Article(id=1304414731016622874, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.04.020, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758384000000, receivedDateStr=2025-09-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788926306727, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788926306727, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788926306727, creator=13701087609, updateTime=1788926306727, updator=13701087609, issue=Issue{id=1304414700964443026, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='4', pageStart='1209', pageEnd='1596', issueExtLink='null', onlineDate='null', pubDate='1772208000000', pubDateStr='2026-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788926299563, creator='13701087609', updateTime=1788926573099, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304415848316297970, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304415848316297971, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1435, endPage=1449, ext={EN=ArticleExt(id=1304414731339584284, articleId=1304414731016622874, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Current status, hotspots, and trends of research on polysaccharides in traditional Chinese medicine formulas: A bibliometric analysis based on CiteSpace and VOSviewer, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective As key water-soluble components in traditional Chinese medicine (TCM) formulas, polysaccharides play a critical role in elucidating the mechanisms of these formulas. Clarifying their functions is a key breakthrough to decipher the mysteries of TCM formulas and advance its modernization. This study employs bibliometric methods to comprehensively analyze the current status, hotspots, and trends of research on polysaccharides from TCM formulas between 2005 and 2025, aiming to provide a reference for future development in this field. Methods Relevant Chinese and English literature were retrieved from the China national knowledge infrastructure (CNKI) and Web of Science (WOS) databases, respectively. Bibliometric tools including CiteSpace and VOSviewer were employed to analyze publication output, journals, authors/institutions, citation frequency, and keywords of both Chinese and English literature, respectively. Results Over the past two decades, a total of 227 literature that met the requirements were retrieved. The annual publication output showed a fluctuating upward trend, with Chinese literature (199 papers, 87.7%) dominating, underscoring the distinct characteristics and advantage of China in this field. The most prolific institutions were Shihezi University (40 articles) for Chinese publications and Shanghai Jiao Tong University (six articles) for English publications. Gu Xinli ranked first among Chinese authors with 40 publications, while Li Xiaobo and Peng Ying tied for the lead among English authors, each with six publications. Keyword analysis revealed that research evolution within the past 20 years can be divided into three main phases: establishment of basic technologies, expansion of activity studies, and the intervention of microecological functions. Hot topics included optimization of extraction processes, characterization of basic properties, investigations into classic formulas such as Sijunzi Tang and Yupingfeng San, along with studies on immunomodulation, antioxidant and antitumor effects, and gut microbiota-mediated mechanisms. Conclusion Research on polysaccharides in TCM formulas constitutes a relatively niche yet steadily evolving area, marked by distinctive Chinese characteristics and regional advantages. However, limitations remain, including insufficient research coverage, limited research depth, and inadequate exploration of synergistic mechanisms. Future breakthroughs will require interdisciplinary integration to tackle these core challenges, thereby potentially accelerating the modernization and internationalization of TCM formulas., authors=ZENG Shaowei, GONG Jiajie, GAO Siqi, LIU Wei, LI Rongsheng, QIN Luping, WU Jianjun, authorsList=ZENG Shaowei, GONG Jiajie, GAO Siqi, LIU Wei, LI Rongsheng, QIN Luping, WU Jianjun, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304414731268281115, articleId=1304414731016622874, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=中药复方多糖的研究现状、热点及趋势：基于CiteSpace和VOSviewer的文献计量分析, columnId=1304140194819629763, journalTitle=中草药, columnName=数据挖掘与循证医学, runingTitle=null, highlight=null, articleAbstract=目的 多糖作为中药复方中的关键水溶性成分，阐明其在中药复方中的功能是破解中药复方奥秘、推动中药现代化的一个关键突破口。