中草药

基于多组织eQTL-MR研究“归经理论”下丹参治疗心力衰竭的器官作用偏好

PDF下载

郭俊池 ¹,,² , 张明妍 ² , 王启隆 ² , 徐强 ¹, , 路美娟 ¹,

中草药 | 数据挖掘与循证医学 2026,57(16): 6450-6458

收起

中草药 |数据挖掘与循证医学 2026 , 57 (16) : 6450 -6458

基于多组织eQTL-MR研究“归经理论”下丹参治疗心力衰竭的器官作用偏好

全屏

[Author(id=1319981740630848289, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=郭俊池, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981740718928677, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, authorId=1319981740630848289, language=CN, stringName=郭俊池, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,,², address=³,^2.天津中医药大学, 天津 301617天津中医药大学第二附属医院, 天津 300250, bio=郭俊池: 郭俊池(2001—),男,硕士研究生,研究方向为中医药防治心血管疾病临床与基础。E-mail:Guo_Junchi20010723@163.com, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981740341441310, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, xref=3^*, ext=[AuthorCompanyExt(id=1319981740349829919, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, companyId=1319981740341441310, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学第二附属医院, 天津 300250, departmentName=null, remark=^3.天津中医药大学第二附属医院, 天津 300250)]), AuthorCompany(id=1319981740274332444, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, xref=2, ext=[AuthorCompanyExt(id=1319981740282721053, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, companyId=1319981740274332444, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=^2.天津中医药大学, 天津 301617)])]), Author(id=1319981740781843239, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=张明妍, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981741050278697, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, authorId=1319981740781843239, language=CN, stringName=张明妍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.天津中医药大学, 天津 301617天津中医药大学, 天津 301617, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981740274332444, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, xref=2, ext=[AuthorCompanyExt(id=1319981740282721053, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, companyId=1319981740274332444, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=^2.天津中医药大学, 天津 301617)])]), Author(id=1319981742732194602, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=王启隆, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981742837052204, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, authorId=1319981742732194602, language=CN, stringName=王启隆, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.天津中医药大学, 天津 301617天津中医药大学, 天津 301617, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981740274332444, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, xref=2, ext=[AuthorCompanyExt(id=1319981740282721053, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, companyId=1319981740274332444, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学, 天津 301617, departmentName=null, remark=^2.天津中医药大学, 天津 301617)])]), Author(id=1319981742916743981, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=徐强, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981743151625007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, authorId=1319981742916743981, language=CN, stringName=徐强, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=³天津中医药大学第二附属医院, 天津 300250, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981740341441310, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, xref=3^*, ext=[AuthorCompanyExt(id=1319981740349829919, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, companyId=1319981740341441310, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学第二附属医院, 天津 300250, departmentName=null, remark=^3.天津中医药大学第二附属医院, 天津 300250)])]), Author(id=1319981743218733872, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=路美娟, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981743302619954, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, authorId=1319981743218733872, language=CN, stringName=路美娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=³天津中医药大学第二附属医院, 天津 300250, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981740341441310, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, xref=3^*, ext=[AuthorCompanyExt(id=1319981740349829919, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981738521113367, companyId=1319981740341441310, language=CN, country=null, province=null, city=null, postcode=null, companyName=天津中医药大学第二附属医院, 天津 300250, departmentName=null, remark=^3.天津中医药大学第二附属医院, 天津 300250)])])]

郭俊池¹,,², 张明妍², 王启隆², 徐强¹,, 路美娟¹,

作者信息

^1.天津中医药大学第二附属医院, 天津 300250

^2.天津中医药大学, 天津 301617

^3.天津中医药大学第二附属医院, 天津 300250

通讯作者:

路美娟

作者简介:

郭俊池: 郭俊池(2001—),男,硕士研究生,研究方向为中医药防治心血管疾病临床与基础。E-mail:Guo_Junchi20010723@163.com

Study on organ-specific action preference of Salvia miltiorrhiza in treatment of heart failure under theory of meridian tropism based on multi-tissue eQTL-MR

