ,6 军事科学院军事医学研究院, 北京 100850, bio=南易: 南易,博士研究生,研究方向是天然药物化学。E-mail:nanyi96@126.com, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])]), Author(id=1319981819492151455, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=宋娟, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981819576037537, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981819492151455, language=CN, stringName=宋娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,, address=5 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)])]), Author(id=1319981819894804642, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=梁海珍, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981820335206564, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981819894804642, language=CN, stringName=梁海珍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,, address=5 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)])]), Author(id=1319981820414898341, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=石宇浩, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981820796580008, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981820414898341, language=CN, stringName=石宇浩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,,2 ,, address=5 ,6 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])]), Author(id=1319981820863688873, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=黄长亮, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981821601886379, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981820863688873, language=CN, stringName=黄长亮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,, address=5 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)])]), Author(id=1319981822012928173, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=于德鑫, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981824135246000, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981822012928173, language=CN, stringName=于德鑫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,,2 ,, address=5 ,6 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])]), Author(id=1319981825355788465, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=陈晓娟, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981825812967603, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981825355788465, language=CN, stringName=陈晓娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,, address=5 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)])]), Author(id=1319981826643439796, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=李海涛, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981828698648759, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981826643439796, language=CN, stringName=李海涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3 , address=3. 中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816153485459, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=3, ext=[AuthorCompanyExt(id=1319981816170262676, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816153485459, language=CN, country=null, province=null, city=null, postcode=null, companyName=中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100, departmentName=null, remark=3. 中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100)])]), Author(id=1319981828832866488, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=9, firstName=null, middleName=null, lastName=null, nameCn=郭宝林, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981829193576634, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981828832866488, language=CN, stringName=郭宝林, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4 , address=4. 中国医学科学院北京协和医学院 药用植物研究所, 北京 100193中国医学科学院北京协和医学院 药用植物研究所, 北京 100193, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816614858901, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=4* , ext=[AuthorCompanyExt(id=1319981816623247510, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816614858901, language=CN, country=null, province=null, city=null, postcode=null, companyName=中国医学科学院北京协和医学院 药用植物研究所, 北京 100193, departmentName=null, remark=4. 