Article(id=1304735413684425241, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.14.009, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1777737600000, receivedDateStr=2026-05-03, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1789002763434, onlineDateStr=2026-09-10, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789002763434, onlineIssueDateStr=2026-09-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789002763434, creator=13701087609, updateTime=1789002763434, updator=13701087609, issue=Issue{id=1304735403429356361, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='14', pageStart='5353', pageEnd='5788', issueExtLink='null', onlineDate='null', pubDate='1785168000000', pubDateStr='2026-07-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789002760989, creator='13701087609', updateTime=1789002916821, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304736057073889492, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304736057073889493, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=5470, endPage=5475, ext={EN=ArticleExt(id=1304735414007386651, articleId=1304735413684425241, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=X-ray diffraction analysis and fingerprint establishment of Crassostrea hongkongensis , columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To establish X-ray diffraction (XRD) fingerprint profiles of Crassostrea hongkongensis and determine its calcium carbonate content. Methods A total of 16 batches of C. hongkongensis samples were analyzed by XRD to establish the fingerprint. Based on hierarchical clustering analysis (HCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA), characteristic information for identification of Crassostrea Hongkongensis concha was screened with variable importance in projection (VIP) value > 1. The content of calcium carbonate in the samples was determined by EDTA complexometric titration. Results The XRD fingerprint of C. hongkongensis was established, and its phase structure belongs to calcite-type calcium carbonate, with 13 common peaks identified. The similarity of all 16 batches of samples was greater than 0.99. HCA divided the 16 batches into 3 categories, and the VIP values of OPLS-DA showed that 5 diffraction angles made great contributions, which were 47.41°, 65.51°, 61.28°, 47.04° and 57.34° respectively. Among the 16 batches of samples, 15 batches had a calcium carbonate content exceeding 94%. Conclusion The established XRD fingerprint can be used for the identification and analysis of C. hongkongensis . Their quality meets the standards specified under Ostreae Concha recorded in the Pharmacopoeia of the People’s Republic of China (2025 edition), offering technical support for their development as traditional Chinese medicinal material and comprehensive utilization., authors=MI Shunli, LI Qiqi, CHEN Yiping, CHEN