中草药

冰片介导的脑部递药系统构建策略及性能研究进展

PDF下载

胡盛谋, 王灿坚, 林婉晴, 孙晓丽, 曾奕琦, 张万春, 王甜甜, 张国松

中草药 | 综述 2026,57(14): 5709-5722

收起

中草药 |综述 2026 , 57 (14) : 5709 -5722

冰片介导的脑部递药系统构建策略及性能研究进展

全屏

胡盛谋, 王灿坚, 林婉晴, 孙晓丽, 曾奕琦, 张万春, 王甜甜, 张国松

作者信息

通讯作者:

王甜甜

作者简介:

胡盛谋: 胡盛谋，硕士研究生，研究方向为药物新剂型与新技术。E-mail:3130994113@qq.com

Research progress on construction strategies and performance of borneol-mediated brain-targeted drug delivery systems

HU Shengmou, WANG Canjian, LIN Wanqing, SUN Xiaoli, ZENG Yiqi, ZHANG Wanchun, WANG Tiantian, ZHANG Guosong

Affiliations

doi: 10.7501/j.issn.0253-2670.2026.14.029

文章导航

摘要

收起

血脑屏障是中枢神经系统药物递送的核心瓶颈。而冰片Borneolum Syntheticum作为传统“引经”药，可通过可逆调节血脑屏障通透性，为脑靶向递送提供独特的天然增效工具。因此，将冰片整合入现代递药系统构建策略，是实现协同增效的有力途径。通过检索CNKI和PubMed数据库2018年以来冰片介导脑部递药系统的相关文献，聚焦该递药系统的构建策略，将其归纳为物理负载、化学偶联与生物融合3类策略，详细阐述了各类策略的设计原理、载体特性及代表性系统，并深入分析构建策略与递药系统稳定性、释放能力、跨血脑屏障与递送能力等关键性能间的影响规律，最终提炼出“治疗需求-策略匹配-工艺评估”的决策原则，为该类系统的设计、性能提升及临床转化提供科学依据与策略参考。

关键词

冰片 / 神经系统疾病 / 药物递送系统 / 血脑屏障 / 构建策略

Abstract

收起

The blood-brain barrier is the core bottleneck for drug delivery to the central nervous system. Bingpian (Borneolum Syntheticum), as a traditional “guide” drug, can reversibly modulate blood-brain barrier permeability, thereby providing a unique natural efficacy-enhancing tool for brain-targeted delivery. Therefore, integrating Borneolum Syntheticum into the construction strategies of modern drug delivery systems is a powerful approach to achieve synergistic enhancement. By retrieving relevant literature on Borneolum Syntheticum-mediated brain-targeted drug delivery systems published since 2018 from CNKI and PubMed databases, focusing on the construction strategies of such drug delivery systems, this study summarized them into three categories: physical loading, chemical conjugation, and biological fusion. The design principles, carrier characteristics, and representative systems of each strategy are elaborated in detail. The influence rules between construction strategies and key properties of drug delivery systems, including stability, release capacity, blood-brain barrier crossing ability, and delivery efficacy, are deeply analyzed. Finally, the core decision-making principle of “treatment needs-strategy matching-process evaluation” is distilled, providing scientific basis and strategic references for the design, performance optimization, and clinical translation of such systems.

Key words

Borneolum Syntheticum / nervous system diseases / drug delivery systems / blood-brain barrier / construction strategies

引用本文

胡盛谋, 王灿坚, 林婉晴, 孙晓丽, 曾奕琦, 张万春, 王甜甜, 张国松. 冰片介导的脑部递药系统构建策略及性能研究进展. 中草药, 2026 , 57 (14) : 5709 -5722 . DOI: 10.7501/j.issn.0253-2670.2026.14.029

HU Shengmou, WANG Canjian, LIN Wanqing, SUN Xiaoli, ZENG Yiqi, ZHANG Wanchun, WANG Tiantian, ZHANG Guosong. Research progress on construction strategies and performance of borneol-mediated brain-targeted drug delivery systems[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (14) : 5709 -5722 . DOI: 10.7501/j.issn.0253-2670.2026.14.029

基金

收起

国家自然科学基金资助项目 (82260771); 江西省“双千计划”创新领军人才长期（青年）项目 (jxsq2023101090); 江西省中医药标准化项目 (2023A20); 江西省“科技＋中医药”联合计划项目 (S2023KJSLG0037); 江西省大学生创新创业训练计划项目 (202410412297)

