Article(id=1304735424354739132, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.14.023, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1773417600000, receivedDateStr=2026-03-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1789002765977, onlineDateStr=2026-09-10, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789002765977, onlineIssueDateStr=2026-09-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789002765977, creator=13701087609, updateTime=1789002765977, updator=13701087609, issue=Issue{id=1304735403429356361, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='14', pageStart='5353', pageEnd='5788', issueExtLink='null', onlineDate='null', pubDate='1785168000000', pubDateStr='2026-07-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789002760989, creator='13701087609', updateTime=1789002916821, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304736057073889492, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304736057073889493, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=5628, endPage=5647, ext={EN=ArticleExt(id=1304735425772413888, articleId=1304735424354739132, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Analysis of research hotspots and trends of Gentiana based on CiteSpace and VOSviewer visualized knowledge maps, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective CiteSpace and VOSviewer softwares were used to conduct a visualized analysis of the current status of research on Gentiana worldwide, so as to predict its future research hotspots and developmental trends based on bibliometric methods. Methods Relevant literatures on Gentiana from January 1, 2005 to December 31, 2025 were retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) Core Collection databases. After manually excluding duplicate and ineligible literatures and standardizing keywords, Excel, VOSviewer and CiteSpace were used to perform visualized analyses on the annual publication volume, publication journals, institutions, authors, countries and keywords of Chinese and English literatures in the field of Gentiana, respectively. Results A total of 7 449 eligible literature were retrieved, including 6 121 Chinese literature and 1 328 English literature. The annual publication volume of Chinese literature showed a fluctuating trend, while that of English literature presented a rapid upward trend. The Chinese and English journals publishing the most Gentiana-related studies were Chinese Traditional and Herbal Drugs (114 publications) and Journal of Ethnopharmacology (44 publications), respectively. The authors with the highest publication outputs were Wang Yuanzhong (61 publications) and Zhang Ji (27 publications). The institutions with the largest number of Chinese and English publications were Heilongjiang University of Chinese Medicine (118 publications) and Chinese Academy of Sciences (110 publications), respectively. The top three countries in terms of the number of articles published were China (709 publications), India (111 publications), and Japan (105 publications). The keyword analysis revealed that the current research hotspots mainly focused on the analysis of compound formulations, clinical applications, species identification, chemical composition, pharmacological effects, and mechanisms of action related to the Gentiana genus. In addition, traditional Chinese medicine preparations containing Gentiana have also been used to treat symptoms such as coughing and wheezing in patients during the COVID-19 pandemic. Conclusion Research on the Gentiana genus both domestically and internationally is currently showing an overall upward trend. In recent years, studies are gradually shifting from the single analysis of chemical components and pharmacological effects to the exploration of “multi-components and multi-targets” synergistic mechanisms. This research is deeply integrating modern technological methods such as genomics, molecular docking, and network pharmacology, providing important directions for the analysis of the efficacy mechanisms and innovative applications of Gentiana-related species. Future research in this field can also promote the precision and multi-layered development of Gentiana studies by strengthening international collaboration and deepening the integration of modern technologies., authors=ZHAO Yimai, BORJIGIDAI Almaz, YU Hongzhen, YU Yuanyuan, XU Weiwei, GUO Guangying, YU Jiaoneng, ZHANG Yuxia, GUO Ruixin, XORGAN Uranghai, VANJIL Gundegmaa, BATTSEREN Tsambaa, BATZAYA Gachmaa, URTNASAN Mandakh, authorsList=ZHAO Yimai, BORJIGIDAI Almaz, YU Hongzhen, YU Yuanyuan, XU Weiwei, GUO Guangying, YU Jiaoneng, ZHANG Yuxia, GUO Ruixin, XORGAN Uranghai, VANJIL Gundegmaa, BATTSEREN Tsambaa, BATZAYA Gachmaa, URTNASAN Mandakh, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304735425671750591, articleId=1304735424354739132, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于CiteSpace和VOSviewer可视化知识图谱的龙胆属研究热点和趋势分析, columnId=1304140194819629763, journalTitle=中草药, columnName=数据挖掘与循证医学, runingTitle=null, highlight=null, articleAbstract=目的 基于文献计量学方法,运用CiteSpace和VOSviewer软件对国内外龙胆属领域研究现状进行可视化分析,预测其未来研究热点和发展趋势。