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In addition, when sex hormones are dysregulated, it significantly increases both the risk of developing depression and the likelihood of its worsening over time, and the disorder of cholesterol metabolism can lead to depression by disrupting the homeostasis of sex hormone microenvironment in the brain. Therefore, drugs can exert antidepressant effects by mediating cholesterol metabolism, regulating the levels of sex hormones and their receptors, and restoring the homeostasis of brain sex hormone microenvironment. This article aims to review the mechanism of the imbalance of brain sex hormone homeostasis caused by cholesterol mediated metabolic disorders of neurosteroid deficiency, hypothalamic-pituitary-adrenal axis hyperactivation, and inflammatory pathway activation. Furthermore, stable isotope tracing, metabolomics, biological network regulation and other technologies were applied to reveal the internal mechanism of “cholesterol metabolism sex hormone homeostasis depression”, as well as the regulatory effect of drug intervention on depression. It provides novel research strategies for revealing the mechanism of depression and drug intervention from the perspective of homeostatic regulation of sex hormone microenvironment., authors=XIE Jiamei, JIA Chongning, WANG Yujing, Li Kaiwen, ZHAO Yunhao, TIAN Junsheng, authorsList=XIE Jiamei, JIA Chongning, WANG Yujing, Li Kaiwen, ZHAO Yunhao, TIAN Junsheng, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304415572805046299, articleId=1304415572515639322, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=胆固醇代谢紊乱致脑内性激素稳态失衡与抑郁症及抗抑郁中药干预的研究策略, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=胆固醇作为性激素合成的前体，其代谢过程与抑郁症发生及抗抑郁药物干预密切相关。研究表明性激素稳态失衡与抑郁症易感性及进展高度相关，胆固醇代谢紊乱可通过破坏脑内性激素微环境稳态导致抑郁症发生。而药物可通过介导胆固醇代谢、调控性激素及其受体水平、恢复脑内性激素微环境稳态发挥抗抑郁作用。通过综述胆固醇介导神经甾体缺乏、下丘脑-垂体-肾上腺轴过度激活、炎症通路激活3个途径的代谢紊乱致脑内性激素稳态失衡的机制；并应用稳定同位素示踪、代谢组学、生物网络调控等技术揭示“胆固醇代谢-性激素稳态-抑郁症发生”的内在机制，及药物干预对抑郁症的调控效应。为从性激素微环境稳态调控角度揭示抑郁症发生及药物干预机制提供研究策略。, authors=谢佳美¹, 贾崇宁¹, 王育静¹, 李凯文¹, 赵云昊¹, 田俊生^1,2, authorsList=谢佳美, 贾崇宁, 王育静, 李凯文, 赵云昊, 田俊生, authorCompany=1 山西大学 中医药现代研究中心, 山西 太原 030006;
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包晓琳,魏洪娟,边鑫鑫,等. 1990-2021年中国老年抑郁症的疾病负担分析及预测[J].协和医学杂志,2025, 16(2):361-369.
Song X D, Yan S Y, Lai S K, et al. Gender differences of neurometabolic and neuroendocrine alternations and its lateralization in adolescents with major depressive disorder[J]. BMC Psychiatry, 2024, 24(1):949.
王艳辉,张洪友,杨威,等.胆固醇在哺乳动物体内的代谢调节[J].现代畜牧兽医, 2016(11):53-57.
赵谭军,付可沁,施树成,等.雷公藤红素促进小肠上皮细胞肝X受体α表达调控胆固醇代谢研究[J].中草药, 2024, 55(11):3716-3725.
Miller W L. Steroid hormone synthesis in mitochondria[J]. Mol Cell Endocrinol, 2013, 379(1/2):62-73.
McHenry J, Carrier N, Hull E, et al. Sex differences in anxiety and depression:Role of testosterone[J]. Front Neuroendocrinol, 2014, 35(1):42-57.
Mohammedsaeed W. Exploring the interplay between DHCR7, vitamin D deficiency, and type 2 diabetes mellitus(T2DM):A systematic review[J]. Mol Biol Rep,2024, 51(1):1123.
张军霞,马娇娇,李艳杰,等.基于肠道菌群的中药治疗高脂血症作用机制研究进展[J].中草药, 2025,56(6):2171-2183.
崔旅纯,洪武,方贻儒.神经甾体在抑郁发作治疗中的作用[J].上海交通大学学报:医学版, 2018, 38(6):685-689.
George M S, Guidotti A, Rubinow D, et al. CSF neuroactive steroids in affective disorders:Pregnenolone,progesterone, and DBI[J]. Biol Psychiatry, 1994, 35(10):775-780.
Sun S Q, Yang S, Mao Y J, et al. Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor[J].Lipds Health Dis, 2015, 14(1):22.
李媛媛. δ-GABAAR在青春期雌性小鼠抑郁行为中的作用机制研究[D].天津:天津医科大学, 2020.
Edinoff A N, Odisho A S, Lewis K, et al. Brexanolone, a GABAA modulator, in the treatment of postpartum depression in adults:A comprehensive review[J]. Front Psychiatry, 2021, 12:699740.
曾九僧,陈力,彭希,等.逍遥散拆方药队醋酸乙酯部位抗抑郁作用的HPA轴-神经可塑性关联调控机制研究[J].中草药, 2023, 54(11):3534-3547.
Wang T, Wang X Y, Wang K K, et al. Chronic stressinduced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response[J]. Proc Natl Acad Sci USA, 2025, 122(5):e2415042122.
Xu M J, Zhang Z Y, Zhang Z D, et al. The pathogenesis and medical treatment of depression:Opportunity and challenge[J]. Neurol Int, 2025, 17(8):120.
陈伟康,令狐婷,任燕.中药治疗抑郁症作用机制研究进展[J].中草药, 2025, 56(11):4090-4102.
Gao Q, Tang Z W, Wang H L, et al. Human PERIOD3variants lead to winter depression-like behaviours via glucocorticoid signalling[J]. Nat Metab, 2024, 6(12):2267-2280.
Huang S C, Lee C T, Chung B C. Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis[J]. Sci Signal, 2014,7(314):ra20.
杨文山,王一晨,王元博,等.脑内脂质代谢在抑郁症发生发展中作用的研究进展[J].大连医科大学学报,2022, 44(3):239-243.
Salminen A. Role of indoleamine 2,3-dioxygenase 1(IDO1)and kynurenine pathway in the regulation of the aging process[J]. Ageing Res Rev, 2022, 75:101573.
高巧月,孙晓惠,李丽美,等.天然药物化学史话:他汀创造的史上第一畅销药物传奇[J].中草药, 2018,49(23):5485-5495.
周昶,黄蓉,蔡园,等.天然产物中生物碱类成分调血脂作用机制研究进展[J].中草药, 2024, 55(5):1717-1727.
Ke R, Xu Q C, Li C, et al. Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism[J].Cell Biol Int, 2018, 42(4):384-392.
Longo J, Mullen P J, Yu R, et al. An actionable sterolregulated feedback loop modulates statin sensitivity in prostate cancer[J]. Mol Metab, 2019, 25:119-130.
Steiner R D, Linck L M, Flavell D P, et al. Sterol balance in the Smith-Lemli-Opitz syndrome:Reduction in whole body cholesterol synthesis and normal bile acid production[J]. J Lipid Res, 2000, 41(9):1437-1447.
Yu C X, Jiang F J, Zhang M J, et al. HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells[J]. J Cell Mol Med, 2019,23(5):3140-3150.
Xu Y F, Hutchison S M, Hernández-Ledezma J J, et al.Increased 27-hydroxycholesterol production during luteolysis may mediate the progressive decline in progesterone secretion[J]. Mol Hum Reprod, 2018, 24(1):2-13.
钱宏梁,潘志强,李亚,等.不同中药药对调节氢化可的松药源性证候小鼠肾上腺皮质功能的研究[J].中草药, 2019, 50(10):2383-2389.
Koganti P P, Zhao A H, Kern M C, et al. STAR/STARD1:A mitochondrial intermembrane space cholesterol shuttle degraded through mitophagy[J]. Proc Natl Acad Sci USA,2025, 122(41):e2508809122.
