Article(id=1319981635894882584, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1319981498787279574, articleNumber=PA20260909_9fhRjtWA, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.16.010, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1768147200000, receivedDateStr=2026-01-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792637746071, onlineDateStr=2026-10-22, pubDate=1787846400000, pubDateStr=2026-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792637746070, onlineIssueDateStr=2026-10-22, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792637746070, creator=admin, updateTime=1792637746070, updator=admin, issue=Issue{id=1319981498787279574, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='16', pageStart='6209', pageEnd='6660', issueExtLink='null', onlineDate='null', pubDate='1787846400000', pubDateStr='2026-08-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792637713380, creator='ztmeta', updateTime=1792637713380, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=6329, endPage=6342, ext={EN=ArticleExt(id=1319981640823189786, articleId=1319981635894882584, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Preparation, pharmacokinetics and hypoglycemic effects evaluation of diosgenin-rebaudioside A self-assembled nanomicelles based on “combined drug-excipient” strategy, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To prepare diosgenin-rebaudioside A self-assembled nanomicelles (Dio-Reb A-SNM), and evaluate its oral pharmacokinetics and hypoglycemic effects in vivo. Methods Single factor experiment was employed to investigate the prescriptions of Dio-Reb A-SNM. The amounts ratio of rebaudioside A to diosgenin, diosgenin concentration and ultrasonic time were selected as main influencing factor, the overall desirability of envelopment efficiency and drug loading was employed as optimization index, and Box-Behnken response surface design method (BBD-RSM) was employed to optimize prescriptions of Dio-Reb A-SNM. Transmission electron microscope (TEM) was employed to observe the microscopic appearance of Dio-Reb A-SNM, and X-ray powder diffraction (XRPD) was employed to analyze the crystal form of diosgenin in Dio-Reb A-SNM powder. The saturated solubility and release behavior of Dio-Reb A-SNM were determined in different pH media. SD rats were administered intragastrically with diosgenin and Dio-Reb A-SNM, respectively. Blood drug concentration was determined, and the relative oral bioavailability of Dio-Reb A-SNM was calculated. The model of type 2 diabetes mellitus (T2DM) in rats was established, and the effects of diosgenin and Dio-Reb A-SNM on hypoglycemic effects, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen and creatinine level were compared. The histopathological state of liver and kidney was observed by HE staining method. Results The optimal formulations of Dio-Reb A-SNM: amounts ratio of rebaudioside A to diosgenin was 12.32:1, diosgenin concentration was 1.97 mg/mL and ultrasonic time was 20.20 min. Envelopment efficiency, drug loading, particle size and ζ potential were (93.59 ±0.63)%, (5.65 ±0.07)%, (25.66 ±1.76) nm and (−24.59 ±1.18) mV, respectively. The appearance of Dio-Reb A-SNM were spherical. The crystal form of diosgenin changed into an amorphous form in Dio-Reb A-SNM powder. Dio-Reb A-SNM greatly improved the saturated solubility of diosgenin in different pH media. Drug release behavior of Dio-Reb A-SNM in vitro had obvious sustained-release characteristics, the cumulative release rate was increased to 90.94% in 18 h, and the drug release process conformed to Weibull model. Pharmacokinetics showed that t_max of Dio-Reb A-SNM was shortened to (2.06 ±0.29) h, t_1/2 was increased to (8.39 ±1.94) h, C_max and oral relative bioavailability were increased to 3.59-fold and 