方法 以中国知网(CNKI)和Web of Science(WOS)核心合集数据库为数据来源,检索2005年1月1日—2025年12月31日龙胆属领域的相关文献。经人工剔除重复及不符合标准文献并统一规范关键词后,利用Excel、VOSviewer及CiteSpace软件分别对龙胆属领域中英文文献的年发文量、期刊、机构、作者、国家、关键词等进行可视化分析。结果 检索得到符合要求的文献共7 449篇,其中中文文献6 121篇,英文文献1 328篇。中文文献年发文量呈波动趋势,英文文献年发文量则呈上升趋势且增势迅速,刊载龙胆属研究文献最多的中英文期刊分别是《中草药》(114篇)和Journal of Ethnopharmacology(44篇);发文量最高的作者分别是王元忠(61篇)和Zhang Ji(27篇);发文量最多的机构分别为黑龙江中医药大学(118篇)和Chinese Academy of Sciences(110篇);发文量排名前3的国家分别是中国(709篇)、印度(111篇)以及日本(105篇);通过关键词分析发现,当前研究热点主要集中于龙胆属复方分析、临床应用、物种鉴定、化学成分、药理作用和作用机制研究等方面。此外,在新冠疫情期间,含有龙胆的中药制剂也被用于治疗患者咳嗽、气喘等症状。结论 目前国内外对龙胆属领域的研究总体呈上升趋势,近年来其研究正逐步从化学成分和药理作用的单一分析转向为“多组分、多靶点”协同机制的探讨,深度融合基因组学、分子对接、网络药理学等现代技术方法,为龙胆属物种的药效机制解析及创新应用提供了重要方向。未来对于该领域的研究也可通过加强国际化协作,深化现代技术融合,从而推动龙胆属领域研究向精准化和多层次发展。, authors=赵一迈1, 阿里穆斯1, 于红珍1, 于媛媛1, 许炜炜1, 郭光瑛1, 余姣能1, 张玉霞1, 郭蕊昕1, 希古日干1, VANJIL Gundegmaa2, BATTSEREN Tsambaa3, BATZAYA Gachmaa3, URTNASAN Mandakh4, authorsList=赵一迈, 阿里穆斯, 于红珍, 于媛媛, 许炜炜, 郭光瑛, 余姣能, 张玉霞, 郭蕊昕, 希古日干, VANJIL Gundegmaa, BATTSEREN Tsambaa, BATZAYA Gachmaa, URTNASAN Mandakh, authorCompany=1 中央民族大学民族医药教育部重点实验室, 北京 100800;
2 蒙古国立教育大学数学与自然科学学院, 蒙古国 乌兰巴托 14191;
3 蒙古科学院植物园与研究所, 蒙古国 乌兰巴托 13330;
4 蒙古科学院地理与生态研究所, 蒙古国 乌兰巴托 15170, correspAuthors=阿里穆斯, authorNote=赵一迈: 赵一迈(2003—),女,回族,硕士研究生,研究方向为民族药资源保护与可持续发展研究。E-mail:15066639720@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=aY0CD/ucQMYzeBuzwbQdUw==, pdfFileSize=1956600, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目 (32570457); 国家重点研发计划-政府间国际科技创新合作项目 (2022YFE0119300); 中央高校基本科研业务费)}, authors=null, keywords=[Keyword(id=1304735425935991745, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735424354739132, language=CN, orderNo=1, keyword=龙胆属), Keyword(id=1304735426011489218, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735424354739132, language=CN, orderNo=2, keyword=龙胆苦苷), 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provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.14.023, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.14.023, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.14.023, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.14.023, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1789002765977, fullTextJson=null, articleText=null, reference=车彦云, 梁敬钰. 龙胆属植物研究进展[J]. 海峡药学, 2008, 20(3): 1-4.
Jiang M, Cui B W, Wu Y L, et al. Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism [J]. J Ethnopharmacol, 2021, 264: 113391.
Ponticelli M, Lela L, Moles M, et al. The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review [J]. Phytochemistry, 2023, 206: 113518.
王彩君, 王智民, 王维皓, 等. 龙胆属植物中的化学成分及药理活性研究进展[J]. 中国中药杂志, 2009, 34(23): 2987-2994.
李生浩, 李俊义, 武昆利, 等. 龙胆苦苷的药理作用及分子机制研究进展[J]. 昆明医科大学学报, 2020, 41(1): 158-162.
张居文, 刘娟, 于凡雅, 等. 十味龙胆花颗粒/胶囊治疗支气管炎有效性与安全性的系统评价与Meta分析[J]. 中国中药杂志, 2026, 51(3): 880-889.
陈骋. 龙胆苦苷对急性肺损伤及慢性肺纤维化的防治作用研究[D]. 云南:昆明医科大学, 2018.
赵芡, 张英睿, 李轩豪, 等. 基于网络药理学和分子对接技术的藏药三味龙胆花片用于新型冠状病毒肺炎(COVID-19)的作用机制探讨[J]. 中药药理与临床, 2020, 36(3): 35-41.
李仙仙, 邓清月, 和映玉, 等. 基于CiteSpace和VOSviewer可视化分析药食同源中药罗汉果的发展态势[J]. 中草药, 2023, 54(17): 5671-5683.
韩昕, 李莎莎, 陈曦, 等. 基于CiteSpace和VOSviewer对女贞子的研究现状与热点分析[J]. 特产研究, 2024, 46(3): 47-55.
凌金忠, 李珊珊, 朱国旗, 等. 人参的文献计量学研究: 热点与趋势分析[J]. 中草药, 2024, 55(17): 5952-5963.
胡鹏杰, 杜彦锫, 夏冰, 等. 基于Web of Science对土壤胶体影响重金属行为研究的计量分析[J]. 土壤学报, 2024, 61(2): 445-455.
冯梅, 钟志兵, 周欣欣. 近五年龙胆泻肝汤临床应用研究概况[J]. 亚太传统医药, 2016, 12(16): 90-92.
Falcone G, Di Matteo G, Mannina L, et al. Phytochemical profiling and anti-inflammatory activity of Gentiana lutea roots from Pollino National Park [J]. J Ethnopharmacol, 2025, 353: 120430.
刘凯强, 郑芳. 基于CiteSpace的数字乡村研究现状、热点及趋势分析[J]. 云南农业大学学报: 社会科学版, 2023, 17(2): 80-89.
董国豪, 潜伟. 普赖斯与科学史定量研究[J]. 科学学研究, 2017, 35(5): 667-675.
褚博文, 张霁, 李智敏, 等. 滇龙胆化学成分和药理作用研究进展[J]. 中国实验方剂学杂志, 2016, 22(13): 213-222.
张霁, 王元忠, 杨绍兵, 等. 不同胁迫条件对滇龙胆种子萌发的影响[J]. 南方农业学报, 2013, 44(10): 1629-1633.
杨维泽, 金航, 杨美权, 等. 云南滇龙胆居群表型多样性及其与环境关系研究[J]. 西北植物学报, 2011, 31(7): 1326-1334.
