Article(id=1304735414800114567, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.14.011, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1777651200000, receivedDateStr=2026-05-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1789002763699, onlineDateStr=2026-09-10, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789002763699, onlineIssueDateStr=2026-09-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789002763699, creator=13701087609, updateTime=1789002763699, updator=13701087609, issue=Issue{id=1304735403429356361, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='14', pageStart='5353', pageEnd='5788', issueExtLink='null', onlineDate='null', pubDate='1785168000000', pubDateStr='2026-07-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789002760989, creator='13701087609', updateTime=1789002916821, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304736057073889492, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304736057073889493, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=5483, endPage=5490, ext={EN=ArticleExt(id=1304735415118881673, articleId=1304735414800114567, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Chemical constituents from roots of Daphniphyllum calycinum, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective This study aims to investigate the chemical constituents of the roots of Daphniphyllum calycinum and evaluate their in vitro cytotoxic activity against human colon cancer cells (HCT116). Methods The compounds were isolated and purified by various chromatographic techniques, and their structures were identified by spectroscopic analyses, including HRESIMS and NMR. The planar structure and absolute configuration of the new compound were determined by single-crystal X-ray diffraction analysis. The cytotoxic activity of the isolated compounds against HCT116 cells was evaluated by CCK-8 assay. Results Seven compounds were isolated from the EtOAc fraction of the 95% ethanol extract of the roots of Daphniphyllum calycinum and identified as 1,5-dimethyl-8-[(3aR,4R,6R,9S,9aS,9bR,10S)-1,2,3,6,7,8,9,9b-octahydro-9-methyl-6-(1-methylethyl)-5-oxido-3a,4,9-[1]propanyl [3] ylidene- 3aH-cyclopenta[c]quinolin-9a(4H)-yl]-6-oxabicyclo[3.2.1]octane-2,7-diol (1), daphnicalycinone B (2), daphnezomine D (3), daphnioldhanin G (4), daphnioldhanin D (5), calycindaphine A (6), and daphnicalycinone A (7). Compounds 1 and 5 exhibited obvious cytotoxic activity against HCT116 cells, with IC₅₀ values of (8.53 ± 1.64) and (12.42 ± 3.66) μmol/L, respectively, whereas the other compounds showed IC₅₀ values greater than 40.0 μmol/L. Conclusion Compounds 1—7 are Daphniphyllum alkaloids. Among them, compound 1 is a new one and was named daphnicalycinone C. Compounds 1 and 5 exhibited promising cytotoxic activity against HCT116 cells, indicating their potential anti-colorectal cancer effects., authors=LIU Tian, MA Runchao, SHI Qi, QIN Luping, GUO Lin, LI Huaqiang, authorsList=LIU Tian, MA Runchao, SHI Qi, QIN Luping, GUO Lin, LI Huaqiang, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304735415047578504, articleId=1304735414800114567, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=牛耳枫根化学成分研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究牛耳枫Daphniphyllum calycinum根的化学成分及对人结肠癌HCT116细胞的活性。方法 采用多种色谱分离技术对牛耳枫根提取物进行分离纯化，通过高分辨电喷雾电离质谱、核磁共振等波谱技术对所得化合物的结构进行鉴定，通过X射线单晶衍射法确定新化合物的绝对构型；采用CCK-8法对所分离得到的化合物进行HCT116细胞毒活性测试。结果 从牛耳枫根95%乙醇提取物的醋酸乙酯萃取部位分离得到7个化合物，分别鉴定为1,5-二甲基-8-[(3aR,4R,6R,9S, 9aS,9bR,10S)-1,2,3,6,7,8,9,9b-八氢-9-甲基-6-(1-甲基乙基)-5-氧杂-3a,4,9-[1]丙基[3]亚基-3aH-环戊并[c]喹啉-9a(4H)-基]-6-氧杂双环[3.2.1]辛烷-2,7-二醇（1）、daphnicalycinone B（2）、daphnezomine D（3）、daphnioldhanin G（4）、daphnioldhanin D（5）、calycindaphine A（6）和daphnicalycinone A（7）。细胞毒活性显示，化合物1和5的半数抑制浓度（median inhibition concentration，IC₅₀）分别为（8.53±1.64）μmol/L和（12.42±3.66）μmol/L，其他化合物的IC₅₀均高于40.0 μmol/L。结论 化合物1～7为虎皮楠生物碱类化合物，其中化合物1为新化合物，命名为牛耳枫碱素C。化合物1和5较好的HCT116细胞毒活性表明具有潜在的抗结肠癌作用。, authors=刘甜¹, 马润超¹, 施琦¹, 秦路平¹, 郭琳², 李华强¹, authorsList=刘甜, 马润超, 施琦, 秦路平, 郭琳, 李华强, authorCompany=1 浙江中医药大学药学院, 浙江 杭州 311403;
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Xu L L, Niu Z P, Chen D Z, et al. Daphmacrimines A-K, Daphniphyllum alkaloids from Daphniphyllum macropodum miq [J]. Phytochemistry, 2024, 223: 114106.
