Article(id=1304414957370630258, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414955046985824, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.07.005, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1760457600000, receivedDateStr=2025-10-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788926360694, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788926360694, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788926360694, creator=13701087609, updateTime=1788926360694, updator=13701087609, issue=Issue{id=1304414955046985824, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='7', pageStart='2445', pageEnd='2876', issueExtLink='null', onlineDate='null', pubDate='1775923200000', pubDateStr='2026-04-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788926360140, creator='13701087609', updateTime=1788926711174, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304416427457409395, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414955046985824, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304416427457409396, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414955046985824, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2482, endPage=2492, ext={EN=ArticleExt(id=1304414957693591668, articleId=1304414957370630258, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Study on improving fluidity and hygroscopicity of fermented Cordyceps powder by particle size gradation design, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To address the issues of poor flowability and high hygroscopicity of fermented Cordyceps powder, the particle size gradation strategy and investigates the relationship between flowability parameters, particle size, and particle size distribution, so as to provide theoretical support and technical guidance for enhancing powder performance and optimizing processing strategies. Methods A laser particle size analyzer, powder characteristics tester, and powder rheometer were employed to systematically characterize the particle size distribution, static flowability parameters (angle of repose, Hausner ratio, and flat plate angle, etc.), and rheological properties (flow energy, aeration, permeability, and shear behavior) of the fermented Cordyceps powder. The effects of different particle size ratios on powder packing behavior and hygroscopicity were analyzed. Results Particle size is a critical factor affecting powder flowability. A particle size ratio of 24-80 (95:5) mesh yielded optimal packing performance. Hygroscopic kinetics modeling showed that both the double exponential and Weibull models provided good fits for describing the moisture absorption behavior of powders with different particle sizes, offering quantitative indicators of hygroscopicity. Conclusion Particle size gradation design provides a new strategy for improving the flowability and stability of fermented Cordyceps powder., authors=WAN Qingzhao, ZHANG Huinan, WANG Shengsheng, PENG Xulong, PENG Changchun, XU Yun, WU Zhenfeng, WANG Yaqi, authorsList=WAN Qingzhao, ZHANG Huinan, WANG Shengsheng, PENG Xulong, PENG Changchun, XU Yun, WU Zhenfeng, WANG Yaqi, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304414957613899891, articleId=1304414957370630258, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=粒度级配设计改善发酵虫草菌粉粉体流动性与吸湿性研究, columnId=1304140189132149234, journalTitle=中草药, columnName=药剂与工艺, runingTitle=null, highlight=null, articleAbstract=目的 针对发酵虫草菌粉流动性差、易受潮的问题,引入粒度级配方法,探讨流动性参数与粒度分布之间的关系,为提升粉体性能、优化工艺处理策略提供依据。