赵磊, 李智敏, 白艳婷, 等. 滇龙胆地上部分的化学成分研究[J]. 云南中医学院学报, 2009, 32(2): 27-31.
何微微, 韦翡翡, 吕蓉, 等. 秦艽的资源现状和可持续利用[J]. 时珍国医国药, 2019, 30(7): 1754-1756.
杨燕梅, 马晓辉, 卢有媛, 等. UPLC法测定7种秦艽中7种指标成分的量[J]. 中草药, 2016, 47(11): 1968-1973.
葛珊, 魏昀, 吴晨, 等. 秦艽、威灵仙主要成分龙胆苦苷、木兰花碱对RA模型大鼠抗炎作用机制研究[J]. 中药药理与临床, 2022, 38(4): 62-67.
魏莉霞, 王国祥, 漆燕玲, 等. 秦艽新品种‘陇秦1号’和‘陇秦2号’ [J]. 园艺学报, 2018, 45(3): 609-610.
魏莉霞, 漆燕玲, 赵玮, 等. 栽培因子对秦艽产量和龙胆苦苷含量的影响[J]. 安徽农业科学, 2008, 36(23): 10022-10023.
Liu Z M, Shen T, Zhang J, et al. A novel multi-preprocessing integration method for the qualitative and quantitative assessment of wild medicinal plants: Gentiana rigescens as an example [J]. Front Plant Sci, 2021, 12: 759248.
Liu Y N, Liu Q, Chen D N, et al. Inokosterone from Gentiana rigescens Franch. extends the longevity of yeast and mammalian cells via antioxidative stress and mitophagy induction [J]. Antioxidants, 2022, 11(2): 214.
Liang Y, Meng X X, Mu Z J, et al. The complete chloroplast genome and phylogenetic analysis of Gentiana manshurica Kitag from China [J]. Mitochondrial DNA Part B, 2020, 5(2): 1625-1626.
武红欣, 陈杰, 胡立俊, 等. 基于CiteSpace的无人机遥感技术在农业中的研究进展[J]. 智慧农业导刊, 2024, 4(11): 6-10.
锡林呼, 张胜利, 闫艳秋, 等. 基于CiteSpace西伯利亚杏文献可视化分析[J]. 安徽农学通报, 2024, 30(13): 55-60.
庞宇航, 管伟, 胡晓阳, 等. 尖叶假龙胆的化学成分及药理作用研究进展[J]. 中草药, 2018, 49(22): 5468-5476.
郭从嘉. 秦艽—威灵仙组分配伍对RA模型大鼠抗炎作用机制研究[D]. 兰州: 甘肃中医药大学, 2023.
杨燕梅. 秦艽商品规格等级与其质量的相关性研究[D]. 兰州: 甘肃中医药大学, 2016.
李明秀, 李青松, 杨晓彤, 等. 龙胆苦苷作用于疾病的分子机制[J]. 世界科学技术-中医药现代化, 2025, 27(4): 950-961.
朱广伟, 李西文, 李琦, 等. 基于传统煎药工艺的龙胆饮片标准汤剂制备及质量评价方法研究[J]. 中草药, 2017, 48(20): 4253-4260.
Zhang J, Wang Y Z, Cai C T. Multielemental stoichiometry in plant organs: A case study with the Alpine herb Gentiana rigescens across southwest China [J]. Front Plant Sci, 2020, 11: 441.
Mladenović Ž, Kuzmanović N, Lakušić D, et al. Comparative leaf anatomy of Balkan representatives of Gentiana L. sect. ciminalis (Adans.) Dum. (Gentianaceae): Implications for species delimitation [J]. Plants, 2025, 14(19): 2977.
杨钰莹, 全云云, 尤晓舟, 等. 中药麝香研究现状与趋势: 基于CiteSpace和VOSviewer的文献计量学分析[J]. 中药药理与临床, 2023, 39(4): 106-115.
和映玉, 邓清月, 李仙仙, 等. 基于VOSviewer和CiteSpace的菟丝子知识图谱可视化分析[J]. 中草药, 2023, 54(15): 4958-4972.
He M L, Zhou J, Wang R R, et al. Exploration of the therapeutic mechanism of Gentiana scabra Bunge for gouty arthritis based on network pharmacology and molecular docking technology [J]. Asian J Surg, 2023, 46(12): 5666-5668.
Yang A M, Han H, Li J Y, et al. Triterpenoids from Gentiana algida [J]. Chem Nat Compd, 2015, 51(2): 381-382.
Ya H Y, Miao Y W. Complete plastid genome of Gentiana leucomelaena Maxim. (Gentianaceae) and phylogenetic analysis [J]. Mitochondrial DNA Part B, 2021, 6(10): 2953-2954.
Anilkumar K A, Kumar K M P, Udayan P S. Gentiana kurumbae, a new species of Gentianaceae from the Western Ghats of Kerala, India [J]. Taiwania, 2015, 60(2):81-85.
Mubashir K, Ganai B A, Ghazanfar K, et al. Evaluation of antiarthritic potential of methanolic extract of Gentiana kurroo Royle [J]. Arthritis, 2014, 2014(1): 810615.
Takase T, Shimizu M, Takahashi S, et al. De novo transcriptome analysis reveals flowering-related genes that potentially contribute to flowering-time control in the Japanese cultivated gentian Gentiana triflora [J]. Int J Mol Sci, 2022, 23(19): 11754.
Kitić N, Živković J, Šavikin K, et al. Spasmolytic activity of Gentiana lutea L. root extracts on the rat ileum: Underlying mechanisms of action [J]. Plants, 2024, 13(3): 453.
