中草药

智能响应型水凝胶在皮肤光老化修复中的研究进展

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中草药 | 综述 2026,57(4): 1528-1537

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中草药 |综述 2026 , 57 (4) : 1528 -1537

智能响应型水凝胶在皮肤光老化修复中的研究进展

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程浩然¹, 梁颢¹, 陈求芳¹, 卢思婷¹, 戴家勤¹, 时军^1,2

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陈求芳

作者简介:

程浩然: 程浩然，男，硕士研究生，研究方向为中药制剂研究与开发。E-mail:2386937570@qq.com

Research progress of intelligent responsive hydrogels in skin photoaging repair

CHENG Haoran, LIANG Hao, CHEN Qiufang, LU Siting, DAI Jiaqin, SHI Jun

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doi: 10.7501/j.issn.0253-2670.2026.04.028

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皮肤光老化是因长期紫外线辐射引起的一种皮肤损伤，临床表现主要包括皱纹形成、色素沉着、皮肤弹性减弱，甚至可进展为癌前病变。在治疗皮肤光老化方面，传统药物制剂常存在透皮性能差、靶向能力弱及药物滞留时间短等问题。近年来，以酚酸类、多糖、皂苷等活性成分为基础构建的智能响应型水凝胶，为皮肤光老化的修复提供了新型治疗策略。此类水凝胶不仅能负载具备抗氧化、抗炎及促进胶原合成等功能活性成分，还可对光老化皮肤的微环境产生自主响应，从而实现药物的精准递送。通过系统综述智能响应型水凝胶的响应机制及其在皮肤光老化治疗中的研究进展，为开发高效、精准的外用制剂并推动其在该领域的应用提供新思路与理论参考。

关键词

水凝胶 / 智能响应 / 刺激响应性 / 光老化 / 药物递送 / 精准递送

Abstract

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Skin photoaging is a type of skin damage caused by long-term exposure to ultraviolet radiation, clinically characterized mainly by wrinkle formation, pigmentation, reduced skin elasticity, and potential progression to precancerous lesions. In the treatment of skin photoaging, conventional pharmaceutical formulations often face challenges such as poor transdermal performance, weak targeting capability, and short drug retention time. In recent years, intelligent responsive hydrogels constructed based on various active ingredients such as phenolic acids, polysaccharides, and saponins have provided novel therapeutic strategies for the repair of skin photoaging. These hydrogels can not only load functional components with activities such as antioxidant, anti-inflammatory, and collagen synthesis promotion but also autonomously respond to the microenvironment of photoaged skin, thereby achieving precise drug delivery. This paper systematically reviews the response mechanisms of intelligent responsive hydrogels and their research progress in the treatment of skin photoaging, aiming to provide new insights and theoretical references for the development of efficient and accurate topical formulations and to promote their application in this field.

Key words

hydrogel / intelligent responsive / stimulus responsiveness / photoaging / drug delivery / precision delivery

引用本文

程浩然, 梁颢, 陈求芳, 卢思婷, 戴家勤, 时军. 智能响应型水凝胶在皮肤光老化修复中的研究进展. 中草药, 2026 , 57 (4) : 1528 -1537 . DOI: 10.7501/j.issn.0253-2670.2026.04.028

CHENG Haoran, LIANG Hao, CHEN Qiufang, LU Siting, DAI Jiaqin, SHI Jun. Research progress of intelligent responsive hydrogels in skin photoaging repair[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (4) : 1528 -1537 . DOI: 10.7501/j.issn.0253-2670.2026.04.028

基金

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国家自然科学基金资助项目 (82173982); 广东省自然科学基金资助项目 (2022A1515011382)

