首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1319981664839774594, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1319981498787279574, articleNumber=PA20260909_xUuQF8Im, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.16.012, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1772553600000, receivedDateStr=2026-03-04, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792637752971, onlineDateStr=2026-10-22, pubDate=1787846400000, pubDateStr=2026-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792637752970, onlineIssueDateStr=2026-10-22, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792637752970, creator=admin, updateTime=1792637752970, updator=admin, issue=Issue{id=1319981498787279574, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='16', pageStart='6209', pageEnd='6660', issueExtLink='null', onlineDate='null', pubDate='1787846400000', pubDateStr='2026-08-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792637713380, creator='ztmeta', updateTime=1792637713380, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=6356, endPage=6370, ext={EN=ArticleExt(id=1319981669055050117, articleId=1319981664839774594, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Effect and mechanism of cuttlebone/bovine serum albumin photocrosslinked hydrogel on promoting bone healing, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To investigate the effect and potential mechanism of cuttlebone (CB)/bovine serum albumin (BSA) photocrosslinked hydrogel on rats with critical sized bone defects (CSBD) model in skull tissues. Methods SD rats were randomly divided into control group, positive control group, BSA group, 0.5% CB/BSA group, 1.5% CB/BSA group and 3.0% CB/BSA group, with six rats in each group. A rat CSBD model was established using a 5 mm outer diameter ring drill, while the control group only underwent modeling without implants, positive control group implanted with Bio-Oss® collagen bone filling material, CB/BSA photocrosslinked hydrogels with CB mass fraction of 0, 0.5%, 1.5% and 3% were implanted in BSA group, 0.5% CB/BSA group, 1.5% CB/BSA group and 3.0% CB/BSA group, respectively. After eight weeks after surgery, the microstructural changes of bone tissue were analyzed using micro computed tomography (Micro CT). Hematoxylin-eosin (HE) and Masson staining were used to observe pathological changes in skull tissue. Immunohistochemistry and immunofluorescence were used to detect the positive expressions and fluorescence intensity of collagen type I alpha 1 (COL1A1), platelet endothelial cell adhesion molecule-1 (PECAM-1) and osteocalcin (OCN) in skull tissue, respectively. qRT-PCR and Western blotting were used to detect the gene and protein expressions of Wnt family members 3A (WNT3A), β-catenin, vascular endothelial growth factor A (VEGFA), COL1A1, PECAM-1 and OCN in skull tissue, respectively. In order to evaluate the safety of hydrogel in vivo, the abdominal aorta blood of rats was collected to analyze the changes of blood routine and serum liver and kidney function indexes. Results Micro-CT results showed that no new bone formation was observed in the bone defect area of rats in control group, indicating that bone healing was not achieved during the observation period. The pathological tissue section results showed that the defect area in control group was mainly composed of loose fibrous tissue. In CB/BSA photocrosslinked hydrogel group, new bone formation was observed. Compared with control group, bone volume/tissue volume (BV/TV), bone mineral density (BMD and trabecular thickness (Tb.Th) of rats in CB/BSA photocrosslinked hydrogel group were significantly increased (P < 0.05), bone surface/bone volume (BS/BV) was significantly decreased (P < 0.05), the positive expressions and fluorescence intensity of COL1A1, PECAM-1, OCN in skull tissue were significantly increased (P < 0.05), and the expression levels of COL1A1, PECAM-1, β-catenin, WNT3A, VEGFA, OCN were significantly increased (P < 0.05), among which, the 3.0% CB/BSA photocrosslinked hydrogel group had the best comprehensive effect. No significant abnormalities were found in the blood routine and serum liver and kidney function indicators of rats in each group, and no pathological changes such as inflammation, necrosis or fibrosis were observed in the main organs. Conclusion CB/BSA photocrosslinked hydrogel shows good bone repair effect and safety in vivo, and its osteogenic effect may be mediated by activation of Wnt/β-catenin signaling pathway., authors=WU Sixian1,2, ZHUO Tao1,2, WANG Guowei1,2, LI Mengying2, HE Yi1,2, LIU Jianhang2, authorsList=WU Sixian, ZHUO Tao, WANG Guowei, LI Mengying, HE Yi, LIU Jianhang, authorCompany=1 Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China;
2 Department of Orthopedics and Traumatology, Beihai Hospital of Chinese Medicine, Beihai 536006, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319981668962775428, articleId=1319981664839774594, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=海螵蛸/牛血清白蛋白光交联水凝胶促进骨愈合作用及机制, columnId=1304140191707456168, journalTitle=中草药, columnName=药理与临床, runingTitle=null, highlight=null, articleAbstract=目的 探讨海螵蛸（cuttlebone，CB）/牛血清白蛋白（bovine serum albumin，BSA）光交联水凝胶干预大鼠颅骨临界尺寸骨缺损（critical-sized bone defects，CSBD）模型的作用与潜在机制。方法 SD大鼠随机分为对照组、阳性对照组、BSA组、0.5% CB/BSA组、1.5% CB/BSA组和3.0% CB/BSA组，每组6只。采用5 mm外径环钻建立大鼠CSBD模型，对照组仅造模，无植入物；阳性对照组植入Bio-Oss® Collagen骨填充材料；BSA组、0.5% CB/BSA组、1.5% CB/BSA组和3.0% CB/BSA组分别植入CB质量分数为0、0.5%、1.5%和3%的CB/BSA光交联水凝胶。术后8周，通过微型计算机断层扫描（micro-computed tomography，Micro-CT）对骨组织微结构变化进行分析；苏木素-伊红（hematoxylin-eosin，HE）和Masson染色观察颅骨组织病理改变；免疫组化和免疫荧光法分别检测颅骨组织I型胶原α1（collagen type I alpha 1，COL1A1）、血小板内皮细胞黏附分子-1（platelet endothelial cell adhesion molecule-1，PECAM-1）及骨钙素（osteocalcin，OCN）的阳性表达及荧光强度；qRT-PCR和Western blotting分别检测颅骨组织Wnt家族成员3A（Wnt family members 3A，WNT3A）、β-连环蛋白（β-catenin）、血管内皮生长因子A（vascular endothelial growth factor A，VEGFA）、COL1A1、PECAM-1、OCN的基因及蛋白表达。为评估水凝胶的体内安全性，采集大鼠腹主动脉血分析血常规和血清肝肾功能指标变化。结果 Micro-CT结果显示，对照组大鼠骨缺损区未见新生骨形成，表明其在观察期内未能实现骨性愈合。病理组织切片结果显示，对照组缺损区以疏松的纤维组织为主；而CB/BSA光交联水凝胶组可见新骨形成。与对照组比较，CB/BSA光交联水凝胶组大鼠的骨体积分数、骨密度、骨小梁厚度显著升高（P＜0.05），骨表面积与骨体积比显著降低（P＜0.05），颅骨组织COL1A1、PECAM-1、OCN阳性表达和荧光强度显著增加（P＜0.05），COL1A1、PECAM-1、β-catenin、WNT3A、VEGFA、OCN的表达水平显著上调（P＜0.05），其中以3.0% CB/BSA光交联水凝胶组的综合效果最佳。各组大鼠血常规和血清肝肾功能指标均未见明显异常，主要脏器未见炎症、坏死或纤维化等病理改变。结论 CB/BSA光交联水凝胶展现出良好的骨修复作用与体内安全性，其促成骨效应可能是通过激活Wnt/β-catenin信号通路介导。, authors=吴思贤1,2, 卓涛1,2, 王国威1,2, 李梦颖2, 何毅1,2, 刘建航2, authorsList=吴思贤, 卓涛, 王国威, 李梦颖, 何毅, 刘建航, authorCompany=1 广西中医药大学研究生院, 广西 南宁 530200;