Hamza A A, Gamel M, Abdalla A, et al. Gentiana lutea attenuates hepatotoxicity induced by ketoconazole in rats by fortifying the cellular antioxidant defense system [J]. J Basic Appl Zool, 2023, 84(1): 1.
Ai Y Z, Xing Y X, Yan L M, et al. Atrial fibrillation and depression: A bibliometric analysis from 2001 to 2021[J]. Front Cardiovasc Med, 2022, 9: 775329.
王小娟, 吴伟, 刘云鹤, 等. 基于CiteSpace和VOSviewer的赤芍研究现状及研究热点可视化分析[J]. 中草药, 2025, 56(19): 7146-7156.
张战胜, 张哂. 龙胆泻肝汤对带状疱疹患者临床疗效及血清CGRP、5-HT、ICAM-1水平的影响[J]. 实验与检验医学, 2018, 36(1): 85-87.
朱芳, 漆涛, 吴丹, 等. 龙胆泻肝汤联合耳穴揿针治疗带状疱疹急性期患者的临床疗效及对其血清炎症因子、相关细胞因子、免疫功能指标的影响[J]. 世界中西医结合杂志, 2025, 20(12): 2408-2414.
雷琼, 王芝林, 白雪. 胶束毛细管电泳法测定龙胆属藏药中环烯醚萜类成分[J]. 中药材, 2018, 41(8): 1929-1932.
巩红冬. 青藏高原东缘龙胆属藏药植物资源调查[J]. 北方园艺, 2011(7): 104-105.
李彩霞, 王元忠, 王梅媛, 等. 龙胆苦苷生物合成候选调控基因GrbHLH1的挖掘、克隆与表达分析[J]. 生命科学研究, 2020, 24(2): 118-126.
张延智, 刘佳乐, 杜一民, 等. 滇龙胆化学成分和药理作用的研究进展[J]. 山东化工, 2019, 48(16): 71-74.
许亮, 石达理, 谢明, 等. 龙胆本草考证与东北龙胆属一新变型: 白花粗糙龙胆[J]. 中华中医药学刊, 2017, 35(7): 1658-1661.
武文雅, 吴可心, 张迈, 等. 基于GC-MS的3种龙胆属植物的代谢差异分析[J]. 西北林学院学报, 2023, 38(6): 203-210.
耿铮. 蓝玉簪龙胆治疗呼吸系统疾病的有效组分研究[D]. 西安: 第四军医大学, 2010.
李志芳, 贺晓云, 许孟霞, 等. 龙胆苦苷对CCl4诱导的肝纤维化大鼠肝损伤、肝纤维化、氧化应激和Nrf2通路的影响[J]. 中国老年学杂志, 2024, 44(6): 1405-1410.
Li Y, Zhang J, Fan J Y, et al. Tibetan medicine Bang Jian: A comprehensive review on botanical characterization, traditional use, phytochemistry, and pharmacology [J]. Front Pharmacol, 2023, 14: 1295789.
Nakatsuka T, Saito M, Yamada E, et al. Isolation and characterization of GtMYBP3 and GtMYBP4, orthologues of R2R3-MYB transcription factors that regulate early flavonoid biosynthesis, in gentian flowers [J]. J Exp Bot, 2012, 63(18): 6505-6517.
Zhao R, Yin S Y, Xue J N, et al. Sequencing and comparative analysis of chloroplast genomes of three medicinal plants: Gentiana manshurica, G. scabra and G. triflora [J]. Physiol Mol Biol Plants, 2022, 28(7): 1421-1435.
沈刚, 龚普阳, 鄢红书, 等. 基于CiteSpace和VOSviewer可视化知识图谱的竹节参研究动态与热点分析[J]. 中草药, 2025, 56(13): 4752-4764.
张娜, 谢鸣. 龙胆泻肝汤中关木通配伍的肾毒性研究[J]. 中国实验方剂学杂志, 2006, 12(5): 58-61.
桑滨生. 《中医药发展战略规划纲要(2016—2030年)》解读[J]. 世界科学技术—中医药现代化, 2016, 18(7): 1088-1092.
雷慧博, 吴立宏, 王峥涛, 等. 龙胆中龙胆苦苷和落干酸含量的高效液相色谱法测定[J]. 时珍国医国药, 2016, 27(10): 2397-2399.
关皎, 朱鹤云, 尹树铸, 等. HPLC法同时测定龙胆泻肝丸中8个活性成分的含量[J]. 药物分析杂志, 2017, 37(12): 2253-2259.
张启立. 龙胆苦苷衍生物的合成及其抗炎活性研究[D]. 兰州: 甘肃中医药大学, 2017.
曹悦, 左代英, 吴晓兰, 等. 超高效液相色谱法测定龙胆药材中的獐芽菜苦苷和龙胆苦苷[J]. 时珍国医国药, 2009, 20(5): 1079-1080.
周春巧, 文君, 陈宇. 龙胆泻肝汤的药理作用及其临床应用研究进展[J]. 临床合理用药杂志, 2018, 11(33): 180-181.
陈雷, 王海波, 孙晓丽, 等. 龙胆苦苷镇痛抗炎药理作用研究[J]. 天然产物研究与开发, 2008, 20(5): 903-906.
区淑雅, 李灿涛, 邵颖颖, 等. 龙胆苦苷基于尿酸转运蛋白和NLRP3炎性小体信号通路改善小鼠高尿酸血症和肾脏炎症[J]. 中南药学, 2021, 19(11): 2334-2340.
哈申其木格, 道日娜. 浅谈龙胆泻肝丸临床应用[J]. 世界最新医学信息文摘, 2016, 16(97): 163.
任雪. 龙胆道地性形成生境机制研究[D]. 沈阳: 辽宁中医药大学, 2021.)