中国医学科学院北京协和医学院 药用植物研究所, 北京 100193)])]), Author(id=1319981829596229819, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, orderNo=10, firstName=null, middleName=null, lastName=null, nameCn=马百平, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981830384758974, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, authorId=1319981829596229819, language=CN, stringName=马百平, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1 ,,2 ,, address=5 ,6 军事科学院军事医学研究院, 北京 100850, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981816975569047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=5* , ext=[AuthorCompanyExt(id=1319981816988151960, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981816975569047, language=CN, country=null, province=null, city=null, postcode=null, companyName=军事科学院军事医学研究院, 北京 100850, departmentName=null, remark=5. 军事科学院军事医学研究院, 北京 100850)]), AuthorCompany(id=1319981817072038041, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, xref=6* , ext=[AuthorCompanyExt(id=1319981817080426650, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981808645681291, companyId=1319981817072038041, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=6. 天津中医药大学, 天津 301617)])])]
南易 1 ,,2 ,, 宋娟 1 ,, 梁海珍 1 ,, 石宇浩 1 ,,2 ,, 黄长亮 1 ,, 于德鑫 1 ,,2 ,, 陈晓娟 1 ,, 李海涛 3 , 郭宝林 4 , 马百平 1 ,,2 ,
作者信息
1. 军事科学院军事医学研究院, 北京 100850
2. 天津中医药大学, 天津 301617
3. 中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100
4. 中国医学科学院北京协和医学院 药用植物研究所, 北京 100193
5. 军事科学院军事医学研究院, 北京 100850
6. 天津中医药大学, 天津 301617
通讯作者:
郭宝林
作者简介:
南易: 南易,博士研究生,研究方向是天然药物化学。E-mail:nanyi96@126.com
Chemical exploration on origin of “Tong-guan-teng” and analysis of its main components
Affiliations
出版时间: 2026-08-28
doi: 10.7501/j.issn.0253-2670.2026.16.026
文章导航
目的 探究通关藤的基原，建立其半定量分析方法，为药材质量控制与标准完善提供科学依据。方法 收集通关藤的对照药材、市场销售药材及2种可能基原植物（通光散Masdenia tenacissima 和灵药牛奶菜M. cavaleriei ）的藤茎样品，采用超高效液相色谱-电雾式检测器（UHPLC-CAD）技术，使用ACQUITY BEH C₁₈色谱柱（100 mm×2.1 mm，1.7 μm），以0.1%甲酸水溶液-乙腈作为流动相进行梯度洗脱，体积流量0.5 mL/min，进样量2 μL。通过《中药色谱指纹图谱相似度评价系统（2012版）》分析样品谱图相似度。以UHPLC-CAD指纹图谱中8个主要成分的色谱峰面积为指标，开展相对含量及批次间总相对含量的半定量分析。结果 所建立的UHPLC-CAD指纹图谱分析方法的精密度、稳定性及重复性良好，符合中药指纹图谱分析的方法要求。通关藤对照药材与市场上12批药材指纹图谱的相似度为0.927～0.988，通关藤药材对照指纹图谱与通光散藤茎的指纹图谱差异显著，而与灵药牛奶菜藤茎的指纹谱图一致性良好，相似度均大于0.85，且主成分含量较为一致。8个主要成分的相对含量依次为通关藤苷A＞marsdenoside H＞marsdenoside K＞通关藤苷B＞通关藤苷H＞通关藤苷D＞通关藤苷I＞通关藤苷E。结论 除了《中国药典》2025年版规定的指标成分通关藤苷H外，通关藤苷A、marsdenoside H、marsdenoside K和通关藤苷B的含量较高，可以作为潜在质量标志物，从化学成分角度为中药通关藤的基原鉴定提供理论基础。
通关藤
/
UHPLC-CAD
/
指纹图谱
/
通光散
/
灵药牛奶菜
/
相似度评价
Objective To explore the botanical origin of traditional Chinese medicine Tong-guan-teng and establish a semi-quantitative analysis method, and provide a scientific basis for the quality control and criterion improvement of the medicinal material. Methods Reference sample of Tong-guan-teng, market-available materials, and vine samples of two possible origin plants (Marsdenia tenacissima and M. cavaleriei ) were collected. Ultra-high-performance liquid chromatography coupled with charged aerosol detector (UHPLC-CAD) was employed, and an ACQUITY BEH C18 column (100 mm×2.1 mm, 1.7 μm) was used. The mobile phase consisted of 0.1% formic acid aqueous solution and acetonitrile, at a flow rate of 0.5 mL/min, with an injection volume of 2 μL. The similarity of sample chromatograms was analyzed by the “Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine (2012 edition) ”. Based on the chromatographic peak areas of eight main components in the UHPLC-CAD fingerprint, semi-quantitative analysis of relative contents and total relative contents among batches was carried out. Results The established fingerprint was validated by methodology, with demonstrated satisfactory precision, stability and repeatability, which met the requirements of traditional Chinese medicine fingerprint analysis. The similarity of fingerprints among the reference sample and 12 batches of commercial Tong-guan-teng samples ranged from 0.927 to 0.988. Significant differences were observed between the reference fingerprint of Tong-guan-teng and those of M. tenacissima stems, while a high degree of consistency was achieved with M. cavaleriei stems (similarity > 0.85) and the total contents of major components were relatively consistent. The relative contents of the eight major components followed the order: tenacissoside A > marsdenoside H > marsdenoside K > tenacissoside B > tenacissoside H > tenacissoside D > tenacissoside I > tenacissoside E. Conclusion In addition to tenacissoside H (the index component specified in the 2025 edition of the Chinese Pharmacopoeia ), tenacissoside A, marsdenoside H, marsdenoside K and tenacissoside B have relatively high contents, which can serve as potential quality markers and provide a theoretical basis for the botanical origin identification of the traditional Chinese medicine Tong-guan-teng from the perspective of chemical composition.