6.82-fold, respectively. Compared with diosgenin group (30 mg/kg), Dio-Reb A-SNM (30 mg/kg) could significantly reduce the blood glucose of T2DM rats at the fourth week (P < 0.01), and effectively reduced the AST, ALT, urea nitrogen and creatinine level in serum (P < 0.01). The pathological damage of liver and kidney was further alleviated by Dio-Reb A-SNM. Conclusion Dio-Reb A-SNM significantly promoted the oral absorption of diosgenin and improved hypoglycemic efficacy in vivo., authors=CAI Lijun¹, WANG Haijun², ZHANG Li¹, DING Shuming¹, JUE Lili³, authorsList=CAI Lijun, WANG Haijun, ZHANG Li, DING Shuming, JUE Lili, authorCompany=1 Zhengzhou University of Industrial Technology, Zhengzhou 451100, China;
2 The 988th Hospital of the Joint Logistics Support Force of the People's Liberation Army, Zhengzhou 450000, China;
3 Zhoukou Vocational Technical College, Zhoukou 466001, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319981640470868249, articleId=1319981635894882584, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于“药辅合一”理念薯蓣皂苷元-莱鲍迪苷A自组装胶束的制备、药动学及降血糖作用评价, columnId=1304140189132149234, journalTitle=中草药, columnName=药剂与工艺, runingTitle=null, highlight=null, articleAbstract=目的 以莱鲍迪苷A为载体制备薯蓣皂苷元自组装胶束（diosgenin-rebaudioside A self-assembled nanomicelles，Dio-Reb A-SNM），考察体内口服药动学及降血糖作用。方法 单因素实验考察Dio-Reb A-SNM处方工艺。选择莱鲍迪苷A与薯蓣皂苷元用量比、薯蓣皂苷元质量浓度和超声时间为主要影响因素，包封率和载药量的总评归一值为优化指标，采用Box-Behnken设计-效应面法（Box-Behnken design-response surface method，BBD-RSM）优化Dio-Reb A-SNM处方工艺。透射电子显微镜（transmission electron microscope，TEM）观察Dio-Reb A-SNM微观形态，X-射线粉末衍射法（X-ray powder diffraction，XRPD）分析薯蓣皂苷元在Dio-Reb A-SNM粉末中的晶型。考察Dio-Reb A-SNM在不同pH值介质中的饱和溶解度及体外释药行为。SD大鼠分别ig给予薯蓣皂苷元和Dio-Reb A-SNM，测定血药浓度，计算Dio-Reb A-SNM相对生物利用度。构建大鼠2型糖尿病（type 2 diabetes mellitus，T2DM）模型，比较薯蓣皂苷元和Dio-Reb A-SNM对T2DM大鼠血糖、血清天冬氨酸氨基转移酶（aspartate aminotransferase，AST）、丙氨酸氨基转移酶（alanine aminotransferase，ALT）、尿素氮和肌酸酐水平的影响。HE染色法观察大鼠肝、肾病理情况。结果 Dio-Reb A-SNM最佳处方：莱鲍迪苷A与薯蓣皂苷元用量比为12.32∶1，薯蓣皂苷元质量浓度为1.97 mg/mL，超声时间为20.20 min。Dio-Reb A-SNM的包封率、载药量、粒径及ζ电位分别为（93.59±0.63）%和（5.65±0.07）%、（25.66±1.76）nm和（-24.59±1.18）mV。Dio-Reb A-SNM外貌为类球形，薯蓣皂苷元在Dio-Reb A-SNM粉末中转变为无定形态。Dio-Reb A-SNM极大提高了薯蓣皂苷元在不同pH介质中的饱和溶解度。Dio-Reb A-SNM体外释药具有缓释特征，18 h内累积释放度提高至90.94%，释药过程符合Weibull模型。药动学结果显示，Dio-Reb A-SNM的达峰时间（tmax）提前至（2.06±0.29）h，半衰期（t₁/₂）延长至（8.39±1.94）h，达峰浓度（Cmax）和相对生物利用度分别增加至3.59倍和6.82倍。与薯蓣皂苷元（30 mg/kg）相比，Dio-Reb A-SNM（30 mg/kg）可使T2DM大鼠第4周血糖极显著下降（P＜0.01），血清中AST、ALT、尿素氮、肌酸酐水平均极显著降低（P＜0.01），且肝、肾病理损伤进一步减轻。结论 Dio-Reb A-SNM显著促进了薯蓣皂苷元口服吸收，并提高了体内降血糖药效。, authors=蔡理军¹, 王海军², 张莉¹, 丁书明¹, 决利利³, authorsList=蔡理军, 王海军, 张莉, 丁书明, 决利利, authorCompany=1 郑州工业应用技术学院, 河南 郑州 451100;
2 中国人民解放军联勤保障部队第九八八医院, 河南 郑州 450000;
3 周口职业技术学院, 河南 周口 466001, correspAuthors=决利利, authorNote=蔡理军: 蔡理军(1991—),男,汉族,高级实验师,研究方向为临床药学及解剖学研究。Tel:(0371)62623434 E-mail:2090512870@qq.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=https://oss.bj-dx-dzqywjd-hlw-icp.inspurcloudoss.com:6063/cast-journal-prod/2097521198041731073/excel/pdfs/4479947acaca42978323a7f1d7bfddd5.pdf?response-content-disposition=attachment%3B%20filename%3D%2220261610.pdf%22&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20261022T025336Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=NjRlNmUzOGMtM2Y3OC00MDQ3LThkMmYtN2JkODRmYmI3MTgw%2F20261022%2Fbj-dx-dzqywjd-hlw-icp%2Fs3%2Faws4_request&X-Amz-Signature=8e6153b62adc79c20a78cddbb8889ec7ff822bd5234cb49d1507e742f12fd52e, pdf=/2tcmTWQrJhScMtMTXaV9A==, pdfFileSize=1714972, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=河南省科技厅软科学研究项目 (252400410062); 河南省高等学校重点科研项目计划 (23B310010))}, authors=[Author(id=1319981642916147489, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=蔡理军, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981643385909539, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, authorId=1319981642916147489, language=CN, stringName=蔡理军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.