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Iqbal J, Abbasi B A, Ahmad R, et al. Potential phytochemicals in the fight against skin cancer: Current landscape and future perspectives [J]. Biomed Pharmacother, 2019, 109: 1381-1393.
Loureiro J B, Ribeiro R, Nazareth N, et al. Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis [J]. Pharmacol Res, 2022, 175: 106026.
黄琳, 王雄. 传统中医药防治皮肤光老化的作用机制[J]. 中国美容医学, 2024, 33(5): 188-191.
Gromkowska-Kępka K J, Puścion-Jakubik A, Markiewicz-Żukowska R, et al. The impact of ultraviolet radiation on skin photoaging: Review of in vitro studies [J]. J Cosmet Dermatol, 2021, 20(11): 3427-3431.
Li J, Lu Y R, Lin I F, et al. Reversing UVB-induced photoaging with Hibiscus sabdariffa Calyx aqueous extract [J]. J Sci Food Agric, 2020, 100(2): 672-681.
Wang M, Charareh P, Lei X, et al. Autophagy: Multiple mechanisms to protect skin from ultraviolet radiation-driven photoaging [J]. Oxid Med Cell Longev, 2019, 2019: 8135985.
Cho J L, Allanson M, Reeve V E. Hypoxia inducible factor-1α contributes to UV radiation-induced inflammation, epidermal hyperplasia and immunosuppression in mice [J]. Photochem Photobiol Sci, 2012, 11(2): 309-317.
Dakup P, Gaddameedhi S. Impact of the circadian clock on UV-induced DNA damage response and photocarcinogenesis [J]. Photochem Photobiol, 2017, 93(1): 296-303.
Endo K, Katsuyama Y, Taira N, et al. Impairment of the autophagy system in repetitively UVA-irradiated fibroblasts [J]. Photodermatol Photoimmunol Photomed, 2020, 36(2): 111-117.
Martic I, Wedel S, Jansen-Dürr P, et al. A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes [J]. Mech Ageing Dev, 2020, 190: 111322.
Papaccio F, D Arino A, Caputo S, et al. Focus on the contribution of oxidative stress in skin aging [J]. Antioxidants, 2022, 11(6): 1121.
Pittayapruek P, Meephansan J, Prapapan O, et al. Role of matrix metalloproteinases in photoaging and photocarcinogenesis [J]. Int J Mol Sci, 2016, 17(6): 868.
Wang Y J, Zhang P, Zhang J Y, et al. Inhibitory effect of bisdemethoxycurcumin on DNCB-induced atopic dermatitis in mice [J]. Molecules, 2022, 28(1): 293.
朱姗, 赵志月, 王子静, 等. 皮肤老化分子机制及中药防治皮肤老化研究进展[J]. 天津中医药大学学报, 2021, 40(4): 431-439.
Su Z, Hu Q H, Li X, et al. The influence of circadian rhythms on DNA damage repair in skin photoaging [J]. Int J Mol Sci, 2024, 25(20): 10926.
Beani J C. Ultraviolet A-induced DNA damage: Role in skin cancer [J]. Bull Acad Natl Med, 2014, 198(2): 273-295.
Emanuele E, Spencer J M, Braun M. From DNA repair to proteome protection: New molecular insights for preventing non-melanoma skin cancers and skin aging [J]. J Drugs Dermatol, 2014, 13(3): 274-281.
Jo J Y, Chae S J, Ryu H J. Update on melasma treatments [J]. Ann Dermatol, 2024, 36(3): 125.
Lai D H, Zhou S N, Cheng S W, et al. Laser therapy in the treatment of melasma: A systematic review and Meta-analysis [J]. Lasers Med Sci, 2022, 37(4): 2099-2110.
Mei X L, Wang L. Ablative fractional carbon dioxide laser combined with intense pulsed light for the treatment of photoaging skin in Chinese population: A split-face study [J]. Medicine, 2018, 97(3): e9494.
耿雅琼, 陈晓辉, 田伟, 等. 非剥脱性1565 nm点阵激光联合强脉冲光治疗面颈部皮肤光老化疗效分析[J]. 中国美容医学, 2025, 34(6): 119-122.