Affiliations

出版时间: 2026-08-28 doi: 10.7501/j.issn.0253-2670.2026.16.019

文章导航

摘要

收起

目的基于中医“归经理论”，从遗传调控、因果推断及转录组学等多层证据出发，系统解析丹参治疗心力衰竭的器官作用偏好及其关键分子机制。方法通过TCMSP、ETCM、HERB及文献资料筛选丹参主要活性成分，并预测潜在靶基因。随后整合基因型-组织表达（genotype-tissue expression，GTEx）数据库的多组织表达数量性状位点（expression quantitative trait loci，eQTL）与心力衰竭全基因组关联研究（genome-wide association study，GWAS）数据，采用两样本孟德尔随机化（Mendelian randomization，MR）评估靶基因在心脏、肝脏、肺组织及肾组织中的组织特异性因果效应，并构建器官作用偏好指数（volume of interest，VOI）量化其器官定向特征，结合心力衰竭转录组数据分析关键基因的表达特征。结果多组织MR显示，丹参靶基因在心脏、肝脏及肺组织中均呈现一定的遗传效应特征。VOI分析提示乙醛脱氢酶2（aldehyde dehydrogenase 2，ALDH2）、丙酮酸脱氢酶E1β亚基（pyruvate dehydrogenase E1 beta subunit，PDHB）、胆固醇酯转移蛋白（cholesteryl ester transfer protein，CETP）等靶基因在心脏和肝脏中贡献较高，而蛋白激酶Cα（protein kinase C alpha，PRKCA）等靶基因在肺组织中亦表现出较强的组织偏好。跨器官一致受保护的关键基因半胱氨酸蛋白酶-7（Caspase-7，CASP7）在MR分析中表现为降低心力衰竭风险的方向性效应，且在心力衰竭转录组中显著下调。结论构建了“归经-器官调控-疾病因果效应”一体化分析框架。丹参相关靶基因表现出以心、肝为主并涉及肺组织的多器官作用特征，为丹参传统归经理论提供了新的量化研究线索且提出CASP7可能是其发挥跨器官抗心力衰竭作用的重要候选靶点。

关键词

丹参 / 心力衰竭 / 归经理论 / 孟德尔随机化 / 器官作用偏好

Abstract

收起

Objective Based on the traditional Chinese medicine (TCM) theory of meridian tropism, this study aimed to systematically elucidate the organ-specific therapeutic preference of Salvia miltiorrhiza in heart failure (HF) and its key molecular mechanisms by integrating multi-level evidence from genetic regulation, causal inference, and transcriptomics. Methods Major active components of S. miltiorrhiza were screened through TCMSP, ETCM, HERB, and document literature, and potential target genes were predicted. Genotype-tissue expression (GTEx) multi-tissue expression quantitative trait loci (eQTL) data and heart failure genome-wide association study (GWAS) data were then integrated, and a two-sample Mendelian randomization (MR) framework was applied to evaluate the tissue-specific causal effects of target genes in the heart, liver, lung, and kidney. The volume of interest (VOI) was further constructed to quantify organ-oriented characteristics, and HF transcriptomic data were used to analyze the expression patterns of key genes. Results Multi-tissue MR showed that S. miltiorrhiza target genes exhibited certain genetic effect patterns in the heart, liver, and lung. VOI analysis indicated that genes such as aldehyde dehydrogenase 2 (ALDH2), pyruvate dehydrogenase E1 beta subunit (PDHB), and cholesteryl ester transfer protein (CETP) contributed more prominently in the heart and liver, whereas genes such as protein kinase C alpha (PRKCA) also showed relatively strong tissue preference in the lung. The cross-organ consistently protective key gene Caspase-7 (CASP7) showed a directional effect associated with reduced HF risk in MR analysis and was significantly downregulated in HF transcriptomic data. Conclusion This study established an integrated framework linking meridian tropism, organ regulation, and disease-related causal effects. The results suggest that S. miltiorrhiza-related target genes exhibit a multi-organ action pattern dominated by the heart and liver while also involving lung tissue, providing new quantitative clues for the traditional meridian tropism theory of S. miltiorrhiza and suggesting that CASP7 may be an important candidate target mediating its cross-organ anti-HF effects.

Key words

Salvia miltiorrhiza Bge. / heart failure / meridian tropism / Mendelian randomization / organ-specific action preference

引用本文

郭俊池, 张明妍, 王启隆, 徐强, 路美娟. 基于多组织eQTL-MR研究“归经理论”下丹参治疗心力衰竭的器官作用偏好. 中草药, 2026 , 57 (16) : 6450 -6458 . DOI: 10.7501/j.issn.0253-2670.2026.16.019

GUO Junchi, ZHANG Mingyan, WANG Qilong, XU Qiang, LU Meijuan. Study on organ-specific action preference of Salvia miltiorrhiza in treatment of heart failure under theory of meridian tropism based on multi-tissue eQTL-MR[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (16) : 6450 -6458 . DOI: 10.7501/j.issn.0253-2670.2026.16.019

基金

收起

国家自然科学基金面上项目
国家自然科学基金面上项目
天津市卫健委中医中西医结合科研课题

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

Beggs S A S, Petrie M C, Wright S, et al. Why do people with heart failure die? Rationale and design of the RHYTHM-HF study [J]. Eur J Heart Fail, 2025, 27(10): 1918-1926.