2 北海市中医医院 骨伤科, 广西北海 536006, correspAuthors=刘建航, authorNote=吴思贤: 吴思贤,博士研究生,研究方向为中医骨伤科学。E-mail:494090516@qq.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=https://oss.bj-dx-dzqywjd-hlw-icp.inspurcloudoss.com:6063/cast-journal-prod/2097521198041731073/excel/pdfs/1c844938b5294e62b6cc727119cb8f4e.pdf?response-content-disposition=attachment%3B%20filename%3D%2220261612.pdf%22&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20261022T025340Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=NjRlNmUzOGMtM2Y3OC00MDQ3LThkMmYtN2JkODRmYmI3MTgw%2F20261022%2Fbj-dx-dzqywjd-hlw-icp%2Fs3%2Faws4_request&X-Amz-Signature=4af4f8d4884bd2dee5ad7db06cd9aebc3369e9a55a27aff15aa9e1617a7cc981, pdf=vkZafg9RF6Bc+N/WtoiuCw==, pdfFileSize=1929387, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金地区基金项目 (8216140594); 广西壮族自治区科技厅自然科学基金项目 (2022JJA140818); 广西中医药大学2025年校级博士研究生科研创新项目 (YCBXJ2025026); 广西中医药大学2025年自治区级硕士研究生科研创新项目 (YCSW2025452); 广西中医药大学研究生科研创新项目 (YCLT2025008); 北海市科技局研发项 (北科合2023258021))}, authors=[Author(id=1319981671085093260, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=吴思贤, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981671164785039, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981671085093260, language=CN, stringName=吴思贤, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,2,, address=1.广西中医药大学研究生院, 广西 南宁 530200,3广西中医药大学研究生院, 广西 南宁 530200, bio=吴思贤: 吴思贤,博士研究生,研究方向为中医骨伤科学。E-mail:494090516@qq.com, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981671441609104, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=卓涛, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981671546466708, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981671441609104, language=CN, stringName=卓涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,2,, address=1.广西中医药大学研究生院, 广西 南宁 530200,3广西中医药大学研究生院, 广西 南宁 530200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981671848456597, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=王国威, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981671957508504, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981671848456597, language=CN, stringName=王国威, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,2,, address=1.广西中医药大学研究生院, 广西 南宁 530200,3广西中医药大学研究生院, 广西 南宁 530200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981672343384473, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=李梦颖, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981672699900316, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981672343384473, language=CN, stringName=李梦颖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2,, address=3北海市中医医院 骨伤科, 广西北海 536006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981672750231965, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=何毅, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981672838312352, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981672750231965, language=CN, stringName=何毅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,2,, address=1.广西中医药大学研究生院, 广西 南宁 530200,3广西中医药大学研究生院, 广西 南宁 530200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981672913809825, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=刘建航, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981673001890211, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981672913809825, language=CN, stringName=刘建航, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2,, address=3北海市中医医院 骨伤科, 广西北海 536006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])])], keywords=[Keyword(id=1322633164527354004, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=CN, orderNo=1, keyword=海螵蛸), Keyword(id=1322633164628017301, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=CN, orderNo=2, keyword=牛血清白蛋白), Keyword(id=1322633164690931862, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=CN, orderNo=3, keyword=光交联水凝胶), Keyword(id=1322633164753846423, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=CN, orderNo=4, keyword=骨修复), Keyword(id=1322633164829343896, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=CN, orderNo=5, keyword=Wnt/β-catenin信号通路), Keyword(id=1322633164959367321, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=EN, orderNo=1, keyword=cuttlebone), Keyword(id=1322633165026476186, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=EN, orderNo=2, keyword=bovine serum albumin), Keyword(id=1322633165089390747, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=EN, orderNo=3, keyword=photocrosslinked hydrogel), Keyword(id=1322633166750335132, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=EN, orderNo=4, keyword=bone repair), Keyword(id=1322633166842609821, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, language=EN, orderNo=5, keyword=Wnt/β-catenin signaling pathway)], refs=[Reference(id=1319981675912737204, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=1, rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=Fernandez de Grado G, Keller L, Idoux-Gillet Y, et al. Bone substitutes: A review of their characteristics, clinical use, and perspectives for large bone defects management [J]. J Tissue Eng, 2018, 9: 2041731418776819., articleTitle=null, refAbstract=null), Reference(id=1319981675916931509, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=2, rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=Jimi E, Hirata S, Osawa K, et al. The current and future therapies of bone regeneration to repair bone defects [J]. Int J Dent, 2012, 2012: 148261., articleTitle=null, refAbstract=null), Reference(id=1319981675916931510, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=3, rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=Huang L, Guo Z Y, Yang X X, et al. Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration [J]. Theranostics, 2025, 15(2): 460-493., articleTitle=null, refAbstract=null), Reference(id=1319981675916931511, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=4, rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=Ferracci G, Zhu M X, Ibrahim M S, et al. Photocurable albumin methacryloyl hydrogels as a versatile platform for tissue engineering [J]. ACS Appl Bio Mater, 2020, 3(2): 920-934., articleTitle=null, refAbstract=null), Reference(id=1319981675916931512, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=5, rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=覃淮, 杨宽, 伍静, 等. 光交联甲基丙烯酸水凝胶在伤口修复中的研究进展[J]. 中国塑料, 2025, 39(10): 141-150., articleTitle=null, refAbstract=null), Reference(id=1319981675916931513, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=6, rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=Huang Y Q, Zhu Q C, Zhu Y, et al. Rapid UV photo-cross-linking of α-lactalbumin hydrogel biomaterial to enable wound healing [J]. ACS Omega, 2024, 9(1): 401-412., articleTitle=null, refAbstract=null), Reference(id=1319981675916931514, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=7, rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=陈兴华. 海螵蛸的药用认识沿革[J]. 中药材, 2024, 47(7): 1840-1846., articleTitle=null, refAbstract=null), Reference(id=1319981675916931515, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=8, rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=刘睿, 魏爽, 王欣之, 等. 海螵蛸蛋白质、肽类物质基础研究[J]. 