中草药

姜黄素药理作用、药动学及制剂开发的研究进展

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中草药 | 综述 2026,57(6): 2394-2405

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中草药 |综述 2026 , 57 (6) : 2394 -2405

姜黄素药理作用、药动学及制剂开发的研究进展

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马萌萌^1,2, 王雪娇^1,2, 姚亚轩², 孙士玲¹, 关徐涛¹, 蒋立峰³, 高萍¹, 李含雪², 毕梦瑶²

作者信息

作者简介:

马萌萌: 马萌萌,硕士研究生,研究方向为中西医结合防治恶性肿瘤疾病。E-mail:1592141245@qq.com

Research progress on pharmacological effects, pharmacokinetics and formulation development of curcumin

MA Mengmeng, WANG Xuejiao, YAO Yaxuan, SUN Shiling, GUAN Xutao, JIANG Lifeng, GAO Ping, LI Hanxue, BI Mengyao

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doi: 10.7501/j.issn.0253-2670.2026.06.031

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摘要

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姜黄素是姜黄Curcumae Longae Rhizoma中的一种多酚类活性单体，具有抗肿瘤、抗炎、抗氧化、代谢调节等药理作用。现有研究表明，姜黄素在肿瘤疾病、炎症性疾病及代谢性疾病等领域表现出广泛的生物学潜力。然而，其在吸收、分布、代谢和排泄等药动学过程中存在水溶性差、生物利用度低等问题，限制了临床应用的进一步推进。针对上述不足，国内外学者采用聚合物纳米粒、聚合物胶束、纳米乳等新剂型技术，以提高姜黄素的溶解度、稳定性、靶向性和生物利用度。通过系统综述姜黄素的“药理-临床研究-药动-剂型”等方面最新进展，检索中国知网、PubMed、Web of Science等数据库中姜黄素药理作用、临床研究、药动学及制剂开发的最新研究进展进行归纳总结，并结合新型递送系统的设计策略讨论其临床转化潜力，为姜黄素的深入研究与应用提供参考。

关键词

姜黄素 / 药动学 / 制剂开发 / 抗肿瘤 / 抗炎 / 抗氧化 / 代谢调节

Abstract

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Curcumin is a polyphenolic active compound in Jianghuang (Curcumae Longae Rhizoma), exhibiting pharmacological effects such as antitumor, anti-inflammatory, antioxidant, and metabolic regulation properties. Existing research indicates that curcumin demonstrates broad biological potential in fields including tumor diseases, inflammatory diseases, and metabolic disorders. However, issues such as poor water solubility and low bioavailability during its pharmacokinetic processes—including absorption, distribution, metabolism, and excretion—have limited further advancement in clinical applications. To address these limitations, researchers worldwide have employed novel delivery technologies such as polymeric nanoparticles, polymeric micelles, and nanoemulsions to enhance curcumin's solubility, stability, targeting efficiency, and bioavailability. This systematic review summarizes the latest advances in curcumin's pharmacology, clinical research, pharmacokinetics, and formulation development by analyzing databases including CNKI, PubMed, and Web of Science. It also discusses the clinical translation potential of novel delivery systems and their design strategies, providing a reference for further research and application of curcumin.

Key words

curcumin / pharmacokinetics / formulation development / antitumor / anti-inflammatory / antioxidant / metabolic regulation

引用本文

马萌萌, 王雪娇, 姚亚轩, 孙士玲, 关徐涛, 蒋立峰, 高萍, 李含雪, 毕梦瑶. 姜黄素药理作用、药动学及制剂开发的研究进展. 中草药, 2026 , 57 (6) : 2394 -2405 . DOI: 10.7501/j.issn.0253-2670.2026.06.031

MA Mengmeng, WANG Xuejiao, YAO Yaxuan, SUN Shiling, GUAN Xutao, JIANG Lifeng, GAO Ping, LI Hanxue, BI Mengyao. Research progress on pharmacological effects, pharmacokinetics and formulation development of curcumin[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (6) : 2394 -2405 . DOI: 10.7501/j.issn.0253-2670.2026.06.031

基金

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国家自然科学基金资助项目 (U1704181); 河南省高等学校重点科研项目 (24A360006); 河南省中医药科学研究专项 (20-21ZY1010); 第七批全国老中医专家学术经验继承工作及继承人 (国中医药人教函[2022]76号); 河南省卫生健康委员会 (2023ZY2004); 河南省本科高校青年骨干教师 (2023GGJS083); 河南省科技攻关计划 (252102310481)

参考文献

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2026年第57卷第6期

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doi: 10.7501/j.issn.0253-2670.2026.06.031

接收时间：2025-09-01
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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