Güder G, Reiter T, Bauer W R, et al. Cardiac magnetic resonance imaging vs coronary angiography as primary strategy in newly diagnosed heart failure [J]. JACC Heart Fail, 2025, 13(9):102528.

Zeder K, Mak S, Galie N, et al. Right heart catheterization in heart failure: Indications, interpretation, and pitfalls [J]. Eur Heart J, 2025, 46(34): 3354-3372.

孙静, 梁雪娟. 基于中医瘀血理论探讨线粒体自噬与心力衰竭的关系[J]. 时珍国医国药, 2022, 33(11): 2718-2720.

王晶, 李莉, 刘冰, 等. 基于网络药理学和实验验证研究丹参饮治疗心衰的作用机制[J]. 中国药理学通报, 2024, 40(9): 1773-1780.

杨溶海, 方长庚, 梁建光. 丹参多酚酸盐对冠心病心力衰竭患者左心功能及血清心型脂肪酸结合蛋白的影响[J]. 中国老年学杂志, 2014, 34(9): 2323-2324.

曹灿, 董肖, 田颐, 等. 中药归经理论的历史沿革、研究现状与思考[J]. 中华中医药杂志, 2023, 38(1): 38-45.

于小刚, 辛二旦, 卢玉俊, 等. 黄芪-丹参药对防治心血管疾病的研究进展[J]. 华西药学杂志, 2025, 40(1): 105-109.

刘川杨, 曹昊妹, 付怡茗, 等. 基于现代药理学研究进展的西洋参归经探讨[J]. 时珍国医国药, 2022(5): 1185-1187.

Wong Z Q, Deng L, Cengnata A, et al. Expression quantitative trait loci (eQTL): From population genetics to precision medicine [J]. J Genet Genom, 2025, 52(4): 449-459.

蒋先伟, 王明航, 李慧茹, 等. 基于孟德尔随机化和GEO数据库识别支气管哮喘的潜在靶点及干预中药预测[J]. 中草药, 2025, 56(3): 919-932.

Mudappathi R, Patton T, Chen H, et al. Reg-eQTL: Integrating transcription factor effects to unveil regulatory variants [J]. Am J Hum Genet, 2025, 112(3): 659-674.

Leyden G M, Sobczyk M K, Richardson T G, et al. Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: Comparison of novel Mendelian randomization approaches [J]. Genome Med, 2025, 17(1): 54.

古丽加马力·卡哈尔, 谢汶辰, 潘思润, 等. 基于网络药理学、分子对接及细胞实验探究高良姜素诱导肝细胞癌凋亡的作用机制[J]. 中草药, 2026, 57(2): 564-573.

李涛, 葛银芳, 陈洪晓, 等. 基于网络药理学和体外实验探讨六味地黄丸治疗乳腺癌的作用机制[J]. 药物评价研究, 2026, 49(1): 156-165.

Li D, Lin J, Yang H X, et al. Causal association of modifiable factors with cardiometabolic multimorbidity: An exposome-wide Mendelian randomization investigation [J]. Cardiovasc Diabetol, 2025, 24(1): 241.

Wang X H, Cheng W M, Xu T T, et al. Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: A Mendelian randomization study [J]. Cardiovasc Diabetol, 2025, 24(1): 308.

Gudicha D W, Schmittmann V D, Vermunt J K. Statistical power of likelihood ratio and Wald tests in latent class models with covariates [J]. Behav Res Meth, 2017, 49(5): 1824-1837.

Brion M A, Shakhbazov K, Visscher P M. Calculating statistical power in Mendelian randomization studies [J]. Int J Epidemiol, 2013, 42(5): 1497-1501.

汪阳, 刘晓婷, 刘广野, 等. 基于“心合小肠”和小肠“泌别清浊”探析中医治疗心力衰竭的作用[J]. 世界中医药, 2025, 20(16): 2915-2921.

