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2 省部共建安徽道地中药材品质提升协同创新中心, 安徽 合肥 230012;
3 中药资源保护与开发研究所, 安徽 合肥 230012;
4 安徽省中药复方重点实验室, 安徽 合肥 230012;
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中药鲜药“因鲜而效”活性成分的动态演变规律研究进展
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中草药 | 综述 2026,57(14): 5677-5690
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中草药 |综述 2026 , 57 (14) : 5677 -5690
中药鲜药“因鲜而效”活性成分的动态演变规律研究进展
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刘雨珍1, 姚亮1,2, 王妍妍1,2,3, 邵沐辰1, 陈晗1, 方茜1, 陈卫东1,2,3,4, 季俊虬5
作者信息
    1 安徽中医药大学药学院, 安徽 合肥 230012;
    2 省部共建安徽道地中药材品质提升协同创新中心, 安徽 合肥 230012;
    3 中药资源保护与开发研究所, 安徽 合肥 230012;
    4 安徽省中药复方重点实验室, 安徽 合肥 230012;
    5 合肥立方制药股份有限公司, 安徽 合肥 230088
通讯作者:
陈卫东
作者简介:
刘雨珍: 刘雨珍,博士研究生,研究方向为道地药材品质提升与开发。E-mail:953931482@qq.com
Research progress on dynamic evolution rules of active components in fresh traditional Chinese medicines “effective due to freshness”
  • LIU Yuzhen, YAO Liang, WANG Yanyan, SHAO Muchen, CHEN Han, FANG Qian, CHEN Weidong, JI Junqiu
  • Affiliations
    doi: 10.7501/j.issn.0253-2670.2026.14.027
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    中药鲜药素有“因鲜而效”的独特优势,其核心在于活性成分保留完整、生理活性高。然而,鲜药在生长和采后成分易变、保鲜技术滞后及标准缺失制约其临床推广。通过系统梳理鲜药应用的历史沿革,阐释“因鲜而效”的物质基础,归纳鲜药活性成分在采前遵循时空积累、采后发生物理逸散、酶促氧化及水解聚合等动态变化,提出以保留优势活性成分为核心的分类加工与精准贮藏策略。旨在揭示鲜药“因鲜而效”的科学内涵,为鲜药活性成分保护、品质提升与现代化应用提供理论依据与思路。
    中药  /  鲜药  /  应用历史  /  活性成分  /  动态演变规律
    Fresh traditional Chinese medicine (Fresh herbs) has the unique advantage of being effective due to its freshness, with the core being the complete retention of active ingredients and high physiological activity. However, the clinical promotion of fresh drugs is restricted by the variability of their components during growth and after harvest, the lagging preservation technology and the lack of standards. This article systematically reviews the historical evolution of the application of fresh herbs and explains the material basis for efficacy due to freshness, summarizes the dynamic changes of the active ingredients of fresh herbs, such as spatio-temporal accumulation before harvest, physical escape, enzymatic oxidation and hydrolytic polymerization after harvest, and proposes a classification processing and precise storage strategy centered on retaining dominant active ingredients. It aims to reveal the scientific connotation of efficacy due to freshness of fresh herbs, and provide theoretical basis and ideas for the protection of active ingredients, quality improvement and modern application of fresh herbs.
    traditional Chinese medicine  /  fresh herbs  /  history of application  /  active components  /  evolution rules
    刘雨珍, 姚亮, 王妍妍, 邵沐辰, 陈晗, 方茜, 陈卫东, 季俊虬. 中药鲜药“因鲜而效”活性成分的动态演变规律研究进展. 中草药, 2026 , 57 (14) : 5677 -5690 . DOI: 10.7501/j.issn.0253-2670.2026.14.027
    LIU Yuzhen, YAO Liang, WANG Yanyan, SHAO Muchen, CHEN Han, FANG Qian, CHEN Weidong, JI Junqiu. Research progress on dynamic evolution rules of active components in fresh traditional Chinese medicines “effective due to freshness”[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (14) : 5677 -5690 . DOI: 10.7501/j.issn.0253-2670.2026.14.027

      安徽高等研究院校企联合科研与人才培养项目 (2024HZ067); 国家中医药管理局传统中医药学高水平重点学科建设项目—中药资源学(药用植物学) (zyyzdxk-2023095); 省部共建安徽道地中药材品质提升协同创新中心 (教科信厅函[2022] 4号)

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    2026年第57卷第14期
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    doi: 10.7501/j.issn.0253-2670.2026.14.027
    • 接收时间:2026-02-26
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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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