Meijuan, GAO Chenghai, YI Xiangxi, authorsList=MI Shunli, LI Qiqi, CHEN Yiping, CHEN Meijuan, GAO Chenghai, YI Xiangxi, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304735413915111962, articleId=1304735413684425241, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=香港巨牡蛎X射线衍射分析及指纹图谱建立, columnId=1304735404209496906, journalTitle=中草药, columnName=海洋中药研究, runingTitle=null, highlight=null, articleAbstract=目的 建立香港巨牡蛎的X射线衍射(X-ray diffraction,XRD)指纹图谱并测定其碳酸钙含量。方法 采用XRD法对16批香港巨牡蛎样品进行分析建立指纹图谱;根据层次聚类分析(hierarchical clustering analysis,HCA)及正交偏最小二乘法-判别分析(orthogonal partial least squares-discriminant analysis,OPLS-DA),以变量重要性投影(variable importance projection,VIP)值>1筛选出可用于香港巨牡蛎鉴别的特征信息;运用EDTA络合滴定法测定样品中碳酸钙的含量。结果 建立了香港巨牡蛎的XRD指纹图谱,其物相结构归属于碳酸钙的方解石型,并确定了13个共有峰,16批样品相似度均大于0.99;HCA将16批香港巨牡蛎样品分为3类,OPLS-DA的VIP值显示5个衍射角贡献较大,分别为47.41°、65.51°、61.28°、47.04°、57.34°;16批香港巨牡蛎样品中,有15批碳酸钙含量均超过了94%。结论 XRD指纹图谱可用于香港巨牡蛎的鉴定与分析,香港巨牡蛎的质量符合《中国药典》2025年版对牡蛎的项下规定,为其开发为中药材及综合应用提供参考。, authors=米顺利1,2,3,4 , 李琪琦1,2,3,4 , 陈艺萍4 , 陈美娟1,2,3,4 , 高程海1,2,3,4 , 易湘茜1,3,4 , authorsList=米顺利, 李琪琦, 陈艺萍, 陈美娟, 高程海, 易湘茜, authorCompany=1 广西海洋药物重点实验室, 广西 南宁 530200; 2 海洋中药资源高效利用广西高校工程研究中心, 广西 南宁 530200; 3 北部湾海洋药物和生物制品开发利用工程技术创新中心, 广西 南宁 530200; 4 广西中医药大学海洋药物研究院/药学院, 广西 南宁 530200, correspAuthors=高程海, authorNote=米顺利: 米顺利,研究员/正高级工程师,研究方向海洋中药研究。E-mail:mishunli@126.com
李琪琦: 李琪琦,硕士研究生,研究方向为中药学。E-mail:25782377772@qq.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=YckKV8ZvEYm0tU8QNN7piA==, pdfFileSize=1144401, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=中药壮瑶药创新药物教育部工程研究中心经费资助 (ZYZYY2025036); 广西海洋药物重点实验室能力强化建设项目资助 (桂科LT2600640033); 2026年广西向海经济人才培养支持专项; 广西青年岐黄学者培养项目 (GXQH202412); 广西中医药大学岐黄工程高层次人才团队培育项目 (202404); 广西重点研发计划项目 (桂科AB25069014); 广西中医药大学研究生教育创新计划项目 (YCSY2023066))}, authors=null, keywords=[Keyword(id=1304735414124827164, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=CN, orderNo=1, keyword=香港巨牡蛎), Keyword(id=1304735414200324637, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=CN, orderNo=2, keyword=X射线衍射), Keyword(id=1304735414267433502, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=CN, orderNo=3, keyword=指纹图谱), Keyword(id=1304735414321959455, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=CN, orderNo=4, keyword=相似度), Keyword(id=1304735414393262624, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=CN, orderNo=5, keyword=碳酸钙), Keyword(id=1304735414502314529, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=EN, orderNo=1, keyword=Crassostrea hongkongensis Dunker), Keyword(id=1304735414611366434, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=EN, orderNo=2, keyword=X-ray diffraction), Keyword(id=1304735414741389859, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=EN, orderNo=3, keyword=fingerprint), Keyword(id=1304735414821081636, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=EN, orderNo=4, keyword=similarity), Keyword(id=1304735414892384805, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304735413684425241, language=EN, orderNo=5, keyword=calcium