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基于CiteSpace和VOSviewer可视化知识图谱的龙胆属研究热点和趋势分析
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中草药 | 数据挖掘与循证医学 2026,57(14): 5628-5647
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中草药 |数据挖掘与循证医学 2026 , 57 (14) : 5628 -5647
基于CiteSpace和VOSviewer可视化知识图谱的龙胆属研究热点和趋势分析
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赵一迈1, 阿里穆斯1, 于红珍1, 于媛媛1, 许炜炜1, 郭光瑛1, 余姣能1, 张玉霞1, 郭蕊昕1, 希古日干1, VANJIL Gundegmaa2, BATTSEREN Tsambaa3, BATZAYA Gachmaa3, URTNASAN Mandakh4
作者信息
    1 中央民族大学民族医药教育部重点实验室, 北京 100800;
    2 蒙古国立教育大学数学与自然科学学院, 蒙古国 乌兰巴托 14191;
    3 蒙古科学院植物园与研究所, 蒙古国 乌兰巴托 13330;
    4 蒙古科学院地理与生态研究所, 蒙古国 乌兰巴托 15170
通讯作者:
阿里穆斯
作者简介:
赵一迈: 赵一迈(2003—),女,回族,硕士研究生,研究方向为民族药资源保护与可持续发展研究。E-mail:15066639720@163.com
Analysis of research hotspots and trends of Gentiana based on CiteSpace and VOSviewer visualized knowledge maps
  • ZHAO Yimai, BORJIGIDAI Almaz, YU Hongzhen, YU Yuanyuan, XU Weiwei, GUO Guangying, YU Jiaoneng, ZHANG Yuxia, GUO Ruixin, XORGAN Uranghai, VANJIL Gundegmaa, BATTSEREN Tsambaa, BATZAYA Gachmaa, URTNASAN Mandakh
  • Affiliations
    doi: 10.7501/j.issn.0253-2670.2026.14.023
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    目的 基于文献计量学方法,运用CiteSpace和VOSviewer软件对国内外龙胆属领域研究现状进行可视化分析,预测其未来研究热点和发展趋势。方法 以中国知网(CNKI)和Web of Science(WOS)核心合集数据库为数据来源,检索2005年1月1日—2025年12月31日龙胆属领域的相关文献。经人工剔除重复及不符合标准文献并统一规范关键词后,利用Excel、VOSviewer及CiteSpace软件分别对龙胆属领域中英文文献的年发文量、期刊、机构、作者、国家、关键词等进行可视化分析。结果 检索得到符合要求的文献共7 449篇,其中中文文献6 121篇,英文文献1 328篇。中文文献年发文量呈波动趋势,英文文献年发文量则呈上升趋势且增势迅速,刊载龙胆属研究文献最多的中英文期刊分别是《中草药》(114篇)和Journal of Ethnopharmacology(44篇);发文量最高的作者分别是王元忠(61篇)和Zhang Ji(27篇);发文量最多的机构分别为黑龙江中医药大学(118篇)和Chinese Academy of Sciences(110篇);发文量排名前3的国家分别是中国(709篇)、印度(111篇)以及日本(105篇);通过关键词分析发现,当前研究热点主要集中于龙胆属复方分析、临床应用、物种鉴定、化学成分、药理作用和作用机制研究等方面。此外,在新冠疫情期间,含有龙胆的中药制剂也被用于治疗患者咳嗽、气喘等症状。结论 目前国内外对龙胆属领域的研究总体呈上升趋势,近年来其研究正逐步从化学成分和药理作用的单一分析转向为“多组分、多靶点”协同机制的探讨,深度融合基因组学、分子对接、网络药理学等现代技术方法,为龙胆属物种的药效机制解析及创新应用提供了重要方向。未来对于该领域的研究也可通过加强国际化协作,深化现代技术融合,从而推动龙胆属领域研究向精准化和多层次发展。
    龙胆属  /  龙胆苦苷  /  CiteSpace  /  VOSviewer  /  可视化分析  /  文献计量学
    Objective CiteSpace and VOSviewer softwares were used to conduct a visualized analysis of the current status of research on Gentiana worldwide, so as to predict its future research hotspots and developmental trends based on bibliometric methods. Methods Relevant literatures on Gentiana from January 1, 2005 to December 31, 2025 were retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) Core Collection databases. After manually excluding duplicate and ineligible literatures and standardizing keywords, Excel, VOSviewer and CiteSpace were used to perform visualized analyses on the annual publication volume, publication journals, institutions, authors, countries and keywords of Chinese and English literatures in the field of Gentiana, respectively. Results A total of 7 449 eligible literature were retrieved, including 6 121 Chinese literature and 1 328 English literature. The annual publication volume of Chinese literature showed a fluctuating trend, while that of English literature presented a rapid upward trend. The Chinese and English journals publishing the most Gentiana-related studies were Chinese Traditional and Herbal Drugs (114 publications) and Journal of Ethnopharmacology (44 publications), respectively. The authors with the highest publication outputs were Wang Yuanzhong (61 publications) and Zhang Ji (27 publications). The institutions with the largest number of Chinese and English publications were Heilongjiang University of Chinese Medicine (118 publications) and Chinese Academy of Sciences (110 publications), respectively. The top three countries in terms of the number of articles published were China (709 publications), India (111 publications), and Japan (105 publications). The keyword analysis revealed that the current research hotspots mainly focused on the analysis of compound formulations, clinical applications, species identification, chemical composition, pharmacological effects, and mechanisms of action related to the Gentiana genus. In addition, traditional Chinese medicine preparations containing Gentiana have also been used to treat symptoms such as coughing and wheezing in patients during the COVID-19 pandemic. Conclusion Research on the Gentiana genus both domestically and internationally is currently showing an overall upward trend. In recent years, studies are gradually shifting from the single analysis of chemical components and pharmacological effects to the exploration of “multi-components and multi-targets” synergistic mechanisms. This research is deeply integrating modern technological methods such as genomics, molecular docking, and network pharmacology, providing important directions for the analysis of the efficacy mechanisms and innovative applications of Gentiana-related species. Future research in this field can also promote the precision and multi-layered development of Gentiana studies by strengthening international collaboration and deepening the integration of modern technologies.