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

Huang Y, Li Y A, Pan H Y, et al. Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide [J]. J Glob Health, 2023, 13: 04160.
Qin R X, Xu W, Xu H Y, et al. The burden of common neurological disorders in Asia: Insights from the global burden of disease study (1990—2021) [J]. J Neurol, 2025, 272(5): 333.
Wang Y, Liang J J, Fang Y T, et al. Burden of common neurologic diseases in Asian countries, 1990—2019: An analysis for the global burden of disease study 2019[J]. Neurology, 2023, 100(21): e2141-e2154.
ZiHua G, Saadullah K, Ahmar M R, et al. Role of nanomedicine-based therapeutics in the treatment of CNS disorders [J]. Molecules, 2023, 28(3): 1283-1283.
Zhang Y B, Liu M H, Wang Y S, et al. Nasal nanotherapeutics for central nervous system disorders: Bridging the translational gap in central nervous system drug delivery [J]. Eur J Pharmacol, 2025, 1003: 177958.
Kang Y J, Cutler E G, Cho H. Therapeutic nanoplatforms and delivery strategies for neurological disorders [J]. Nano Convergence, 2018, 5(1): 35.
Golshany H, Ni Y, Yu Q, et al. Nano-delivery systems for carotenoids: Enhancing bioavailability and therapeutic potential in neurodegenerative diseases [J]. Food Rev Int, 2025, 41(7): 2007-2032.
Zhao Y M, Du L B, Liu Y. Novel nano antioxidant drug delivery systems for the treatment of neurodegenerative diseases [J]. Free Radic Biol Med, 2018, 120: S150.
张历元, 李元文, 林欢儿, 等. 中药冰片的商品种类与现代药理学研究进展[J]. 世界中医药, 2018, 13(4): 1025-1029.
梁妍, 刘丽宁, 刘玥含, 等. 天然冰片的本草考证[J]. 中药材, 2025, 48(10): 2641-2647.
尹东阁, 王开心, 刘曼婷, 等.《中华人民共和国药典》2020年版收载含冰片、薄荷的中药成方制剂质量标准分析[J]. 中华中医药学刊, 2023, 41(2): 24-31.
Hu X X, Yan Y, Liu W J, et al. Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol [J]. Phytomedicine, 2024, 132: 155848.
方亮, 陶文康, 程红艳, 等. 中药引药上行的作用机制及其脑靶向制剂研究进展[J]. 中草药, 2023, 54(10): 3312-3321.
Kulkarni M, Sawant N, Kolapkar A, et al. Borneol: A promising monoterpenoid in enhancing drug delivery across various physiological barriers [J]. AAPS PharmSciTech, 2021, 22(4): 145.
黄思琪, 杨皓宇, 孔雨朦, 等. 知识图谱视角下的冰片研究热点与前沿动态可视化分析[J]. 中草药, 2024, 55(16): 5583-5595.
张英睿, 王建, 董泰玮, 等. 冰片对血脑屏障通透性影响机制的研究进展[J]. 中成药, 2020, 42(12): 3236-3240.
刘雪茹, 刘叶, 刘超, 等. 复合纳米载体在微波可控释药方面的研究进展[J]. 工程科学与技术, 2024, 56(2): 139-150.
Shi Y L, Zhang Y R, Zhu L L, et al. Tailored drug delivery platforms: Stimulus-responsive core-shell structured nanocarriers [J]. Adv Healthc Mater, 2024, 13(1): 2301726.
王雪磊, 杨剪瑜, 钱洪安, 等. 冰片茶多酚纳米乳对AD模型小鼠Aβ、BACE-1表达和认知功能的影响[J]. 脑与神经疾病杂志, 2024, 32(2): 76-82.
任君刚, 许可. 冰片修饰卡马西平PLGA纳米粒的制备及其在小鼠体内的组织分布[J]. 中国医药工业杂志, 2023, 54(8): 1224-1232.
叶晓莉, 王丛瑶, 何佳, 等. 冰片修饰多柔比星/丹参酮II_A磺酸钠双载药纳米粒的制备及其理化性质[J]. 中国临床药学杂志, 2024, 33(1): 23-29.
Khajuria D K, Vasireddi R, Priydarshi M K, et al. Ionic diffusion and drug release behavior of core-shell-functionalized alginate-chitosan-based hydrogel [J]. ACS Omega, 2020, 5(1): 758-765.
Paramita V D, Kasapis S. Rate of fatty acid transport in glassy biopolymers: A free volume based predictive approach [J]. Food Hydrocoll, 2018, 78: 128-131.
Tang S N, Wang A P, Yan X J, et al. Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease [J]. Drug Deliv, 2019, 26(1): 700-707.