中国中药杂志, 2020, 45(16): 3883-3889., articleTitle=null, refAbstract=null), Reference(id=1319981675916931516, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=9, rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=Mao A R, Zhao N F, Liang Y H, et al. Mechanically efficient cellular materials inspired by cuttlebone [J]. Adv Mater, 2021, 33(15): 2007348., articleTitle=null, refAbstract=null), Reference(id=1319981675916931517, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=10, rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=Barrera Bernal J L, Gaytán Salvatella Í, del Campo B I M, et al. Synthesis of hydroxyapatite-gelatin composite hydrogel for bone tissue application [J]. Gels, 2025, 11(8): 630., articleTitle=null, refAbstract=null), Reference(id=1319981675916931518, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=11, rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=Sudhakar M P, Ali S, Chitra S. Scrutinizing the effect of rGO-cuttlefish bone hydroxyapatite composite infused carrageenan membrane towards wound reconstruction [J]. Int J Biol Macromol, 2024, 262: 130155., articleTitle=null, refAbstract=null), Reference(id=1319981675916931519, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=12, rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=Chen Y, Zhai M J, Mehwish N, et al. Comparison of globular albumin methacryloyl and random-coil gelatin methacryloyl: Preparation, hydrogel properties, cell behaviors, and mineralization [J]. Int J Biol Macromol, 2022, 204: 692-708., articleTitle=null, refAbstract=null), Reference(id=1319981675916931520, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=13, rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=Tan B Z, Liu X, Chen S, et al. An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1/Akt signaling [J]. J Adv Res, 2026, 80:411-422., articleTitle=null, refAbstract=null), Reference(id=1319981675916931521, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=14, rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=Liu Y, Fang J R, Zhang Q, et al. Wnt10b-overexpressing umbilical cord mesenchymal stem cells promote critical size rat calvarial defect healing by enhanced osteogenesis and VEGF-mediated angiogenesis [J]. J Orthop Transl, 2020, 23: 29-37., articleTitle=null, refAbstract=null), Reference(id=1319981675916931522, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=15, rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=赵越, 许燕, 周建平, 等. 骨组织工程中传统与仿生支架结构设计的差异[J]. 中国组织工程研究, 2025, 29(16):3458-3468., articleTitle=null, refAbstract=null), Reference(id=1319981675916931523, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=16, rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=刘潇, 郑晓勇, 刘道宏, 等. 骨组织工程生物材料结构改性策略的研究进展[J]. 中华骨与关节外科杂志, 2025, 18(5):462-469., articleTitle=null, refAbstract=null), Reference(id=1319981675916931524, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=17, rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=Fu J, in het Panhuis M. Hydrogel properties and applications [J]. J Mater Chem B, 2019, 7(10): 1523-1525., articleTitle=null, refAbstract=null), Reference(id=1319981675916931525, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=18, rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=王霏扬, 马语卓, 吕雪蓉, 等. 牙周疾病动物模型复制研究进展[J]. 四川大学学报: 医学版, 2025, 56(2): 339-344., articleTitle=null, refAbstract=null), Reference(id=1319981675916931526, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=19, rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=孙明策, 徐珊珊, 金明, 等. 脂肪间充质干细胞联合三维水凝胶支架在大鼠颅骨缺损修复中的成骨效应[J]. 中国老年学杂志, 2025, 45(13): 3196-3200., articleTitle=null, refAbstract=null), Reference(id=1319981675916931527, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=20, rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=巫旭娜, 许碧莲, 田佳, 等. 用Micro-CT评价大鼠骨质疏松合并骨性关节炎模型[J]. 中国老年学杂志, 2020, 40(5): 1044-1047., articleTitle=null, refAbstract=null), Reference(id=1319981675916931528, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=21, rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=Kanczler J M, Oreffo R O C. Osteogenesis and angiogenesis: The potential for engineering bone [J]. Eur Cell Mater, 2008, 15: 100-114., articleTitle=null, refAbstract=null), Reference(id=1319981675916931529, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=22, rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=Eyre D R, Weis M A. Bone collagen: New clues to its mineralization mechanism from recessive osteogenesis imperfecta [J]. Calcif Tissue Int, 2013, 93(4): 338-347., articleTitle=null, refAbstract=null), Reference(id=1319981675916931530, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=23, rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=Chen X, Chen J S, Xu D L, et al. Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs [J]. BMC Musculoskelet Disord, 2017, 18(1): 423., articleTitle=null, refAbstract=null), Reference(id=1319981675916931531, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=24, rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=Yang M, Li C J, Xiao Y, et al. Ophiopogonin D promotes bone regeneration by stimulating CD31hiEMCNhi vessel formation [J]. Cell Prolif, 2020, 53(3): e12784., articleTitle=null, refAbstract=null), Reference(id=1319981675916931532, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=25, rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=Wei Y Q, Ju M M, Zheng F, et al. Cuttlebone-derived organic matrix: A facile periosteum substitute for bone regeneration [J]. Adv Funct Mater, 2023, 33(31): 2214095., articleTitle=null, refAbstract=null), Reference(id=1319981675921125814, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=26, rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=Hu K, Olsen B R.Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair [J]. J Clin Investig, 2016, 126(2): 509-526., articleTitle=null, refAbstract=null), Reference(id=1319981675921125815, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=27, rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=雷群, 林东, 黄文秀, 等. 钙离子对人成骨细胞迁移与成骨分化的影响[J]. 华西口腔医学杂志, 2018, 36(6): 602-608., articleTitle=null, refAbstract=null), Reference(id=1319981675921125816, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=28, rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=张崛, 冯玉旭, 徐勇, 等. 钙敏感受体缺失对小鼠成骨细胞增殖与分化的影响及机制研究[J]. 中华创伤骨科杂志, 2013, 15(5): 430-434., articleTitle=null, refAbstract=null), Reference(id=1319981675921125817, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=29, rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=杨刚, 刘鑫, 王元银. 牙源性双相磷酸钙与两种临床骨替代材料在兔上颌窦中成骨效果的对比研究[J]. 安徽医科大学学报, 2022, 57(11): 1699-1704., articleTitle=null, refAbstract=null), Reference(id=1319981675921125818, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=30, rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=席雪瑶, 高亚男, 王加启, 等. 锶的成骨机制及富锶食品的研发现状[J]. 