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2 河南省中药开发工程技术研究中心, 河南郑州 450046;
3 赤水芝绿金钗石斛生态园开发有限公司, 贵州遵义 564700;
4 呼吸疾病中医药防治省部共建协同创新中心, 河南郑州 450046, correspAuthors=冯卫生, authorNote=张俊阳: 张俊阳,女,硕士研究生,从事中药药效物质基础与作用机制研究。E-mail:zjyy031128@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=d9/R2rGoOZ9fJ5WJrvoZeA==, pdfFileSize=1253039, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=中央引导地方科技发展专项资金 ([2016]149); 河南省科技攻关项目 (212102311091))}, authors=null, keywords=[Keyword(id=1304414821756195809, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414821017998302, language=CN, orderNo=1, keyword=金钗石斛), Keyword(id=1304414821827498978, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414821017998302, language=CN, orderNo=2, keyword=生物碱), Keyword(id=1304414821923967971, 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范欣悦, 何汶璐, 董丽, 等. 金钗石斛提取物对秀丽隐杆线虫帕金森病模型的神经保护作用研究[J]. 中国比较医学杂志, 2025, 35(4): 31-42.
蒋勇炫, 毛黔华, 林夏萍, 等. 金钗石斛生物碱对对乙酰氨基酚诱导小鼠急性肝损伤的保护作用[J]. 遵义医科大学学报, 2024, 47(11): 1047-1053.
林聪, 刘紫玉, 何成芬, 等. 关于金钗石斛抗氧化损伤作用的微综述[J]. 生物资源, 2024, 46(3): 304-309.
何鹏飞, 高敏, 王胤骁, 等. 金钗石斛药理作用研究进展[J]. 云南中医中药杂志, 2025, 46(7): 104-107.
时应兰, 李军, 石谍, 等. 金钗石斛总生物碱对大鼠后发性白内障的影响[J]. 精细化工中间体, 2024, 54(6): 20-24.
陈思屹. 金钗石斛浸泡酒制备工艺的研究[J]. 广东化工, 2022, 49(24): 59-62.
Du Y E, Lee J S, Kim H M, et al. Chemical constituents of the roots of Codonopsis lanceolata[J]. Arch Pharm Res, 2018, 41(11): 1082-1091.
张亚伦, 朱研洁, 代向阳, 等. 肉桂叶化学成分研究[J]. 天然产物研究与开发, 2024, 36(7): 1142-1148.
Pathak A, Kulshreshtha D K, Maurya R. Coumaroyl triterpene lactone, phenolic and naphthalene glycoside from stem bark of Diospyros angustifolia[J]. Phytochemistry, 2004, 65(14): 2153-2158.
侯奋争, 姚桂彬, 徐伟, 等. 高山红景天首次分离的化合物(I)[J]. 中国现代中药, 2009, 11(4): 18-20.
欧阳春杰, 贾芳欣, 黄佳佳, 等. 铁皮石斛花中杂环类和酚苷类成分研究[J]. 中国中药杂志, 2023, 48(15): 4115-4123.
张东东, 李婧伊, 石燕红, 等. 板蓝根中糖苷类化学成分研究[J]. 中草药, 2019, 50(15): 3575-3580.)
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赤水金钗石斛中2个新化学成分
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中草药 | 化学成分 2026,57(5): 1597-1602
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中草药 |化学成分 2026 , 57 (5) : 1597 -1602
赤水金钗石斛中2个新化学成分
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张俊阳1,2, 杨梦1,2, 郝志友1,2, 王小兰1,2, 刘志霞3, 马旭东1,2, 肖超远1,2, 郑晓珂1,2, 冯卫生1,2,4
作者信息
    1 河南中医药大学药学院, 河南郑州 450046;
    2 河南省中药开发工程技术研究中心, 河南郑州 450046;
    3 赤水芝绿金钗石斛生态园开发有限公司, 贵州遵义 564700;
    4 呼吸疾病中医药防治省部共建协同创新中心, 河南郑州 450046
通讯作者:
冯卫生
作者简介:
张俊阳: 张俊阳,女,硕士研究生,从事中药药效物质基础与作用机制研究。E-mail:zjyy031128@163.com
wo new compounds from Chishui Dendrobium nobile
  • ZHANG Junyang, YANG Meng, HAO Zhiyou, WANG Xiaolan, LIU Zhixia, MA Xudong, XIAO Chaoyuan, ZHENG Xiaoke, FENG Weisheng
  • Affiliations
    doi: 10.7501/j.issn.0253-2670.2026.05.001
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    目的 研究赤水金钗石斛Dendrobium nobile的化学成分。方法 采用硅胶、Toyopearl HW-40C以及半制备液相等方法和手段进行系统的化学成分研究,通过HRESIMS、NMR、IR、UV等波谱学方法进行结构鉴定。结果 从金钗石斛95%乙醇提取物的正丁醇部位分离得到6个化合物,分别鉴定为6,7-二甲基-1-[(2S,3R,4R)-2,3,5-三羟基-4-β-D-葡萄糖]-1,4-二氢喹噁嗪-2,3-二酮(1)、2-苯乙基 3-O-β-D-吡喃葡萄糖基-β-D-葡萄糖苷(2)、diospyrososide(3)、苄基-β-D-葡萄糖苷(4)、淫羊藿次苷D₂(5)、2-methoxyphenyl-β-D-glucopyranoside(6)。结论 化合物1为1个新的生物碱类化合物,2为1个新的苯乙醇苷类化合物,分别命名为金钗石斛碱A1(1)和金钗石斛苷A1(2);化合物36均为首次从金钗石斛中分离得到。
    金钗石斛  /  生物碱  /  糖苷  /  金钗石斛碱A1  /  金钗石斛苷A1  /  苄基-β-D-葡萄糖苷  /  淫羊藿次苷D2