Miller W L, Bose H S. Early steps in steroidogenesis:Intracellular cholesterol trafficking[J]. J Lipid Res, 2011,52(12):2111-2135.
Huang X D, Ma T Y, Chen X Y. Tributyltin inhibits development of pubertal Leydig cells in rats[J]. Reprod Toxicol, 2022, 111:49-58.
Pabisz P, Bazak J, Girotti A W, et al. Anti-steroidogenic effects of cholesterol hydroperoxide trafficking in MA-10Leydig cells:Role of mitochondrial lipid peroxidation and inhibition thereof by selenoperoxidase GPX4[J]. Biochem Biophys Res Commun, 2022, 591:82-87.
Houben T, Bitorina A V, Oligschlaeger Y, et al. Sexopposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling[J]. J Pathol, 2020, 251(4):429-439.
令狐婷,刘少博,高耀,等.稳定同位素示踪技术在内源性物质代谢调控中的应用进展[J].中草药, 2018,49(11):2678-2685.
Crick P J, Yutuc E, Abdel-Khalik J, et al. Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation:Lessons learnt from deuteriumenrichment experiments and the CYP46A1 transgenic mouse[J]. J Steroid Biochem Mol Biol, 2019, 195:105475.
刘慧敏,张悦,王佳艺,等.代谢组学前沿技术进展及在中药现代研究中的应用[J].中草药, 2024, 55(3):969-977.
李丁,王婉9),孙璐,等.组学新技术在中药毒性研究中的应用进展[J].中草药, 2025, 56(2):731-741.
Ma B, Zhang Q, Wang G J, et al. GC-TOF/MS-based metabolomic profiling of estrogen deficiency-induced obesity in ovariectomized rats[J]. Acta Pharmacol Sin,2011, 32(2):270-278.
于强,杨敏,潘萍,等.基于广泛靶向代谢组学技术的掌叶覆盆子不同部位代谢产物差异分析[J].食品科学, 2025, 46(17):231-243.
王雪文.基于靶向代谢组学技术探究党参水提物对脑衰老小鼠海马的保护作用[D].兰州:甘肃中医药大学, 2025.
Moon J Y, Choi M H, Kim J. Metabolic profiling of cholesterol and sex steroid hormones to monitor urological diseases[J]. Endocr Relat Cancer, 2016, 23(10):R455-R467.
武文泽,令狐婷,高耀,等.稳定同位素示踪代谢组学技术在葡萄糖分解代谢研究中的应用进展[J].药学学报, 2021, 56(5):1286-1292.
陈鲁宁,胡扬,辛国松,等.菟丝子化学成分、药理作用研究进展及其质量标志物(Q-Marker)预测[J].中草药, 2024, 55(15):5298-5314.
宋安东,李国花,袁博,等.基于UCP2/TXNIP/NLRP3通路探讨菟丝子总黄酮对CUMS小鼠抗抑郁的作用机制[J].中国实验方剂学杂志, 2025, 31(21):109-119.
史若怡.基于脂质代谢途径探讨菟丝子改善抑郁症卵巢功能异常的机制研究[D].武汉:湖北中医药大学,2024.
Tian J S, Qin P F, Xu T, et al. Chaigui Granule exerts antidepressant effects by regulating the synthesis of estradiol and the downstream of CYP19A1-E2-ERKs signaling pathway in CUMS-induced depressed rats[J]. Front Pharmacol, 2022, 13:1005438.
许腾.柴归颗粒治疗性给药的抗抑郁药效及其调控CYP19A1-E2-ERKs通路作用机制研究[D].太原:山西大学, 2020.
秦鹏飞.柴归颗粒调节CUMS大鼠雌二醇合成与分解代谢平衡抗抑郁作用机制研究[D].太原:山西大学,2023.
张卫健.同位素稀释UPLC-MS/MS同时测定大鼠体内17种性激素的方法及柴归颗粒的干预作用研究[D].太原:山西大学, 2025.
张卫健,赵云昊,贾崇宁,等.性激素微环境稳态与抑郁症及中药调控作用机制研究进展[J].神经药理学报, 2025, 15(1):25-32.)