Article(id=1304414744375481191, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.04.015, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1760457600000, receivedDateStr=2025-10-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788926309913, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788926309913, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788926309913, creator=13701087609, updateTime=1788926309913, updator=13701087609, issue=Issue{id=1304414700964443026, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='4', pageStart='1209', pageEnd='1596', issueExtLink='null', onlineDate='null', pubDate='1772208000000', pubDateStr='2026-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788926299563, creator='13701087609', updateTime=1788926573099, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304415848316297970, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304415848316297971, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1366, endPage=1376, ext={EN=ArticleExt(id=1304414744694248297, articleId=1304414744375481191, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Sodium new houttuyfonate inhibits hepatocellular carcinoma progression through USP22-mediated SIRT1 deubiquitination regulating autophagy, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective Methods Human liver cancer HepG2 cells were treated with SNH or sorafenib for 24 h, cell viability was detected by CCK-8 assay, cell apoptosis was detected by flow cytometry, and cell invasion ability was detected by Transwell assay. After plasmid transfection induced overexpression of USP22, the USP22-SIRT1 interaction was verified by co-immunoprecipitation (Co-IP). USP22 and SIRT1 protein expressions, as well as SIRT1 ubiquitination were detected by Western blotting. After treatment with SIRT1 activator, autophagy activity was evaluated through mRFP-GFP-LC3 dual fluorescence labeling, adenosine triphosphate (ATP) level measurement, lactate production assay, and analysis of USP22, SIRT1, microtubule-associated protein light chain 3 (LC3)-II/I and p62 protein expressions. For in vivo experiments, 40 BALB/c-nu nude mice were eutectopically transplanted with HepG2 cells and intervened with SNH or sorafenib for 12 d. Tumor volume and weight were monitored every 3 d. Hematoxylin-eosin (HE) staining and TUNEL staining were performed on tumor tissues, and immunohistochemistry was used to detect the protein expressions of nuclear proliferation antigens Ki67, USP22 and SIRT1. Results SNH dose-dependently suppressed HepG2 cell viability and invasion (P < 0.01, 0.001), induced cell apoptosis (P < 0.001). The effect of high-dose SNH was comparable to sorafenib. Co-IP confirmed USP22-SIRT1 protein interaction, which was significantly reduced by high-dose SNH (P < 0.01). High-dose SNH significantly down-regulated USP22 and SIRT1 protein expressions (P < 0.01, 0.001), increased SIRT1 ubiquitination (P < 0.001). These effects were reversed by USP22 overexpression (P < 0.05, 0.001). SNH inhibited autophagy in HepG2 cells, manifested by enhanced GFP/mRFP fluorescence signal (P < 0.01), decreased ATP level (P < 0.001), increased