郑州工业应用技术学院, 河南 郑州 451100郑州工业应用技术学院, 河南 郑州 451100, bio=蔡理军: 蔡理军(1991—),男,汉族,高级实验师,研究方向为临床药学及解剖学研究。Tel:(0371)62623434 E-mail:2090512870@qq.com, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981641313923355, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, xref=1, ext=[AuthorCompanyExt(id=1319981641330700572, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, companyId=1319981641313923355, language=CN, country=null, province=null, city=null, postcode=null, companyName=郑州工业应用技术学院, 河南 郑州 451100, departmentName=null, remark=^1.郑州工业应用技术学院, 河南 郑州 451100)])]), Author(id=1319981643788562724, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=王海军, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981644187021606, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, authorId=1319981643788562724, language=CN, stringName=王海军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.中国人民解放军联勤保障部队第九八八医院, 河南 郑州 450000中国人民解放军联勤保障部队第九八八医院, 河南 郑州 450000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981641653661981, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, xref=2, ext=[AuthorCompanyExt(id=1319981641716576542, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, companyId=1319981641653661981, language=CN, country=null, province=null, city=null, postcode=null, companyName=中国人民解放军联勤保障部队第九八八医院, 河南 郑州 450000, departmentName=null, remark=^2.中国人民解放军联勤保障部队第九八八医院, 河南 郑州 450000)])]), Author(id=1319981644262519079, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=张莉, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981644631617833, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, authorId=1319981644262519079, language=CN, stringName=张莉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.郑州工业应用技术学院, 河南 郑州 451100郑州工业应用技术学院, 河南 郑州 451100, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981641313923355, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, xref=1, ext=[AuthorCompanyExt(id=1319981641330700572, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, companyId=1319981641313923355, language=CN, country=null, province=null, city=null, postcode=null, companyName=郑州工业应用技术学院, 河南 郑州 451100, departmentName=null, remark=^1.郑州工业应用技术学院, 河南 郑州 451100)])]), Author(id=1319981645021688106, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=丁书明, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981645126545709, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, authorId=1319981645021688106, language=CN, stringName=丁书明, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.郑州工业应用技术学院, 河南 郑州 451100郑州工业应用技术学院, 河南 郑州 451100, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981641313923355, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, xref=1, ext=[AuthorCompanyExt(id=1319981641330700572, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, companyId=1319981641313923355, language=CN, country=null, province=null, city=null, postcode=null, companyName=郑州工业应用技术学院, 河南 郑州 451100, departmentName=null, remark=^1.郑州工业应用技术学院, 河南 郑州 451100)])]), Author(id=1319981645420146990, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=决利利, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981645894103344, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, authorId=1319981645420146990, language=CN, stringName=决利利, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.周口职业技术学院, 河南 周口 466001周口职业技术学院, 河南 周口 466001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981642152784159, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, xref=3^*, ext=[AuthorCompanyExt(id=1319981642488328480, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, companyId=1319981642152784159, language=CN, country=null, province=null, city=null, postcode=null, companyName=周口职业技术学院, 河南 周口 466001, departmentName=null, remark=^3.