Article(id=1304415005059871701, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414997581427653, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.08.012, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1767715200000, receivedDateStr=2026-01-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788926372064, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788926372064, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788926372064, creator=13701087609, updateTime=1788926372064, updator=13701087609, issue=Issue{id=1304414997581427653, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='8', pageStart='2877', pageEnd='3260', issueExtLink='null', onlineDate='null', pubDate='1777305600000', pubDateStr='2026-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788926370282, creator='13701087609', updateTime=1788926758667, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304416626649096991, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414997581427653, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304416626649096992, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414997581427653, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2989, endPage=2999, ext={EN=ArticleExt(id=1304415005412193239, articleId=1304415005059871701, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Chemical constituents and anti-inflammatory activities of Triplostegia glandulifera, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To systematically investigate the chemical constituents and in vitro anti-inflammatory activities of the dried tuberous roots of Triplostegia glandulifera. Method Compounds were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatography and semi-preparative HPLC. Their structures were identified by physicochemical properties and spectroscopic data. The cytotoxicity and inhibitory effects on nitric oxide (NO) production were evaluated by CCK-8 assay and Griess method, respectively. Results Twenty-four compounds were isolated and identified as 3,4-dimethoxybenzyl alcohol-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside] (1), sysamarin B (2), primulagenin A (3), oleanolic acid-3-O-[α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside] (4), oleanolic acid-3-O-α-L-arabinopyranoside (5), caffeic acid (6), ethyl caffeate (7), (2'R,3'R)-2',3'-dihydroxy-4'-methoxy caffeoyl butyrate (8), 5-O-[(E)-caffeoyl]-quinic acid (9), methyl 4,5-di-O-caffeoyl quinate (10), eugenyl-O-β-D-gucopyranoside (11), rel-(2α,3β)-7-O-methylcedrusin (12), (7S,8R)-erythro-7,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan-4-O-β-D-glucopyranoside (13), (＋)-pinoresinol (14), (-)-pinoresinol (15), (＋)-syringaresinol-O-β-D-diglucopyranoside (16), ethyl protocatechuate (17), tangeretin (18), hesperidin (19), (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (20), nonialkaloid B (21), strych-novoline (22), 1-(β-D-ribofuranosyl)-1H-1,2,4-triazone (23), and inosine (24). Compounds 2, 4, 5 and 19 showed significant inhibitory activities against NO production. The IC₅₀ values of compounds 4 and 5 were (23.76 ± 1.22) and (23.87 ± 0.23) μmol/L, respectively, which were comparable to that of dexamethasone. Conclusion Compound 1 is a new compound. Compounds 2-5 and 7-24 were isolated from the genus Triplostegia for the first time. Compounds 2, 4, 5 and 19 possess potent in vitro anti-inflammatory activities., authors=DENG Maoxin, ZHANG Hongchuan, MA Kaiyue, WANG Haiming, ZHANG Ying, SHI Qiongxian, LIU Jing, LI Weijiao, DONG Fawu, authorsList=DENG Maoxin, ZHANG Hongchuan, MA Kaiyue, WANG Haiming, ZHANG Ying, SHI Qiongxian, LIU Jing, LI Weijiao, DONG Fawu, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304415005319918550, articleId=1304415005059871701, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=双参的化学成分及抗炎活性研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究彝药双参Triplostegia glandulifera干燥块根的化学成分，并评价其体外抗炎活性。方法 综合运用硅胶、SephadexLH-20、ODS及半制备型高效液相色谱技术等进行分离纯化；通过理化性质与波谱数据鉴定化合物结构；采用CCK-8法与Griess法分别测定化合物的细胞毒性及对一氧化氮（NO）释放的抑制作用。结果 从双参干燥块根的乙醇提取物中分离得到24个化合物，分别鉴定为3,4-二甲氧基苯甲醇-O-[β-D-呋喃芹糖基(1→6)-β-D-吡喃葡萄糖苷]（1）、sysamarin B（2）、primulagenin A（3）、齐墩果酸-3-O-[α-L-吡喃鼠李糖基-(1→3)-β-D-吡喃木糖基-(1→3)-α-L-吡喃鼠李糖基-(1→2)-α-L-吡喃阿拉伯糖苷]（4）、齐墩果酸-3-O-α-L-吡喃阿拉伯糖苷（5）、咖啡酸（6）、咖啡酸乙酯（7）、(2'R,3'R)-2',3'-二羟基- 4'-甲氧基咖啡酰丁酸酯（8）、5-O-[(E)-咖啡酰基]-奎宁酸（9）、4,5-二-O-咖啡酰奎宁酸甲酯（10）、丁香酚基-O-β-D-吡喃葡萄糖苷（11）、(2α,3β)-7-O-甲基雪松素（12）、(7S,8R)-赤式-7,9,9'-三羟基-3,3'-二甲氧基-8-O-4'-新木脂素-4-O-β-D-吡喃葡萄糖苷（13）、(＋)-松脂醇（14）、(-)-松脂醇（15）、(＋)-丁香脂素-O-β-D-双吡喃葡萄糖苷（16）、原儿茶酸乙酯（17）、橘皮素（18）、橙皮苷（19）、(1S,3S)-1-甲基-1,2,3,4-四氢-β-咔啉-3-羧酸（20）、诺宁生物碱B（21）、士的宁灵碱（22）、1-(β-D-ribofuranosyl)-1H-1,2,4-triazone（23）、肌苷（24）。化合物2、4、5、19可显著抑制NO释放，其中化合物4、5的半数抑制浓度（median inhibition concentration，IC₅₀）分别为（23.76±1.22）、（23.87±0.23）μmol/L。结论 化合物1为新化合物，命名为双参酚苷A（triplostegia phenolic glycoside A）；化合物2～5、7～24均为首次从双参属植物中分离得到；化合物2、4、5和19具有较强体外抗炎活性。, authors=邓茂鑫¹, 张洪川², 马开悦¹, 王海名¹, 张颖¹, 施琼仙¹, 刘晶¹, 李维蛟¹, 董发武¹, authorsList=邓茂鑫, 张洪川, 马开悦, 王海名, 张颖, 施琼仙, 刘晶, 李维蛟, 董发武, authorCompany=1 云南中医药大学 中药学院/云南省中药材加工与炮制重点实验室/云南省教育厅云南特色饮片炮制研究重点实验室(筹), 云南 昆明 650500;
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