    Gentiana L.  /  gentiopicroside  /  CiteSpace  /  VOSviewer  /  visualized analysis  /  bibliometrics
    赵一迈, 阿里穆斯, 于红珍, 于媛媛, 许炜炜, 郭光瑛, 余姣能, 张玉霞, 郭蕊昕, 希古日干, VANJIL Gundegmaa, BATTSEREN Tsambaa, BATZAYA Gachmaa, URTNASAN Mandakh. 基于CiteSpace和VOSviewer可视化知识图谱的龙胆属研究热点和趋势分析. 中草药, 2026 , 57 (14) : 5628 -5647 . DOI: 10.7501/j.issn.0253-2670.2026.14.023
    ZHAO Yimai, BORJIGIDAI Almaz, YU Hongzhen, YU Yuanyuan, XU Weiwei, GUO Guangying, YU Jiaoneng, ZHANG Yuxia, GUO Ruixin, XORGAN Uranghai, VANJIL Gundegmaa, BATTSEREN Tsambaa, BATZAYA Gachmaa, URTNASAN Mandakh. Analysis of research hotspots and trends of Gentiana based on CiteSpace and VOSviewer visualized knowledge maps[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (14) : 5628 -5647 . DOI: 10.7501/j.issn.0253-2670.2026.14.023

      国家自然科学基金项目 (32570457); 国家重点研发计划-政府间国际科技创新合作项目 (2022YFE0119300); 中央高校基本科研业务费

    参考文献 引证文献
    排序方式:
    车彦云, 梁敬钰. 龙胆属植物研究进展[J]. 海峡药学, 2008, 20(3): 1-4.
    Jiang M, Cui B W, Wu Y L, et al. Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism [J]. J Ethnopharmacol, 2021, 264: 113391.
    Ponticelli M, Lela L, Moles M, et al. The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review [J]. Phytochemistry, 2023, 206: 113518.
    王彩君, 王智民, 王维皓, 等. 龙胆属植物中的化学成分及药理活性研究进展[J]. 中国中药杂志, 2009, 34(23): 2987-2994.
    李生浩, 李俊义, 武昆利, 等. 龙胆苦苷的药理作用及分子机制研究进展[J]. 昆明医科大学学报, 2020, 41(1): 158-162.
    张居文, 刘娟, 于凡雅, 等. 十味龙胆花颗粒/胶囊治疗支气管炎有效性与安全性的系统评价与Meta分析[J]. 中国中药杂志, 2026, 51(3): 880-889.
    陈骋. 龙胆苦苷对急性肺损伤及慢性肺纤维化的防治作用研究[D]. 云南:昆明医科大学, 2018.
    赵芡, 张英睿, 李轩豪, 等. 基于网络药理学和分子对接技术的藏药三味龙胆花片用于新型冠状病毒肺炎(COVID-19)的作用机制探讨[J]. 中药药理与临床, 2020, 36(3): 35-41.
    李仙仙, 邓清月, 和映玉, 等. 基于CiteSpace和VOSviewer可视化分析药食同源中药罗汉果的发展态势[J]. 中草药, 2023, 54(17): 5671-5683.
    韩昕, 李莎莎, 陈曦, 等. 基于CiteSpace和VOSviewer对女贞子的研究现状与热点分析[J]. 特产研究, 2024, 46(3): 47-55.
    凌金忠, 李珊珊, 朱国旗, 等. 人参的文献计量学研究: 热点与趋势分析[J]. 中草药, 2024, 55(17): 5952-5963.
    胡鹏杰, 杜彦锫, 夏冰, 等. 基于Web of Science对土壤胶体影响重金属行为研究的计量分析[J]. 土壤学报, 2024, 61(2): 445-455.
    冯梅, 钟志兵, 周欣欣. 近五年龙胆泻肝汤临床应用研究概况[J]. 亚太传统医药, 2016, 12(16): 90-92.
    Falcone G, Di Matteo G, Mannina L, et al. Phytochemical profiling and anti-inflammatory activity of Gentiana lutea roots from Pollino National Park [J]. J Ethnopharmacol, 2025, 353: 120430.
    刘凯强, 郑芳. 基于CiteSpace的数字乡村研究现状、热点及趋势分析[J]. 云南农业大学学报: 社会科学版, 2023, 17(2): 80-89.
    董国豪, 潜伟. 普赖斯与科学史定量研究[J]. 科学学研究, 2017, 35(5): 667-675.
    褚博文, 张霁, 李智敏, 等. 滇龙胆化学成分和药理作用研究进展[J]. 中国实验方剂学杂志, 2016, 22(13): 213-222.
    张霁, 王元忠, 杨绍兵, 等. 不同胁迫条件对滇龙胆种子萌发的影响[J]. 南方农业学报, 2013, 44(10): 1629-1633.
    杨维泽, 金航, 杨美权, 等. 云南滇龙胆居群表型多样性及其与环境关系研究[J]. 西北植物学报, 2011, 31(7): 1326-1334.
    赵磊, 李智敏, 白艳婷, 等. 滇龙胆地上部分的化学成分研究[J]. 云南中医学院学报, 2009, 32(2): 27-31.