现代食品科技, 2023, 39(9): 380-392., articleTitle=null, refAbstract=null), Reference(id=1319981675921125819, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=31, rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=宋跃, 郭澍, 吕梦竹, 等. 锶通过CaSR途径促进脂肪来源干细胞成骨分化的研究[J]. 中国美容整形外科杂志, 2018, 29(8):478-481., articleTitle=null, refAbstract=null), Reference(id=1319981675921125820, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=32, rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=马振, 孙伟, 叶丹丹, 等. 含镁介孔生物活性玻璃/锌黄长石复合支架的成骨活性[J]. 硅酸盐学报, 2022, 50(7): 1964-1971., articleTitle=null, refAbstract=null), Reference(id=1319981675921125821, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=33, rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=钟宁莹, 王丽萍. 锶成骨机制的研究进展[J]. 华西口腔医学杂志, 2020, 38(6): 697-703., articleTitle=null, refAbstract=null), Reference(id=1319981675921125822, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=34, rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=Ye J T, Miao B Z, Xiong Y J, et al. 3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair: Enhancing angiogenesis and osteogenesis [J]. J Nanobiotechnol, 2025, 23(1): 160., articleTitle=null, refAbstract=null), Reference(id=1319981675921125823, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=35, rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=Liu W J, Sun J, Sun Y, et al. Multifunctional injectable protein-based hydrogel for bone regeneration [J]. Chem Eng J, 2020, 394: 124875., articleTitle=null, refAbstract=null), Reference(id=1319981675921125824, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=36, rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=程若昱, 燕宇飞, 陈皓, 等. 双效骨诱导性的有机-无机水凝胶的构建及其骨再生研究[J]. 上海交通大学学报: 医学版, 2018, 38(8): 900-909., articleTitle=null, refAbstract=null)], funds=[Fund(id=1319981675463946670, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, awardId=2097521931025715202, language=CN, fundingSource=国家自然科学基金地区基金项目, fundOrder=null, country=null), Fund(id=1319981675522666927, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, awardId=2097521931025715203, language=CN, fundingSource=广西壮族自治区科技厅自然科学基金项目, fundOrder=null, country=null), Fund(id=1319981675606553008, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, awardId=2097521931025715204, language=CN, fundingSource=广西中医药大学2025年校级博士研究生科研创新项目, fundOrder=null, country=null), Fund(id=1319981675682050481, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, awardId=2097521931029909506, language=CN, fundingSource=广西中医药大学2025年自治区级硕士研究生科研创新项目, fundOrder=null, country=null), Fund(id=1319981675744965042, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, awardId=2097521931029909507, language=CN, fundingSource=广西中医药大学研究生科研创新项目, fundOrder=null, country=null), Fund(id=1319981675799490995, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, awardId=2097521931029909508, language=CN, fundingSource=北海市科技局研发项, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981670795686280, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=2, ext=[AuthorCompanyExt(id=1319981670804074889, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981670795686280, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=2.北海市中医医院 骨伤科, 广西北海 536006)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])], figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.16.012, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.16.012, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.16.012, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.16.012, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1787846400000, fullTextJson=null, articleText=null, reference=Fernandez de Grado G, Keller L, Idoux-Gillet Y, et al. Bone substitutes: A review of their characteristics, clinical use, and perspectives for large bone defects management [J]. J Tissue Eng, 2018, 9: 2041731418776819.
Jimi E, Hirata S, Osawa K, et al. The current and future therapies of bone regeneration to repair bone defects [J]. Int J Dent, 2012, 2012: 148261.
Huang L, Guo Z Y, Yang X X, et al. Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration [J]. Theranostics, 2025, 15(2): 460-493.
Ferracci G, Zhu M X, Ibrahim M S, et al. Photocurable albumin methacryloyl hydrogels as a versatile platform for tissue engineering [J]. ACS Appl Bio Mater, 2020, 3(2): 920-934.
覃淮, 杨宽, 伍静, 等. 光交联甲基丙烯酸水凝胶在伤口修复中的研究进展[J]. 中国塑料, 2025, 39(10): 141-150.
Huang Y Q, Zhu Q C, Zhu Y, et al. Rapid UV photo-cross-linking of α-lactalbumin hydrogel biomaterial to enable wound healing [J]. ACS Omega, 2024, 9(1): 401-412.
陈兴华. 海螵蛸的药用认识沿革[J]. 中药材, 2024, 47(7): 1840-1846.
刘睿, 魏爽, 王欣之, 等. 海螵蛸蛋白质、肽类物质基础研究[J]. 中国中药杂志, 2020, 45(16): 3883-3889.
Mao A R, Zhao N F, Liang Y H, et al. Mechanically efficient cellular materials inspired by cuttlebone [J]. Adv Mater, 2021, 33(15): 2007348.
Barrera Bernal J L, Gaytán Salvatella Í, del Campo B I M, et al. Synthesis of hydroxyapatite-gelatin composite hydrogel for bone tissue application [J]. Gels, 2025, 11(8): 630.
Sudhakar M P, Ali S, Chitra S. Scrutinizing the effect of rGO-cuttlefish bone hydroxyapatite composite infused carrageenan membrane towards wound reconstruction [J]. Int J Biol Macromol, 2024, 262: 130155.
Chen Y, Zhai M J, Mehwish N, et al. Comparison of globular albumin methacryloyl and random-coil gelatin methacryloyl: Preparation, hydrogel properties, cell behaviors, and mineralization [J]. Int J Biol Macromol, 2022, 204: 692-708.
Tan B Z, Liu X, Chen S, et al. An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1/Akt signaling [J]. J Adv Res, 2026, 80:411-422.
Liu Y, Fang J R, Zhang Q, et al. Wnt10b-overexpressing umbilical cord mesenchymal stem cells promote critical size rat calvarial defect healing by enhanced osteogenesis and VEGF-mediated angiogenesis [J]. J Orthop Transl, 2020, 23: 29-37.
赵越, 许燕, 周建平, 等. 骨组织工程中传统与仿生支架结构设计的差异[J]. 中国组织工程研究, 2025, 29(16):3458-3468.
刘潇, 郑晓勇, 刘道宏, 等. 骨组织工程生物材料结构改性策略的研究进展[J]. 中华骨与关节外科杂志, 2025, 18(5):462-469.
Fu J, in het Panhuis M. Hydrogel properties and applications [J]. J Mater Chem B, 2019, 7(10): 1523-1525.
王霏扬, 马语卓, 吕雪蓉, 等. 牙周疾病动物模型复制研究进展[J]. 四川大学学报: 医学版, 2025, 56(2): 339-344.
孙明策, 徐珊珊, 金明, 等. 脂肪间充质干细胞联合三维水凝胶支架在大鼠颅骨缺损修复中的成骨效应[J]. 中国老年学杂志, 2025, 45(13): 3196-3200.
巫旭娜, 许碧莲, 田佳, 等. 用Micro-CT评价大鼠骨质疏松合并骨性关节炎模型[J]. 中国老年学杂志, 2020, 40(5): 1044-1047.
Kanczler J M, Oreffo R O C. Osteogenesis and angiogenesis: The potential for engineering bone [J]. Eur Cell Mater, 2008, 15: 100-114.
Eyre D R, Weis M A. Bone collagen: New clues to its mineralization mechanism from recessive osteogenesis imperfecta [J]. Calcif Tissue Int, 2013, 93(4): 338-347.
Chen X, Chen J S, Xu D L, et al. Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs [J]. BMC Musculoskelet Disord, 2017, 18(1): 423.
Yang M, Li C J, Xiao Y, et al. Ophiopogonin D promotes bone regeneration by stimulating CD31hiEMCNhi vessel formation [J]. Cell Prolif, 2020, 53(3): e12784.