方法 采用激光粒度仪、粉体特性测试仪和粉体流变仪,对发酵虫草菌粉的粒度分布、静态流动性(休止角、豪森纳比、平板角等)和流变性质(流动能性质、充气性质、透气性质和剪切性质)进行系统表征,分析不同粒度配比对粉体填充行为和吸湿性能的影响。结果 粒径是影响发酵虫草菌粉流动性的关键因素,粒度级配为24-80(95∶5)目的混合粉末填充性最优。吸湿动力学研究表明,双指数模型和威布尔模型均能较好地拟合不同粒径发酵虫草菌粉的吸湿行为,为其吸湿性提供量化指标。结论 粒度级配设计为提升发酵虫草菌粉的流动性和稳定性提供新思路。, authors=万倾兆1 , 张慧楠1 , 王生生1 , 彭旭龙1 , 彭常春2 , 许云2 , 伍振峰1 , 王雅琪1,3 , authorsList=万倾兆, 张慧楠, 王生生, 彭旭龙, 彭常春, 许云, 伍振峰, 王雅琪, authorCompany=1 江西中医药大学 经典名方现代中药创制全国重点实验室, 江西 南昌 330004; 2 江西济民可信集团有限公司, 江西 南昌 330224; 3 江西中医药大学 中药制药技术协同创新研究院, 江西 南昌 330004, correspAuthors=王雅琪, authorNote=万倾兆: 万倾兆,硕士研究生,研究方向为中药质量分析与控制。Tel:(0791)87118108 E-mail:wqz302005@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, 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Prediction of granule packing and flow behavior based on particle size and shape analysis[J].J Pharm Sci, 2010, 99(2):958-968. Zegzulka J, Gelnar D, Jezerska L, et al. Characterization and flowability methods for metal powders[J]. Sci Rep,2020, 10(1):21004. 高健,黄璐琦,李哲,等.不同干燥方式制备巴西人参提取物粉体性质比较[J].中国新药杂志, 2024, 33(4):383-389. 罗聪,陆海峰,郭晓镭,等.粉体流动性的静力学及动力学表征研究[J].化工新型材料, 2020, 48(10):186-191. 李嘉懿,宋汝骁,董龙涛,等.药用乳糖粉体流动性表征方法的研究[J].沈阳药科大学学报, 2024, 41(1):55-64. 王嘉绍,刘朝贤,鲁端峰,等.不同粒径与含水率的烟粉颗粒流动性及影响因素[J].烟草科技, 2020, 53(4):75-81. 张力锋,杨建伟,吕玺,等.不同粒度级配的硼基粉末燃料装填特性和流动性[J].火炸药学报, 2024, 47(1):91-96. 徐冰,崔向龙,杨婵,等.质量源于设计在银杏叶片制粒工艺中的应用(Ⅱ):颗粒关键质量属性辨识[J].中国中药杂志, 2017, 42(6):1043-1047. 王子千,吴凡,钟志坚,等.健胃消食颗粒物性参数测定与离散元仿真参数标定[J].中国中药杂志, 2024,49(24):6558-6564. 王昌镇,王森,张元彬,等.钛合金粉末的流动性研究[J].粉末冶金技术, 2016, 34(5):330-335. Suhaidi D, Dong Y D, Wynne P, et al. Bulk flow optimisation of amorphous solid dispersion excipient powders through surface modification[J]. Pharmaceutics,2023, 15(5):1447. 胡恢权.基于粉体学性质的发酵虫草粉质量均一性及填充行为影响和优化研究[D].南昌:江西中医药大学, 2024. 王洁,赵国巍,廖正根,等.肿节风混合粉的粉体学基本性质与吸湿性的相关性研究[J].中草药, 2014,45(2):188-193. 朱诗竟,丁青龙,狄留庆,等.不同湿度环境下中药浸膏粉体吸湿动力学模型拟合优选[J].中草药, 2013,44(20):2833-2840. 朱卫丰,陈富财,刘文君,等.基于粒子设计原理的中药粉体改性研究进展[J].药学学报, 2022, 57(6):1781-1791. 陈绪龙,赵国巍,廖正根,等.不同粒径三七粉体物理特陛及体外溶出行为的比较[J].中华中医药杂志,2011, 26(9):1971-1974. 林泳鸿,毕金峰,李一鸣,等.基于固态基质模拟体系的枣粉吸湿行为评价[J].中国食品学报, 2025, 25(7):284-294. 敖腾,张俊芳,赵国巍,等.基于多元数据分析的固体分散体粉体学性质及其与重结晶过程中相对结晶度的相关性研究[J].中国现代应用药学, 2023, 40(16):2260-2267. 陈国鑫,尧军平,梁超群,等.基于实际三维微观结构研究颗粒混杂对SiC/AZ91D复合材料力学行为及其变形失效机理的影响[J].中国材料进展, 2025, 44(8):770-777. Stavrou A G, Hare C, Hassanpour A, et al. Investigation of powder flowability at low stresses:Influence of particle size and size distribution[J]. Powder Technol, 2020, 364:98-114. 王雅洁,汤成成,贾艾玲,等.黄芪水提取物吸湿模型的拟合[J].中成药, 2017, 39(1):65-70. Zhang H N, Liu Y, Zhang H L, et al. Effect of different drying and grinding techniques on the physicochemical properties and biological activities of fungal polysaccharides[J]. Food Med Homol, 2025, 2(1):9420045.)