    何微微, 韦翡翡, 吕蓉, 等. 秦艽的资源现状和可持续利用[J]. 时珍国医国药, 2019, 30(7): 1754-1756.
    杨燕梅, 马晓辉, 卢有媛, 等. UPLC法测定7种秦艽中7种指标成分的量[J]. 中草药, 2016, 47(11): 1968-1973.
    葛珊, 魏昀, 吴晨, 等. 秦艽、威灵仙主要成分龙胆苦苷、木兰花碱对RA模型大鼠抗炎作用机制研究[J]. 中药药理与临床, 2022, 38(4): 62-67.
    魏莉霞, 王国祥, 漆燕玲, 等. 秦艽新品种‘陇秦1号’和‘陇秦2号’ [J]. 园艺学报, 2018, 45(3): 609-610.
    魏莉霞, 漆燕玲, 赵玮, 等. 栽培因子对秦艽产量和龙胆苦苷含量的影响[J]. 安徽农业科学, 2008, 36(23): 10022-10023.
    Liu Z M, Shen T, Zhang J, et al. A novel multi-preprocessing integration method for the qualitative and quantitative assessment of wild medicinal plants: Gentiana rigescens as an example [J]. Front Plant Sci, 2021, 12: 759248.
    Liu Y N, Liu Q, Chen D N, et al. Inokosterone from Gentiana rigescens Franch. extends the longevity of yeast and mammalian cells via antioxidative stress and mitophagy induction [J]. Antioxidants, 2022, 11(2): 214.
    Liang Y, Meng X X, Mu Z J, et al. The complete chloroplast genome and phylogenetic analysis of Gentiana manshurica Kitag from China [J]. Mitochondrial DNA Part B, 2020, 5(2): 1625-1626.
    武红欣, 陈杰, 胡立俊, 等. 基于CiteSpace的无人机遥感技术在农业中的研究进展[J]. 智慧农业导刊, 2024, 4(11): 6-10.
    锡林呼, 张胜利, 闫艳秋, 等. 基于CiteSpace西伯利亚杏文献可视化分析[J]. 安徽农学通报, 2024, 30(13): 55-60.
    庞宇航, 管伟, 胡晓阳, 等. 尖叶假龙胆的化学成分及药理作用研究进展[J]. 中草药, 2018, 49(22): 5468-5476.
    郭从嘉. 秦艽—威灵仙组分配伍对RA模型大鼠抗炎作用机制研究[D]. 兰州: 甘肃中医药大学, 2023.
    杨燕梅. 秦艽商品规格等级与其质量的相关性研究[D]. 兰州: 甘肃中医药大学, 2016.
    李明秀, 李青松, 杨晓彤, 等. 龙胆苦苷作用于疾病的分子机制[J]. 世界科学技术-中医药现代化, 2025, 27(4): 950-961.
    朱广伟, 李西文, 李琦, 等. 基于传统煎药工艺的龙胆饮片标准汤剂制备及质量评价方法研究[J]. 中草药, 2017, 48(20): 4253-4260.
    Zhang J, Wang Y Z, Cai C T. Multielemental stoichiometry in plant organs: A case study with the Alpine herb Gentiana rigescens across southwest China [J]. Front Plant Sci, 2020, 11: 441.
    Mladenović Ž, Kuzmanović N, Lakušić D, et al. Comparative leaf anatomy of Balkan representatives of Gentiana L. sect. ciminalis (Adans.) Dum. (Gentianaceae): Implications for species delimitation [J]. Plants, 2025, 14(19): 2977.
    杨钰莹, 全云云, 尤晓舟, 等. 中药麝香研究现状与趋势: 基于CiteSpace和VOSviewer的文献计量学分析[J]. 中药药理与临床, 2023, 39(4): 106-115.
    和映玉, 邓清月, 李仙仙, 等. 基于VOSviewer和CiteSpace的菟丝子知识图谱可视化分析[J]. 中草药, 2023, 54(15): 4958-4972.
    He M L, Zhou J, Wang R R, et al. Exploration of the therapeutic mechanism of Gentiana scabra Bunge for gouty arthritis based on network pharmacology and molecular docking technology [J]. Asian J Surg, 2023, 46(12): 5666-5668.
    Yang A M, Han H, Li J Y, et al. Triterpenoids from Gentiana algida [J]. Chem Nat Compd, 2015, 51(2): 381-382.
    Ya H Y, Miao Y W. Complete plastid genome of Gentiana leucomelaena Maxim. (Gentianaceae) and phylogenetic analysis [J]. Mitochondrial DNA Part B, 2021, 6(10): 2953-2954.
    Anilkumar K A, Kumar K M P, Udayan P S. Gentiana kurumbae, a new species of Gentianaceae from the Western Ghats of Kerala, India [J]. Taiwania, 2015, 60(2):81-85.
    Mubashir K, Ganai B A, Ghazanfar K, et al. Evaluation of antiarthritic potential of methanolic extract of Gentiana kurroo Royle [J]. Arthritis, 2014, 2014(1): 810615.
    Takase T, Shimizu M, Takahashi S, et al. De novo transcriptome analysis reveals flowering-related genes that potentially contribute to flowering-time control in the Japanese cultivated gentian Gentiana triflora [J]. Int J Mol Sci, 2022, 23(19): 11754.
    Kitić N, Živković J, Šavikin K, et al. Spasmolytic activity of Gentiana lutea L. root extracts on the rat ileum: Underlying mechanisms of action [J]. Plants, 2024, 13(3): 453.
    Hamza A A, Gamel M, Abdalla A, et al. Gentiana lutea attenuates hepatotoxicity induced by ketoconazole in rats by fortifying the cellular antioxidant defense system [J]. J Basic Appl Zool, 2023, 84(1): 1.