Shen X, Cui Z X, Wei Y D, et al. Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider [J]. Asian J Pharm Sci, 2023, 18(6): 100778.
Luo X, Wu H Z, Jiang Z, et al. Polylysine-polyglyceryl-10-decanoate derivatives: Enhanced antioxidant properties, stability, and bioaccessibility of resveratrol nanoemulsions [J]. Food Chem, 2025, 496: 146564.
Sarheed O, Dibi M, Ramesh K V R N S, et al. Fabrication of alginate-based O/W nanoemulsions for transdermal drug delivery of lidocaine: Influence of the oil phase and surfactant [J]. Molecules, 2021, 26(9): 2556.
Lorenzett A K P, de Lima V A, da Fonseca C O P, et al. Nanoemulsions and microemulsions for intranasal drug delivery: A bibliometric analysis and emerging trends (2004—2024) [J]. Pharmaceutics, 2025, 17(9): 1104.
Elzoghby A O, Abdelmoneem M A, Hassanin I A, et al. Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier .htm targeting ligand [J]. Biomaterials, 2020, 263: 120355.
马跃, 邓莉, 李善刚. 纳米粒子在CRISPR/Cas9基因治疗中的应用[J]. 生物工程学报, 2022, 38(6): 2087-2104.
Apolinário A C, Hauschke L, Nunes J R, et al. Lipid nanovesicles for biomedical applications: ‘What is in a name’? [J]. Prog Lipid Res, 2021, 82: 101096.
Long Y, Liu S Y, Wan J Y, et al. Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1α/VEGF/eNOS/NO signal pathway [J]. Biomed Pharmacother, 2023, 160: 114240.
Chen T, Zeng M T, Xiong L J, et al. Enhancing the antidepressant efficacy of quercetin via brain-targeted lipid nanocarriers: Fabrication, characterization, and evaluation [J]. Int J Nanomed, 2025, 20: 15793-15811.
Ye X L, Peng X Y, Song Q, et al. Borneol-modified tanshinone II_A liposome improves cerebral ischemia reperfusion injury by suppressing NF-κB and ICAM-1 expression [J]. Drug Dev Ind Pharm, 2021, 47(4): 609-617.
叶晓莉, 吴梅君, 王丛瑶, 等. 冰片修饰的葛根素脂质体的制备及脑组织分布研究[J]. 中国现代应用药学, 2023, 40(5): 632-637.
叶晓莉, 王丛瑶, 刘汀, 等. 冰片修饰的姜黄素阳离子脂质体的制备及其脑靶向作用研究[J]. 中国现代应用药学, 2021, 38(12): 1469-1473.
付丽娜, 赵宁, 李伟泽, 等. 冰片阿司匹林固体脂质纳米粒的制备及脑靶向分布[J]. 化工科技, 2021, 29(5): 6-10.
Cai S H, Yuan Z W, Chen Y F, et al. Transferrin and borneol-enhanced liposomes for targeted rapamycin delivery in TBI [J]. Int J Nanomed, 2025, 20: 4503-4518.
陈晨, 王彦阁, 宋亚男, 等. 冰片修饰金丝桃苷脂质体的制备及经鼻给药药动学行为和脑靶向性考察[J]. 中草药, 2025, 56(6): 1967-1978.
Zhang Y L, Liu S Y, Wan J Y, et al. Preparation, characterization and in vivo study of borneol-baicalin-liposomes for treatment of cerebral ischemia-reperfusion injury [J]. Int J Nanomed, 2020, 15: 5977-5989.
Ding H, Wang K, He L Q, et al. A novel nano material for anti-cerebral ischaemia: Preparation and application of borneol Angelica polysaccharide liposomes [J]. J Liposome Res, 2023, 33(2): 144-153.
Tong Z R, Jie X L, Chen Z W, et al. Borneol and lactoferrin dual-modified crocetin-loaded nanoliposomes enhance neuroprotection in HT22 cells and brain targeting in mice [J]. Eur J Med Chem, 2024, 276: 116674.
Pereira L, Ferreira F C, Pires F, et al. Magnetic-responsive liposomal hydrogel membranes for controlled release of small bioactive molecules: An insight into the release kinetics [J]. Membranes, 2023, 13(7): 674.
Yu S, Li D, Shi A, et al. Multidrug-loaded liposomes prevent ischemic stroke through intranasal administration [J]. Biomed Pharmacother, 2023, 162: 114542.