Wei Y Q, Ju M M, Zheng F, et al. Cuttlebone-derived organic matrix: A facile periosteum substitute for bone regeneration [J]. Adv Funct Mater, 2023, 33(31): 2214095.
Hu K, Olsen B R.Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair [J]. J Clin Investig, 2016, 126(2): 509-526.
雷群, 林东, 黄文秀, 等. 钙离子对人成骨细胞迁移与成骨分化的影响[J]. 华西口腔医学杂志, 2018, 36(6): 602-608.
张崛, 冯玉旭, 徐勇, 等. 钙敏感受体缺失对小鼠成骨细胞增殖与分化的影响及机制研究[J]. 中华创伤骨科杂志, 2013, 15(5): 430-434.
杨刚, 刘鑫, 王元银. 牙源性双相磷酸钙与两种临床骨替代材料在兔上颌窦中成骨效果的对比研究[J]. 安徽医科大学学报, 2022, 57(11): 1699-1704.
席雪瑶, 高亚男, 王加启, 等. 锶的成骨机制及富锶食品的研发现状[J]. 现代食品科技, 2023, 39(9): 380-392.
宋跃, 郭澍, 吕梦竹, 等. 锶通过CaSR途径促进脂肪来源干细胞成骨分化的研究[J]. 中国美容整形外科杂志, 2018, 29(8):478-481.
马振, 孙伟, 叶丹丹, 等. 含镁介孔生物活性玻璃/锌黄长石复合支架的成骨活性[J]. 硅酸盐学报, 2022, 50(7): 1964-1971.
钟宁莹, 王丽萍. 锶成骨机制的研究进展[J]. 华西口腔医学杂志, 2020, 38(6): 697-703.
Ye J T, Miao B Z, Xiong Y J, et al. 3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair: Enhancing angiogenesis and osteogenesis [J]. J Nanobiotechnol, 2025, 23(1): 160.
Liu W J, Sun J, Sun Y, et al. Multifunctional injectable protein-based hydrogel for bone regeneration [J]. Chem Eng J, 2020, 394: 124875.
程若昱, 燕宇飞, 陈皓, 等. 双效骨诱导性的有机-无机水凝胶的构建及其骨再生研究[J]. 上海交通大学学报: 医学版, 2018, 38(8): 900-909.)
收藏切换
海螵蛸/牛血清白蛋白光交联水凝胶促进骨愈合作用及机制
收藏切换
PDF下载
吴思贤 1,2, , 卓涛 1,2, , 王国威 1,2, , 李梦颖 2, , 何毅 1,2, , 刘建航 2,
中草药 | 药理与临床 2026,57(16): 6356-6370
收起
收藏切换
中草药 |药理与临床 2026 , 57 (16) : 6356 -6370
海螵蛸/牛血清白蛋白光交联水凝胶促进骨愈合作用及机制
全屏
[Author(id=1319981671085093260, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=吴思贤, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981671164785039, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981671085093260, language=CN, stringName=吴思贤, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,2,, address=1.广西中医药大学研究生院, 广西 南宁 530200,3广西中医药大学研究生院, 广西 南宁 530200, bio=吴思贤: 吴思贤,博士研究生,研究方向为中医骨伤科学。E-mail:494090516@qq.com, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981671441609104, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=卓涛, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981671546466708, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981671441609104, language=CN, stringName=卓涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,2,, address=1.广西中医药大学研究生院, 广西 南宁 530200,3广西中医药大学研究生院, 广西 南宁 530200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981671848456597, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=王国威, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981671957508504, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981671848456597, language=CN, stringName=王国威, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,2,, address=1.广西中医药大学研究生院, 广西 南宁 530200,3广西中医药大学研究生院, 广西 南宁 530200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981672343384473, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=李梦颖, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981672699900316, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981672343384473, language=CN, stringName=李梦颖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2,, address=3北海市中医医院 骨伤科, 广西北海 536006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981672750231965, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=何毅, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981672838312352, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981672750231965, language=CN, stringName=何毅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,2,, address=1.广西中医药大学研究生院, 广西 南宁 530200,3广西中医药大学研究生院, 广西 南宁 530200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981669336068486, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=1, ext=[AuthorCompanyExt(id=1319981669357040007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981669336068486, language=CN, country=null, province=null, city=null, postcode=null, companyName=广西中医药大学研究生院, 广西 南宁 530200, departmentName=null, remark=1.广西中医药大学研究生院, 广西 南宁 530200)]), AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])]), Author(id=1319981672913809825, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=刘建航, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981673001890211, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, authorId=1319981672913809825, language=CN, stringName=刘建航, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2,, address=3北海市中医医院 骨伤科, 广西北海 536006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981671009595786, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, xref=3*, ext=[AuthorCompanyExt(id=1319981671013790091, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981664839774594, companyId=1319981671009595786, language=CN, country=null, province=null, city=null, postcode=null, companyName=北海市中医医院 骨伤科, 广西北海 536006, departmentName=null, remark=3.北海市中医医院 骨伤科, 广西北海 536006)])])]
吴思贤1,2,, 卓涛1,2,, 王国威1,2,, 李梦颖2,, 何毅1,2,, 刘建航2,
作者信息
  • 1.广西中医药大学研究生院, 广西 南宁 530200
  • 2.北海市中医医院 骨伤科, 广西北海 536006
  • 3.北海市中医医院 骨伤科, 广西北海 536006
通讯作者:
刘建航
作者简介:
吴思贤: 吴思贤,博士研究生,研究方向为中医骨伤科学。E-mail:494090516@qq.com
Effect and mechanism of cuttlebone/bovine serum albumin photocrosslinked hydrogel on promoting bone healing
Affiliations
出版时间: 2026-08-28 doi: 10.7501/j.issn.0253-2670.2026.16.012
文章导航
收藏切换
摘要
收起
