Article(id=1304735415248900646, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.14.012, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769961600000, receivedDateStr=2026-02-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1789002763806, onlineDateStr=2026-09-10, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789002763806, onlineIssueDateStr=2026-09-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789002763806, creator=13701087609, updateTime=1789002763806, updator=13701087609, issue=Issue{id=1304735403429356361, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='14', pageStart='5353', pageEnd='5788', issueExtLink='null', onlineDate='null', pubDate='1785168000000', pubDateStr='2026-07-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789002760989, creator='13701087609', updateTime=1789002916821, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304736057073889492, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304736057073889493, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=5491, endPage=5500, ext={EN=ArticleExt(id=1304735417140531756, articleId=1304735415248900646, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Preparation and in vitro-in vivo evaluation of Glycyrrhiza polysaccharide-stabilized baicalin nanocrystals, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To prepare Glycyrrhiza polysaccharide-stabilized baicalin nanocrystals (Bai-NCs/GP) and investigate their physicochemical properties and in vivo pharmacokinetics. Methods Bai-NCs/GP were prepared using a media milling method. The formulation and process were optimized through single-factor experiments based on average particle size and polydispersity index (PDI). The optimized Bai-NCs/GP formulation was characterized for morphology, crystal form, solubility, and dissolution rate. LC-MS/MS was used to measure blood concentrations of Bai-NCs/GP and baicalin after oral administration in rats, comparing their bioavailability differences. Results The optimal formulation and processing parameters for Bai-NCs/GP were determined as follows: a baicalin to Glycyrrhiza polysaccharide ratio of 10:5, a baicalin content of 1.00%, a grinding speed of 1 400 r/min, and a grinding time of 24 h. Bai-NCs/GP exhibited irregular nanoparticles with an average particle size of (146.29 ± 8.07) nm, polydispersity index (PDI) of 0.22 ± 0.01, and ζ potential of (-21.60 ± 0.58) mV. Compared to baicalin, Bai-NCs/GP showed reduced crystallinity, 43- fold increased solubility, and significantly improved dissolution rate. The peak concentration (C_max) and AUC_0—t of Bai-NCs/GP were (2 318.65 ± 341.60) ng/mL and (34 439.68 ± 5 548.79) ng·h/mL, respectively, representing 2.31-fold and 2.77-fold increases over baicalin, with markedly enhanced oral bioavailability. Conclusion Glycyrrhiza polysaccharide can serve as a stabilizer in the preparation of baicalin nanocrystals. The resulting Bai-NCs/GP nanocrystals enhance the solubility and in vitro dissolution rate of baicalin, thereby improving its oral bioavailability., authors=CHEN Fangwen, ZHANG Shuangchen, ZHANG Nianzhan, SHEN Chengying, YUE Pengfei, SHEN Baode, authorsList=CHEN Fangwen, ZHANG Shuangchen, ZHANG Nianzhan, SHEN Chengying, YUE Pengfei, SHEN Baode, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304735417044062763, articleId=1304735415248900646, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=甘草多糖稳定的黄芩苷纳米晶的制备及体内外评价, columnId=1304140189132149234, journalTitle=中草药, columnName=药剂与工艺, runingTitle=null, highlight=null, articleAbstract=目的 制备甘草多糖稳定的黄芩苷纳米晶（Glycyrrhiza polysaccharide-stabilized baicalin nanocrystals，Bai-NCs/GP），并考察其理化性质及体内药动学。方法 采用介质研磨法制备Bai-NCs/GP，以平均粒径和多分散性指数（polydispersity index，PDI）为考察指标，单因素实验优化处方和工艺；对优化所得的Bai-NCs/GP进行形态、晶型、溶解度与溶出度表征，LC-MS/MS法测定大鼠分别ig给予Bai-NCs/GP与黄芩苷后的血药浓度，对比其生物利用度差异。结果 Bai-NCs/GP的最佳处方和工艺参数为黄芩苷与甘草多糖质量比为10∶5，黄芩苷的用量为1.00%，研磨转速为1 400 r/min，研磨时间为24 h。Bai-NCs/GP呈不规则纳米颗粒，平均粒径为（146.29±8.07）nm，多分散指数（polydispersity index，PDI）为0.22±0.01，ζ电位为（-21.60±0.58）mV。与黄芩苷原料药相比，Bai-NCs/GP的结晶度降低，溶解度增加了43倍，溶出度显著改善；Bai-NCs/GP的达峰浓度（maximum plasma concentration，Cmax）和药-时曲线下面积（area under the plasma concentration-time curve，AUC₀～t）分别为（2 318.65±341.60）ng/mL和（34 439.68±5 548.79）ng·h/mL，是黄芩苷的2.31倍和2.77倍，口服生物利用度显著提高。结论 甘草多糖可以作为稳定剂用于制备黄芩苷纳米晶，所制备的Bai-NCs/GP能够提高黄芩苷的溶解度和体外溶出度，改善黄芩苷的口服生物利用度。, authors=陈芳雯^1,2, 张双辰^1,2, 张年战^1,2, 沈成英³, 岳鹏飞^1,2, 申宝德^1,2, authorsList=陈芳雯, 张双辰, 张年战, 沈成英, 岳鹏飞, 申宝德, authorCompany=1 江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004;
2 经典名方现代中药创制全国重点实验室, 江西 南昌 330004;
3 江西省人民医院(南昌医学院第一附属医院)药学部, 江西 南昌 330006, correspAuthors=岳鹏飞, authorNote=陈芳雯: 陈芳雯，硕士研究生，研究方向为中药新剂型与新技术。E-mail:2973170947@qq.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=I8g7EqZ22Py+Ym0IwwaHJQ==, pdfFileSize=1198587, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目 (82460852); 国家自然科学基金项目 (82260848); 江西省自然科学基金项目 (20232BAB216139); 国家青年岐黄学者培养项目 (2022256); 江西中医药大学校级科技创新团队发展计划项目 (CXTD22006))}, authors=null, keywords=[Keyword(id=1304735417308303917, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735415248900646, language=CN, orderNo=1, keyword=黄芩苷), Keyword(id=1304735417371218478, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735415248900646, 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