中草药

基于数据挖掘和实验验证探讨药食同源类中药治疗血管性痴呆的用药规律及作用机制

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中草药 | 数据挖掘与循证医学 2026,57(2): 583-594

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中草药 |数据挖掘与循证医学 2026 , 57 (2) : 583 -594

基于数据挖掘和实验验证探讨药食同源类中药治疗血管性痴呆的用药规律及作用机制

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朱小敏¹, 陈炜², 卓桂锋¹, 符钰岚¹, 黄颖睿¹, 张金枝¹, 吴林^1,3

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通讯作者:

吴林

作者简介:

朱小敏: 朱小敏（1997—），女，湖北荆州人，博士研究生，研究方向为中医药防治脑系疾病研究。E-mail: 671369756@qq.com Tel: 15002797626

Exploration of medication patterns and mechanisms of medicinal and food homologous traditional Chinese medicines in treatment of vascular dementia based on data mining and experimental validation

ZHU Xiaomin, CHEN Wei, ZHUO Guifeng, FU Yulan, HUANG Yingrui, ZHANG Jinzhi, WU Lin

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doi: 10.7501/j.issn.0253-2670.2026.02.018

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摘要

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目的挖掘药食同源类中药治疗血管性痴呆（vascular dementia，VD）的用药规律，运用网络药理学阐明其潜在作用机制并进行实验验证，为VD的防治提供科学依据。方法通过检索中国知网、万方、维普以及中国生物医学文献数据库中关于中药方剂治疗VD的临床文献，与药食同源类中药名单进行比对，得到与VD相关的药食同源方药集并分析这些方药的用药规律，筛选出核心中药。利用网络药理学方法获得核心中药的活性成分及其治疗VD的作用靶点进行基因本体（gene ontology，GO）功能和京都基因与基因组百科全书（Kyoto encyclopedia of genes and genomes，KEGG）通路富集分析；对核心靶点和主要活性成分进行分子对接；并通过动物实验验证核心中药的治疗效果。结果数据挖掘得到药食同源类中药方剂531首，高频次且具有强关联性组合药对3个，筛选出黄芪、当归、桃仁和山茱萸为治疗VD的药食同源类核心中药。其抗VD的机制与调控白细胞介素-17（interleukin-17，IL-17）、肿瘤坏死因子（tumor necrosis factor，TNF）等通路相关。核心中药的主要活性成分槲皮素和山柰酚与VD关键靶点肿瘤蛋白P53（tumor protein p53，TP53）、蛋白激酶B1（protein kinase B1，AKT1）、TNF、IL-6具有较好的结合能力。动物实验显示药食同源方可改善VD大鼠的学习记忆能力，减轻线粒体及突触损伤，下调VD大鼠海马组织TP53、TNF、IL-6 mRNA相对表达水平及TP53的阳性表达量。结论黄芪、当归、桃仁和山茱萸是药食同源类治疗VD的核心中药，其抗VD的作用机制与调控TP53、TNF、IL-6等靶点减轻突触损伤与神经炎症有关。

关键词

血管性痴呆 / 药食同源 / 数据挖掘 / 网络药理学 / 黄芪 / 当归 / 桃仁 / 山茱萸

Abstract

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Objective To explore the medication patterns of medicinal and food homologous traditional Chinese medicines (TCMs) in treatment of vascular dementia (VD), to elucidate their potential mechanisms using network pharmacology, and to validate these findings experimentally, providing a scientific basis for the prevention and treatment of VD. Methods Clinical literature on TCM prescriptions for VD was retrieved from China National Knowledge Infrastructure (CNKI), Wanfang, China Science and Technology Journal Database (VIP), and the China Biology Medicine databases. After comparing with the list of TCMs that are both food and medicine, we obtained a set of VD-related TCM prescriptions. We analyzed the medication patterns and screened for core herbs. Using network pharmacology, we identified the active components of the core herbs and their target points in VD treatment, followed by gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) analyses. Molecular docking was performed on core targets and major active components. Animal experiments were conducted to verify the therapeutic effects of the core herbs. Results Data mining yielded 531 TCM prescriptions that are both food and medicine, revealing three high-frequency and strongly associated herbal pairs. Huangqi (Astragali Radix), Danggui (Angelicae Sinensis Radix), Taoren (Persicae Semen), and Shanzhuyu (Corni Fructus) were selected as the core herbs for treating VD. The anti-VD mechanisms involve regulating pathways such as interleukin‑17 (IL-17) and tumor necrosis factor (TNF). The main active components, quercetin and kaempferol, showed good binding affinity with key VD targets including tumor protein p53 (TP53), protein kinase B1 (AKT1), TNF, and IL-6. Animal experiments demonstrated that the TCM prescriptions improved learning and memory in VD rats, reduced mitochondrial and synaptic damage, and downregulated the mRNA expression levels of TP53, TNF, and IL-6 in the hippocampus, as well as the positive expression of TP53. Conclusion Astragali Radix, Angelicae Sinensis Radix, Persicae Semen, and Corni Fructus are core herbs in the category of TCMs that are both food and medicine for treating VD. Their anti-VD mechanisms are related to the regulation of targets such as TP53, TNF, and IL-6, which help alleviate synaptic injury and neuroinflammation. This study provides valuable insights into the use of these herbs for VD prevention and treatment.