    Objective Study on the chemical components of Chishui Dendrobium nobile (Orchidaceae).Methods A systematic chemical study was conducted on the n-butanol fraction of the 95% ethanol extract of Chishui D. nobile using methods and techniques such as silica gel, Toyopearl HW-40C, and semi-preparative liquid chromatography, with structural identification carried out through HRESIMS, NMR, IR, UV, and other spectroscopic methods. Results A total of six compounds were isolated and identified as 6,7-dimethyl-1-[(2S,3R,4R)-2,3,5-trihydroxy-4-O-β-D-glucopyranosyl]-1,4-dihydroquinoxaline-2,3-dione (1), 2-phenylethyl 3-O-β-D-glucopyranosyl-β-D-glucopyranoside (2), diospyrososide (3), benzyl-β-D-glucoside (4), icariside D2 (5), 2-methoxyphenyl-β-D-glucopyranoside (6). Conclusion Compound 1 was identified as a new alkaloid, named dendronobiline A1, while compound 2 was identified as a new phenylethanoid glycoside, named dendronobiside A1. Compounds 36 are isolated from the plant for the first time.
    Dendrobium nobile Lindl.  /  alkaloid  /  glycoside  /  dendronobiline A1  /  dendronobiside A1  /  benzyl-β-D-glucoside  /  icariside D2
    张俊阳, 杨梦, 郝志友, 王小兰, 刘志霞, 马旭东, 肖超远, 郑晓珂, 冯卫生. 赤水金钗石斛中2个新化学成分. 中草药, 2026 , 57 (5) : 1597 -1602 . DOI: 10.7501/j.issn.0253-2670.2026.05.001
    ZHANG Junyang, YANG Meng, HAO Zhiyou, WANG Xiaolan, LIU Zhixia, MA Xudong, XIAO Chaoyuan, ZHENG Xiaoke, FENG Weisheng. wo new compounds from Chishui Dendrobium nobile[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (5) : 1597 -1602 . DOI: 10.7501/j.issn.0253-2670.2026.05.001

      中央引导地方科技发展专项资金 ([2016]149); 河南省科技攻关项目 (212102311091)

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    杜佩雯, 韦晓愉, 张斌, 等. 金钗石斛中2个新的二苯乙烷类衍生物及其抗肿瘤活性研究[J]. 中国中药杂志, 2025, 50(19): 5417-5421.
    范欣悦, 何汶璐, 董丽, 等. 金钗石斛提取物对秀丽隐杆线虫帕金森病模型的神经保护作用研究[J]. 中国比较医学杂志, 2025, 35(4): 31-42.
    蒋勇炫, 毛黔华, 林夏萍, 等. 金钗石斛生物碱对对乙酰氨基酚诱导小鼠急性肝损伤的保护作用[J]. 遵义医科大学学报, 2024, 47(11): 1047-1053.
    林聪, 刘紫玉, 何成芬, 等. 关于金钗石斛抗氧化损伤作用的微综述[J]. 生物资源, 2024, 46(3): 304-309.
    何鹏飞, 高敏, 王胤骁, 等. 金钗石斛药理作用研究进展[J]. 云南中医中药杂志, 2025, 46(7): 104-107.
    时应兰, 李军, 石谍, 等. 金钗石斛总生物碱对大鼠后发性白内障的影响[J]. 精细化工中间体, 2024, 54(6): 20-24.
    陈思屹. 金钗石斛浸泡酒制备工艺的研究[J]. 广东化工, 2022, 49(24): 59-62.
    Du Y E, Lee J S, Kim H M, et al. Chemical constituents of the roots of Codonopsis lanceolata[J]. Arch Pharm Res, 2018, 41(11): 1082-1091.
    张亚伦, 朱研洁, 代向阳, 等. 肉桂叶化学成分研究[J]. 天然产物研究与开发, 2024, 36(7): 1142-1148.
    Pathak A, Kulshreshtha D K, Maurya R. Coumaroyl triterpene lactone, phenolic and naphthalene glycoside from stem bark of Diospyros angustifolia[J]. Phytochemistry, 2004, 65(14): 2153-2158.
    侯奋争, 姚桂彬, 徐伟, 等. 高山红景天首次分离的化合物(I)[J]. 中国现代中药, 2009, 11(4): 18-20.
    欧阳春杰, 贾芳欣, 黄佳佳, 等. 铁皮石斛花中杂环类和酚苷类成分研究[J]. 中国中药杂志, 2023, 48(15): 4115-4123.
    张东东, 李婧伊, 石燕红, 等. 板蓝根中糖苷类化学成分研究[J]. 中草药, 2019, 50(15): 3575-3580.
    2026年第57卷第5期
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    doi: 10.7501/j.issn.0253-2670.2026.05.001
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    • 首发时间:2026-09-09
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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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