Article(id=1304414704814814115, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.04.003, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1762358400000, receivedDateStr=2025-11-06, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788926300480, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788926300480, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788926300480, creator=13701087609, updateTime=1788926300480, updator=13701087609, issue=Issue{id=1304414700964443026, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='4', pageStart='1209', pageEnd='1596', issueExtLink='null', onlineDate='null', pubDate='1772208000000', pubDateStr='2026-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788926299563, creator='13701087609', updateTime=1788926573099, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304415848316297970, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304415848316297971, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414700964443026, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1228, endPage=1233, ext={EN=ArticleExt(id=1304414705150358437, articleId=1304414704814814115, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Chemical constituents from Dendrobium huoshanense, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To study on the chemical constituents from Dendrobium huoshanense. Methods The chemical constituents were separated and purified by silica gel, Sephadex LH-20, semi-prepared HPLC and other chromatography techniques. Their structures were elucidated by MS, 1D and 2D NMR spectroscopic data. Results Eleven compounds (1—11) were isolated, and were identified as trans-ferulic acid nonadecyl ester (1), trans-p-hydroxycinnamic acid nonadecyl ester (2), 2,4,7-trihydroxy-9,10-dihydrophenanthrene (3), naringenin (4), 5-hydroxy-3,4′-dimethoxybibenzyl (5), 5-hydroxy-3-methoxybibenzyl (6), dendrogratiol A (7), amoenylin (8), methyl ferulate (9), protocatechuic acid (10), p-hydroxybenzaldehyde (11). At a concentration of 100 μmol/L, compounds 4 and 7 exhibited inhibitory rates of 39.0% and 38.3% against tyrosinase, respectively. Conclusion Compounds 1 and 2 are new compounds, named dendrohuoshanin A and dendrohuoshanin B. Compounds 3, 5, 7—9 were isolated for the first time from this plant. Compound 3 was the first to be separated and purified through phytochemical methods from this plant. Compounds 1, 2, and 9 belong to simple phenylpropanoids, compound 3 is a dihydrophenanthrene, compound 4 is a dihydroflavone, and compounds 5—8 are bibenzyls. Compounds 4 and 7 show potential skin-whitening effects., authors=JIAO Yang, ZHOU Wanqing, TANG Shengan, LIAO Maoliang, authorsList=JIAO Yang, ZHOU Wanqing, TANG Shengan, LIAO Maoliang, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304414705066472356, articleId=1304414704814814115, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=霍山石斛化学成分研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究兰科石斛属植物霍山石斛Dendrobium huoshanense的化学成分及其酪氨酸酶抑制活性。方法 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱及半制备高效液相色谱等色谱分离方法分离纯化得到单体化合物，利用MS、1D, 2D NMR等波谱学方法鉴定单体化合物的结构。同时以酪氨酸酶为筛选模型对分离得到的单体化合物进行酪氨酸酶抑制活性测试。结果 从霍山石斛的茎中分离得到了11个化合物，分别鉴定为反式阿魏酸十九烷酯（1）、反式对羟基桂皮酸十九烷酯（2）、2,4,7-三羟基-9,10-二氢菲（3）、柚皮素（4）、5-羟基-3,4'-二甲氧基联苄（5）、5-羟基-3-甲氧基联苄（6）、杯鞘石斛酚A（7）、4-羟基-3,5,4'-三甲氧基联苄（8）、阿魏酸甲酯（9）、原儿茶酸（10）、对羟基苯甲醛（11）。化合物4、7在100μmol/L浓度下对酪氨酸酶的抑制率为39.0%、38.3%。结论 化合物1、2为新化合物，命名为霍山石斛脂素A、霍山石斛脂素B；化合物3、5、7～9为首次从该植物中分离得到。化合物1、2、9为简单苯丙素类成分，3为二氢菲类成分，4为二氢黄酮类成分，5～8为联苄类成分。化合物4、7显示出潜在美白功效。, authors=焦扬¹, 周婉晴^2,3, 唐生安⁴, 廖茂梁^2,3, authorsList=焦扬, 周婉晴, 唐生安, 廖茂梁, authorCompany=1 天津中医药大学第一附属医院药学部, 国家中医针灸临床医学研究中心, 天津 300193;
2 皖西学院生物与制药工程学院, 安徽六安 237012;
3 安徽省中药资源保护与利用工程研究中心, 安徽六安 237012;
4 天津医科大学药学院, 天津市临床药物关键技术重点实验室, 天津 300070, correspAuthors=唐生安, authorNote=焦扬: 焦扬（1987—），女，主管药师，硕士，研究方向为临床药学。E-mail:jiaoyang198809@126.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=xNLXrnZM+OR1KkpRi3YOvw==, pdfFileSize=1202482, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=安徽省自然科学基金面上项目 (2308085MH301); 安徽省中药资源保护与持续利用工程实验室开放课题 (TCMRPSU-2022-01); 皖西学院高层次人才基金项目 (WGKQ2022074))}, authors=[Author(id=1307443239598978005, tenantId=1146029695717560320, journalId=null, articleId=1304414704814814115, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={EN=AuthorExt(id=null, tenantId=null, journalId=1302319053441957962, articleId=1304414704814814115, authorId=1307443239598978005, language=EN, stringName=JIAO Yang, ZHOU Wanqing, TANG Shengan, LIAO Maoliang, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=null, tenantId=null, journalId=1302319053441957962, articleId=1304414704814814115, authorId=1307443239598978005, language=CN, stringName=焦扬, 周婉晴, 唐生安, 廖茂梁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=null)], keywords=[Keyword(id=1304414705288770470, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414704814814115, language=CN, orderNo=1, keyword=霍山石斛), Keyword(id=1304414705355879335, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414704814814115, language=CN, orderNo=2, keyword=霍山石斛脂素A), Keyword(id=1304414705443959720, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414704814814115, language=CN, orderNo=3, keyword=霍山石斛脂素B), Keyword(id=1304414705523651497, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414704814814115, language=CN, orderNo=4, keyword=2,4,7-三羟基-9,10-二氢菲), Keyword(id=1304414705594954666, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414704814814115, language=CN, orderNo=5, keyword=5-羟基-3,4'-二甲氧基联苄), Keyword(id=1304414705683035051, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414704814814115, language=CN, orderNo=6, keyword=杯鞘石斛酚A), Keyword(id=1304414705745949612, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414704814814115, language=CN, orderNo=7, keyword=阿魏酸甲酯), Keyword(id=1304414705850807213, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414704814814115, language=EN, orderNo=1, keyword=Dendrobium huoshanense C. 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orderTime=1788926300480, fullTextJson=null, articleText=null, reference=中国药典[S]. 一部. 2020: 98.
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