Tong-guan-teng
/
UHPLC-CAD
/
fingerprint
/
Masdenia tenacissima (Roxb.) Wight et Arn.
/
Masdenia cavaleriei Lé
/
veillé
/
similarity evaluation
南易, 宋娟, 梁海珍, 石宇浩, 黄长亮, 于德鑫, 陈晓娟, 李海涛, 郭宝林, 马百平.
通关藤基原的化学探究及其主要成分分析.
中草药,
2026
, 57
(16)
: 6543
-6551
.
DOI: 10.7501/j.issn.0253-2670.2026.16.026
NAN Yi, SONG Juan, LIANG Haizhen, SHI Yuhao, HUANG Changliang, YU Dexin, CHEN Xiaojuan, LI Haitao, GUO Baolin, MA Baiping.
Chemical exploration on origin of “Tong-guan-teng” and analysis of its main components[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(16)
: 6543
-6551
.
DOI: 10.7501/j.issn.0253-2670.2026.16.026
参考文献
引证文献
1
贾祎萍, 吴子薇, 李晓波, 等. 通关藤化学成分及其细胞毒活性[J]. 中成药, 2023, 45(9): 2910-2916.
2
Wang P L, Yang J, Zhu Z F,
et al .
Marsdenia tenacissima : A review of traditional uses, phytochemistry and pharmacology [J].
Am J Chin Med , 2018: 1-32.
3
中国药典[S]. 一部. 2025: 317-318.
4
中国科学院中国植物志编辑委员会. 中国植物志（第63卷）[M]. 北京: 科学出版社, 1977.
5
William Roxbujgh M D.
Plant of the coast of Coromandel: Vol. 3 [M]. London: W. Bulmer and Co., 1819, 35-36.
6
Flora of China Editorial Committee.
Flora of China [M]. Beijing: Science Press, 1995, 16: 245.
7
李金月, 谭运洪, 李海涛, 等. 基于分子与形态证据的傣药“傣百解” 基原考证[J]. 广西植物, 2023, 43(1): 32-42.
8
于绍帅, 陈明苍, 李志雄, 等. 通关藤的化学成分与药理活性研究进展[J]. 中国实验方剂学杂志, 2011, 17(21): 279-283.
9
李双凤, 黄家彦, 韩笑, 等. 通关藤抗肿瘤主要成分及作用机制研究进展[J]. 药物评价研究, 2023, 46(1): 187-197.
10
李思雨, 张冬月, 韩丽, 等. HPLC-DAD-ELSD法同时测定22个产地通关藤中3种皂苷[J]. 中成药, 2019, 41(5): 1144-1146.
11
吕磊, 杨伟, 吴于初, 等. HPLC法同时测定不同产地通关藤中通关藤苷GIH的含量[J]. 解放军药学学报, 2017, 33(4): 323-325.
12
徐凯, 乔佳, 韩丽, 等. HPLC法测定不同产地通关藤中通关藤苷G和I的含量[J]. 药物分析杂志, 2016, 36(4): 607-610.
13
陈敏, 李媛媛, 李先荣. HPLC测定通关藤药材及消癌平片中通关藤苷A含量[J]. 中国中医药信息杂志, 2013, 20(3): 55-57.
14
董占军, 安静, 王祁民, 等. UPLC-MS/MS同时检测消癌平注射液中通关藤苷A、I、H的含量[J]. 中国现代应用药学, 2018, 35(3): 396-398.
15
邹纯才, 鄢海燕. 我国中药色谱指纹图谱相似度评价方法30年(1988—2017年)研究进展与展望[J]. 中国中药杂志, 2018, 43(10): 1969-1977.
16
Eom H Y, Park S Y, Kim M K,
et al . Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins [J].
J Chromatogr A , 2010, 1217(26): 4347-4354.