lactate level (P < 0.001), increased p62 expression and decreased expression levels of USP22, SIRT1 and LC3-II/I proteins (P < 0.05, 0.001). SIRT1 activation partially counteracted the autophagic inhibition of SNH (P < 0.05, 0.01, 0.001). In vivo , high-dose SNH significantly reduced tumor volume, weight and malignancy degree (P < 0.001), induced tumor cell apoptosis and decreased Ki67, USP22, and SIRT1 expressions (P < 0.001). Conclusion SNH inhibits HCC progression by suppressing autophagy through USP22-mediated regulation of SIRT1 deubiquitination, providing a potential therapeutic strategy for HCC., authors=ZHANG Xuexi, DONG Changhong, ZI Chen, SUN Xiangjun, authorsList=ZHANG Xuexi, DONG Changhong, ZI Chen, SUN Xiangjun, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304414744618750824, articleId=1304414744375481191, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=新鱼腥草素钠通过USP22介导SIRT1去泛素化调控自噬抑制肝细胞癌进展, columnId=1304140191707456168, journalTitle=中草药, columnName=药理与临床, runingTitle=null, highlight=null, articleAbstract=目的 探究新鱼腥草素钠（sodium new houttuyfonate，SNH）通过泛素特异性肽酶22（ubiquitin-specific peptidase 22，USP22）介导的沉默调节蛋白1（silent mating type information regulation 2 homolog 1，SIRT1）去泛素化调控自噬抑制肝细胞癌进展的作用机制。方法 人肝癌HepG2细胞给予SNH或索拉非尼处理24 h后，采用CCK-8法检测细胞活力，流式细胞术检测细胞凋亡，Transwell实验检测细胞侵袭能力。质粒转染诱导USP22过表达，免疫共沉淀（co-immunoprecipitation，Co-IP）验证USP22和SIRT1之间的相互作用，Western blotting检测USP22、SIRT1蛋白表达和SIRT1泛素化水平。使用SIRT1激活剂处理后，通过mRFP-GFP-LC3双荧光标记、三磷酸腺苷（adenosine triphosphate，ATP）水平测定、乳酸生成测定以及USP22、SIRT1、微管相关蛋白轻链3（microtubule-associated protein light chain 3，LC3）-Ⅱ/Ⅰ、p62的蛋白表达分析评估自噬活性。在体内实验中，40只BALB/c-nu裸鼠异位移植HepG2细胞，给予SNH或索拉非尼干预12 d，每3天监测肿瘤体积和质量。对肿瘤组织进行苏木素-伊红（hematoxylin-eosin，HE）染色、TUNEL染色，采用免疫组化法检测核增殖抗原Ki67、USP22和SIRT1的蛋白表达。结果 SNH呈剂量相关性地抑制HepG2细胞活力和侵袭（P ＜0.01、0.001），诱导细胞凋亡（P ＜0.001），其中高剂量SNH的作用与索拉非尼相当。Co-IP证实了USP22-SIRT1蛋白相互作用，高剂量SNH显著降低USP22-SIRT1蛋白相互作用（P ＜0.01）。高剂量SNH显著下调USP22和SIRT1蛋白表达（P ＜0.01、0.001），增加SIRT1的泛素化（P ＜0.001），以上作用被USP22过表达逆转（P ＜0.05、0.001）。SNH抑制HepG2细胞自噬，表现为GFP/mRFP荧光信号增强（P ＜0.01），ATP水平降低（P ＜0.001），乳酸水平升高（P ＜0.001），p62表达增加以及USP22、SIRT1、LC3-II/I蛋白表达水平降低（P ＜0.05、0.001）。SIRT1激活部分抵消了SNH的自噬抑制作用（P ＜0.05、0.01、0.001）。在体内，高剂量SNH显著降低肿瘤体积、质量和恶性程度（P ＜0.001），诱导肿瘤细胞凋亡以及Ki67、USP22和SIRT1表达降低（P ＜0.001）。结论 SNH调控USP22表达介导SIRT1去泛素化来抑制自噬，从而抑制肝细胞癌的进展，为肝细胞癌的治疗提供了潜在策略。, authors=张学习1 , 董长虹1 , 訾臣2 , 孙象军1 , authorsList=张学习, 董长虹, 訾臣, 孙象军, authorCompany=1 广州中医药大学 临沂市人民医院研究生培养基地, 山东 临沂 276000; Int J Mol Sci , 2023, 24(15): 12224.Adv Cancer Res , 2021, 149: 61.et al . Mechanisms of drug resistance in HCC [J]. Hepatology , 2024, 79(4): 926-940.et al . Remodeling tumor microenvironment with natural products to overcome drug resistance [J]. Front Immunol , 2022, 13: 1051998.et al . Pharmacological effects of Houttuynia cordata Thunb (H. cordata ): A comprehensive review [J]. Pharmaceuticals , 2022, 15(9): 1079.et al . Sodium new houttuyfonate effectively improves phagocytosis and inhibits the excessive release of inflammatory factors by repressing TLR4/NF-κB pathway in macrophages [J]. Curr Pharm Biotechnol , 2023, 24(15): 1964-1971.et al . Sodium new houttuyfonate induces apoptosis of breast cancer cells via ROS/PDK1/AKT/GSK3β axis [J]. Cancers , 2023, 15(5): 1614.et al . Autophagy in cancer development, immune evasion, and drug resistance [J]. Drug Resist Updat , 2025, 78: 101170.et al . Immune evasion and drug resistance mediated by USP22 in cancer: Novel targets and mechanisms [J]. Front Immunol , 2022, 13: 918314.et al . Clinicopathological and prognostic value of USP22 expression in gastric cancer: A systematic review and Meta-analysis and database validation [J]. Front Surg , 2022, 9: 920595.et al . Targeting ferroptosis with miR-144-3p to attenuate pancreatic β cells dysfunction via regulating USP22/SIRT1 in type 2 diabetes [J]. Diabetol Metab Syndr , 2022, 14(1): 89.et al . SIRT1 is a regulator of autophagy: Implications for the progression and treatment of myocardial ischemia-reperfusion [J]. Pharmacol Res , 2024, 199: 106957.et al . PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner in hepatocellular carcinoma [J]. J Exp Clin Cancer Res , 2024, 43(1): 143.et al . Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation [J]. Clin Transl Med , 2023, 13(6): e1300.et al . Sodium new houttuyfonate inhibits cancer-promoting Fusobacterium nucleatum (Fn) to reduce colorectal cancer progression [J]. Cancers , 2022, 14(24): 6111.et al . Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation [J]. Mol Cancer , 2025, 24(1): 34.et al . Hepatocellular carcinoma: Updates on epidemiology, surveillance, diagnosis and treatment [J]. Clin Mol Hepatol , 2025, 31(Suppl): S228-S254.et al . A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function [J]. Expert Opin Ther Targets , 2023, 27(10): 1017-1029.et al . P38 mitogen-activated protein kinase protects against retinoblastoma through regulating USP22/SIRT1/SOST axis [J]. Front Oncol , 2022, 12: 781247.et al . Ubiquitin-specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling [J]. MedComm , 2024, 5(8): e684.et al . The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/ PRKCDBP pathway [J]. Cell Prolif , 2023, 56(7): e13402.)
中草药
|药理与临床
2026
, 57
(4) :
1366
-1376
新鱼腥草素钠通过USP22介导SIRT1去泛素化调控自噬抑制肝细胞癌进展
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张学习, 董长虹, 訾臣, 孙象军
作者信息
通讯作者:
孙象军
作者简介:
张学习: 张学习，男，硕士，主治医师，研究方向为中西医结合治疗肝胆疾病。E-mail:18265903921@163.com
Sodium new houttuyfonate inhibits hepatocellular carcinoma progression through USP22-mediated SIRT1 deubiquitination regulating autophagy
ZHANG Xuexi, DONG Changhong, ZI Chen, SUN Xiangjun
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.04.015
文章导航
目的 探究新鱼腥草素钠（sodium new houttuyfonate，SNH）通过泛素特异性肽酶22（ubiquitin-specific peptidase 22，USP22）介导的沉默调节蛋白1（silent mating type information regulation 2 homolog 1，SIRT1）去泛素化调控自噬抑制肝细胞癌进展的作用机制。方法 人肝癌HepG2细胞给予SNH或索拉非尼处理24 h后，采用CCK-8法检测细胞活力，流式细胞术检测细胞凋亡，Transwell实验检测细胞侵袭能力。质粒转染诱导USP22过表达，免疫共沉淀（co-immunoprecipitation，Co-IP）验证USP22和SIRT1之间的相互作用，Western blotting检测USP22、SIRT1蛋白表达和SIRT1泛素化水平。使用SIRT1激活剂处理后，通过mRFP-GFP-LC3双荧光标记、三磷酸腺苷（adenosine triphosphate，ATP）水平测定、乳酸生成测定以及USP22、SIRT1、微管相关蛋白轻链3（microtubule-associated protein light chain 3，LC3）-Ⅱ/Ⅰ、p62的蛋白表达分析评估自噬活性。在体内实验中，40只BALB/c-nu裸鼠异位移植HepG2细胞，给予SNH或索拉非尼干预12 d，每3天监测肿瘤体积和质量。对肿瘤组织进行苏木素-伊红（hematoxylin-eosin，HE）染色、TUNEL染色，采用免疫组化法检测核增殖抗原Ki67、USP22和SIRT1的蛋白表达。