Key words

vascular dementia / medicinal and food homologous / data mining / network pharmacology / Astragali Radix / Angelicae Sinensis Radix / Persicae Semen / Corni Fructus

引用本文

朱小敏, 陈炜, 卓桂锋, 符钰岚, 黄颖睿, 张金枝, 吴林. 基于数据挖掘和实验验证探讨药食同源类中药治疗血管性痴呆的用药规律及作用机制. 中草药, 2026 , 57 (2) : 583 -594 . DOI: 10.7501/j.issn.0253-2670.2026.02.018

ZHU Xiaomin, CHEN Wei, ZHUO Guifeng, FU Yulan, HUANG Yingrui, ZHANG Jinzhi, WU Lin. Exploration of medication patterns and mechanisms of medicinal and food homologous traditional Chinese medicines in treatment of vascular dementia based on data mining and experimental validation[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (2) : 583 -594 . DOI: 10.7501/j.issn.0253-2670.2026.02.018

基金

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国家自然科学基金项目 (82374387,82160885); 广西中医药大学“歧黄工程”高层次人才团队 (202410); 广西研究生教育创新计划项目 (YCBZ2025190); 广西自然科学基金项目 (2025GXNSFAA069990); 广西中医药重点学科建设项目 (GZXK-Z-20-13)