carbonate)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.14.009, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.14.009, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.14.009, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.14.009, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1789002763434, fullTextJson=null, articleText=null, reference=国家贝类产业技术体系. 中国牡蛎产业发展报告[J]. 中国水产, 2021(6): 20-31. 中国药典[S]. 四部. 2025: 128. 唐敏, 石安静, Tang Min, 等. 贝类钙代谢研究概况[J]. 水产学报, 2000, 22(1): 86-91. Bonnard M, Boury B, Parrot I. Key insights, tools, and future prospects on oyster shell end-of-life: A critical analysis of sustainable solutions [J]. Environ Sci Technol, 2020, 54(1): 26-38. 张志军. 龙骨与牡蛎的药理作用[J]. 国外医学: 中医中药分册, 1999(4): 5-8. Wang P, Xin S Y, Wang Z, et al. Chaihu-Longgu-Muli Decoction promotes sleep in mice with insomnia [J]. Trop J Pharm Res, 2023, 22(5): 1037-1042. Cao X L, Peng X M, Li G B, et al. Chaihu-Longgu-Muli decoction improves sleep disorders by restoring orexin-a function in CKD mice [J]. Front Endocrinol, 2023, 14: 1206353. 刘欢欢. 锶对骨生成的影响及其应用的研究进展[J]. 天津医科大学学报, 2019, 25(5): 548-550. 张礼冲. 钴的生物学功能及其对反刍动物的应用研究进展[J]. 湖南畜牧兽医, 2023(6): 56-58. 齐占会, 史荣君, 于宗赫, 等. 滤食性贝类养殖对浮游生物的影响研究进展[J]. 南方水产科学, 2021, 17(3): 115-121. 刘海新, 余颖, 席英玉, 等. 福建闽南沿海养殖牡蛎食用健康风险评估[J]. 上海海洋大学学报, 2017, 26(6): 921-932. 张洪怡, 周靖惟, 刘佳雯, 等. 基于AHP-CRITIC复合加权法优选牡蛎的炮制工艺及其重金属元素健康风险评估[J]. 中草药, 2025, 56(5): 1549-1563. 金翔, 张微, 张德新, 等. 基于MEK/ERK通路探讨柴胡加龙骨牡蛎汤治疗失眠大鼠的机制[J]. 中药药理与临床, 2020, 36(1): 51-54. 张洪怡, 周靖惟, 刘佳雯, 等. 牡蛎(近江牡蛎)药材、煅牡蛎饮片及其标准汤剂的物相变化及量质传递分析[J]. 中国中药杂志, 2025, 50(5): 1209-1223. 闫兴丽, 张建军, 曾凤英. 三种牡蛎矿质元素的含量测定与分析[J]. 中国中医基础医学杂志, 2009, 15(3): 218-218. 陈榕恩, 张岗, 王辉, 等. 海洋中药牡蛎的用药历史、炮制沿革及现代研究进展[J]. 中国海洋药物, 2025, 44(1): 83-94. 唐小华, 宋文东. 紫贻贝壳与牡蛎壳及珍珠的氨基酸和微量元素比较分析[J]. 农村经济与科技, 2016, 27(1): 109-110. Tran N K S, Kwon J E, Kang S C, et al. Crassaostrea gigasOyster shell extract inhibits lipogenesis via suppression of serine palmitoyltransferase [J]. Nat Prod Commun, 2015, 10(2): 1934578X1501000236. 周明慧, 杨永滨, 张永春, 等. 几种常见动物性中药中腺嘌呤含量的测定[J]. 中华保健医学杂志, 2012, 14(5): 343. Yang X, Zhou S L, Ma A C, et al. Chemical profiles and identification of key compound caffeine in marine-derived traditional Chinese medicine Ostreae Concha [J]. Mar Drugs, 2012, 10(5): 1180-1191. Alabaraoye E, Achilonu M, Hester R. Biopolymer (chitin) from various marine seashell wastes: Isolation and characterization [J]. J Polym Environ, 2018, 26(6): 2207-2218.)
中草药
|海洋中药研究
2026
, 57
(14) :
5470
-5475
香港巨牡蛎X射线衍射分析及指纹图谱建立
全屏
米顺利1,2,3,4 , 李琪琦1,2,3,4 , 陈艺萍4 , 陈美娟1,2,3,4 , 高程海1,2,3,4 , 易湘茜1,3,4
作者信息
1 广西海洋药物重点实验室, 广西 南宁 530200; 2 海洋中药资源高效利用广西高校工程研究中心, 广西 南宁 530200; 3 北部湾海洋药物和生物制品开发利用工程技术创新中心, 广西 南宁 530200; 4 广西中医药大学海洋药物研究院/药学院, 广西 南宁 530200
通讯作者:
高程海
作者简介:
米顺利: 米顺利,研究员/正高级工程师,研究方向海洋中药研究。E-mail:mishunli@126.com
李琪琦: 李琪琦,硕士研究生,研究方向为中药学。E-mail:25782377772@qq.com
X-ray diffraction analysis and fingerprint establishment of Crassostrea hongkongensis
MI Shunli, LI Qiqi, CHEN Yiping, CHEN Meijuan, GAO Chenghai, YI Xiangxi
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.14.009
文章导航
目的 建立香港巨牡蛎的X射线衍射(X-ray diffraction,XRD)指纹图谱并测定其碳酸钙含量。方法 采用XRD法对16批香港巨牡蛎样品进行分析建立指纹图谱;根据层次聚类分析(hierarchical clustering analysis,HCA)及正交偏最小二乘法-判别分析(orthogonal partial least squares-discriminant analysis,OPLS-DA),以变量重要性投影(variable importance projection,VIP)值>1筛选出可用于香港巨牡蛎鉴别的特征信息;运用EDTA络合滴定法测定样品中碳酸钙的含量。结果 建立了香港巨牡蛎的XRD指纹图谱,其物相结构归属于碳酸钙的方解石型,并确定了13个共有峰,16批样品相似度均大于0.99;HCA将16批香港巨牡蛎样品分为3类,OPLS-DA的VIP值显示5个衍射角贡献较大,分别为47.41°、65.51°、61.28°、47.04°、57.34°;16批香港巨牡蛎样品中,有15批碳酸钙含量均超过了94%。结论 XRD指纹图谱可用于香港巨牡蛎的鉴定与分析,香港巨牡蛎的质量符合《中国药典》2025年版对牡蛎的项下规定,为其开发为中药材及综合应用提供参考。
香港巨牡蛎
/
X射线衍射
/
指纹图谱
/
相似度
/
碳酸钙
Objective To establish X-ray diffraction (XRD) fingerprint profiles of Crassostrea hongkongensis and determine its calcium carbonate content. Methods A total of 16 batches of C. hongkongensis samples were analyzed by XRD to establish the fingerprint. Based on hierarchical clustering analysis (HCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA), characteristic information for identification of Crassostrea Hongkongensis concha was screened with variable importance in projection (VIP) value > 1. The content of calcium carbonate in the samples was determined by EDTA complexometric titration. Results The XRD fingerprint of C. hongkongensis was established, and its phase structure belongs to calcite-type calcium carbonate, with 13 common peaks identified. The similarity of all 16 batches of samples was greater than 0.99. HCA divided the 16 batches into 3 categories, and the VIP values of OPLS-DA showed that 5 diffraction angles made great contributions, which were 47.41°, 65.51°, 61.28°, 47.04° and 57.34° respectively. Among the 16 batches of samples, 15 batches had a calcium carbonate content exceeding 94%. Conclusion The established XRD fingerprint can be used for the identification and analysis of C. hongkongensis . Their quality meets the standards specified under Ostreae Concha recorded in the Pharmacopoeia of the People’s Republic of China (2025 edition), offering technical support for their development as traditional Chinese medicinal material and comprehensive utilization.
Crassostrea hongkongensis Dunker
/
X-ray diffraction
/
fingerprint
/
similarity
/
calcium carbonate
米顺利, 李琪琦, 陈艺萍, 陈美娟, 高程海, 易湘茜.
香港巨牡蛎X射线衍射分析及指纹图谱建立.
中草药,
2026
, 57
(14)
: 5470
-5475
.
DOI: 10.7501/j.issn.0253-2670.2026.14.009
MI Shunli, LI Qiqi, CHEN Yiping, CHEN Meijuan, GAO Chenghai, YI Xiangxi.
X-ray diffraction analysis and fingerprint establishment of Crassostrea hongkongensis [J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(14)
: 5470
-5475
.