张艺琳, 卫靖靖, 王澳龙, 等. 慢性心力衰竭阳虚血瘀证疗效评价要素[J]. 中国中西医结合杂志, 2025, 45(11):1336-1342.

Pang J J, Wang J L, Zhang Y M, et al. Targeting acetaldehyde dehydrogenase 2(ALDH2) in heart failure: Recent insights and perspectives [J]. Biochim Biophys Acta BBA Mol Basis Dis, 2017, 1863(8): 1933-1941.

Martinelli A E M, Maranhão R C, Carvalho P O, et al. Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure [J]. Lipids Health Dis, 2018, 17: 242.

Fragasso G, Stolfo D, et al. The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the heart failure association of the ESC [J]. Eur J Heart Fail, 2025, 27(9): 1700-1719.

Leahy M G, Wakeham D J, MacNamara J P, et al. Heart-lung interactions in HFpEF dynamic hyperinflation and exercise PCWP [J]. JACC Heart Fail, 2025, 13(8): 102523.

Chen Y Z, Chen H, Zhang L T, et al. Mechanism of Jianxin granules in the treatment of heart failure based on proteomics and metabolomics [J]. Chin Med, 2024, 19(1): 165.

Li L, Zhang L Z, Binkley P F, et al. Regulatory variants modulate protein kinase C α (PRKCA) gene expression in human heart [J]. Pharm Res, 2017, 34(8): 1648-1657.

赵志强, 王贤良, 毛静远. 中医药治疗心力衰竭研究述评[J]. 中华中医药杂志, 2025, 40(8): 4004-4006.

母伟林, 邵欣欣, 弭志成, 等. 丹参及其药对的药理研究进展[J]. 中华中医药学刊, 2024, 42(11): 158-163.

Teixeira V H, Jacq L, Lasbleiz S, et al. Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis[J]. J Rheumatol, 2008, 35(10): 1912-1918.

Li S H, Qu X, Qin Z X, et al. Lncfos/miR-212-5p/CASP7 axis-regulated miR-212-5p protects the brain against ischemic damage [J]. Mol Neurobiol, 2023, 60(5): 2767-2785.

