Wine-processed Huangjing (Polygonati Rhizoma) is one of the primary processed products of the Polygonati Rhizoma, its preparation technology has seen important progress in recent years. Literature research and the latest research results indicate that the chemical composition undergoes notable changes during the wine-processing of Polygonati Rhizoma, particularly generating substances that pose potential health risks to humans, such as 5-hydroxymethylfurfural, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, acrylamide. Following processing, the pharmacological activities such as immunomodulation, antioxidant, hypoglycemic, and hypolipidemic effects are markedly enhanced. Current research on wine-processed Polygonati Rhizoma faces challenges such as inconsistent processing standards, unclear process parameters and difficulties in quality control. This paper systematically summarizes research progress of wine-processed Polygonati Rhizoma, including the historical evolution, modern processing techniques, chemical composition, and pharmacological effects. Future research should focus on standardizing processing techniques, modernizing mechanism analysis, and applying technological innovations to further promote the comprehensive and rapid development of the wine-processed Polygonati Rhizoma industry.
WONG LI SOO, ZHANG Yizhong, SONG Xiankang, SONG Dawei, HUANG Qiubo, WANG Yuting, BAO Kangde, WANG Dan.
Processing, pharmacological activities and current application status of wine-processed Polygonati Rhizoma[J].
Chinese Traditional and Herbal Drugs,
2026
, 57
(14)
: 5736
-5748
.
DOI: 10.7501/j.issn.0253-2670.2026.14.031
陶弘景. 名医别录[M]. 尚志钧, 辑校. 北京: 人民卫生出版社, 1986. 宫江宁, 云成悦, 吴婕, 等. 黄精多糖的提取优化及抗氧化活性研究[J]. 贵州师范大学学报: 自然科学版, 2019, 37(3): 18-23. 郑梅霞, 刘伟, 侯国华, 等. 九蒸九制多花黄精化学成分、抗氧化活性及挥发性风味的动态变化及其机制[J]. 中草药, 2025, 56(20): 7332-7343. Li X Y, Jiang C L, Zheng C, et al. Polygonatum cyrtonema Hua polysaccharide alleviates fatigue by modulating osteocalcin-mediated crosstalk between bones and muscles [J]. J Agric Food Chem, 2023, 71(16): 6468-6479. Shen W D, Li X Y, Deng Y Y, et al. Polygonatum cyrtonema Hua polysaccharide exhibits anti-fatigue activity via regulating osteocalcin signaling [J]. Int J Biol Macromol, 2021, 175: 235-241. Zhang X, Chen Q, Chen L Z, et al. Anti-aging in Caenorhabditis elegans of polysaccharides from Polygonatum cyrtonema Hua [J]. Molecules, 2024, 29(6): 1276. Ma W J, Wei S S, Peng W J, et al. Antioxidant effect of Polygonatum sibiricum polysaccharides in D-galactose-induced heart aging mice [J]. Biomed Res Int, 2021, 