17
卢彭信, 李港, 郑伟, 等. 超高效液相色谱-电雾式检测器测定福建产绞股蓝中绞股蓝皂苷XLVI和LVI [J]. 色谱, 2022, 40(9): 833-842.
18
南易, 郑伟, 马凤霞, 等. HPLC-CAD同时测定知母中芒果苷和知母皂苷B Ⅱ的含量[J]. 药物分析杂志, 2021, 41(1): 111-116.
19
石宇浩, 南易, 郑伟, 等. 酸枣仁种皮和种仁化学成分的定性及半定量分析[J]. 色谱, 2024, 42(3): 234-244.
20
李海涛, 康利平, 郭宝林, 等. 常用傣药“傣百解”的基原考证[J]. 中国中药杂志, 2014, 39(8): 781-792.
21
Pang X, Kang L P, Fang X M,
et al . C(21) steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of
Marsdenia tenacissima , and their screening for anti-HIV activity [J].
J Nat Med , 2018, 72(1): 166-180.
22
Pang X, Kang L P, Fang X,
et al . Polyoxypregnane glycosides from the roots of
Marsdenia tenacissima and their anti-HIV activities [J].
Planta Med , 2017, 83(1/02): 126-134.
23
Nan Y, Song J, Liang H Z,
et al . Qualitative and quantitative analyses of chemical components in different parts of
Marsdenia cavaleriei [J].
J Chromatogr B Analyt Technol Biomed Life Sci , 2025, 1259: 124617.
24
Li X L, He S H, Liang W,
et al .
Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the Akt/GSK3β/STAT3 signaling axis [J].
Chin J Nat Med , 2023, 21(2): 113-126.
25
刘丽, 彭雨晴, 杨晨欣, 等. 消癌平抗肿瘤药理作用及机制研究进展[J]. 药物评价研究, 2025, 48(2): 526-538.
贾祎萍, 吴子薇, 李晓波, 等. 通关藤化学成分及其细胞毒活性[J]. 中成药, 2023, 45(9): 2910-2916.et al . Marsdenia tenacissima : A review of traditional uses, phytochemistry and pharmacology [J]. Am J Chin Med , 2018: 1-32.Plant of the coast of Coromandel: Vol. 3 [M]. London: W. Bulmer and Co., 1819, 35-36.Flora of China [M]. Beijing: Science Press, 1995, 16: 245.et al . Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins [J]. J Chromatogr A , 2010, 1217(26): 4347-4354.et al . C(21) steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima , and their screening for anti-HIV activity [J]. J Nat Med , 2018, 72(1): 166-180.et al . Polyoxypregnane glycosides from the roots of Marsdenia tenacissima and their anti-HIV activities [J]. Planta Med , 2017, 83(1/02): 126-134.et al . Qualitative and quantitative analyses of chemical components in different parts of Marsdenia cavaleriei [J]. J Chromatogr B Analyt Technol Biomed Life Sci , 2025, 1259: 124617.et al . Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the Akt/GSK3β/STAT3 signaling axis [J]. Chin J Nat Med , 2023, 21(2): 113-126.
2026年第57卷第16期
PDF下载
116
10
引用本文
BibTeX
文章信息
doi: 10.7501/j.issn.0253-2670.2026.16.026
接收时间：2025-10-02
首发时间：2026-10-22
出版时间：2026-08-28
1. 军事科学院军事医学研究院, 北京 100850
2. 天津中医药大学, 天津 301617
3. 中国医学科学院北京协和医学院 药用植物研究所云南分所, 云南 昆明 666100
4. 中国医学科学院北京协和医学院 药用植物研究所, 北京 100193
5. 军事科学院军事医学研究院, 北京 100850
6. 天津中医药大学, 天津 301617
通讯作者:
通讯作者:
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.16.026
引用本文
BibTeX
2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
关闭全屏
BibTeX
EndNote
RefWorks
TxT
PDF下载
全屏
116
10
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