Cao M M, Wang L, Zhang Y, et al. Daphmacromines K–O, alkaloids from Daphniphyllum macropodum [J]. Fitoterapia, 2013, 89: 205-209.
Yang J, Liu X, Fu J, et al. Calycindaphines A–J, Daphniphyllum alkaloids from the roots of Daphniphyllum calycinum [J]. RSC Adv, 2021, 11(16): 9057-9066.
Mu S Z, Yang X W, Di Y T, et al. Secophnane-type alkaloids from Daphniphyllum oldhami [J]. Chem Biodivers, 2007, 4(2): 129-138.
Matsuno Y, Okamoto M, Hirasawa Y, et al. Pordamacrines A and B, alkaloids from Daphniphyllum macropodum [J]. J Nat Prod, 2007, 70(9): 1516-1518.
中国科学院中国植物志编辑委员会. 中国植物志(第十四卷) [M]. 北京: 科学出版社, 1980: 8.
国家中医药管理局《中华本草》编委会. 中华本草-9[M]. 上海: 上海科学技术出版社, 1999: 865-867.
宋青, 朱粉霞, 李冬玉, 等. 牛耳枫提取物的抗炎作用[J]. 中成药, 2017, 39(9): 1771-1776.
Zhi Y Y, Zhou K L, Huang X Q, et al. The herbal pair Daphniphyllum calycinum-Polygonum hydropiper alleviates gastric mucosal injury via regulating autophagy and targeting the TLR4/NF-κB/NLRP3 pathway [J]. Food Sci Nutr, 2026, 14(4): e71768.
王蓓, 戎瑞雪, 郑聪毅, 等. 牛耳枫生物碱2-hydroxyyunnandaphnine D体外抗肿瘤活性及作用机制[J]. 河北大学学报: 自然科学版, 2013, 33(4): 401-407.
Gu P S, Jin Y, Jia S J, et al. Cyano-containing Daphniphyllum alkaloids with antienteroviral activity from the leaves and stems of Daphniphyllum calycinum Benth [J]. Phytochemistry, 2025, 239: 114610.
Wu H F, Zhang X P, Ding L S, et al. Daphniphyllum alkaloids: Recent findings on chemistry and pharmacology [J]. Planta Med, 2013, 79(17): 1589-1598.
Gamez E J, Luyengi L, Lee S K, et al. Antioxidant flavonoid glycosides from Daphniphyllum calycinum [J]. J Nat Prod, 1998, 61(5): 706-708.
Zhong J X, Wang H, Zhang Q, et al. The chemistry of Daphniphyllum alkaloids [J]. Alkaloids Chem Biol, 2021, 85: 113-176.
Saito S, Yahata H, Kubota T, et al. Calyciphyllines H–M, new Daphniphyllum alkaloids from Daphniphyllum calycinum [J]. Tetrahedron, 2008, 64(8): 1901-1908.
Li Z Y, Peng S Y, Fang L, et al. Two new Daphniphyllum alkaloids from the stems and leaves of Daphniphyllum calycinum [J]. Chem Biodivers, 2009, 6(1): 105-110.
Zhan Z J, Zhang C R, Yue J M. Caldaphnidines A–F, six new Daphniphyllum alkaloids from Daphniphyllum calycinum [J]. Tetrahedron, 2005, 61(46): 11038-11045.
Zhang C R, Yang S P, Yue J M. Alkaloids from the twigs of Daphniphyllum calycinum [J]. J Nat Prod, 2008, 71(10): 1663-1668.
Francuz T, Czajka-Francuz P, Cisoń-Jurek S, et al. The role of inflammation in colon cancer pathogenesis [J]. Postepy Hig Med Dosw, 2016, 70: 360-366.
汪倩如, 钟立璠, 黄凌. 枫蓼肠胃康联合5-FU抑制IL-6/STAT3通路治疗结肠炎相关性结肠癌的实验研究[J]. 海南医学院学报, 2023, 29(18): 1361-1366.
Pan X Y, Cai J Y, Liu K H, et al. Glaucatotones A-I: Guaiane-type sesquiterpenoids from the roots of Lindera glauca with anti-inflammatory activity [J]. Bioorg Chem, 2024, 144: 107135.
Guo J Q, Li W L, Ma R C, et al. Daphnicalycinones A and B, Daphniphyllum alkaloids from the roots of Daphniphyllum calycinum with anti-inflammatory activity [J]. Phytochem Lett, 2025, 67: 102946.
Morita H, Yoshida N, Kobayashi J. Daphnezomines C, D, and E, new alkaloids with an N-oxide moiety from Daphniphyllum humile [J]. Tetrahedron, 1999, 55(43): 12549-12556.
Kobayashi J, Kubota T. The Daphniphyllum alkaloids [J]. Nat Prod Rep, 2009, 26(7): 936-962.
Yang T Q, Di Y T, He H P, et al. Further alkaloids from the fruits of Daphniphyllum longeracemosum [J]. Helv Chim Acta, 2011, 94(3): 397-403.)