2021: 6688855. He Y F, Huang L, Jiang P, et al. Immunological regulation of the active fraction from Polygonatum sibiricum F. Delaroche based on improvement of intestinal microflora and activation of RAW264.7 cells [J]. J Ethnopharmacol, 2022, 293: 115240. Wang J, Wang F R, Yuan L X, et al. Blood-enriching effects and immune-regulation mechanism of steam-processed Polygonatum sibiricum polysaccharide in blood deficiency syndrome mice [J]. Front Immunol, 2022, 13: 813676. 中国药典[S]. 一部. 2025: 328-329． 孙乐明, 王华磊, 李金玲, 等. 黔产林下多花黄精不同生长年限及采收期质量差异研究[J]. 特产研究, 2022, 44(4): 75-80. Ning L Y, Xu Y S, Luo L, et al. Integrative analyses of metabolome and transcriptome reveal the dynamic accumulation and regulatory network in rhizomes and fruits of Polygonatum cyrtonema Hua [J]. BMC Genom, 2024, 25(1): 706. 廖承树, 叶炜, 周建金. 基于文献信息的黄精最佳采收时间和加工方法分析[J]. 江苏农业科学, 2021, 49(14): 45-49. 苏为耿, 赵永丰, 吴兴兴, 等. 不同种植模式及种植年限对滇黄精产量及品质的影响[J]. 西部林业科学, 2022, 51(5): 113-117. 王鑫, 课净璇, 王亚斌, 等. 提取方法对黄精渣水不溶性膳食纤维结构和功能特性的影响[J]. 食品工业科技, 2024, 45(24): 187-195. 张凯, 张昭, 范永芳, 等. 药食同源药材黄精玉竹营养及生物活性成分分析[J]. 中国现代中药, 2022, 24(8): 1463-1472. Pu W, Yu Y, Shi X, et al. The effect of seasonal and annual variation on the quality of Polygonatum cyrtonema Hua rhizomes [J]. Plants, 2024, 13(24):3459. 王怀隐. 太平圣惠方: 校点本[M]. 郑金生, 汪惟刚, 董志珍, 校点. 北京: 人民卫生出版社, 2016. Zhang Q H, Yang Z Y, Su W K. Review of studies on polysaccharides, lignins and small molecular compounds from three Polygonatum Mill. (Asparagaceae) spp. in crude and processed states [J]. Int J Biol Macromol, 2024, 260: 129511. 雍晋, 王迎香, 唐爽, 等. 黄精酒蒸前后化学成分、炮制工艺及药理作用研究进展[J]. 中药与临床, 2023, 14(6): 97-103. 中国国家卫生健康委员会. 卫生部发布《关于进一步规范保健食品原料管理的通知》 (2002年第51号) [EB/OL]. (2002-02-28) [2026-01-28]. http://www.nhc.gov.cn/sps/s3593/200810/bc239ea3d226449b86379f645dfd881d.shtml. 王丹, 况丹妮, 刘若阳, 等. 焦糖化与美拉德反应中DDMP、HMF及糠醛的生成研究[J]. 食品工业科技, 2022, 43(12): 100-107. 宋艺君, 郭涛, 周晓程. 不同产地黄精经不同方法炮制后多糖、5-羟甲基糠醛的含量变化[J]. 中国药房, 2017, 28(16): 2256-2258. 周鸿立, 季世宇, 付梦霞, 等. 一种黄精不同炮制工艺中5-羟甲基糠醛和丙烯酰胺的测定方法: 中国, CN114858934B [P]. 2023-05-26. 雷敩. 雷公炮制论[M]. 施仲安, 校注. 南京: 江苏科学技术出版社, 1985: 17. 谌瑞林. 酒制黄精的制作工艺: 中国, CN104623273A [P]. 2015-05-20. 吴国学, 张振凌. 酒制共性技术历史沿革[A] // 中华中医药学会中药炮制分会2008年学术研讨会论文集[C]. 樟树: 中华中医药学会中药炮制分会, 2008: 158-160. 沈灵, 曾琳琳, 骆巧媚, 等. 黄精的炮制工艺优化及抗衰老作用研究[J]. 华西药学杂志, 2023, 38(4): 394-398. 赵秋华, 潘乔丹, 黄嫊琳, 等. 基于抗氧化作用成分的黄精炮制工艺优化[J]. 中国民族民间医药, 2024, 33(10): 61-66. 刘露梅, 王能, 陈丹, 等. 基于黄精降血糖功效的酒黄精炮制工艺优选[J]. 时珍国医国药, 2021, 32(8): 1915-1918. 牛世蓉, 李敏敏, 崔伟业, 等. 高压蒸汽热加工对滇黄精抗氧化及抗炎活性的影响[J]. 食品工业科技, 2025, 46(10): 351-359. 李慧, 何亚慧, 史秋月, 等. 不同炮制工艺对酒黄精品质影响的研究[J]. 特产研究, 2025, 47(4): 98-103. 