中草药
|药剂与工艺
2026
, 57
(7) :
2482
-2492
粒度级配设计改善发酵虫草菌粉粉体流动性与吸湿性研究
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万倾兆, 张慧楠, 王生生, 彭旭龙, 彭常春, 许云, 伍振峰, 王雅琪
作者信息
通讯作者:
王雅琪
作者简介:
万倾兆: 万倾兆,硕士研究生,研究方向为中药质量分析与控制。Tel:(0791)87118108 E-mail:wqz302005@163.com
Study on improving fluidity and hygroscopicity of fermented Cordyceps powder by particle size gradation design
WAN Qingzhao, ZHANG Huinan, WANG Shengsheng, PENG Xulong, PENG Changchun, XU Yun, WU Zhenfeng, WANG Yaqi
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.07.005
文章导航
目的 针对发酵虫草菌粉流动性差、易受潮的问题,引入粒度级配方法,探讨流动性参数与粒度分布之间的关系,为提升粉体性能、优化工艺处理策略提供依据。方法 采用激光粒度仪、粉体特性测试仪和粉体流变仪,对发酵虫草菌粉的粒度分布、静态流动性(休止角、豪森纳比、平板角等)和流变性质(流动能性质、充气性质、透气性质和剪切性质)进行系统表征,分析不同粒度配比对粉体填充行为和吸湿性能的影响。结果 粒径是影响发酵虫草菌粉流动性的关键因素,粒度级配为24-80(95∶5)目的混合粉末填充性最优。吸湿动力学研究表明,双指数模型和威布尔模型均能较好地拟合不同粒径发酵虫草菌粉的吸湿行为,为其吸湿性提供量化指标。结论 粒度级配设计为提升发酵虫草菌粉的流动性和稳定性提供新思路。
发酵虫草菌粉
/
粉体
/
粒度级配
/
流动性
/
吸湿性
Objective To address the issues of poor flowability and high hygroscopicity of fermented Cordyceps powder, the particle size gradation strategy and investigates the relationship between flowability parameters, particle size, and particle size distribution, so as to provide theoretical support and technical guidance for enhancing powder performance and optimizing processing strategies. Methods A laser particle size analyzer, powder characteristics tester, and powder rheometer were employed to systematically characterize the particle size distribution, static flowability parameters (angle of repose, Hausner ratio, and flat plate angle, etc.), and rheological properties (flow energy, aeration, permeability, and shear behavior) of the fermented Cordyceps powder. The effects of different particle size ratios on powder packing behavior and hygroscopicity were analyzed. Results Particle size is a critical factor affecting powder flowability. A particle size ratio of 24-80 (95:5) mesh yielded optimal packing performance. Hygroscopic kinetics modeling showed that both the double exponential and Weibull models provided good fits for describing the moisture absorption behavior of powders with different particle sizes, offering quantitative indicators of hygroscopicity. Conclusion Particle size gradation design provides a new strategy for improving the flowability and stability of fermented Cordyceps powder.
fermented Cordyceps powder
/
powder
/
particle size gradation
/
fluidity
/
hygroscopicity
万倾兆, 张慧楠, 王生生, 彭旭龙, 彭常春, 许云, 伍振峰, 王雅琪.
粒度级配设计改善发酵虫草菌粉粉体流动性与吸湿性研究.
中草药,
2026
, 57
(7)
: 2482
-2492
.
DOI: 10.7501/j.issn.0253-2670.2026.07.005
WAN Qingzhao, ZHANG Huinan, WANG Shengsheng, PENG Xulong, PENG Changchun, XU Yun, WU Zhenfeng, WANG Yaqi.
Study on improving fluidity and hygroscopicity of fermented Cordyceps powder by particle size gradation design[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(7)
: 2482
-2492
.