Wen Y, Zhang Z X, Cai Z M, et al. Ligustrazine-loaded borneol liposome alleviates cerebral ischemia-reperfusion injury in rats [J]. ACS Biomater Sci Eng, 2022, 8(11): 4930-4941.
周佳欣, 聂伟东. 膜融合技术赋能抗癌药物与靶点互作[J]. 中国生物工程杂志, 2025, 45(6): 62-69.
Lv Z Y, Yang Y W, Wang J, et al. Optimization of the preparation conditions of borneol-modified ginkgolide liposomes by response surface methodology and study of their blood brain barrier permeability [J]. Molecules, 2018, 23(2): 303.
Wang G L, Zhai Z Z, Wang W H, et al. Tailored borneol-modified lipid nanoparticles nasal spray for enhanced nose-to-brain delivery to central nervous system diseases [J]. ACS Nano, 2024, 18(34): 23684-23701.
Kumar N, Gusain R, Pandey S, et al. Hydrogel nanocomposite adsorbents and photocatalysts for sustainable water purification [J]. Adv Mater Interfaces, 2023, 10(2): 2201375.
Lau C M L, Jahanmir G, Yu Y, et al. Controllable multi-phase protein release from in-situ hydrolyzable hydrogel [J]. J Control Release, 2021, 335: 75-85.
Cook M T, Haddow P, Kirton S B, et al. Polymers exhibiting lower critical solution temperatures as a route to thermoreversible gelators for healthcare [J]. Adv Funct Mater, 2021, 31(8): 2008123.
Yu Y W, Zou Y X, Yang M Y, et al. Quercetin-loaded zeolitic imidazolate framework-8 nanoparticles through borneol-embedded hyaluronic acid hydrogel for ischemic stroke treatment [J]. Int J Biol Macromol, 2026, 340: 149821.
Wu F C, Huang M J, Zuo X, et al. Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice [J]. Front Pharmacol, 2023, 14: 1224856.
Teng C H, Lv W, Chen Y Q, et al. Enhanced the treatment of ischemic stroke through intranasal temperature-sensitive hydrogels of edaravone and borneol inclusion complex [J]. Int J Pharm, 2024, 651: 123748.
Lertsuphotvanit N, Sirirak J, Tamdee P, et al. Ways to assess and regulate the performance of a bi-mechanism-induced borneol-based in situ forming matrix [J]. Pharmaceutics, 2023, 15(8): 2053.
Wu X M, Yuan R X, Xu Y C, et al. Functionalized lipid nanoparticles modulate the blood-brain barrier and eliminate α-synuclein to repair dopamine neurons [J]. Asian J Pharm Sci, 2024, 19(2): 100904.
Wang M L, Lv Y T, Xu H P, et al. Supramolecular cyclodextrin-based reservoir as nasal delivery vehicle for rivastigmine to brain [J]. Carbohydr Polym, 2025, 348: 122881.
Jia Z, Yuan X Y, Wei J, et al. A functionalized octahedral palladium nanozyme as a radical scavenger for ameliorating Alzheimer’s disease [J]. ACS Appl Mater Interfaces, 2021, 13(42): 49602-49613.Bello M G,
Zhang J W, Chen L H. Cyclodextrin metal-organic framework design principles and functionalization for biomedical application [J]. Carbohydr Polym, 2025, 364: 123684.
Rahme K, Dagher N. Chemistry routes for copolymer synthesis containing PEG for targeting, imaging, and drug delivery purposes [J]. Pharmaceutics, 2019, 11(7): 327.
Suk J S, Xu Q G, Kim N, et al. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery [J]. Adv Drug Deliv Rev, 2016, 99: 28-51.
Hong S H, Larocque K, Jaunky D B, et al. Dual disassembly and biological evaluation of enzyme/ oxidation-responsive polyester-based nanoparticulates for tumor-targeting delivery [J]. Colloids Surf B Biointerfaces, 2018, 172: 608-617.