Beggs S A S, Petrie M C, Wright S, et al. Why do people with heart failure die? Rationale and design of the RHYTHM-HF study [J]. Eur J Heart Fail, 2025, 27(10): 1918-1926.
Güder G, Reiter T, Bauer W R, et al. Cardiac magnetic resonance imaging vs coronary angiography as primary strategy in newly diagnosed heart failure [J]. JACC Heart Fail, 2025, 13(9):102528.
Zeder K, Mak S, Galie N, et al. Right heart catheterization in heart failure: Indications, interpretation, and pitfalls [J]. Eur Heart J, 2025, 46(34): 3354-3372.
孙静, 梁雪娟. 基于中医瘀血理论探讨线粒体自噬与心力衰竭的关系[J]. 时珍国医国药, 2022, 33(11): 2718-2720.
王晶, 李莉, 刘冰, 等. 基于网络药理学和实验验证研究丹参饮治疗心衰的作用机制[J]. 中国药理学通报, 2024, 40(9): 1773-1780.
杨溶海, 方长庚, 梁建光. 丹参多酚酸盐对冠心病心力衰竭患者左心功能及血清心型脂肪酸结合蛋白的影响[J]. 中国老年学杂志, 2014, 34(9): 2323-2324.
曹灿, 董肖, 田颐, 等. 中药归经理论的历史沿革、研究现状与思考[J]. 中华中医药杂志, 2023, 38(1): 38-45.
于小刚, 辛二旦, 卢玉俊, 等. 黄芪-丹参药对防治心血管疾病的研究进展[J]. 华西药学杂志, 2025, 40(1): 105-109.
刘川杨, 曹昊妹, 付怡茗, 等. 基于现代药理学研究进展的西洋参归经探讨[J]. 时珍国医国药, 2022(5): 1185-1187.
Wong Z Q, Deng L, Cengnata A, et al. Expression quantitative trait loci (eQTL): From population genetics to precision medicine [J]. J Genet Genom, 2025, 52(4): 449-459.
蒋先伟, 王明航, 李慧茹, 等. 基于孟德尔随机化和GEO数据库识别支气管哮喘的潜在靶点及干预中药预测[J]. 中草药, 2025, 56(3): 919-932.
Mudappathi R, Patton T, Chen H, et al. Reg-eQTL: Integrating transcription factor effects to unveil regulatory variants [J]. Am J Hum Genet, 2025, 112(3): 659-674.
Leyden G M, Sobczyk M K, Richardson T G, et al. Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: Comparison of novel Mendelian randomization approaches [J]. Genome Med, 2025, 17(1): 54.
古丽加马力·卡哈尔, 谢汶辰, 潘思润, 等. 基于网络药理学、分子对接及细胞实验探究高良姜素诱导肝细胞癌凋亡的作用机制[J]. 中草药, 2026, 57(2): 564-573.
李涛, 葛银芳, 陈洪晓, 等. 基于网络药理学和体外实验探讨六味地黄丸治疗乳腺癌的作用机制[J]. 药物评价研究, 2026, 49(1): 156-165.
Li D, Lin J, Yang H X, et al. Causal association of modifiable factors with cardiometabolic multimorbidity: An exposome-wide Mendelian randomization investigation [J]. Cardiovasc Diabetol, 2025, 24(1): 241.
Wang X H, Cheng W M, Xu T T, et al. Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: A Mendelian randomization study [J]. Cardiovasc Diabetol, 2025, 24(1): 308.
Gudicha D W, Schmittmann V D, Vermunt J K. Statistical power of likelihood ratio and Wald tests in latent class models with covariates [J]. Behav Res Meth, 2017, 49(5): 1824-1837.
Brion M A, Shakhbazov K, Visscher P M. Calculating statistical power in Mendelian randomization studies [J]. Int J Epidemiol, 2013, 42(5): 1497-1501.
汪阳, 刘晓婷, 刘广野, 等. 基于“心合小肠”和小肠“泌别清浊”探析中医治疗心力衰竭的作用[J]. 世界中医药, 2025, 20(16): 2915-2921.
张艺琳, 卫靖靖, 王澳龙, 等. 慢性心力衰竭阳虚血瘀证疗效评价要素[J]. 中国中西医结合杂志, 2025, 45(11):1336-1342.
Pang J J, Wang J L, Zhang Y M, et al. Targeting acetaldehyde dehydrogenase 2(ALDH2) in heart failure: Recent insights and perspectives [J]. Biochim Biophys Acta BBA Mol Basis Dis, 2017, 1863(8): 1933-1941.
Martinelli A E M, Maranhão R C, Carvalho P O, et al. Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure [J]. Lipids Health Dis, 2018, 17: 242.
Fragasso G, Stolfo D, et al. The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the heart failure association of the ESC [J]. Eur J Heart Fail, 2025, 27(9): 1700-1719.
Leahy M G, Wakeham D J, MacNamara J P, et al. Heart-lung interactions in HFpEF dynamic hyperinflation and exercise PCWP [J]. JACC Heart Fail, 2025, 13(8): 102523.
Chen Y Z, Chen H, Zhang L T, et al. Mechanism of Jianxin granules in the treatment of heart failure based on proteomics and metabolomics [J]. Chin Med, 2024, 19(1): 165.
Li L, Zhang L Z, Binkley P F, et al. Regulatory variants modulate protein kinase C α (PRKCA) gene expression in human heart [J]. Pharm Res, 2017, 34(8): 1648-1657.
赵志强, 王贤良, 毛静远. 中医药治疗心力衰竭研究述评[J]. 中华中医药杂志, 2025, 40(8): 4004-4006.
母伟林, 邵欣欣, 弭志成, 等. 丹参及其药对的药理研究进展[J]. 中华中医药学刊, 2024, 42(11): 158-163.
Teixeira V H, Jacq L, Lasbleiz S, et al. Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis[J]. J Rheumatol, 2008, 35(10): 1912-1918.
Li S H, Qu X, Qin Z X, et al. Lncfos/miR-212-5p/CASP7 axis-regulated miR-212-5p protects the brain against ischemic damage [J]. Mol Neurobiol, 2023, 60(5): 2767-2785.

2026年第57卷第16期

PDF下载

128

引用本文

BibTeX

文章信息

doi: 10.7501/j.issn.0253-2670.2026.16.019

接收时间：2026-03-01
首发时间：2026-10-22
出版时间：2026-08-28

补充材料

相关文章

文章信息

作者

出版历史

收稿日期：2026-03-01

基金

国家自然科学基金面上项目

天津市卫健委中医中西医结合科研课题

作者信息

^1.天津中医药大学第二附属医院, 天津 300250

^2.天津中医药大学, 天津 301617

^3.天津中医药大学第二附属医院, 天津 300250

通讯作者:

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.16.019

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT