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2 山东中医药大学中医学院, 山东 济南 250355;
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Burki T. WHO's 2024 global hepatitis report[J]. Lancet Infect Dis, 2024, 24(6):e362-e363.
李健, 王富珍, 陈仲丹, 等. 中国病毒性肝炎疾病负担研究进展[J]. 临床肝胆病杂志, 2025, 41(2):221-227.
李宁, 张国龙, 赵东阳. 河南省丙型肝炎防治实践与成效分析[J]. 现代疾病预防控制, 2024, 35(12):884-888.
罗锋, 周洋, 苏颖, 等. 2005-2022年浙江省急性乙型病毒性肝炎发病趋势的Joinpoint回归和年龄-时期-队列模型分析[J]. 中国疫苗和免疫, 2024, 30(1):19-24.
Cao G Y, Liu J, Liu M. Trends in mortality of liver disease due to hepatitis B in China from 1990 to 2019:Findings from the Global Burden of Disease Study[J]. Chin Med J, 2022, 135(17):2049-2055.
张敏, 张裕晓, 江山佳美, 等. 中国居民1990-2019年乙型病毒性肝炎及其危险因素所致疾病负担变化趋势分析[J]. 中国公共卫生, 2024, 40(5):593-597.
Zheng H, Wang Y, Wang F Z, et al. New progress in HBV control and the cascade of health care for people living with HBV in China:Evidence from the fourth national serological survey, 2020[J]. Lancet Reg Health West Pac, 2024, 51:101193.
覃武海, 黎裕朝, 张荣臻. HBeAg阴性慢性乙型肝炎的中医治疗研究进展[J]. 大众科技, 2023, 25(9):50-53.
Wang M J, Wang Y T, Feng X S, et al. Contribution of hepatitis B virus and hepatitis C virus to liver cancer in China north areas:Experience of the Chinese National Cancer Center[J]. Int J Infect Dis, 2017, 65:15-21.
Pietschmann T, Brown R J P. Hepatitis C virus[J]. Trends Microbiol, 2019, 27(4):379-380.
卞丹丹, 蒋莹莹, 周海洋, 等. 中国大陆丙肝相关肝硬化及肝癌患者抗病毒治疗现状调查[J]. 胃肠病学和肝病学杂志, 2019, 28(7):750-754.
Seto W K, Lo Y R, Pawlotsky J M, et al. Chronic hepatitis B virus infection[J]. Lancet, 2018, 392(10161):2313-2324.
Wu Y H. Naturally derived anti-hepatitis B virus agents and their mechanism of action[J]. World J Gastroenterol, 2016, 22(1):188-204.
Lee M H, Lee B H, Lee S, et al. Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides[J]. J Food Sci, 2013, 78(9):M1412-M1415.
刘海燕, 付明月, 孙海珍, 等. 汉黄芩素对乙型肝炎病毒大鼠肝功能的影响[J]. 世界中医药, 2025, 20(3):419-423.
Rendina M, D'Amato M, Castellaneta A, et al. Antiviral activity and safety profile of silibinin in HCV patients with advanced fibrosis after liver transplantation:A randomized clinical trial[J]. Transpl Int, 2014, 27(7):696-704.
赵霏, 安利峰, 马艳庆, 等. 单味中草药体内外抗乙肝病毒疗效的系统评价[J]. 中成药, 2015, 37(10):2282-2286.
郭敏卓, 韩晶, 刘凌. 乙型肝炎病毒基因分型及相关应用的研究进展[J]. 中国口岸科学技术, 2024, 6(7):13-17.
罗瑞虹, 赵志新, 周旭毓, 等. 中国人群HBV感染与原发性肝癌关系病例对照研究的Meta分析[J]. 热带医学杂志, 2005, 5(4):419-423.
谢晓. 乙型肝炎肝硬化抗病毒治疗的进展[J]. 实用肝脏病杂志, 2018, 21(1):140-144.
斯崇文. 从HBV的复制过程认识抗HBV药物的作用、效果和抗HBV的策略[J]. 临床肝胆病杂志, 2000, 16(3):131.
汪俊韬, 吴昊. 甲、乙、丙、丁、戊型肝炎病原学研究进展[J]. 北京医学, 1993, 15(4):229-231.
董娜, 刘涓, 张云智. 丙型肝炎病毒分类和宿主动物的研究进展[J]. 中国病原生物学杂志, 2019, 14(12):1481-1484.
邹坚, 陈鸿珊. 抗HCV药物研究进展[J]. 中国药学杂志, 2004, 39(6):403-408.
陈埔. 正链RNA病毒复制关键酶的结构、功能及抑制剂研究[D]. 北京:北京协和医学院, 2021.
杜江龙, 薛宇佳, 冶昡青, 等. 甲型肝炎病毒免疫控制研究进展[J]. 动物医学进展, 2019, 40(4):112-115.
王彦. 我国丁型肝炎病毒感染情况调查和病毒分子特性研究[D]. 北京:中国疾病预防控制中心, 2018.
徐亮, 黄霞. 警惕甲肝与戊肝[J]. 开卷有益-求医问药, 2024(7):36-37.
贾荣曼, 詹磊. 病毒性肝炎家族的"五兄弟"[J]. 中医健康养生, 2020, 6(7):48-51.
陈玥舟. 病毒性肝炎相关明清文献中医诊治经验挖掘的方法学研究[D]. 北京:中国中医科学院, 2014.
管海斌. 小柴胡汤联合恩替卡韦治疗肝郁脾虚型慢性乙型病毒性肝炎的疗效研究[J]. 北方药学, 2025, 22(1):42-44.
滕飞, 骆欢. 加味茵陈蒿汤治疗湿热中阻型乙型病毒性肝炎患者的效果[J]. 中外医学研究, 2025, 23(4):1-5.
马昆, 刘燕玲, 周春梅, 等. 中药苦参抗乙型肝炎病毒的研究进展[J]. 辽宁中医杂志, 2015, 42(11):2261-2264.
Lin L J, Zhang M X, Xie H J, et al. Effects of Schisandrae Fructus alone or in combination in viral hepatitis treatment:A systematic review and meta-analysis of randomized controlled trials[J]. Sci Tradit Chin Med, 2025, 3(1):69-80.
曹梦珍, 赵旭, 郑艳芳, 等. 基于分子对接与实验验证的板蓝根及其活性成分抗乙型肝炎病毒作用机制研究[J]. 中草药, 2023, 54(7):2127-2134.
沈宇煌, 梁志达, 艾兆秀, 等. 中医药联合核苷 (酸) 类似物治疗慢性乙型病毒性肝炎抗病毒疗效及安全性:基于随机、双盲、对照临床试验的Meta分析[J]. 环球中医药, 2024, 17(8):1562-1572.
邓小够, 潘永良. 乙型肝炎患者干扰素治疗的不良反应及临床护理[J]. 当代医学, 2014, 20(10):109-109.
Li S H, Hao L Y, Yu F, et al. Novel mechanism of Guizhi Jia Huangqi decoction disrupting HBV lifecycle via cAMP/PKC/PKB axis beyond NTCP blockade[J]. J Ethnopharmacol, 2026, 358:120885.
Guo Y Y, Wen J C, Wang X T, et al. Sophora tonkinensis enhances activation of cGAS-STING pathway and restrains HBV replication[J]. Front Pharmacol, 2025, 16:1630460.
Huang H, Huang H C, Chiou W C, et al. Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCP[J]. Antiviral Res, 2021, 195:105184.
刘丽娟, 赵亚, 吴亚运, 等. 醋柴胡多糖对拉米夫定体外抗乙型肝炎病毒的增效作用研究[J]. 世界中医药, 2023, 18(8):1079-1084.
Ying Y, Ling Z, Chao Q C, et al. Inhibition of hepatitis B virus in HepG2.2.15 by indirubin through suppression of a polypyrimidine tract-binding protein[J]. Int J Clin Exp Med, 2017, 10(8):11961-11968.
李彩东, 吴斌, 师彦平. 复方苦味叶下珠胶囊抗肝炎病毒作用研究[J]. 中国药业, 2007, 16(19):3-4.
韩晶晶, 张元奎, 洪丽蓉. 二仙汤合苦味叶下珠治疗慢性乙型肝炎32例疗效观察[J]. 浙江中医药大学学报, 2010, 34(5):728-729.
Guo Q L, Zhao L, You Q D, et al. Anti-hepatitis B virus activity of wogonin in vitro and in vivo[J]. Antiviral Res, 2007, 74(1):16-24.
赵志鸿, 侯迎迎, 郑立运, 等. 艾叶乙酸乙酯提取物对 HBV的抑制作用[J]. 郑州大学学报:医学版, 2013, 48(6):783-785.
赵志鸿, 王丽阳, 郑立运, 等.艾 叶挥发油对HBV的抑制作用[J]. 郑州大学学报:医学版, 2015, 50(2):301-304.
Xu H B, Ma Y B, Huang X Y, et al. Bioactivity-guided isolation of anti-hepatitis B virus active sesquiterpenoids from the traditional Chinese medicine:Rhizomes of Cyperus rotundus[J]. J Ethnopharmacol, 2015, 171:131-140.
Cao T W, Geng C G, Jiang F Q, et al. Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity[J]. Fitoterapia, 2013, 89:175-182.
Huang Q F, Huang R B, Wei L, et al. Antiviral activity of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) against hepatitis B virus[J]. Antiviral Res, 2013, 100(2):373-381.
Huang Q F, Zhang S J, Huang R B, et al. Isolation and identification of an anti-hepatitis B virus compound from Hydrocotyle sibthorpioides Lam[J]. J Ethnopharmacol, 2013, 150(2):568-575.
Yao D C, Li H W, Gou Y L, et al. Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression[J]. FEBS J, 2009, 276(9):2599-2614.
Zhou W B, Zeng G Z, Xu H M, et al. Astataricusones A-D and astataricusol A, five new anti-HBV shionane-type triterpenes from Aster tataricus L. f[J]. Molecules, 2013, 18(12):14585-14596.
Zhao Y, Geng C G, Sun C L, et al. Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris[J]. Fitoterapia, 2014, 95:187-193.
刘文晶, 孙世杰, 韩冰, 等. 槲皮素调节AMPK/SIRT1/NF-κB通路对乙型肝炎大鼠肝组织损伤的影响[J]. 现代生物医学进展, 2023, 23(4):624-629.
Zhao X T, Wang J, Deng Y, et al. Quercetin as a protective agent for liver diseases:A comprehensive descriptive review of the molecular mechanism[J]. Phytother Res, 2021, 35(9):4727-4747.
唐爱存, 王明刚, 卢秋玉, 等. 葫芦茶苷调控JAK/STAT信号通路抗乙肝病毒作用及其机制研究[J]. 中药药理与临床, 2017, 33(1):74-77.
Zhao J, Xu G, Hou X R, et al. Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication[J]. J Ethnopharmacol, 2023, 311:116427.
李转, 王提, 王慧莹. 柴胡疏肝散调控Th17/Treg平衡对乙型病毒性肝炎小鼠肝功能的影响及其机制[J]. 现代医学, 2024, 52(4):606-611.
Zhang Y, Wang Y T, Luo J X, et al. Effect of WSP, a Chinese herbal formula, on Th17/Treg ratio and HBeAg seroconversion in telbivudine-treated HBeAg-positive chronic hepatitis B patients with high baseline ALT levels (20-30 times the ULN)[J]. Evid Based Complement Alternat Med, 2019, 2019:7260369.
刘力锋. 猪苓多糖联合乙肝疫苗治疗慢性乙型肝炎128例[J]. 临床医学, 2009, 29(6):15-16.
李声方, 王兮, 桂希恩, 等. 当归多糖对乙肝病毒转基因小鼠树突状细胞功能状态的影响[J]. 实用诊断与治疗杂志, 2005, 19(5):313-314.
罗燕额, 苏惠萍, 何沂蓉, 等. 半枝莲水提物体内抗鸭乙型肝炎病毒及护肝作用的实验研究[J]. 中国民族民间医药, 2025, 34(13):31-36.
和秋芬. 拉米夫定联合乌鸡白凤丸对慢性乙型肝炎抗病毒疗效的临床观察[J]. 中医临床研究, 2012, 4(13):92-93.
Wang Y P, Zhao W, Xue R, et al. Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance[J]. Antiviral Res, 2011, 89(3):227-231.
高丹. 氧化苦参碱联合拉米夫定对慢性乙型肝炎患者血清IL-2、IL-4、IL-10水平的影响[J]. 中国现代医生, 2016, 54(24):1-3.
程晓云, 神和正. 补肾健脾方对聚乙二醇干扰素α-2b在慢性乙型肝炎临床治愈过程中不良反应的影响[J]. 湖南中医杂志, 2024, 40(6):12-16.
邹小云, 魏民敏, 祁培宏."益气补肾健脾方"联合恩替卡韦治疗青海高原地区慢性乙型肝炎40例临床研究[J]. 江苏中医药, 2024, 56(9):48-52.
马云峰, 杨俊恩. 柔肝化浊补肾方治疗老年慢性乙型肝炎肝纤维化疗效及机制[J]. 中国老年学杂志, 2021, 41(18):3959-3962.
王大勇. 柴胡疏肝散联合西药治疗肝气郁结型慢性乙型肝炎随机平行对照研究[J]. 实用中医内科杂志, 2015, 29(8):121-123.
陈兆, 饶慧瑛. 直接抗病毒药物在急性丙型肝炎治疗中的研究进展[J]. 肝脏, 2025, 30(6):753-755.
苏立, 张金良, 蔡峻岭. 不同基因分型丙型肝炎病毒感染相关严重肝病患者直接抗病毒药物应答特点及其预后影响因素[J]. 新乡医学院学报, 2025, 42(7):597-601.
Howe A Y M, Rodrigo C, Cunningham E B, et al. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals[J]. JHEP Rep, 2022, 4(5):100462.
Calland N, Albecka A, Belouzard S, et al. (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry[J]. Hepatology, 2012, 55(3):720-729.
Ciesek S, von Hahn T, Colpitts C C, et al. The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry[J]. Hepatology, 2011, 54(6):1947-1955.
Anggakusuma, Colpitts C C, Schang L M, et al. Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells[J]. Gut, 2014, 63(7):1137-1149.
Hsu W C, Chang S P, Lin L C, et al. Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entry[J]. Antiviral Res, 2015, 118:139-147.
Lin L T, Chung C Y, Hsu W C, et al. Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry[J]. J Hepatol, 2015, 62(3):541-548.
Calland N, Sahuc M E, Belouzard S, et al. Polyphenols inhibit hepatitis C virus entry by a new mechanism of action[J]. J Virol, 2015, 89(19):10053-10063.
杨欣, 肖俊伟, 唐婷婷, 等. 基于荧光法及分子对接研究黄褐毛忍冬抑制丙型肝炎病毒NS3/4A蛋白酶活性[J]. 安徽医科大学学报, 2023, 58(5):731-734.
van Rossum T G J, Vulto A G, Hop W C J, et al. Glycyrrhizin-induced reduction of alt in European patients with chronic hepatitis C[J]. Am J Gastroenterol, 2001, 96(8):2432-2437.
徐若欣, 尹雪, 陈颜. 中药干预治疗Child-pugh C级丙肝后肝硬化医案1则[J]. 光明中医, 2021, 36(21):3687-3689.
Lee J C, Tseng C K, Wu S F, et al. San-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expression[J]. J Viral Hepat, 2011, 18(7):e315-e324.
郑金萍, 么作义, 王红, 等. 龙虎愈肝方治疗丙肝肝硬化腹腔积液的疗效观察[J]. 中国煤炭工业医学杂志, 2016, 19(5):736-739.
管敏, 陆爽, 张先明. 以索磷布韦为基础的直接抗病毒药物联合肝爽颗粒对慢性HCV感染的临床疗效[J]. 贵州医科大学学报, 2025, 50(3):450-455.
李绍佐, 徐方明, 李世波. 茵陈蒿汤加减治疗黄疸型病毒性肝炎120例疗效观察[J]. 浙江中医药大学学报, 2012, 36(3):267-269.
郭玉刚. 解毒化肝汤联合干扰素治疗丙型肝炎肝硬化随机平行对照研究[J]. 实用中医内科杂志, 2016, 30(10):51-53.
刘应东, 何伟, 汪超, 等. 软肝化积丸对瘀血内结型丙型肝炎肝硬化患者纤维化指标和炎症因子的影响[J]. 山东中医杂志, 2023, 42(12):1274-1281.
Tsukuda S, Watashi K, Hojima T, et al. A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins[J]. Hepatology, 2017, 65(4):1104-1116.
Chiou W C, Lyu Y S, Hsia T L, et al. Ergosterol peroxide blocks HDV infection as a novel entry inhibitor by targeting human NTCP receptor[J]. Biomed Pharmacother, 2024, 170:116077.
Park G, Parveen A, Kim J E, et al. Spicatoside A derived from Liriope platyphylla root ethanol extract inhibits hepatitis E virus genotype 3 replication in vitro[J]. Sci Rep, 2019, 9(1):4397.
Gong W Y, Liu L, Li M Y, et al. Evaluation of antiviral efficacy of Chinese traditional medicine Babao Dan in rabbits infected with hepatitis E virus[J]. J Gen Virol, 2018, 99(8):1036-1043.
姚超, 俞冲, 朱琦琦. 退高黄汤治疗戊型肝炎 (瘀热互结证) 的临床观察[J]. 中国中医急症, 2025, 34(2):314-317.
郭其裕, 陈建能, 郑瑞丹. 中医药治疗黄疸型肝炎的临床研究现状[J]. 临床肝胆病杂志, 2017, 33(5):833-837.
郑小梅, 胡振斌, 谢婷婷. 从《内经》"肝传之脾"论治黄疸型病毒性肝炎[J]. 实用中医内科杂志, 2025, 39(3):61-63.
杨晓彤. 中医湿热辨证治疗急性黄疸型甲型病毒性肝炎疗效观察[J]. 贵州中医药大学学报, 2020, 42(4):54-58.
贺强兴, 赵崇, 蔡正阳. 苦黄注射液联合甘草酸二胺注射液对急性黄疸型病毒性肝炎的治疗疗效及其影响因素[J]. 罕少疾病杂志, 2025, 32(1):96-98.
徐雪芹. 茵陈蒿汤治疗急性黄疸型肝炎的临床研究[J]. 中外医疗, 2023, 42(23):177-180.
于希. 茵陈蒿汤联合西医治疗急性黄疸型肝炎临床观察[J]. 中国中医药现代远程教育, 2022, 20(8):126-127.
蔡媛媛, 蔡敏. 黎药解毒通利方对慢性乙型黄疸型肝炎的疗效研究[J]. 国医论坛, 2023, 38(4):28-30.
彭双福. 舒肝宁治疗急性黄疸型病毒性肝炎的临床疗效[J]. 临床合理用药杂志, 2021, 14(9):123-125.
李彩虹, 马俊杰, 高延玲, 等. 复方黄栌口服液治疗急性病毒性黄疸型肝炎湿热蕴结证临床研究[J]. 河南中医, 2018, 38(10):1527-1530.
Chen H, Ma Y B, Huang X Y, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents[J]. Bioorg Med Chem Lett, 2014, 24(10):2353-2359.)