结果 SNH呈剂量相关性地抑制HepG2细胞活力和侵袭（P ＜0.01、0.001），诱导细胞凋亡（P ＜0.001），其中高剂量SNH的作用与索拉非尼相当。Co-IP证实了USP22-SIRT1蛋白相互作用，高剂量SNH显著降低USP22-SIRT1蛋白相互作用（P ＜0.01）。高剂量SNH显著下调USP22和SIRT1蛋白表达（P ＜0.01、0.001），增加SIRT1的泛素化（P ＜0.001），以上作用被USP22过表达逆转（P ＜0.05、0.001）。SNH抑制HepG2细胞自噬，表现为GFP/mRFP荧光信号增强（P ＜0.01），ATP水平降低（P ＜0.001），乳酸水平升高（P ＜0.001），p62表达增加以及USP22、SIRT1、LC3-II/I蛋白表达水平降低（P ＜0.05、0.001）。SIRT1激活部分抵消了SNH的自噬抑制作用（P ＜0.05、0.01、0.001）。在体内，高剂量SNH显著降低肿瘤体积、质量和恶性程度（P ＜0.001），诱导肿瘤细胞凋亡以及Ki67、USP22和SIRT1表达降低（P ＜0.001）。结论 SNH调控USP22表达介导SIRT1去泛素化来抑制自噬，从而抑制肝细胞癌的进展，为肝细胞癌的治疗提供了潜在策略。
新鱼腥草素钠
/
肝细胞癌
/
自噬
/
USP22
/
SIRT1
Objective Methods Human liver cancer HepG2 cells were treated with SNH or sorafenib for 24 h, cell viability was detected by CCK-8 assay, cell apoptosis was detected by flow cytometry, and cell invasion ability was detected by Transwell assay. After plasmid transfection induced overexpression of USP22, the USP22-SIRT1 interaction was verified by co-immunoprecipitation (Co-IP). USP22 and SIRT1 protein expressions, as well as SIRT1 ubiquitination were detected by Western blotting. After treatment with SIRT1 activator, autophagy activity was evaluated through mRFP-GFP-LC3 dual fluorescence labeling, adenosine triphosphate (ATP) level measurement, lactate production assay, and analysis of USP22, SIRT1, microtubule-associated protein light chain 3 (LC3)-II/I and p62 protein expressions. For in vivo experiments, 40 BALB/c-nu nude mice were eutectopically transplanted with HepG2 cells and intervened with SNH or sorafenib for 12 d. Tumor volume and weight were monitored every 3 d. Hematoxylin-eosin (HE) staining and TUNEL staining were performed on tumor tissues, and immunohistochemistry was used to detect the protein expressions of nuclear proliferation antigens Ki67, USP22 and SIRT1. Results SNH dose-dependently suppressed HepG2 cell viability and invasion (P < 0.01, 0.001), induced cell apoptosis (P < 0.001). The effect of high-dose SNH was comparable to sorafenib. Co-IP confirmed USP22-SIRT1 protein interaction, which was significantly reduced by high-dose SNH (P < 0.01). High-dose SNH significantly down-regulated USP22 and SIRT1 protein expressions (P < 0.01, 0.001), increased SIRT1 ubiquitination (P < 0.001). These effects were reversed by USP22 overexpression (P < 0.05, 0.001). SNH inhibited autophagy in HepG2 cells, manifested by enhanced GFP/mRFP fluorescence signal (P < 0.01), decreased ATP level (P < 0.001), increased lactate level (P < 0.001), increased p62 expression and decreased expression levels of USP22, SIRT1 and LC3-II/I proteins (P < 0.05, 0.001). SIRT1 activation partially counteracted the autophagic inhibition of SNH (P < 0.05, 0.01, 0.001). In vivo , high-dose SNH significantly reduced tumor volume, weight and malignancy degree (P < 0.001), induced tumor cell apoptosis and decreased Ki67, USP22, and SIRT1 expressions (P < 0.001). Conclusion SNH inhibits HCC progression by suppressing autophagy through USP22-mediated regulation of SIRT1 deubiquitination, providing a potential therapeutic strategy for HCC.
sodium new houttuyfonate
/
hepatocellular carcinoma
/
autophagy
/
USP22
/
SIRT1
张学习, 董长虹, 訾臣, 孙象军.