罗诚, 蔡文菲, 张阿凤, 等. 基于Box-Behnken设计-响应面法优化酒黄精炮制工艺[J]. 安徽医药, 2024, 28(10): 1930-1934. 贺海花, 杨云, 王爽, 等. 不同蒸制方法和时间对黄精中多糖含量的影响[J]. 中药材, 2009, 32(6): 861-862. 詹智洪, 魏家保, 唐双燕, 等. 基于HPLC特征图谱与多成分动态分析的黄精酒制过程成分变化规律及质量评价研究[J]. 天然产物研究与开发, 2025, 37(5): 849-858. 管彦辉, 梁正维, 施扬, 等. 滇黄精炮制前后化学成分变化研究[J]. 中草药, 2024, 55(11): 3647-3658. 李得天, 封亮, 贾晓斌, 等. 黄精炮制原理解析及工艺优化策略[J]. 中草药, 2024, 55(20): 7110-7121. Wang S Z, He F, Hu R B, et al. Dynamic variation of secondary metabolites from Polygonatum cyrtonema Hua rhizomes during repeated steaming–drying processes [J]. Molecules, 2025, 30(9): 1923. 杨婧娟, 张希, 马雅鸽, 等. 发酵对黄精主要活性成分及其抗氧化活性和刺激性的影响[J]. 食品工业科技, 2020, 41(2): 52-58. 唐美玲. 生黄精的刺激性成分及其炮制减毒增效作用研究[D]. 昆明: 昆明理工大学, 2022. Su L L, Li X M, Guo Z J, et al. Effects of different steaming times on the composition, structure and immune activity of Polygonatum polysaccharide [J]. J Ethnopharmacol, 2023, 310: 116351. 徐如静, 梁娟, 俞年军, 等. 九华黄精炮制前后多糖类成分结构变化研究[J]. 安徽中医药大学学报, 2021, 40(2): 91-96. 王帅, 王丽丽, 房娟娟, 等. 滇黄精酒制过程中颜色与5种成分含量变化的相关性分析[J]. 中国实验方剂学杂志, 2022, 28(21): 156-162. Huang R, He X J, Wang X, et al. The analysis of raw and processed Polygonatum kingianum saponins and stimulatory mechanism in Caenorhabditis elegans [J]. Fitoterapia, 2024, 179: 106242. 周鸿立, 李硕, 赵晶丽, 等. 一种酒黄精炮制工艺的智能优化方法: 中国, CN120544725A [P]. 2025-08-26. Li M M, Jiang H J, Hao Y L, et al. A systematic review on botany, processing, application, phytochemistry and pharmacological action of Radix Rehmnniae [J]. J Ethnopharmacol, 2022, 285: 114820. 姜哲轶, 吴婷月, 沈传斌, 等. 5-羟甲基糠醛的药理作用研究进展[J]. 新乡医学院学报, 2022, 39(1): 92-95. Ya B L, Li H F, Wang H Y, et al. 5-HMF attenuates striatum oxidative damage via Nrf2/ARE signaling pathway following transient global cerebral ischemia [J]. Cell Stress Chaperones, 2017, 22(1): 55-65. Liu A J, Zhao X, Li H, et al. 5-Hydroxymethylfurfural, an antioxidant agent from Alpinia oxyphylla Miq. improves cognitive impairment in Aβ1-42 mouse model of Alzheimer’s disease [J]. Int Immunopharmacol, 2014, 23(2): 719-725. Ya B L, Yin H Y, Yuan L L, et al. 5-Hydroxymethylfurfural alleviates lipopolysaccharide-induced depression-like behaviors by suppressing hypothalamic oxidative stress and regulating neuroinflammation in mice [J]. Antioxidants, 2025, 14(11): 1366. 李恩灿, 贺玖明, 靳洪涛, 等. 5-羟甲基糠醛的药理和毒理研究进展[J]. 中国药物警戒, 2018, 15(4): 210-215. Capuano E, Fogliano V. Acrylamide and 5-hydroxymethylfurfural (HMF): A review on metabolism, toxicity, occurrence in food and mitigation strategies [J]. LWT Food Sci Technol, 2011, 44(4): 793-810. 曾林燕, 曾鸿莲, 谭淑仪, 等. 基于5-HMF的产生机理、代谢、生物活性及其在中药加工过程变化的研究概述[J]. 