通过文献计量学方法对2005—2025年国内外中药复方多糖研究的现状、热点及趋势进行全面分析，为中药复方多糖领域的后续研究发展提供参考。方法 分别从中国知网（China National Knowledge Infrastructure，CNKI）和Web of Science（WOS）数据库中检索相关中英文文献，利用CiteSpace和VOSviewer文献计量学工具，分别对中英文文献的发文量、期刊、作者/机构、被引用频次以及关键词等进行全面分析。结果 近20年来，中药复方多糖领域共发表227篇文献，发文量呈波浪式增长态势，其中中文文献（199篇）占比87.7%，表明该领域研究具有鲜明的中国特色和优势。中英文发文最多的机构分别是石河子大学（40篇）和上海交通大学（6篇），谷新利以40篇居于中文文献发表作者第1位，Li Xiaobo和Peng Ying以6篇并列英文文献发表作者榜首。通过关键词分析发现，近20年，中药复方多糖领域研究大致经历基础技术建立期、活性研究拓展期以及微生态作用介入期3个阶段，研究热点包括提取工艺优化、基本特征表征、四君子汤、玉屏风散、免疫调节、抗氧化、抗肿瘤、肠道菌群介导的作用机制等方面。结论 中药复方多糖研究是一个相对小众但稳定发展的细分领域，具有明显的中国特色和区域优势，存在研究覆盖度不高，研究深度不够以及协同作用研究不足3个方面的局限性。未来的突破必须依赖于多学科交叉融合，着力解决现有局限的核心挑战，进而有望推动中药复方的现代化和国际化。, authors=曾绍炜1 , 龚佳杰1 , 高思琦1 , 刘伟1,2 , 李荣胜1 , 秦路平1 , 吴建军1 , authorsList=曾绍炜, 龚佳杰, 高思琦, 刘伟, 李荣胜, 秦路平, 吴建军, authorCompany=1 浙江中医药大学药学院, 浙江 杭州 310053; et al . Shenxiong Yixin Decoction polysaccharides exert therapeutic effects against myocardial ischemia-reperfusion injury via intestinal exosomal microRNA-21 regulation [J]. Pharmacol Res , 2025, 215: 107725.et al . Sini decoction-polysaccharide compound regulates proliferation, apoptosis, and glycolysis of liver cancer cells through PHLDA2/ANXA2[J]. Transl Cancer Res , 2024, 13(10): 5574-5587.et al . Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro [J]. J Ethnopharmacol , 2018, 224: 465-473.et al . Polysaccharides derived from Shenling Baizhu San improve colitis via modulating tryptophan metabolism in mice [J]. Int J Biol Macromol , 2022, 222(Pt A): 1127-1136.et al . Zexie Tang polysaccharides (ZXTPs) alleviate high-fat diet-induced NAFL in mice through improving intestinal microbiota imbalance and liver metabolic dysfunction [J]. Carbohydr Polym , 2025, 367: 123937.et al . Kai-Xin-San polysaccharides exert therapeutic effects on D-gal and Aβ25-35 -induced AD rats by regulating gut microbiota and metabolic profile [J]. Int J Biol Macromol , 2025, 306: 141850.et al . Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis [J]. Biomed Pharmacother , 2023, 161: 114525.et al . Regulation of polysaccharide in Wu-Tou decoction on intestinal microflora and pharmacokinetics of small molecular compounds in AIA rats [J]. Chin Med , 2024, 19(1): 9.et al . Bupleuri Radix polysaccharides enhance the efficacy and intestinal absorption of baicalin via regulating intestinal β-glucuronidase activity in MASH mice [J]. Phytomedicine , 2025, 145: 157092.)
中草药
|数据挖掘与循证医学
2026
, 57
(4) :
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中药复方多糖的研究现状、热点及趋势：基于CiteSpace和VOSviewer的文献计量分析
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曾绍炜, 龚佳杰, 高思琦, 刘伟, 李荣胜, 秦路平, 吴建军
作者信息
通讯作者:
秦路平
作者简介:
曾绍炜: 曾绍炜，男，硕士研究生，从事中药多糖化学及其生物学方向研究。E-mail:17815719560@163.com
Current status, hotspots, and trends of research on polysaccharides in traditional Chinese medicine formulas: A bibliometric analysis based on CiteSpace and VOSviewer
ZENG Shaowei, GONG Jiajie, GAO Siqi, LIU Wei, LI Rongsheng, QIN Luping, WU Jianjun
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.04.020
文章导航
目的 多糖作为中药复方中的关键水溶性成分，阐明其在中药复方中的功能是破解中药复方奥秘、推动中药现代化的一个关键突破口。通过文献计量学方法对2005—2025年国内外中药复方多糖研究的现状、热点及趋势进行全面分析，为中药复方多糖领域的后续研究发展提供参考。方法 分别从中国知网（China National Knowledge Infrastructure，CNKI）和Web of Science（WOS）数据库中检索相关中英文文献，利用CiteSpace和VOSviewer文献计量学工具，分别对中英文文献的发文量、期刊、作者/机构、被引用频次以及关键词等进行全面分析。结果 近20年来，中药复方多糖领域共发表227篇文献，发文量呈波浪式增长态势，其中中文文献（199篇）占比87.7%，表明该领域研究具有鲜明的中国特色和优势。中英文发文最多的机构分别是石河子大学（40篇）和上海交通大学（6篇），谷新利以40篇居于中文文献发表作者第1位，Li Xiaobo和Peng Ying以6篇并列英文文献发表作者榜首。通过关键词分析发现，近20年，中药复方多糖领域研究大致经历基础技术建立期、活性研究拓展期以及微生态作用介入期3个阶段，研究热点包括提取工艺优化、基本特征表征、四君子汤、玉屏风散、免疫调节、抗氧化、抗肿瘤、肠道菌群介导的作用机制等方面。结论 中药复方多糖研究是一个相对小众但稳定发展的细分领域，具有明显的中国特色和区域优势，存在研究覆盖度不高，研究深度不够以及协同作用研究不足3个方面的局限性。未来的突破必须依赖于多学科交叉融合，着力解决现有局限的核心挑战，进而有望推动中药复方的现代化和国际化。
中药复方多糖
/
CiteSpace
/
VOSviewer
/
可视化分析
/
肠道菌群
/
免疫调节
Objective As key water-soluble components in traditional Chinese medicine (TCM) formulas, polysaccharides play a critical role in elucidating the mechanisms of these formulas. Clarifying their functions is a key breakthrough to decipher the mysteries of TCM formulas and advance its modernization. This study employs bibliometric methods to comprehensively analyze the current status, hotspots, and trends of research on polysaccharides from TCM formulas between 2005 and 2025, aiming to provide a reference for future development in this field. Methods Relevant Chinese and English literature were retrieved from the China national knowledge infrastructure (CNKI) and Web of Science (WOS) databases, respectively. Bibliometric tools including CiteSpace and VOSviewer were employed to analyze