新鱼腥草素钠通过USP22介导SIRT1去泛素化调控自噬抑制肝细胞癌进展.
中草药,
2026
, 57
(4)
: 1366
-1376
.
DOI: 10.7501/j.issn.0253-2670.2026.04.015
ZHANG Xuexi, DONG Changhong, ZI Chen, SUN Xiangjun.
Sodium new houttuyfonate inhibits hepatocellular carcinoma progression through USP22-mediated SIRT1 deubiquitination regulating autophagy[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(4)
: 1366
-1376
.
DOI: 10.7501/j.issn.0253-2670.2026.04.015
参考文献
引证文献
Foglia B, Turato C, Cannito S. Hepatocellular carcinoma: Latest research in pathogenesis, detection and treatment [J]. Int J Mol Sci , 2023, 24(15): 12224.Adv Cancer Res , 2021, 149: 61.et al . Mechanisms of drug resistance in HCC [J]. Hepatology , 2024, 79(4): 926-940.et al . Remodeling tumor microenvironment with natural products to overcome drug resistance [J]. Front Immunol , 2022, 13: 1051998.et al . Pharmacological effects of Houttuynia cordata Thunb (H. cordata ): A comprehensive review [J]. Pharmaceuticals , 2022, 15(9): 1079.et al . Sodium new houttuyfonate effectively improves phagocytosis and inhibits the excessive release of inflammatory factors by repressing TLR4/NF-κB pathway in macrophages [J]. Curr Pharm Biotechnol , 2023, 24(15): 1964-1971.et al . Sodium new houttuyfonate induces apoptosis of breast cancer cells via ROS/PDK1/AKT/GSK3β axis [J]. Cancers , 2023, 15(5): 1614.et al . Autophagy in cancer development, immune evasion, and drug resistance [J]. Drug Resist Updat , 2025, 78: 101170.et al . Immune evasion and drug resistance mediated by USP22 in cancer: Novel targets and mechanisms [J]. Front Immunol , 2022, 13: 918314.et al . Clinicopathological and prognostic value of USP22 expression in gastric cancer: A systematic review and Meta-analysis and database validation [J]. Front Surg , 2022, 9: 920595.et al . Targeting ferroptosis with miR-144-3p to attenuate pancreatic β cells dysfunction via regulating USP22/SIRT1 in type 2 diabetes [J]. Diabetol Metab Syndr , 2022, 14(1): 89.et al . SIRT1 is a regulator of autophagy: Implications for the progression and treatment of myocardial ischemia-reperfusion [J]. Pharmacol Res , 2024, 199: 106957.et al . PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner in hepatocellular carcinoma [J]. J Exp Clin Cancer Res , 2024, 43(1): 143.et al . Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation [J]. Clin Transl Med , 2023, 13(6): e1300.et al . Sodium new houttuyfonate inhibits cancer-promoting Fusobacterium nucleatum (Fn) to reduce colorectal cancer progression [J]. Cancers , 2022, 14(24): 6111.et al . Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation [J]. Mol Cancer , 2025, 24(1): 34.et al . Hepatocellular carcinoma: Updates on epidemiology, surveillance, diagnosis and treatment [J]. Clin Mol Hepatol , 2025, 31(Suppl): S228-S254.et al . A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function [J]. Expert Opin Ther Targets , 2023, 27(10): 1017-1029.et al . P38 mitogen-activated protein kinase protects against retinoblastoma through regulating USP22/SIRT1/SOST axis [J]. Front Oncol , 2022, 12: 781247.et al . Ubiquitin-specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling [J]. MedComm , 2024, 5(8): e684.et al . The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/ PRKCDBP pathway [J]. Cell Prolif , 2023, 56(7): e13402.
2026年第57卷第4期
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doi: 10.7501/j.issn.0253-2670.2026.04.015
接收时间：2025-10-15
首发时间：2026-09-09
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.04.015
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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