周口职业技术学院, 河南 周口 466001)])])], keywords=[Keyword(id=1322633162400841862, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=CN, orderNo=1, keyword=薯蓣皂苷元), Keyword(id=1322633162522476679, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=CN, orderNo=2, keyword=莱鲍迪苷A), Keyword(id=1322633162648305800, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=CN, orderNo=3, keyword=自组装胶束), Keyword(id=1322633162711220361, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=CN, orderNo=4, keyword=Box-Behnken设计-效应面法), Keyword(id=1322633162799300746, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=CN, orderNo=5, keyword=药动学), Keyword(id=1322633162878992523, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=CN, orderNo=6, keyword=生物利用度), Keyword(id=1322633162950295692, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=CN, orderNo=7, keyword=降血糖作用), Keyword(id=1322633163088707725, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=EN, orderNo=1, keyword=diosgenin), Keyword(id=1322633163164205198, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=EN, orderNo=2, keyword=rebaudioside A), Keyword(id=1322633163248091279, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=EN, orderNo=3, keyword=self-assembled nanomicelles), Keyword(id=1322633163336171664, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=EN, orderNo=4, keyword=Box-Behnken response surface design method), Keyword(id=1322633163394891921, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=EN, orderNo=5, keyword=pharmacokinetic), Keyword(id=1322633163474583698, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=EN, orderNo=6, keyword=bioavailability), Keyword(id=1322633163541692563, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, language=EN, orderNo=7, keyword=hypoglycemic effects)], refs=[Reference(id=1319981650923073858, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=1, rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=刘姿宇, 朱文斌, 冯博, 等. 薯蓣皂苷元的药理活性及其机制研究进展[J]. 中国医药科学, 2023, 13(3): 34-37., articleTitle=null, refAbstract=null), Reference(id=1319981650923073859, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=2, rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=钟玉杰. 薯蓣皂苷元对3-氯-1,2-丙二醇肾细胞毒性的保护作用及机制研究[D]. 杨凌: 西北农林科技大学, 2019., articleTitle=null, refAbstract=null), Reference(id=1319981650923073860, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=3, rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=郭亚春, 安高, 赵晓菲, 等. 薯蓣皂苷元对昆明鼠的亚慢性毒性实验[J]. 世界科学技术—中医药现代化, 2015, 17(9):1823-1827., articleTitle=null, refAbstract=null), Reference(id=1319981650923073861, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=4, rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=董亚楠, 柳超, 董姣姣, 等. 薯蓣皂苷元白蛋白纳米粒制备及其体内药动学研究[J]. 中成药, 2023, 45(7): 2110-2116., articleTitle=null, refAbstract=null), Reference(id=1319981650923073862, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=5, rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=Okawara M, Tokudome Y, Todo H, et al. Enhancement of diosgenin distribution in the skin by cyclodextrin complexation following oral administration [J]. Biol Pharm Bull, 2013, 36(1): 36-40., articleTitle=null, refAbstract=null), Reference(id=1319981650923073863, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=6, rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=段黎娟, 黄小强, 贾安, 等. 薯蓣皂苷元滴丸制备工艺优化及其体内药动学研究[J]. 中成药, 2024, 46(3): 947-951., articleTitle=null, refAbstract=null), Reference(id=1319981650923073864, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=7, rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=Liu P, Zhou J Y, Chang J H, et al. Soluplus-mediated diosgenin amorphous solid dispersion with high solubility and high stability: Development, characterization and oral bioavailability [J]. Drug Des Dev Ther, 2020, 14: 2959-2975., articleTitle=null, refAbstract=null), Reference(id=1319981650923073865, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=8, rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=王慧弟, 张金坤, 郭进. 负载α-常春藤皂苷聚合物胶束的制备与体内外评价[J]. 药物评价研究, 2024, 47(1): 123-129., articleTitle=null, refAbstract=null), Reference(id=1319981650923073866, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=9, rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=缪晴, 萨比哈·帕合尔丁, 曾思瑀, 等. 基于天然低共熔溶剂的甜叶菊中甜菊糖绿色提取方法及优化[J]. 植物学报, 2021, 56(6): 722-731., articleTitle=null, refAbstract=null), Reference(id=1319981650923073867, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=10, rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=Gupta E, Mohammed A, Mishra N, et al. Antioxidant and anti-diabetic potential of rebaudioside A and a mixture of steviol glycosides in alloxan-induced diabetic rats [J]. Indian J Nat Prod Resour, 2021, 12(3): 391-399., articleTitle=null, refAbstract=null), Reference(id=1319981650923073868, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=11, rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=Wang T, Gao Z, Guo C L, et al. A novel nanomicelle based on rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin [J]. Int J Pharm X, 2025, 10:100389., articleTitle=null, refAbstract=null), Reference(id=1319981650923073869, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=12, rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=Liu C Z, Niu M C, Wang Y B, et al. Self-assembled rebaudioside a nanomicelles: A novel delivery system for mangiferin to increase oral bioavailability [J]. J Agric Food Chem, 2025, 73(29): 18303-18315., articleTitle=null, refAbstract=null), Reference(id=1319981650923073870, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=13, rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=王酩, 张佩琛, 范高洁, 等. 玉米肽负载芹菜素纳米粒的制备、口服药动学及对高血压大鼠的治疗作用[J]. 药物评价研究, 2026, 49(2): 603-616., articleTitle=null, refAbstract=null), Reference(id=1319981650923073871, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=14, rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=吕小改, 张攀, 李梦, 等. 葡聚糖涂层的芹菜素-玉米醇溶蛋白纳米复合物的制备及理化性质评价[J]. 化学研究与应用, 2025, 37(10):2965-2976., articleTitle=null, refAbstract=null), Reference(id=1319981650923073872, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=15, rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=尚丹, 张广辉, 李晓婷, 等. 基于“药辅合一”的甜菊素-隐丹参酮自胶束化固体分散体制备、表征及体内评价[J]. 中草药, 2025, 56(13): 4621-4633., articleTitle=null, refAbstract=null), Reference(id=1319981650923073873, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=16, rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=王涛丽, 张广辉, 张莉, 等. 负载二氢杨梅素ZIF-8纳米粒的制备、表征及抗肿瘤评价[J]. 药物评价研究, 2025, 48(5): 1224-1235., articleTitle=null, refAbstract=null), Reference(id=1319981650923073874, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=17, rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=王群, 唐甜甜, 刘文, 等. 黄芪六一汤抗糖尿病肾病的药效组分筛选研究[J]. 药物评价研究, 2024, 47(4): 730-745., articleTitle=null, refAbstract=null), Reference(id=1319981650923073875, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=18, rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=曹伶俐, 刘素梅. 甜菊糖苷-高良姜素纳米复合物的制备及其理化性质评价[J]. 化学研究与应用, 2025, 37(6): 1506-1514., articleTitle=null, refAbstract=null), Reference(id=1319981650923073876, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=19, rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=李俊. OpiCa1-PEG-PLGA纳米胶束的制备及其对小鼠致死性心脏猝死的拮抗效应[D]. 太谷:山西农业大学, 2024., articleTitle=null, refAbstract=null), Reference(id=1319981650923073877, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=20, rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=董亚楠, 任书强, 柳超, 等. 蒙花苷巯基化纳米胶束的制备、表征及其口服吸收生物利用度评价[J]. 中草药, 2023, 54(23): 7776-7787., articleTitle=null, refAbstract=null), Reference(id=1319981650923073878, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=21, rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=孙丽, 李瑞华, 吉媛媛, 等. 高良姜素自胶束化固体分散体的制备、口服药动学和降血糖作用评价[J]. 药物评价研究, 2025, 48(1): 143-156., articleTitle=null, refAbstract=null), Reference(id=1319981650927268163, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=22, rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=决利利, 梁婧, 李晓婷, 等. 松果菊苷固体脂质纳米粒的制备及其在体肠吸收特性、体内药动学研究[J]. 中成药, 2022, 44(8):2429-2434., articleTitle=null, refAbstract=null), Reference(id=1319981650927268164, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=23, rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=王改利, 高青, 李晓蒙, 等. 半乳糖修饰的桔皮素仿生纳米粒的制备、表征和药动学评价[J]. 中草药, 2025, 56(23): 8534-8547., articleTitle=null, refAbstract=null), Reference(id=1319981650927268165, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=24, rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=赵文萃, 赵庆兰, 赵洪昌, 等. 胆甾醇琥珀酰基白及多糖自组装纳米粒的制备及其表征[J]. 解放军药学学报, 2023, 36(4): 283-286., articleTitle=null, refAbstract=null), Reference(id=1319981650927268166, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=25, rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=王鑫, 范鑫, 郑佳俊, 等. 基于“药辅合一”的牛至精油-石榴皮多酚纳米乳制备及性能研究[J]. 中草药, 2025, 56(10): 3513-3522., articleTitle=null, refAbstract=null)], funds=[Fund(id=1319981650134544704, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, awardId=2097521922062487553, language=CN, fundingSource=河南省科技厅软科学研究项目, fundOrder=null, country=null), Fund(id=1319981650478477633, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, awardId=2097521922062487554, language=CN, fundingSource=河南省高等学校重点科研项目计划, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1319981641313923355, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, xref=1, ext=[AuthorCompanyExt(id=1319981641330700572, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, companyId=1319981641313923355, language=CN, country=null, province=null, city=null, postcode=null, companyName=郑州工业应用技术学院, 河南 郑州 451100, departmentName=null, remark=^1.郑州工业应用技术学院, 河南 郑州 451100)]), AuthorCompany(id=1319981641653661981, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, xref=2, ext=[AuthorCompanyExt(id=1319981641716576542, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, companyId=1319981641653661981, language=CN, country=null, province=null, city=null, postcode=null, companyName=中国人民解放军联勤保障部队第九八八医院, 河南 郑州 450000, departmentName=null, remark=^2.中国人民解放军联勤保障部队第九八八医院, 河南 郑州 450000)]), AuthorCompany(id=1319981642152784159, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, xref=3^*, ext=[AuthorCompanyExt(id=1319981642488328480, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981635894882584, companyId=1319981642152784159, language=CN, country=null, province=null, city=null, postcode=null, companyName=周口职业技术学院, 河南 周口 466001, departmentName=null, remark=^3.周口职业技术学院, 河南 周口 466001)])], figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.16.010, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.16.010, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.16.010, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.16.010, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1787846400000, fullTextJson=null, articleText=null, reference=刘姿宇, 朱文斌, 冯博, 等. 薯蓣皂苷元的药理活性及其机制研究进展[J]. 中国医药科学, 2023, 13(3): 34-37.
钟玉杰. 薯蓣皂苷元对3-氯-1,2-丙二醇肾细胞毒性的保护作用及机制研究[D]. 杨凌: 西北农林科技大学, 2019.
郭亚春, 安高, 赵晓菲, 等. 薯蓣皂苷元对昆明鼠的亚慢性毒性实验[J]. 世界科学技术—中医药现代化, 2015, 17(9):1823-1827.
董亚楠, 柳超, 董姣姣, 等. 薯蓣皂苷元白蛋白纳米粒制备及其体内药动学研究[J]. 中成药, 2023, 45(7): 2110-2116.
Okawara M, Tokudome Y, Todo H, et al. Enhancement of diosgenin distribution in the skin by cyclodextrin complexation following oral administration [J]. Biol Pharm Bull, 2013, 36(1): 36-40.
段黎娟, 黄小强, 贾安, 等. 薯蓣皂苷元滴丸制备工艺优化及其体内药动学研究[J]. 中成药, 2024, 46(3): 947-951.
Liu P, Zhou J Y, Chang J H, et al. Soluplus-mediated diosgenin amorphous solid dispersion with high solubility and high stability: Development, characterization and oral bioavailability [J]. Drug Des Dev Ther, 2020, 14: 2959-2975.
王慧弟, 张金坤, 郭进. 负载α-常春藤皂苷聚合物胶束的制备与体内外评价[J]. 药物评价研究, 2024, 47(1): 123-129.
缪晴, 萨比哈·帕合尔丁, 曾思瑀, 等. 基于天然低共熔溶剂的甜叶菊中甜菊糖绿色提取方法及优化[J]. 植物学报, 2021, 56(6): 722-731.
Gupta E, Mohammed A, Mishra N, et al. Antioxidant and anti-diabetic potential of rebaudioside A and a mixture of steviol glycosides in alloxan-induced diabetic rats [J]. Indian J Nat Prod Resour, 2021, 12(3): 391-399.
Wang T, Gao Z, Guo C L, et al. A novel nanomicelle based on rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin [J]. Int J Pharm X, 2025, 10:100389.
Liu C Z, Niu M C, Wang Y B, et al. Self-assembled rebaudioside a nanomicelles: A novel delivery system for mangiferin to increase oral bioavailability [J]. J Agric Food Chem, 2025, 73(29): 18303-18315.
王酩, 张佩琛, 范高洁, 等. 玉米肽负载芹菜素纳米粒的制备、口服药动学及对高血压大鼠的治疗作用[J]. 药物评价研究, 2026, 49(2): 603-616.
吕小改, 张攀, 李梦, 等. 葡聚糖涂层的芹菜素-玉米醇溶蛋白纳米复合物的制备及理化性质评价[J]. 化学研究与应用, 2025, 37(10):2965-2976.
尚丹, 张广辉, 李晓婷, 等. 基于“药辅合一”的甜菊素-隐丹参酮自胶束化固体分散体制备、表征及体内评价[J]. 中草药, 2025, 56(13): 4621-4633.
王涛丽, 张广辉, 张莉, 等. 负载二氢杨梅素ZIF-8纳米粒的制备、表征及抗肿瘤评价[J]. 药物评价研究, 2025, 48(5): 1224-1235.
王群, 唐甜甜, 刘文, 等. 黄芪六一汤抗糖尿病肾病的药效组分筛选研究[J]. 药物评价研究, 2024, 47(4): 730-745.
曹伶俐, 刘素梅. 甜菊糖苷-高良姜素纳米复合物的制备及其理化性质评价[J]. 化学研究与应用, 2025, 37(6): 1506-1514.
李俊. OpiCa1-PEG-PLGA纳米胶束的制备及其对小鼠致死性心脏猝死的拮抗效应[D]. 太谷:山西农业大学, 2024.
董亚楠, 任书强, 柳超, 等. 蒙花苷巯基化纳米胶束的制备、表征及其口服吸收生物利用度评价[J]. 中草药, 2023, 54(23): 7776-7787.
孙丽, 李瑞华, 吉媛媛, 等. 高良姜素自胶束化固体分散体的制备、口服药动学和降血糖作用评价[J]. 药物评价研究, 2025, 48(1): 143-156.
决利利, 梁婧, 李晓婷, 等. 松果菊苷固体脂质纳米粒的制备及其在体肠吸收特性、体内药动学研究[J]. 中成药, 2022, 44(8):2429-2434.
王改利, 高青, 李晓蒙, 等. 半乳糖修饰的桔皮素仿生纳米粒的制备、表征和药动学评价[J]. 中草药, 2025, 56(23): 8534-8547.
赵文萃, 赵庆兰, 赵洪昌, 等. 胆甾醇琥珀酰基白及多糖自组装纳米粒的制备及其表征[J]. 解放军药学学报, 2023, 36(4): 283-286.
王鑫, 范鑫, 郑佳俊, 等. 基于“药辅合一”的牛至精油-石榴皮多酚纳米乳制备及性能研究[J]. 中草药, 2025, 56(10): 3513-3522.)