中国中医基础医学杂志, 2023, 29(3): 507-514. Hou Y Y, Zhang X Y, Liu X X, et al. Comparison of the effects of 5-hydroxymethylfurfural in milk powder matrix and standard water on oxidative stress system of zebrafish [J]. Foods, 2022, 11(12): 1814. 雷高明, 冯卫生, 冯云霞, 等. 酒黄精饮片质量标准研究[J]. 中药材, 2011, 34(9): 1346-1348. Lee C H, Chen K T, Lin J A, et al. Recent advances in processing technology to reduce 5-hydroxymethylfurfural in foods [J]. Trends Food Sci Technol, 2019, 93: 271-280. 曾林燕, 宋志前, 魏征, 等. 黄精炮制过程中新产生成分分离及含量变化[J]. 中草药, 2013, 44(12): 1584-1588. 康显杰, 叶佩, 李亚飞, 等. 九蒸九晒多花黄精的多个成分动态研究[J]. 时珍国医国药, 2024, 35(14): 3193-3198. 钱晓东, 周桂芬, 吕圭源. 不同产地当归炮制前后多糖与新产生成分5-羟甲基糠醛和5-羟基麦芽酚含量变化规律性研究[J]. 中华中医药学刊, 2014, 32(6): 1320-1323. 张艳雪, 周巧, 张学兰, 等. 黄精炮制前后寡糖与单糖类成分含量变化与转化机制研究[J]. 中药材, 2020, 43(2): 318-322. Zhong R X, Shen L, Fan Y L, et al. Anti-aging mechanism and effect of treatment with raw and wine-steamed Polygonatum sibiricum on D-galactose-induced aging in mice by inhibiting oxidative stress and modulating gut microbiota [J]. Front Pharmacol, 2024, 15: 1335786. 王慧楠, 岳珠珠, 姜明瑞, 等. 基于16S rDNA高通量测序研究酒蒸前后黄精多糖对免疫抑制大鼠肠道菌群的影响[J]. 中华中医药杂志, 2024, 39(11): 6091-6095. Hassan H A, Ahmed H S, Hassan D F. Free radicals and oxidative stress: Mechanisms and therapeutic targets [J]. Hum Antibodies, 2024, 32(4): 151-167. Li K X, Deng Z, Lei C R, et al. The role of oxidative stress in tumorigenesis and progression [J]. Cells, 2024, 13(5): 441. Santos D F, Simão S, Nóbrega C, et al. Oxidative stress and aging: Synergies for age related diseases [J]. FEBS Lett, 2024, 598(17): 2074-2091. Guan Y H, Liang Z W, Li R Y, et al. Chemical composition and antioxidant activity of Polygonatum kingianum processed by the traditional method of “Nine Cycles of Steaming and Sun-Drying” [J]. Food Chem X, 2024, 22: 101292. Li Q Y, Zeng J, Gong P X, et al. Effect of steaming process on the structural characteristics and antioxidant activities of polysaccharides from Polygonatum sibiricum rhizomes [J]. Glycoconj J, 2021, 38(5): 561-572. Zhao Y Y, Wang Z, Fu R Z, et al. Structural characterization and antioxidant activity of processed polysaccharides PCP-F1 from Polygonatum cyrtonema Hua [J]. Front Nutr, 2023, 10: 1272977. 薛妙, 郭凯丽, 袁盼盼, 等. 酒黄精总黄酮提取工艺及其抗氧化作用研究[J]. 中南药学, 2023, 21(2): 351-356. Teng H H, Zhang Y, Jin C S, et al. Polysaccharides from steam-processed Polygonatum cyrtonema Hua protect against D-galactose-induced oxidative damage in mice by activation of Nrf2/HO-1 signaling [J]. J Sci Food Agric, 2023, 103(2): 779-791. 冯婧, 胡娟娟, 何先元, 等. 不同炮制方法对渝产黄精体外抗氧化作用的影响[J]. 中国药业, 2020, 29(19): 25-30. 刘政祥, 陈文军, 李九九, 等. 