DOI: 10.7501/j.issn.0253-2670.2026.07.005
参考文献
引证文献
Sandler N, Wilson D. Prediction of granule packing and flow behavior based on particle size and shape analysis[J].J Pharm Sci, 2010, 99(2):958-968. Zegzulka J, Gelnar D, Jezerska L, et al. Characterization and flowability methods for metal powders[J]. Sci Rep,2020, 10(1):21004. 高健,黄璐琦,李哲,等.不同干燥方式制备巴西人参提取物粉体性质比较[J].中国新药杂志, 2024, 33(4):383-389. 罗聪,陆海峰,郭晓镭,等.粉体流动性的静力学及动力学表征研究[J].化工新型材料, 2020, 48(10):186-191. 李嘉懿,宋汝骁,董龙涛,等.药用乳糖粉体流动性表征方法的研究[J].沈阳药科大学学报, 2024, 41(1):55-64. 王嘉绍,刘朝贤,鲁端峰,等.不同粒径与含水率的烟粉颗粒流动性及影响因素[J].烟草科技, 2020, 53(4):75-81. 张力锋,杨建伟,吕玺,等.不同粒度级配的硼基粉末燃料装填特性和流动性[J].火炸药学报, 2024, 47(1):91-96. 徐冰,崔向龙,杨婵,等.质量源于设计在银杏叶片制粒工艺中的应用(Ⅱ):颗粒关键质量属性辨识[J].中国中药杂志, 2017, 42(6):1043-1047. 王子千,吴凡,钟志坚,等.健胃消食颗粒物性参数测定与离散元仿真参数标定[J].中国中药杂志, 2024,49(24):6558-6564. 王昌镇,王森,张元彬,等.钛合金粉末的流动性研究[J].粉末冶金技术, 2016, 34(5):330-335. Suhaidi D, Dong Y D, Wynne P, et al. Bulk flow optimisation of amorphous solid dispersion excipient powders through surface modification[J]. Pharmaceutics,2023, 15(5):1447. 胡恢权.基于粉体学性质的发酵虫草粉质量均一性及填充行为影响和优化研究[D].南昌:江西中医药大学, 2024. 王洁,赵国巍,廖正根,等.肿节风混合粉的粉体学基本性质与吸湿性的相关性研究[J].中草药, 2014,45(2):188-193. 朱诗竟,丁青龙,狄留庆,等.不同湿度环境下中药浸膏粉体吸湿动力学模型拟合优选[J].中草药, 2013,44(20):2833-2840. 朱卫丰,陈富财,刘文君,等.基于粒子设计原理的中药粉体改性研究进展[J].药学学报, 2022, 57(6):1781-1791. 陈绪龙,赵国巍,廖正根,等.不同粒径三七粉体物理特陛及体外溶出行为的比较[J].中华中医药杂志,2011, 26(9):1971-1974. 林泳鸿,毕金峰,李一鸣,等.基于固态基质模拟体系的枣粉吸湿行为评价[J].中国食品学报, 2025, 25(7):284-294. 敖腾,张俊芳,赵国巍,等.基于多元数据分析的固体分散体粉体学性质及其与重结晶过程中相对结晶度的相关性研究[J].中国现代应用药学, 2023, 40(16):2260-2267. 陈国鑫,尧军平,梁超群,等.基于实际三维微观结构研究颗粒混杂对SiC/AZ91D复合材料力学行为及其变形失效机理的影响[J].中国材料进展, 2025, 44(8):770-777. Stavrou A G, Hare C, Hassanpour A, et al. Investigation of powder flowability at low stresses:Influence of particle size and size distribution[J]. Powder Technol, 2020, 364:98-114. 王雅洁,汤成成,贾艾玲,等.黄芪水提取物吸湿模型的拟合[J].中成药, 2017, 39(1):65-70. Zhang H N, Liu Y, Zhang H L, et al. Effect of different drying and grinding techniques on the physicochemical properties and biological activities of fungal polysaccharides[J]. Food Med Homol, 2025, 2(1):9420045.
2026年第57卷第7期
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doi: 10.7501/j.issn.0253-2670.2026.07.005
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2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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