Dong H N, Pang L, Cong H L, et al. Application and design of esterase-responsive nanoparticles for cancer therapy [J]. Drug Deliv, 2019, 26(1): 416-432.
Sun J, Wei C F, Liu Y N, et al. Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer’s disease [J]. Biomaterials, 2019, 197: 417-431.
Dong Z Q, Kang Y, Yuan Q J, et al. H₂O₂-responsive nanoparticle based on the supramolecular self-assemble of cyclodextrin [J]. Front Pharmacol, 2018, 9: 552.
Liu B, Thayumanavan S. Mechanistic investigation on oxidative degradation of ROS-responsive thioacetal/ thioketal moieties and their implications [J]. Cell Rep Phys Sci, 2020, 1(12): 100271.
Wang Y N, Ma X T, Wang X Y, et al. Traditional Chinese medicine borneol-based polymeric micelles intracerebral drug delivery system for precisely pathogenesis-adaptive treatment of ischemic stroke [J]. Adv Sci, 2025, 12(9): 2410889.
Ma X T, Zhang X, Wang Y N, et al. Dynamic ROS-responsive hyperbranched polymer-based neuroprotective drug delivery system for pathogenesis-adaptive sequential therapy of cerebral ischemic stroke [J]. Biomaterials, 2026, 326: 123683.
王誉晓, 王新鸿, 王丽梅, 等. 催化酰胺类药物水解代谢酶的研究进展[J]. 中国药科大学学报, 2025, 56(2): 244-251.
吴小伟, 王江, 柳红. 先导化合物结构优化策略(六): 改善化合物血浆稳定性[J]. 药学学报, 2018, 53(2): 192-201.
Vrettos E I, Karampelas T, Sayyad N, et al. Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable “click” oxime bond tethers and preclinical evaluation against prostate cancer [J]. Eur J Med Chem, 2021, 211: 113018.
Song Y J, Huang Q, Pu Q, et al. Gastrodin liposomes block crosstalk between astrocytes and glioma cells via downregulating Cx43 to improve antiglioblastoma efficacy of temozolomide [J]. Bioconjugate Chem, 2024, 35(9): 1380-1390.
李晶晶. 冰片和叶酸共修饰的阿霉素聚酰胺-胺复合物在动物体内的研究[J]. 中国现代应用药学, 2019, 36(23): 2923-2929.
Yu S M, Wang X Y, Lv L L, et al. Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg₁ against depression [J]. Int J Pharm, 2023, 643: 123284.
Pulukuri A J, Burt A J, Opp L K, et al. Acquired drug resistance enhances imidazoquinoline efflux by P-glycoprotein [J]. Pharmaceuticals, 2021, 14(12): 1292.
Yang R, Chen Z X, Xie F D, et al. (+/–)-Borneol reverses mitoxantrone resistance against P-glycoprotein [J]. J Chem Inf Model, 2021, 61(1): 252-262.
Zhao X, Ni S T, Song Y J, et al. Intranasal delivery of borneol/R8dGR peptide modified PLGA nanoparticles co-loaded with curcumin and cisplatin alleviate hypoxia in pediatric brainstem glioma which improves the synergistic therapy [J]. J Control Release, 2023, 362: 121-137.
Wang L Q, Cai Q Y, Yang Y L, et al. Multi-enzyme active CeVO₄ nanocubes targetedly reverse apoptosis in AD neurons: Dual pathway mechanism of mitochondrial homeostasis reconstruction and oxidative stress regulation [J]. Chem Eng J, 2025, 523: 168781.
Dali P, Shende P. Self-assembled lipid polymer hybrid nanoparticles using combinational drugs for migraine via intranasal route [J]. AAPS PharmSciTech, 2022, 24(1): 20.
Zhang Y J, Zhang N, Song H, et al. Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome [J]. Drug Deliv, 2019, 26(1): 70-77.
Meng L W, Chu X Y, Xing H Y, et al. Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol [J]. Int J Pharm, 2019, 567: 118485.