目的 探讨海螵蛸（cuttlebone，CB）/牛血清白蛋白（bovine serum albumin，BSA）光交联水凝胶干预大鼠颅骨临界尺寸骨缺损（critical-sized bone defects，CSBD）模型的作用与潜在机制。方法 SD大鼠随机分为对照组、阳性对照组、BSA组、0.5% CB/BSA组、1.5% CB/BSA组和3.0% CB/BSA组，每组6只。采用5 mm外径环钻建立大鼠CSBD模型，对照组仅造模，无植入物；阳性对照组植入Bio-Oss® Collagen骨填充材料；BSA组、0.5% CB/BSA组、1.5% CB/BSA组和3.0% CB/BSA组分别植入CB质量分数为0、0.5%、1.5%和3%的CB/BSA光交联水凝胶。术后8周，通过微型计算机断层扫描（micro-computed tomography，Micro-CT）对骨组织微结构变化进行分析；苏木素-伊红（hematoxylin-eosin，HE）和Masson染色观察颅骨组织病理改变；免疫组化和免疫荧光法分别检测颅骨组织I型胶原α1（collagen type I alpha 1，COL1A1）、血小板内皮细胞黏附分子-1（platelet endothelial cell adhesion molecule-1，PECAM-1）及骨钙素（osteocalcin，OCN）的阳性表达及荧光强度；qRT-PCR和Western blotting分别检测颅骨组织Wnt家族成员3A（Wnt family members 3A，WNT3A）、β-连环蛋白（β-catenin）、血管内皮生长因子A（vascular endothelial growth factor A，VEGFA）、COL1A1、PECAM-1、OCN的基因及蛋白表达。为评估水凝胶的体内安全性，采集大鼠腹主动脉血分析血常规和血清肝肾功能指标变化。结果 Micro-CT结果显示，对照组大鼠骨缺损区未见新生骨形成，表明其在观察期内未能实现骨性愈合。病理组织切片结果显示，对照组缺损区以疏松的纤维组织为主；而CB/BSA光交联水凝胶组可见新骨形成。与对照组比较，CB/BSA光交联水凝胶组大鼠的骨体积分数、骨密度、骨小梁厚度显著升高（P＜0.05），骨表面积与骨体积比显著降低（P＜0.05），颅骨组织COL1A1、PECAM-1、OCN阳性表达和荧光强度显著增加（P＜0.05），COL1A1、PECAM-1、β-catenin、WNT3A、VEGFA、OCN的表达水平显著上调（P＜0.05），其中以3.0% CB/BSA光交联水凝胶组的综合效果最佳。各组大鼠血常规和血清肝肾功能指标均未见明显异常，主要脏器未见炎症、坏死或纤维化等病理改变。结论 CB/BSA光交联水凝胶展现出良好的骨修复作用与体内安全性，其促成骨效应可能是通过激活Wnt/β-catenin信号通路介导。
海螵蛸  /  牛血清白蛋白  /  光交联水凝胶  /  骨修复  /  Wnt/β-catenin信号通路
Objective To investigate the effect and potential mechanism of cuttlebone (CB)/bovine serum albumin (BSA) photocrosslinked hydrogel on rats with critical sized bone defects (CSBD) model in skull tissues. Methods SD rats were randomly divided into control group, positive control group, BSA group, 0.5% CB/BSA group, 1.5% CB/BSA group and 3.0% CB/BSA group, with six rats in each group. A rat CSBD model was established using a 5 mm outer diameter ring drill, while the control group only underwent modeling without implants, positive control group implanted with Bio-Oss® collagen bone filling material, CB/BSA photocrosslinked hydrogels with CB mass fraction of 0, 0.5%, 1.5% and 3% were implanted in BSA group, 0.5% CB/BSA group, 1.5% CB/BSA group and 3.0% CB/BSA group, respectively. After eight weeks after surgery, the microstructural changes of bone tissue were analyzed using micro computed tomography (Micro CT). Hematoxylin-eosin (HE) and Masson staining were used to observe pathological changes in skull tissue. Immunohistochemistry and immunofluorescence were used to detect the positive expressions and fluorescence intensity of collagen type I alpha 1 (COL1A1), platelet endothelial cell adhesion molecule-1 (PECAM-1) and osteocalcin (OCN) in skull tissue, respectively. qRT-PCR and Western blotting were used to detect the gene and protein expressions of Wnt family members 3A (WNT3A), β-catenin, vascular endothelial growth factor A (VEGFA), COL1A1, PECAM-1 and OCN in skull tissue, respectively. In order to evaluate the safety of hydrogel in vivo, the abdominal aorta blood of rats was collected to analyze the changes of blood routine and serum liver and kidney function indexes. Results Micro-CT results showed that no new bone formation was observed in the bone defect area of rats in control group, indicating that bone healing was not achieved during the observation period. The pathological tissue section results showed that the defect area in control group was mainly composed of loose fibrous tissue. In CB/BSA photocrosslinked hydrogel group, new bone formation was observed. Compared with control group, bone volume/tissue volume (BV/TV), bone mineral density (BMD and trabecular thickness (Tb.Th) of rats in CB/BSA photocrosslinked hydrogel group were significantly increased (P < 0.05), bone surface/bone volume (BS/BV) was significantly decreased (P < 0.05), the positive expressions and fluorescence intensity of COL1A1, PECAM-1, OCN in skull tissue were significantly increased (P < 0.05), and the expression levels of COL1A1, PECAM-1, β-catenin, WNT3A, VEGFA, OCN were significantly increased (P < 0.05), among which, the 3.0% CB/BSA photocrosslinked hydrogel group had the best comprehensive effect. No significant abnormalities were found in the blood routine and serum liver and kidney function indicators of rats in each group, and no pathological changes such as inflammation, necrosis or fibrosis were observed in the main organs. Conclusion CB/BSA photocrosslinked hydrogel shows good bone repair effect and safety in vivo, and its osteogenic effect may be mediated by activation of Wnt/β-catenin signaling pathway.
cuttlebone  /  bovine serum albumin  /  photocrosslinked hydrogel  /  bone repair  /  Wnt/β-catenin signaling pathway
吴思贤, 卓涛, 王国威, 李梦颖, 何毅, 刘建航. 海螵蛸/牛血清白蛋白光交联水凝胶促进骨愈合作用及机制. 中草药, 2026 , 57 (16) : 6356 -6370 . DOI: 10.7501/j.issn.0253-2670.2026.16.012
WU Sixian, ZHUO Tao, WANG Guowei, LI Mengying, HE Yi, LIU Jianhang. Effect and mechanism of cuttlebone/bovine serum albumin photocrosslinked hydrogel on promoting bone healing[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (16) : 6356 -6370 . DOI: 10.7501/j.issn.0253-2670.2026.16.012
基金
收起
  • 国家自然科学基金地区基金项目
  • 广西壮族自治区科技厅自然科学基金项目
  • 广西中医药大学2025年校级博士研究生科研创新项目
  • 广西中医药大学2025年自治区级硕士研究生科研创新项目
  • 广西中医药大学研究生科研创新项目
  • 北海市科技局研发项
文献
收起
参考文献 引证文献
排序方式：
1
Fernandez de Grado G, Keller L, Idoux-Gillet Y, et al. Bone substitutes: A review of their characteristics, clinical use, and perspectives for large bone defects management [J]. J Tissue Eng, 2018, 9: 2041731418776819.
2
Jimi E, Hirata S, Osawa K, et al. The current and future therapies of bone regeneration to repair bone defects [J]. Int J Dent, 2012, 2012: 148261.
3
Huang L, Guo Z Y, Yang X X, et al. Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration [J]. Theranostics, 2025, 15(2): 460-493.
4
Ferracci G, Zhu M X, Ibrahim M S, et al. Photocurable albumin methacryloyl hydrogels as a versatile platform for tissue engineering [J]. ACS Appl Bio Mater, 2020, 3(2): 920-934.
5
覃淮, 杨宽, 伍静, 等. 光交联甲基丙烯酸水凝胶在伤口修复中的研究进展[J]. 中国塑料, 2025, 39(10): 141-150.
6
Huang Y Q, Zhu Q C, Zhu Y, et al. Rapid UV photo-cross-linking of α-lactalbumin hydrogel biomaterial to enable wound healing [J]. ACS Omega, 2024, 9(1): 401-412.
7
陈兴华. 海螵蛸的药用认识沿革[J]. 中药材, 2024, 47(7): 1840-1846.
8
刘睿, 魏爽, 王欣之, 等. 海螵蛸蛋白质、肽类物质基础研究[J]. 中国中药杂志, 2020, 45(16): 3883-3889.
9
Mao A R, Zhao N F, Liang Y H, et al. Mechanically efficient cellular materials inspired by cuttlebone [J]. Adv Mater, 2021, 33(15): 2007348.
10
Barrera Bernal J L, Gaytán Salvatella Í, del Campo B I M, et al. Synthesis of hydroxyapatite-gelatin composite hydrogel for bone tissue application [J]. Gels, 2025, 11(8): 630.
11
Sudhakar M P, Ali S, Chitra S. Scrutinizing the effect of rGO-cuttlefish bone hydroxyapatite composite infused carrageenan membrane towards wound reconstruction [J]. Int J Biol Macromol, 2024, 262: 130155.
12
Chen Y, Zhai M J, Mehwish N, et al. Comparison of globular albumin methacryloyl and random-coil gelatin methacryloyl: Preparation, hydrogel properties, cell behaviors, and mineralization [J]. Int J Biol Macromol, 2022, 204: 692-708.
13
Tan B Z, Liu X, Chen S, et al. An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1/Akt signaling [J]. J Adv Res, 2026, 80:411-422.
14
Liu Y, Fang J R, Zhang Q, et al. Wnt10b-overexpressing umbilical cord mesenchymal stem cells promote critical size rat calvarial defect healing by enhanced osteogenesis and VEGF-mediated angiogenesis [J]. J Orthop Transl, 2020, 23: 29-37.
15
赵越, 许燕, 周建平, 等. 骨组织工程中传统与仿生支架结构设计的差异[J]. 中国组织工程研究, 2025, 29(16):3458-3468.
16
刘潇, 郑晓勇, 刘道宏, 等. 骨组织工程生物材料结构改性策略的研究进展[J]. 中华骨与关节外科杂志, 2025, 18(5):462-469.
17
Fu J, in het Panhuis M. Hydrogel properties and applications [J]. J Mater Chem B, 2019, 7(10): 1523-1525.
18
王霏扬, 马语卓, 吕雪蓉, 等. 牙周疾病动物模型复制研究进展[J]. 四川大学学报: 医学版, 2025, 56(2): 339-344.
19
孙明策, 徐珊珊, 金明, 等. 脂肪间充质干细胞联合三维水凝胶支架在大鼠颅骨缺损修复中的成骨效应[J]. 中国老年学杂志, 2025, 45(13): 3196-3200.
20
巫旭娜, 许碧莲, 田佳, 等. 用Micro-CT评价大鼠骨质疏松合并骨性关节炎模型[J]. 中国老年学杂志, 2020, 40(5): 1044-1047.
21
Kanczler J M, Oreffo R O C. Osteogenesis and angiogenesis: The potential for engineering bone [J]. Eur Cell Mater, 2008, 15: 100-114.
22
Eyre D R, Weis M A. Bone collagen: New clues to its mineralization mechanism from recessive osteogenesis imperfecta [J]. Calcif Tissue Int, 2013, 93(4): 338-347.
23
Chen X, Chen J S, Xu D L, et al. Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs [J]. BMC Musculoskelet Disord, 2017, 18(1): 423.
24
Yang M, Li C J, Xiao Y, et al. Ophiopogonin D promotes bone regeneration by stimulating CD31hiEMCNhi vessel formation [J]. Cell Prolif, 2020, 53(3): e12784.
25
Wei Y Q, Ju M M, Zheng F, et al. Cuttlebone-derived organic matrix: A facile periosteum substitute for bone regeneration [J]. Adv Funct Mater, 2023, 33(31): 2214095.
26
Hu K, Olsen B R.Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair [J]. J Clin Investig, 2016, 126(2): 509-526.
27
雷群, 林东, 黄文秀, 等. 钙离子对人成骨细胞迁移与成骨分化的影响[J]. 华西口腔医学杂志, 2018, 36(6): 602-608.
28
张崛, 冯玉旭, 徐勇, 等. 钙敏感受体缺失对小鼠成骨细胞增殖与分化的影响及机制研究[J]. 中华创伤骨科杂志, 2013, 15(5): 430-434.
29
杨刚, 刘鑫, 王元银. 牙源性双相磷酸钙与两种临床骨替代材料在兔上颌窦中成骨效果的对比研究[J]. 安徽医科大学学报, 2022, 57(11): 1699-1704.
30
席雪瑶, 高亚男, 王加启, 等. 锶的成骨机制及富锶食品的研发现状[J]. 现代食品科技, 2023, 39(9): 380-392.
31
宋跃, 郭澍, 吕梦竹, 等. 锶通过CaSR途径促进脂肪来源干细胞成骨分化的研究[J]. 中国美容整形外科杂志, 2018, 29(8):478-481.
32
马振, 孙伟, 叶丹丹, 等. 含镁介孔生物活性玻璃/锌黄长石复合支架的成骨活性[J]. 硅酸盐学报, 2022, 50(7): 1964-1971.
33
钟宁莹, 王丽萍. 锶成骨机制的研究进展[J]. 华西口腔医学杂志, 2020, 38(6): 697-703.
34
Ye J T, Miao B Z, Xiong Y J, et al. 3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair: Enhancing angiogenesis and osteogenesis [J]. J Nanobiotechnol, 2025, 23(1): 160.
35
Liu W J, Sun J, Sun Y, et al. Multifunctional injectable protein-based hydrogel for bone regeneration [J]. Chem Eng J, 2020, 394: 124875.
36
程若昱, 燕宇飞, 陈皓, 等. 双效骨诱导性的有机-无机水凝胶的构建及其骨再生研究[J]. 上海交通大学学报: 医学版, 2018, 38(8): 900-909.
Fernandez de Grado G, Keller L, Idoux-Gillet Y, et al. Bone substitutes: A review of their characteristics, clinical use, and perspectives for large bone defects management [J]. J Tissue Eng, 2018, 9: 2041731418776819.
Jimi E, Hirata S, Osawa K, et al. The current and future therapies of bone regeneration to repair bone defects [J]. Int J Dent, 2012, 2012: 148261.
Huang L, Guo Z Y, Yang X X, et al. Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration [J]. Theranostics, 2025, 15(2): 460-493.
Ferracci G, Zhu M X, Ibrahim M S, et al. Photocurable albumin methacryloyl hydrogels as a versatile platform for tissue engineering [J]. ACS Appl Bio Mater, 2020, 3(2): 920-934.