    Ai Y Z, Xing Y X, Yan L M, et al. Atrial fibrillation and depression: A bibliometric analysis from 2001 to 2021[J]. Front Cardiovasc Med, 2022, 9: 775329.
    王小娟, 吴伟, 刘云鹤, 等. 基于CiteSpace和VOSviewer的赤芍研究现状及研究热点可视化分析[J]. 中草药, 2025, 56(19): 7146-7156.
    张战胜, 张哂. 龙胆泻肝汤对带状疱疹患者临床疗效及血清CGRP、5-HT、ICAM-1水平的影响[J]. 实验与检验医学, 2018, 36(1): 85-87.
    朱芳, 漆涛, 吴丹, 等. 龙胆泻肝汤联合耳穴揿针治疗带状疱疹急性期患者的临床疗效及对其血清炎症因子、相关细胞因子、免疫功能指标的影响[J]. 世界中西医结合杂志, 2025, 20(12): 2408-2414.
    雷琼, 王芝林, 白雪. 胶束毛细管电泳法测定龙胆属藏药中环烯醚萜类成分[J]. 中药材, 2018, 41(8): 1929-1932.
    巩红冬. 青藏高原东缘龙胆属藏药植物资源调查[J]. 北方园艺, 2011(7): 104-105.
    李彩霞, 王元忠, 王梅媛, 等. 龙胆苦苷生物合成候选调控基因GrbHLH1的挖掘、克隆与表达分析[J]. 生命科学研究, 2020, 24(2): 118-126.
    张延智, 刘佳乐, 杜一民, 等. 滇龙胆化学成分和药理作用的研究进展[J]. 山东化工, 2019, 48(16): 71-74.
    许亮, 石达理, 谢明, 等. 龙胆本草考证与东北龙胆属一新变型: 白花粗糙龙胆[J]. 中华中医药学刊, 2017, 35(7): 1658-1661.
    武文雅, 吴可心, 张迈, 等. 基于GC-MS的3种龙胆属植物的代谢差异分析[J]. 西北林学院学报, 2023, 38(6): 203-210.
    耿铮. 蓝玉簪龙胆治疗呼吸系统疾病的有效组分研究[D]. 西安: 第四军医大学, 2010.
    李志芳, 贺晓云, 许孟霞, 等. 龙胆苦苷对CCl4诱导的肝纤维化大鼠肝损伤、肝纤维化、氧化应激和Nrf2通路的影响[J]. 中国老年学杂志, 2024, 44(6): 1405-1410.
    Li Y, Zhang J, Fan J Y, et al. Tibetan medicine Bang Jian: A comprehensive review on botanical characterization, traditional use, phytochemistry, and pharmacology [J]. Front Pharmacol, 2023, 14: 1295789.
    Nakatsuka T, Saito M, Yamada E, et al. Isolation and characterization of GtMYBP3 and GtMYBP4, orthologues of R2R3-MYB transcription factors that regulate early flavonoid biosynthesis, in gentian flowers [J]. J Exp Bot, 2012, 63(18): 6505-6517.
    Zhao R, Yin S Y, Xue J N, et al. Sequencing and comparative analysis of chloroplast genomes of three medicinal plants: Gentiana manshurica, G. scabra and G. triflora [J]. Physiol Mol Biol Plants, 2022, 28(7): 1421-1435.
    沈刚, 龚普阳, 鄢红书, 等. 基于CiteSpace和VOSviewer可视化知识图谱的竹节参研究动态与热点分析[J]. 中草药, 2025, 56(13): 4752-4764.
    张娜, 谢鸣. 龙胆泻肝汤中关木通配伍的肾毒性研究[J]. 中国实验方剂学杂志, 2006, 12(5): 58-61.
    桑滨生. 《中医药发展战略规划纲要(2016—2030年)》解读[J]. 世界科学技术—中医药现代化, 2016, 18(7): 1088-1092.
    雷慧博, 吴立宏, 王峥涛, 等. 龙胆中龙胆苦苷和落干酸含量的高效液相色谱法测定[J]. 时珍国医国药, 2016, 27(10): 2397-2399.
    关皎, 朱鹤云, 尹树铸, 等. HPLC法同时测定龙胆泻肝丸中8个活性成分的含量[J]. 药物分析杂志, 2017, 37(12): 2253-2259.
    张启立. 龙胆苦苷衍生物的合成及其抗炎活性研究[D]. 兰州: 甘肃中医药大学, 2017.
    曹悦, 左代英, 吴晓兰, 等. 超高效液相色谱法测定龙胆药材中的獐芽菜苦苷和龙胆苦苷[J]. 时珍国医国药, 2009, 20(5): 1079-1080.
    周春巧, 文君, 陈宇. 龙胆泻肝汤的药理作用及其临床应用研究进展[J]. 临床合理用药杂志, 2018, 11(33): 180-181.
    陈雷, 王海波, 孙晓丽, 等. 龙胆苦苷镇痛抗炎药理作用研究[J]. 天然产物研究与开发, 2008, 20(5): 903-906.
    区淑雅, 李灿涛, 邵颖颖, 等. 龙胆苦苷基于尿酸转运蛋白和NLRP3炎性小体信号通路改善小鼠高尿酸血症和肾脏炎症[J]. 中南药学, 2021, 19(11): 2334-2340.
    哈申其木格, 道日娜. 浅谈龙胆泻肝丸临床应用[J]. 世界最新医学信息文摘, 2016, 16(97): 163.
    任雪. 龙胆道地性形成生境机制研究[D]. 沈阳: 辽宁中医药大学, 2021.
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    doi: 10.7501/j.issn.0253-2670.2026.14.023
    • 接收时间:2026-03-14
    • 首发时间:2026-09-10
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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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