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Hosoki S, Hansra G K, Jayasena T, et al. Molecular biomarkers for vascular cognitive impairment and dementia[J]. Nat Rev Neurol, 2023, 19(12):737-753.
Jia L F, Du Y F, Chu L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China:A cross-sectional study[J]. Lancet Public Health, 2020, 5(12):e661-e671.
Rundek T, Tolea M, Ariko T, et al. Vascular cognitive impairment (VCI)[J]. Neurotherapeutics, 2022, 19(1):68-88.
曾佑燕, 李欣颖, 周莉, 等. 基于多维数据挖掘药食同源类中药治疗糖尿病足的用药规律及分子机制[J]. 中草药, 2024, 55(4):1255-1267.
胡杨, 赵勉, 邱雨轩, 等. 药食同源中药铁皮石斛的研究进展[J]. 南京中医药大学学报, 2024, 40(1):94-108.
中国药典[S]. 一部. 2020:1-404.
国家中医药管理局《中华本草》编委会. 中华本草(第2~27卷)[M]. 上海:上海科学技术出版社, 1999.
杨欣, 符晋, 蒋萃, 等. 基于网络药理学及实验验证研究半夏白术天麻汤治疗癫痫的机制[J]. 世界科学技术-中医药现代化, 2025, 27(3):776-791.
卓桂锋, 陈炜, 张金枝, 等. 益肺宣肺降浊方抗血管性痴呆的作用机制研究[J]. 中国药房, 2024, 35(18):2207-2212.
黄德庆, 任昕怡, 陈炜, 等. 益肺宣肺降浊方调控miR-485/AIM2炎症小体途径治疗血管性痴呆的机制研究[J]. 海南医科大学学报, 2025, 31(17):1281-1291.
姜晓璩, 蔡静, 吴远华, 等. 近5年中医药防治血管性痴呆实验研究进展[J]. 世界中医药, 2024, 19(11):1680-1685.
Yao B, Zhang M, Zhao S, et al. Research and utilization status of Lophatherum gracile:A medicinal and food homologous plant[J]. Chin Herb Med, 2025, 17(2):261-278.
石娅, 刘文, 刘兴德, 等. 基于PI3K/Akt信号通路探究当归补血汤干预大鼠实验性脑缺血再灌注损伤的作用机制[J]. 中草药, 2022, 53(16):5052-5065.
刘彦宏, 丛树园, 武凤, 等. 补阳还五汤通过调节炎症因子防治血管性痴呆的研究进展[J]. 中国临床药理学杂志, 2024, 40(5):749-753.
吴万丰, 聂慧芳, 胡立娟, 等. 补阳还五汤对缺血性脑卒中气虚血瘀证大鼠肠道菌群及其血浆代谢产物的影响[J]. 中草药, 2021, 52(1):118-128.
王雪可, 崔应麟, 马瑞红, 等. 基于数据挖掘的中药治疗血管性痴呆组方用药规律分析[J]. 中医药通报, 2022, 21(6):46-49.
彭涛, 张慧, 杨一帆, 等. 黄芪治疗血管性痴呆药理机制研究进展[J]. 中国医药, 2024, 19(2):297-302.
刘宗欣, 李孟韩, 万婷, 等. 当归补血汤治疗血管性痴呆作用机制网络药理学研究[J]. 中国药业, 2023, 32(20):58-64.
蔡茜. 基于网络药理学探讨补阳还五汤治疗血管性痴呆的实验研究[D]. 南宁:广西中医药大学, 2023.
陈炜, 朱小敏, 胡跃强, 等. 益肺宣肺降浊方通过EGFR调节PI3K/Akt-MAPK/Erk通路改善血管性痴呆大鼠的记忆[J]. 中华中医药学刊, 2023, 41(8):46-50.
唐森, 方建, 高立功, 等. 基于PINK1/Parkin通路研究槲皮素减轻血管性痴呆大鼠海马神经元损伤的作用机制[J]. 中草药, 2022, 53(20):6529-6535.
张丽阳, 孙军, 陈迪. 山奈酚抑制脑缺血/再灌注大鼠的脑损伤、炎症、氧化应激和凋亡[J]. 中国组织化学与细胞化学杂志, 2022, 31(4):381-386.
Li W H, Cheng X, Yang Y L, et al. Kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion rats[J]. Brain Res, 2019, 1722:146361.
Soelter T M, Howton T C, Clark A D, et al. Altered Glia-neuron communication in Alzheimer's disease affects WNT, p53, and NFkB signaling determined by snRNA-seq[J]. bioRxiv, 2024, doi:11.29.569304.
Wu C Y, Li F L, Han G S, et al. Aβ(1-42) disrupts the expression and function of KLF2 in Alzheimer's disease mediated by p53[J]. Biochem Biophys Res Commun, 2013, 431(2):141-145.
Iadecola C. The pathobiology of vascular dementia[J]. Neuron, 2013, 80(4):844-866.
Liu X, Yao L W, Ye X Y, et al. Danggui-Shaoyao-San (DSS) ameliorating cognitive impairment in ischemia-reperfusion vascular dementia mice through miR-124 regulating PI3K/Akt signaling pathway[J]. Brain Res, 2024, 1845:149135.
Guan T Y, Xiao Y N, Xie X H, et al. Dulaglutide improves gliosis and suppresses apoptosis/autophagy through the PI3K/Akt/mTOR signaling pathway in vascular dementia rats[J]. Neurochem Res, 2023, 48(5):1561-1579.
李龙春, 李晓晔, 杜小华. 针刺通过调控PI3K/Akt/mTOR通路改善血管性痴呆大鼠认知功能的机制研究[J]. 针刺研究, 2021, 46(10):851-856.
Li W Q, Liu Q Q, Shi J C, et al. The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment[J]. Front Immunol, 2023, 14:1074863.
McCusker S M, Curran M D, Dynan K B, et al. Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia:A case-control study[J]. Lancet, 2001, 357(9254):436-439.
Belkhelfa M, Beder N, Mouhoub D, et al. The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia[J]. J Neuroimmunol, 2018, 320:48-57.
Poh L, Sim W L, Jo D G, et al. The role of inflammasomes in vascular cognitive impairment[J]. Mol Neurodegener, 2022, 17(1):4.
Sudduth T L, Weekman E M, Price B R, et al. Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)[J]. Neuroscience, 2017, 341:42-51.
王萍, 杨骏, 孔钰, 等. 基于海马Mst1/NF-κB p65通路探讨化瘀通络灸对血管性痴呆大鼠学习记忆能力的影响[J]. 中国针灸, 2025, 45(1):53-60.
郭会青, 黄静. 277例吡拉西坦口服制剂不良反应报告分析[J]. 临床医药实践, 2024, 33(8):596-599.

2026年第57卷第2期

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doi: 10.7501/j.issn.0253-2670.2026.02.018

接收时间：2025-08-20
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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