中草药

隔山牛皮消中2个新化学成分研究

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中草药 | 化学成分 2026,57(2): 400-404

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中草药 |化学成分 2026 , 57 (2) : 400 -404

隔山牛皮消中2个新化学成分研究

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张露元¹, 周晶¹, 娄红波¹, 普开亮¹, 李云璐¹, 陈超¹, 陈英飞¹, 徐笑宇¹, 沈勇^1,2

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通讯作者:

徐笑宇

作者简介:

张露元: 张露元（2001—），女，硕士研究生，研究方向为药用植物资源化学开发利用。E-mail: 1483669890@qq.com 周晶: 周晶（1999—），男，硕士研究生，研究方向为药用植物资源化学开发利用。E-mail: 2320701463@qq.com

Two new trinorcycloartane triterpenoids from stems and leaves of Astragalus membranaceus

ZHANG Luyuan, ZHOU Jing, LOU Hongbo, PU Kailiang, LI Yunlu, CHEN Chao, CHEN Yingfei, XU Xiaoyu, SHEN Yong

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doi: 10.7501/j.issn.0253-2670.2026.02.002

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目的研究隔山牛皮消Cynanchum wilfordii的化学成分及其抗炎活性。方法采用硅胶、ODS和Sephadex LH-20等多种色谱分离技术开展化合物的分离纯化，运用HR-ESI-MS、ESI-MS、¹H-NMR、¹³C-NMR、HSQC、HMBC多种波谱技术鉴定化合物结构；采用Griess法研究化合物的抗炎活性。结果从隔山牛皮消块根中分离得到2个化合物，分别鉴定为(7'R,8'S)-dehydrodiconiferyl alcohol 9'-O-β-D-xylopyranoside（1）和3β-[(O-β-D-glucopyranosyloxy]-8β,14β-trihydroxycarda-5,20(22)-dienolide（2）。化合物1和2对NO生成的抑制率分别为55.16%和15.34%，化合物1的半数抑制浓度（median inhibition concentration，IC₅₀）为41.37 μmol/L。结论化合物1与2均为新化合物，分别属于木脂素和强心苷类，分别命名为隔山牛皮消素A和隔山牛皮消强心苷A。体外抗炎实验表明，化合物1具有一定的抗炎活性。

关键词

隔山牛皮消 / 木脂素 / 强心苷 / 抗炎活性 / 隔山牛皮消素A / 隔山牛皮消强心苷A

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Objective To investigate the chemical constituents and their anti-inflammatory activity of Cynanchum wilfordii. Methods Various chromatographic techniques including silica gel, ODS, and Sephadex LH-20 column chromatography were employed for the isolation and purification of compounds. Their structures were elucidated through comprehensive spectroscopic analysis including HR-ESI-MS, ESI-MS, ¹H-NMR, ¹³C-NMR, HSQC, and HMBC. The anti-inflammatory activity of the compounds was evaluated using the Griess method. Results Two compounds were isolated and identified as (7'R,8'S)-dehydrodiconiferyl alcohol 9'-O-β-D-xylopyranoside (1) and 3β-[(O-β-D-glucopyranosyl)-oxy]-8β,14β-trihydroxycarda-5,20-(22)-dienolide (2). Compounds 1 and 2 inhibited NO production by 55.16% and 15.34%, respectively, with a median inhibition concentration (IC₅₀) of 41.37 μmol/L for compound 1. Conclusion Compounds 1 and 2 are both new compounds, belonging to lignan and cardenolide types, respectively. They have been assigned the names cynawilforin A (1) and wilforcardenoside A (2). In vitro anti-inflammatory assays indicated that compound 1 exhibits certain anti-inflammatory activity.

Key words

Cynanchum wilfordii(Maxim.) Hemsl / lignan / cardenolide / anti-inflammatory activity / cynawilforin A / wilforcardenoside A

引用本文

张露元, 周晶, 娄红波, 普开亮, 李云璐, 陈超, 陈英飞, 徐笑宇, 沈勇. 隔山牛皮消中2个新化学成分研究. 中草药, 2026 , 57 (2) : 400 -404 . DOI: 10.7501/j.issn.0253-2670.2026.02.002

ZHANG Luyuan, ZHOU Jing, LOU Hongbo, PU Kailiang, LI Yunlu, CHEN Chao, CHEN Yingfei, XU Xiaoyu, SHEN Yong. Two new trinorcycloartane triterpenoids from stems and leaves of Astragalus membranaceus[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (2) : 400 -404 . DOI: 10.7501/j.issn.0253-2670.2026.02.002

基金

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云南省高校服务重点产业科技项目 (FWCY-QYCT2024014); 建设面向南亚东南亚科技创新中心专项项目 (202403AP140013)

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2026年第57卷第2期

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doi: 10.7501/j.issn.0253-2670.2026.02.002

接收时间：2025-11-12
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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