Guo X Y, Wu G J, Wang H, et al. Pep-1.htmborneol-bifunctionalized carmustine-loaded micelles enhance anti-glioma efficacy through tumor-targeting and BBB-penetrating [J]. J Pharm Sci, 2019, 108(5): 1726-1735.
Liu Y, Cai J Y, Liu Y, et al. Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma [J]. Drug Dev Ind Pharm, 2024, 50(2): 135-149.
赵霄, 余双文, 杜俊锋, 等. 冰片/RGD双修饰多烯紫杉醇纳米粒经鼻给药抗脑胶质瘤作用研究[J]. 药学学报, 2021, 56(12): 3233-3242.
安娜. 冰片修饰载紫杉醇纳米结构脂质载体的构建及抗脑胶质瘤作用初步研究[D]. 上海: 上海中医药大学, 2020.
Li F R, Yu Y, Du Y M, et al. Borneol-modified schisandrin B micelles cross the blood-brain barrier to treat Alzheimer’s disease in aged mice [J]. ACS Chem Neurosci, 2024, 15(3): 593-607.
Yu J J, Ma D J, Li S T, et al. Construction of ROS-responsive cascade-targeted liposomes and investigation of their anti-AD effects [J]. Int Immunopharmacol, 2025, 163: 115234.
刘洋, 司佳奇, 蔡佳雨, 等. 冰片修饰多烯紫杉醇/粉防己碱胶束处方优选及体外抗肿瘤作用[J]. 辽宁中医药大学学报, 2023, 25(7): 40-44.
李沣芮, 刘洋, 司佳奇, 等. 冰片修饰五味子乙素胶束处方优选及体外对bEnd.3细胞靶向性评价研究[J]. 中华中医药学刊, 2024, 42(2): 245-249.
陈宁, 韩丽飞, 胡浩霖, 等. 细胞膜包覆的纳米药物在肿瘤治疗中的研究进展[J]. 药学学报, 2025, 60(7): 2132-2141.
Wang C F, Wu S Z. Research update on cell membrane camouflaged nanoparticles for cancer therapy [J]. Front Bioeng Biotechnol, 2022, 10: 944518.
刘怡君, 王红娟, 张靖彬, 等. 植物细胞外囊泡作为药物载体的研究进展[J]. 药学学报, 2025, 60(3): 721-730.
Zhao B, Lin H J, Jiang X C, et al. Exosome-like nanoparticles derived from fruits, vegetables, and herbs: Innovative strategies of therapeutic and drug delivery [J]. Theranostics, 2024, 14(12): 4598-4621.
MuhammedNazaar S, Yao J Q, Necelis M R, et al. The lipid bilayer strengthens the cooperative network of membrane proteins [J]. Sci Adv, 2025, 11(27): eadv9568.
Liu X B, Du J Q, Sun J P, et al. Borneol-functionalized macrophage membrane-encapsulated mesoporous selenium nanoparticles loaded with resveratrol for the treatment of spinal cord injury [J]. ACS Appl Mater Interfaces, 2024, 16(46): 63170-63185.
Yu P C, Yue C X, Dong W Z, et al. Cancer immunotherapy via disruption of integrin αvβ3 and CD47 costabilization on cancer cell surface [J]. Adv Sci, 2026, 13(2): e01602.
Yousefi-Hashemabad M J, Kamroo A, Rezvanimehr A, et al. CD47/SIRPα immune checkpoint modulation: A synergistic strategy for next-generation CAR therapies [J]. Mol Cancer Ther, 2026, doi: 10.1158/1535-7163.MCT-25-0531.
Li T, Jia X, Yu M L. Construction of fibromodulin and borneol-clacked phosphorus dendrimer nanoparticles to reduce inflammation and oxidative stress in BBB to nursing care and ischemic stroke therapy [J]. Naunyn Schmiedeberg's Arch Pharmacol, 2025, 398(11): 16003-16018.
Xia C J, Hu C H, Xu R, et al. An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke [J]. Mater Today Bio, 2025, 34: 102102.
Zhang S S, Asghar S, Yang L, et al. Borneol and poly (ethylene glycol) dual modified BSA nanoparticles as an itraconazole vehicle for brain targeting [J]. Int J Pharm, 2020, 575: 119002.
Kalantarian S M, Wang Z Q, Richter-Bisson Z W, et al. Aggregation, stabilization, and binding between bovine serum albumin and gold nanoparticles of varying sizes [J]. Colloids Surf A Physicochem Eng Aspects, 2025, 726: 137914.
Li N J, Zhu A R, Chen W J, et al. Nasal administration of Xingnaojing biomimetic nanoparticles for the treatment of ischemic stroke [J]. Int J Pharm, 2024, 666: 124830.