产地和炮制次数差异对黄精多糖结构和体内抗氧化活性影响[J]. 辽宁中医药大学学报, 2023, 25(5): 58-62. 单佳洛. 多花黄精多糖对巨噬细胞的免疫调节作用及机制初探[D]. 南昌: 南昌大学, 2024. 孙芸芸, 赵明, 秦诗越, 等. 黄精多糖的分离纯化及其免疫调节活性研究[J]. 中国免疫学杂志, 2025, 41(1): 182-188. 林涛, 田子琦, 宋志前, 等. 黄精酒制前后多糖对肠道免疫调节作用的对比研究[J]. 中国中医基础医学杂志, 2025, 31(12): 2170-2175. Shi S H, Zhang J Q, Zhang J L, et al. Structural characterization of raw and wine-steamed Polygonatum cyrtonema Hua oligosaccharides and their bioactivity on immune regulation via modifying the gut microbiota [J]. Int Immunopharmacol, 2025, 153: 114468. 王民, 陈玉芹. 常用降糖中药的药理分析[J]. 中国医药指南, 2015, 13(10): 223-224. Kato A, Miura T. Hypoglycemic activity of Polygonati Rhizoma in normal and diabetic mice [J]. Biol Pharm Bull, 1993, 16(11): 1118-1120. 石双慧, 王梦琳, 魏晓彤, 等. AHP-熵权法结合Box-Behnken设计-响应面法优选黄精酒制工艺及其炮制前后药效对比研究[J]. 中草药, 2023, 54(14): 4467-4480. Gu W, Wang Y F, Zeng L X, et al. Polysaccharides from Polygonatum kingianum improve glucose and lipid metabolism in rats fed a high fat diet [J]. Biomed Pharmacother, 2020, 125: 109910. Zhang J Q, Shi S H, Zhang J L, et al. Wine-processed Polygonatum cyrtonema Hua polysaccharides alleviating cognitive dysfunction in CUMS mice by regulating intestinal microbiota [J]. Food Sci Nutr, 2025, 13(8): e70711. 吴莉, 王帅康, 曾佳玲, 等. 酒黄精多糖对AD果蝇模型运动、记忆和抗氧化能力影响的研究[J]. 中国实验动物学报, 2025, 33(11): 1619-1628. Liu Y X, Wang Y, Liang Y F, et al. Transcriptomics and metabolomics revealed the effects of Polygonatum Rhizoma polysaccharide on delaying C. elegans senescence and ameliorating Alzheimer’s disease [J]. Int J Biol Macromol, 2025, 327: 147375. Jiang Y, Qiao W, Guo K L, et al. Multi-target renal protection of wine-processed Polygonatum sibiricum against cisplatin-induced nephrotoxicity: Integrated phytochemistry, network pharmacology and experimental validation [J]. Basic Clin Pharmacol Toxicol, 2025, 137(3): e70092. 徐金铭, 张水利, 俞冰. 酒黄精水提液对肝损伤小鼠氧化应激及炎症反应的影响[J]. 浙江临床医学, 2025, 27(10): 1442-1444. 张鑫鑫. 黄精多糖通过PI3K/Akt/mTOR通路减轻CCl4诱导的大鼠急性肝损伤[D]. 合肥: 安徽农业大学, 2023. 刘红梅, 周平兰, 王竹鑫, 等. 基于JAK-STAT/NF-κB通路探究黄精“生熟异治”治疗缺血性脑卒中大鼠的保护作用及分子机制研究[J]. 湖南中医药大学学报, 2025, 45(4): 598-607. 贾璐瑜, 张鹏飞, 黎雄, 等. 黄精多糖纳米颗粒的构建及其对大肠杆菌诱导脓毒症小鼠的保护作用[J]. 中国中药杂志, 2026, 51(9): 2544-2552. 彭腾, 王迎香, 龙飞, 等. 一种具有抗疲劳作用的类黑精及其应用: 中国, CN117653699B [P]. 2025-03-14. 吴志生, 张晓梦. 一种抗疲劳药食同源中药组合物及其制备方法和用途: 中国, CN118078914B [P]. 2025-07-15. 鲍康德, 宋大伟, 黄丽思, 等. 一种酒黄精高效炮制及其多组分提取物制备工艺和应用: 中国, CN120617412A [P]. 2025-09-12. 施扬, 王力川, 马占林, 等. 滇黄精提取物成分与活性测定及细胞毒性评价[J]. 日用化学工业, 2020(11): 788-792. 赵明, 施扬, 陈军文, 等. 具有抗氧化、美白和保护细胞活性的酒制滇黄精提取物及其制备方法与应用: 中国, CN111388388A [P]. 2020-07-10.
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