DOI: 10.7501/j.issn.0253-2670.2026.14.009
中药壮瑶药创新药物教育部工程研究中心经费资助 (ZYZYY2025036); 广西海洋药物重点实验室能力强化建设项目资助 (桂科LT2600640033); 2026年广西向海经济人才培养支持专项; 广西青年岐黄学者培养项目 (GXQH202412); 广西中医药大学岐黄工程高层次人才团队培育项目 (202404); 广西重点研发计划项目 (桂科AB25069014); 广西中医药大学研究生教育创新计划项目 (YCSY2023066)
参考文献
引证文献
国家贝类产业技术体系. 中国牡蛎产业发展报告[J]. 中国水产, 2021(6): 20-31. 中国药典[S]. 四部. 2025: 128. 唐敏, 石安静, Tang Min, 等. 贝类钙代谢研究概况[J]. 水产学报, 2000, 22(1): 86-91. Bonnard M, Boury B, Parrot I. Key insights, tools, and future prospects on oyster shell end-of-life: A critical analysis of sustainable solutions [J]. Environ Sci Technol, 2020, 54(1): 26-38. 张志军. 龙骨与牡蛎的药理作用[J]. 国外医学: 中医中药分册, 1999(4): 5-8. Wang P, Xin S Y, Wang Z, et al. Chaihu-Longgu-Muli Decoction promotes sleep in mice with insomnia [J]. Trop J Pharm Res, 2023, 22(5): 1037-1042. Cao X L, Peng X M, Li G B, et al. Chaihu-Longgu-Muli decoction improves sleep disorders by restoring orexin-a function in CKD mice [J]. Front Endocrinol, 2023, 14: 1206353. 刘欢欢. 锶对骨生成的影响及其应用的研究进展[J]. 天津医科大学学报, 2019, 25(5): 548-550. 张礼冲. 钴的生物学功能及其对反刍动物的应用研究进展[J]. 湖南畜牧兽医, 2023(6): 56-58. 齐占会, 史荣君, 于宗赫, 等. 滤食性贝类养殖对浮游生物的影响研究进展[J]. 南方水产科学, 2021, 17(3): 115-121. 刘海新, 余颖, 席英玉, 等. 福建闽南沿海养殖牡蛎食用健康风险评估[J]. 上海海洋大学学报, 2017, 26(6): 921-932. 张洪怡, 周靖惟, 刘佳雯, 等. 基于AHP-CRITIC复合加权法优选牡蛎的炮制工艺及其重金属元素健康风险评估[J]. 中草药, 2025, 56(5): 1549-1563. 金翔, 张微, 张德新, 等. 基于MEK/ERK通路探讨柴胡加龙骨牡蛎汤治疗失眠大鼠的机制[J]. 中药药理与临床, 2020, 36(1): 51-54. 张洪怡, 周靖惟, 刘佳雯, 等. 牡蛎(近江牡蛎)药材、煅牡蛎饮片及其标准汤剂的物相变化及量质传递分析[J]. 中国中药杂志, 2025, 50(5): 1209-1223. 闫兴丽, 张建军, 曾凤英. 三种牡蛎矿质元素的含量测定与分析[J]. 中国中医基础医学杂志, 2009, 15(3): 218-218. 陈榕恩, 张岗, 王辉, 等. 海洋中药牡蛎的用药历史、炮制沿革及现代研究进展[J]. 中国海洋药物, 2025, 44(1): 83-94. 唐小华, 宋文东. 紫贻贝壳与牡蛎壳及珍珠的氨基酸和微量元素比较分析[J]. 农村经济与科技, 2016, 27(1): 109-110. Tran N K S, Kwon J E, Kang S C, et al. Crassaostrea gigasOyster shell extract inhibits lipogenesis via suppression of serine palmitoyltransferase [J]. Nat Prod Commun, 2015, 10(2): 1934578X1501000236. 周明慧, 杨永滨, 张永春, 等. 几种常见动物性中药中腺嘌呤含量的测定[J]. 中华保健医学杂志, 2012, 14(5): 343. Yang X, Zhou S L, Ma A C, et al. Chemical profiles and identification of key compound caffeine in marine-derived traditional Chinese medicine Ostreae Concha [J]. Mar Drugs, 2012, 10(5): 1180-1191. Alabaraoye E, Achilonu M, Hester R. Biopolymer (chitin) from various marine seashell wastes: Isolation and characterization [J]. J Polym Environ, 2018, 26(6): 2207-2218.
2026年第57卷第14期
PDF下载
26
6
引用本文
BibTeX
文章信息
doi: 10.7501/j.issn.0253-2670.2026.14.009
接收时间:2026-05-03
首发时间:2026-09-10
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.14.009
复制链接
引用本文
BibTeX
2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
关闭全屏
BibTeX
EndNote
RefWorks
TxT