publication output, journals, authors/institutions, citation frequency, and keywords of both Chinese and English literature, respectively. Results Over the past two decades, a total of 227 literature that met the requirements were retrieved. The annual publication output showed a fluctuating upward trend, with Chinese literature (199 papers, 87.7%) dominating, underscoring the distinct characteristics and advantage of China in this field. The most prolific institutions were Shihezi University (40 articles) for Chinese publications and Shanghai Jiao Tong University (six articles) for English publications. Gu Xinli ranked first among Chinese authors with 40 publications, while Li Xiaobo and Peng Ying tied for the lead among English authors, each with six publications. Keyword analysis revealed that research evolution within the past 20 years can be divided into three main phases: establishment of basic technologies, expansion of activity studies, and the intervention of microecological functions. Hot topics included optimization of extraction processes, characterization of basic properties, investigations into classic formulas such as Sijunzi Tang and Yupingfeng San, along with studies on immunomodulation, antioxidant and antitumor effects, and gut microbiota-mediated mechanisms. Conclusion Research on polysaccharides in TCM formulas constitutes a relatively niche yet steadily evolving area, marked by distinctive Chinese characteristics and regional advantages. However, limitations remain, including insufficient research coverage, limited research depth, and inadequate exploration of synergistic mechanisms. Future breakthroughs will require interdisciplinary integration to tackle these core challenges, thereby potentially accelerating the modernization and internationalization of TCM formulas.
polysaccharides of TCM formulas
/
CiteSpace
/
VOSviewer
/
visual analysis
/
gut microbiota
/
immune regulation
曾绍炜, 龚佳杰, 高思琦, 刘伟, 李荣胜, 秦路平, 吴建军.
中药复方多糖的研究现状、热点及趋势：基于CiteSpace和VOSviewer的文献计量分析.
中草药,
2026
, 57
(4)
: 1435
-1449
.
DOI: 10.7501/j.issn.0253-2670.2026.04.020
ZENG Shaowei, GONG Jiajie, GAO Siqi, LIU Wei, LI Rongsheng, QIN Luping, WU Jianjun.
Current status, hotspots, and trends of research on polysaccharides in traditional Chinese medicine formulas: A bibliometric analysis based on CiteSpace and VOSviewer[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(4)
: 1435
-1449
.
DOI: 10.7501/j.issn.0253-2670.2026.04.020
浙江省自然科学基金项目 (ZCLY24H2801); 中华中医药学会青年人才托举工程 (CACM-2024-QNRC2-A05); 浙江中医药大学“5151远志人才工程” (112123A12201/001/004/019)
参考文献
引证文献
景永帅, 张钰炜, 吴兰芳, 等. 中药复方多糖的提取方法和药理活性研究进展[J]. 中国临床药理学与治疗学, 2021, 26(4): 462-468.et al . Shenxiong Yixin Decoction polysaccharides exert therapeutic effects against myocardial ischemia-reperfusion injury via intestinal exosomal microRNA-21 regulation [J]. Pharmacol Res , 2025, 215: 107725.et al . Sini decoction-polysaccharide compound regulates proliferation, apoptosis, and glycolysis of liver cancer cells through PHLDA2/ANXA2[J]. Transl Cancer Res , 2024, 13(10): 5574-5587.et al . Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro [J]. J Ethnopharmacol , 2018, 224: 465-473.et al . Polysaccharides derived from Shenling Baizhu San improve colitis via modulating tryptophan metabolism in mice [J]. Int J Biol Macromol , 2022, 222(Pt A): 1127-1136.et al . Zexie Tang polysaccharides (ZXTPs) alleviate high-fat diet-induced NAFL in mice through improving intestinal microbiota imbalance and liver metabolic dysfunction [J]. Carbohydr Polym , 2025, 367: 123937.et al . Kai-Xin-San polysaccharides exert therapeutic effects on D-gal and Aβ25-35 -induced AD rats by regulating gut microbiota and metabolic profile [J]. Int J Biol Macromol , 2025, 306: 141850.et al . Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis [J]. Biomed Pharmacother , 2023, 161: 114525.et al . Regulation of polysaccharide in Wu-Tou decoction on intestinal microflora and pharmacokinetics of small molecular compounds in AIA rats [J]. Chin Med , 2024, 19(1): 9.et al . Bupleuri Radix polysaccharides enhance the efficacy and intestinal absorption of baicalin via regulating intestinal β-glucuronidase activity in MASH mice [J]. Phytomedicine , 2025, 145: 157092.
2026年第57卷第4期
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doi: 10.7501/j.issn.0253-2670.2026.04.020
接收时间：2025-09-21
首发时间：2026-09-09
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.04.020
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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