Lin L Y, Liao G Y, Chen J G, et al. A systematic review and Meta-analysis on the effects of the ultra-pulse CO₂ fractional laser in the treatment of depressed acne scars [J]. Ann Palliat Med, 2022, 11(2): 743-755.
张昕, 李承新. 皮肤光老化治疗进展[J]. 中国激光医学杂志, 2018, 27(1): 47-51.
邱禾. 重组人源III型胶原(RHCIII)在皮肤光老化治疗中的作用机制研究[D]. 成都: 四川大学, 2021.
Hesseler M J, Shyam N. Platelet-rich plasma and its utility in medical dermatology: A systematic review [J]. J Am Acad Dermatol, 2019, 81(3): 834-846.
Camargo C P, Xia J, Costa C S, et al. Botulinum toxin type A for facial wrinkles [J]. Cochrane Database Syst Rev, 2021, 7(7): CD011301.
王洁仪, 简杏玲, 吴琳, 等. 透明质酸填充注射新进展[J]. 中国医学前沿杂志: 电子版, 2025, 17(5): 43-47.
王恒旭. 皮肤光老化领域可视化分析及中药作用机制研究[D]. 沈阳: 辽宁中医药大学, 2021.
韦惠琴. 全反式维甲酸的临床应用及研究进展[J]. 医学综述, 2014, 20(6): 1088-1090.
邓映, 杜宇, 刘萍, 等. 氧化应激在皮肤光老化中的作用[J]. 中国医疗美容, 2020, 10(8): 117-122.
Wang Z X, Liu J, Chen Q Y, et al. Bioactive glycyrrhizic acid ionic liquid self-assembled nanomicelles for enhanced transdermal delivery of anti-photoaging signal peptides [J]. Adv Sci, 2025, 12(8): 2412581.
UL A N. 甘草和山楂多糖纳米制剂治疗痤疮和皮肤光老化的研究[D]. 苏州: 苏州大学, 2024.
周亚丽. 藻蓝蛋白的制备及其抗UVB诱导的小鼠皮肤光老化作用[D]. 泉州: 华侨大学, 2023.
李雨凡. 盐酸川芎嗪脂质体凝胶的制备及其经皮给药治疗皮肤光老化作用的评价[D]. 合肥: 安徽中医药大学, 2023.
陈江丽. 水飞蓟素脂质体的制备及其对皮肤光老化修复作用的研究[D]. 长春: 长春中医药大学, 2022.
王祥. 白杨素脂质体凝胶制备及局部抗光老化研究[D]. 上海: 上海中医药大学, 2021.
Liu J X, Liu Y Y, Wang F F, et al. Paeonia suffruticosa Andrews root extract ameliorates photoaging via regulating IRS1/PI3K/FoxO pathway [J]. Front Pharmacol, 2025, 16: 1520392.
Kamel R, Abbas H, Fayez A. Diosmin/essential oil combination for dermal photo-protection using a lipoid colloidal carrier [J]. J Photochem Photobiol B, 2017, 170: 49-57.
Nan W H, Ding L, Chen H J, et al. Topical use of quercetin-loaded chitosan nanoparticles against ultraviolet B radiation [J]. Front Pharmacol, 2018, 9: 826.
徐青雨, 张保健, 李红日, 等. 智能响应型水凝胶在关节软骨损伤修复中的应用与进展[J]. 中国修复重建外科杂志, 2025, 39(2): 250-256.
Mo C X, Luo R, Chen Y P. Advances in the stimuli-responsive injectable hydrogel for controlled release of drugs [J]. Macromol Rapid Commun, 2022, 43(10): e2200007.
Jiang Y H, Wang Y, Li Q, et al. Natural polymer-based stimuli-responsive hydrogels [J]. Curr Med Chem, 2020, 27(16): 2631-2657.
Wei T, Wang J Q, Parak W J, et al. Nanobuffering of pH-responsive polymers: A known but sometimes overlooked phenomenon and its biological applications [J]. ACS nano, 2019, 13(5): 4876-4882.
Das I J, Bal T. pH factors in chronic wound and pH-responsive polysaccharide-based hydrogel dressings [J]. Int J Biol Macromol, 2024, 279(Pt1): 135118.
程小曼. 姜黄素脂质体凝胶的制备及其经皮给药治疗皮肤光老化作用的研究[D]. 合肥: 安徽中医药大学, 2024
Schmid-Wendtner M H, Korting H C. The pH of the skin surface and its impact on the barrier function [J]. Skin Pharmacol Physiol, 2006, 19(6): 296-302.
Duffy E, Guzman D K, Wallace R, et al. Non-invasive assessment of skin barrier properties: Investigating emerging tools for in vitro and in vivo applications [J]. Cosmetics, 2017, 4(4): 44.
de Oliveira M M, Nakamura C V, Auzély-Velty R. Boronate-ester crosslinked hyaluronic acid hydrogels for dihydrocaffeic acid delivery and fibroblasts protection against UVB irradiation [J]. Carbohydr Polym, 2020, 247: 116845.
Wang Q, Yan H Y, Yao L Y, et al. A highly bioactive THPC-crosslinked recombinant collagen hydrogel implant for aging skin rejuvenation [J]. Int J Biol Macromol, 2024, 266(Pt2): 131276.
孔子琳, 王子奇, 马俊, 等. ROS响应型水凝胶的制备及其抗菌性能研究[J]. 国外医药: 抗生素分册, 2025, 46(3): 194-203.
刘芳. 一种用于防治皮肤光老化的新型外泌体水凝胶的开发[D]. 杨凌: 西北农林科技大学, 2023.
Guo C L, Du L L, Du X X, et al. ROS-responsive hydrogel loaded with berberine liposome protects against intervertebral disc degeneration by inhibiting mitochondrial fission and apoptosis [J]. Chem Eng J, 2025, 522: 167108.
Kim Y E, Im P, Choi S W, et al. Autocatalytic ceria nanoparticle-embedded tilapia collagen hydrogels as enhanced antioxidative and long-lasting dermal fillers for photoaged skin [J]. Nano Lett, 2025, 25(1): 212-221.
Sangboonruang S, Semakul N, Manokruang K, et al. Multifunctional poloxamer-based thermo-responsive hydrogel loaded with human lactoferricin niosomes: In vitro study on anti-bacterial activity, accelerate wound healing, and anti-inflammation [J]. Int J Pharm X, 2024, 8: 100291.
Chatterjee S, Hui P C. Review of applications and future prospects of stimuli-responsive hydrogel based on thermo-responsive biopolymers in drug delivery systems [J]. Polymers, 2021, 13(13): 2086.
Al-Rajabi M M, Teow Y H. Green synthesis of thermo-responsive hydrogel from oil palm empty fruit bunches cellulose for sustained drug delivery [J]. Polymers, 2021, 13(13): 2153-2153.
Liu Z S, Ma Z Y, Hu P. Stimuli-responsive hydrogels for enhanced skin wound Healing: Mechanisms, applications, and advances [J]. J Drug Deliv Sci Technol, 2025, 112: 107308.
Jahanbekam S, Asare-Addo K, Alipour S, et al. Smart hydrogels and the promise of multi-responsive in-situ systems [J]. J Drug Deliv Sci Technol, 2025, 107: 106758.
Wu L L, Tao Y, Xu Y, et al. Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging [J]. Naunyn Schmiedebergs Arch Pharmacol, 2025, doi: 10.1007/ s00210-025-04411-5.
Wu S J, Liu G D, Shao P, et al. Transdermal sustained release properties and anti-photoaging efficacy of liposome-thermosensitive hydrogel system [J]. Adv Healthc Mater, 2023, 13(2): e2301933.
Li D S, Wang Y H, Li L Q, et al. Injectable methylcellulose/hyaluronic acid/collagen hydrogel loaded with adipose-derived stem cells alleviates skin photoaging via inhibition of HIF-1α: An in vitro and in vivo study [J]. Skin Res Technol, 2025, 31(6): e70192.
Li L, Scheiger J M, Levkin P A. Design and applications of photoresponsive hydrogels [J]. Adv Mater, 2019, 31(26): 1807333.
Kathuria I, Kumar S. Emerging frontiers in spiropyran-driven photoresponsive drug delivery systems and technologies [J]. Dyes Pigm, 2025, 239: 112793.
Wang Y X, Li J X, Tang M M, et al. Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment [J]. Biomed Pharmacother, 2023, 162: 114688.
Prado V C, Marcondes Sari M H, Borin B C, et al. Development of a nanotechnological-based hydrogel containing a novel benzofuroazepine compound in association with vitamin E: An in vitro biological safety and photoprotective hydrogel [J]. Colloids Surf B Biointerfaces, 2021, 199: 111555.
Wang C, Zhang G Y, Liu G H, et al. Photo- and thermo-responsive multicompartment hydrogels for synergistic delivery of gemcitabine and doxorubicin [J]. J Control Release, 2017, 259: 149-159.

2026年第57卷第4期

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doi: 10.7501/j.issn.0253-2670.2026.04.028

接收时间：2025-10-02
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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