覃淮, 杨宽, 伍静, 等. 光交联甲基丙烯酸水凝胶在伤口修复中的研究进展[J]. 中国塑料, 2025, 39(10): 141-150.
Huang Y Q, Zhu Q C, Zhu Y, et al. Rapid UV photo-cross-linking of α-lactalbumin hydrogel biomaterial to enable wound healing [J]. ACS Omega, 2024, 9(1): 401-412.
陈兴华. 海螵蛸的药用认识沿革[J]. 中药材, 2024, 47(7): 1840-1846.
刘睿, 魏爽, 王欣之, 等. 海螵蛸蛋白质、肽类物质基础研究[J]. 中国中药杂志, 2020, 45(16): 3883-3889.
Mao A R, Zhao N F, Liang Y H, et al. Mechanically efficient cellular materials inspired by cuttlebone [J]. Adv Mater, 2021, 33(15): 2007348.
Barrera Bernal J L, Gaytán Salvatella Í, del Campo B I M, et al. Synthesis of hydroxyapatite-gelatin composite hydrogel for bone tissue application [J]. Gels, 2025, 11(8): 630.
Sudhakar M P, Ali S, Chitra S. Scrutinizing the effect of rGO-cuttlefish bone hydroxyapatite composite infused carrageenan membrane towards wound reconstruction [J]. Int J Biol Macromol, 2024, 262: 130155.
Chen Y, Zhai M J, Mehwish N, et al. Comparison of globular albumin methacryloyl and random-coil gelatin methacryloyl: Preparation, hydrogel properties, cell behaviors, and mineralization [J]. Int J Biol Macromol, 2022, 204: 692-708.
Tan B Z, Liu X, Chen S, et al. An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1/Akt signaling [J]. J Adv Res, 2026, 80:411-422.
Liu Y, Fang J R, Zhang Q, et al. Wnt10b-overexpressing umbilical cord mesenchymal stem cells promote critical size rat calvarial defect healing by enhanced osteogenesis and VEGF-mediated angiogenesis [J]. J Orthop Transl, 2020, 23: 29-37.
赵越, 许燕, 周建平, 等. 骨组织工程中传统与仿生支架结构设计的差异[J]. 中国组织工程研究, 2025, 29(16):3458-3468.
刘潇, 郑晓勇, 刘道宏, 等. 骨组织工程生物材料结构改性策略的研究进展[J]. 中华骨与关节外科杂志, 2025, 18(5):462-469.
Fu J, in het Panhuis M. Hydrogel properties and applications [J]. J Mater Chem B, 2019, 7(10): 1523-1525.
王霏扬, 马语卓, 吕雪蓉, 等. 牙周疾病动物模型复制研究进展[J]. 四川大学学报: 医学版, 2025, 56(2): 339-344.
孙明策, 徐珊珊, 金明, 等. 脂肪间充质干细胞联合三维水凝胶支架在大鼠颅骨缺损修复中的成骨效应[J]. 中国老年学杂志, 2025, 45(13): 3196-3200.
巫旭娜, 许碧莲, 田佳, 等. 用Micro-CT评价大鼠骨质疏松合并骨性关节炎模型[J]. 中国老年学杂志, 2020, 40(5): 1044-1047.
Kanczler J M, Oreffo R O C. Osteogenesis and angiogenesis: The potential for engineering bone [J]. Eur Cell Mater, 2008, 15: 100-114.
Eyre D R, Weis M A. Bone collagen: New clues to its mineralization mechanism from recessive osteogenesis imperfecta [J]. Calcif Tissue Int, 2013, 93(4): 338-347.
Chen X, Chen J S, Xu D L, et al. Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs [J]. BMC Musculoskelet Disord, 2017, 18(1): 423.
Yang M, Li C J, Xiao Y, et al. Ophiopogonin D promotes bone regeneration by stimulating CD31hiEMCNhi vessel formation [J]. Cell Prolif, 2020, 53(3): e12784.
Wei Y Q, Ju M M, Zheng F, et al. Cuttlebone-derived organic matrix: A facile periosteum substitute for bone regeneration [J]. Adv Funct Mater, 2023, 33(31): 2214095.
Hu K, Olsen B R.Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair [J]. J Clin Investig, 2016, 126(2): 509-526.
雷群, 林东, 黄文秀, 等. 钙离子对人成骨细胞迁移与成骨分化的影响[J]. 华西口腔医学杂志, 2018, 36(6): 602-608.
张崛, 冯玉旭, 徐勇, 等. 钙敏感受体缺失对小鼠成骨细胞增殖与分化的影响及机制研究[J]. 中华创伤骨科杂志, 2013, 15(5): 430-434.
杨刚, 刘鑫, 王元银. 牙源性双相磷酸钙与两种临床骨替代材料在兔上颌窦中成骨效果的对比研究[J]. 安徽医科大学学报, 2022, 57(11): 1699-1704.
席雪瑶, 高亚男, 王加启, 等. 锶的成骨机制及富锶食品的研发现状[J]. 现代食品科技, 2023, 39(9): 380-392.
宋跃, 郭澍, 吕梦竹, 等. 锶通过CaSR途径促进脂肪来源干细胞成骨分化的研究[J]. 中国美容整形外科杂志, 2018, 29(8):478-481.
马振, 孙伟, 叶丹丹, 等. 含镁介孔生物活性玻璃/锌黄长石复合支架的成骨活性[J]. 硅酸盐学报, 2022, 50(7): 1964-1971.
钟宁莹, 王丽萍. 锶成骨机制的研究进展[J]. 华西口腔医学杂志, 2020, 38(6): 697-703.
Ye J T, Miao B Z, Xiong Y J, et al. 3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair: Enhancing angiogenesis and osteogenesis [J]. J Nanobiotechnol, 2025, 23(1): 160.
Liu W J, Sun J, Sun Y, et al. Multifunctional injectable protein-based hydrogel for bone regeneration [J]. Chem Eng J, 2020, 394: 124875.
程若昱, 燕宇飞, 陈皓, 等. 双效骨诱导性的有机-无机水凝胶的构建及其骨再生研究[J]. 上海交通大学学报: 医学版, 2018, 38(8): 900-909.
2026年第57卷第16期
PDF下载
100
12
引用本文
BibTeX
文章信息
doi: 10.7501/j.issn.0253-2670.2026.16.012
  • 接收时间：2026-03-04
  • 首发时间：2026-10-22
  • 出版时间：2026-08-28
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2026-03-04
基金
国家自然科学基金地区基金项目
广西壮族自治区科技厅自然科学基金项目
广西中医药大学2025年校级博士研究生科研创新项目
广西中医药大学2025年自治区级硕士研究生科研创新项目
广西中医药大学研究生科研创新项目
北海市科技局研发项
作者信息
    1.广西中医药大学研究生院, 广西 南宁 530200
    2.北海市中医医院 骨伤科, 广西北海 536006
    3.北海市中医医院 骨伤科, 广西北海 536006

通讯作者:

参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.16.012
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62662699（运营及技术支持）
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持