Kilasoniya A, Garaeva L, Spitsyna A, et al. Plant-derived vesicles as carries of exogenous functional biomolecules [J]. Ann Nutr Metab, 2022, 78: 59-59.
Savcı Y, Kırbaş O K, Bozkurt B T, et al. Grapefruit-derived extracellular vesicles as a promising cell-free therapeutic tool for wound healing [J]. Food Funct, 2021, 12(11): 5144-5156.
Song H, Wei M, Zhang N, et al. Enhanced permeability of blood-brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle [J]. Int J Nanomed, 2018, 13: 1869-1879.
Wang L P, Zhao X, Du J F, et al. Improved brain delivery of pueraria flavones via intranasal administration of borneol-modified solid lipid nanoparticles [J]. Nanomedicine, 2019, 14(16): 2105-2119.
Wang L T, Xu L, Du J F, et al. Nose-to-brain delivery of borneol modified tanshinone II_A nanoparticles in prevention of cerebral ischemia/reperfusion injury [J]. Drug Deliv, 2021, 28(1): 1363-1375.
Frejková M, Běhalová K, Rubanová D, et al. Polymer nanotherapeutics with the controlled release of acetylsalicylic acid and its derivatives inhibiting cyclooxygenase isoforms and reducing the production of pro-inflammatory mediators [J]. Int J Pharm, 2024, 665: 124742.
Yan T S, Zhu S Y, Hui W X, et al. Chitosan based pH-responsive polymeric prodrug vector for enhanced tumor targeted co-delivery of doxorubicin and siRNA [J]. Carbohydr Polym, 2020, 250: 116781.
Zeng H H, Li M, Wang Z R, et al. Disulfide bond-based oxidation-responsive triptolide-loaded nanodrug for inflammation-targeted treatment of collagen-induced arthritis [J]. Appl Mater Today, 2024, 40: 102350.
Li H, Zhao Y Y, Jia Y, et al. pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy [J]. Chem Commun, 2020, 56(87): 13347-13350.
Cai L, Zhu P, Huan F, et al. Toxicity-attenuated mesoporous silica Schiff-base bonded anticancer drug complexes for chemotherapy of drug resistant cancer [J]. Colloids Surf B Biointerfaces, 2021, 205: 111839.
Jin A H, Wang N Y, Liu Y H, et al. Endogenic transferrin-targeted cell membrane-coated biomimetic lipo-complexes for efficient targeting and enhanced antitumor efficacy in orthotopic glioblastoma [J]. Acta Pharm Sin B, 2026, 16(1): 574-595.
Ma J J, Pei H X, Wang F H, et al. Neutrophil membrane-coated nanoparticles for targeted therapy [J]. Discov Nano, 2025, 20(1): 234.
Liu W Y, Yu Y, Zang J, et al. Menthol-modified quercetin liposomes with brain-targeting function for the treatment of senescent Alzheimer’s disease [J]. ACS Chem Neurosci, 2024, 15(11): 2283-2295.
Cai J Y, Liu Y, Zhang L, et al. Menthol-modified paclitaxel multifunctional cationic liposomes cross the blood-brain barrier and target glioma stem cells for treatment of glioblastoma [J]. J Drug Deliv Sci Technol, 2024, 93: 105387.
高彩芳, 朱颖, 夏加璇, 等. 冰片和薄荷醇在促进纳米制剂跨越生理屏障中的应用[J]. 中草药, 2018, 49(12): 2763-2768.
黄小英, 龚梦雅, 杨建波, 等. 中药精油及其挥发性成分调控血脑屏障通透性的药理学机制研究进展[J]. 中草药, 2025, 56(13): 4875-4889.
帅书苑, 郑琴, 岳鹏飞, 等. 芳香中药及其活性成分提神醒脑机制的研究进展[J]. 中草药, 2021, 52(20): 6403-6412.

2026年第57卷第14期

PDF下载

引用本文

BibTeX

文章信息

doi: 10.7501/j.issn.0253-2670.2026.14.029

接收时间：2026-01-29
首发时间：2026-09-10

补充材料

相关文章

文章信息

作者

出版历史

收稿日期：2026-01-29

基金

作者信息

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.14.029

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT