Article(id=1304406862879813666, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.01.005, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1762444800000, receivedDateStr=2025-11-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788924430818, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788924430818, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788924430818, creator=13701087609, updateTime=1788924430818, updator=13701087609, issue=Issue{id=1304406818550206926, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='1', pageStart='1', pageEnd='389', issueExtLink='null', onlineDate='null', pubDate='1768147200000', pubDateStr='2026-01-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788924420249, creator='13701087609', updateTime=1788924674802, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304407886289986387, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304407886289986388, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=39, endPage=44, ext={EN=ArticleExt(id=1304406863286661156, articleId=1304406862879813666, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=A new isocoumarin isolated from flower buds of Panax notoginseng, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To study the non-saponin chemical constituents of the flower buds of Panax notoginseng and evaluate their antioxidant and anti-inflammatory activities. Methods The extraction was performed by refluxing with 65% aqueous ethanol, followed by successive liquid-liquid extraction with petroleum ether, ethyl acetate (EtOAc) and n-butanol. The compounds were isolated and purified using RP-18, silica gel, MCI gel CHP20P, Sephadex LH-20 column chromatography and semi-preparative liquid chromatography. Structural identification was carried out by comprehensive analysis of nuclear magnetic resonance (NMR) spectroscopy, high-resolution mass spectrometry (HR-MS), ultraviolet (UV) spectroscopy, and computational electronic circular dichroism (ECD) spectroscopy. Some purified compounds were evaluated for preliminary antioxidant activity and anti-inflammatory activity. Results A total of seven non-saponin components were isolated from the EtOAc fraction of P. notoginseng flower buds, including one isocoumarin (1), four simple phenols (25), and two loliolides (6, 7), were obtained from the EtOAc fraction. These were identified as isocoumarin F1 (1), ferulic acid (2), evofolin A (3), p-hydroxybenzoic acid (4), 4-hydroxybenzaldehyde (5), (+)-epiloliolide (6), and (-)-loliolide (7), respectively. Conclusion All compounds (17) were isolated from P. notoginseng for the first time. Of which, compound 1 is a new isocoumarin and named isocoumarin F1, while compound 2 exhibited obvious DPPH radical scavenging ability., authors=YANG Ping, WANG Xinxin, SHANG Jiahuan, ZHU Hongtao, ZHAO Ping, ZHU Guolei, ZHANG Yingjun, authorsList=YANG Ping, WANG Xinxin, SHANG Jiahuan, ZHU Hongtao, ZHAO Ping, ZHU Guolei, ZHANG Yingjun, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304406863123083299, articleId=1304406862879813666, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=三七花中1个新异香豆素, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究三七Panax notoginseng花中的非皂苷类化学成分及其抗氧化和抗炎活性。方法 采用65%乙醇水溶液热回流提取,石油醚、醋酸乙酯与正丁醇萃取,通过RP-18、硅胶、MCI gel CHP20P、Sephadex LH-20等柱色谱及半制备液相色谱等方法进行化合物的分离及纯化,综合运用核磁共振谱、高分辨质谱、紫外、计算ECD等技术进行结构鉴定,并对部分化合物进行初步的抗氧化活性和抗炎活性评价。结果 从三七花醋酸乙酯部分分离纯化得到7个非皂苷类化合物,包括1个异香豆素类(1)、4个简单酚类(25)和2个黑麦草内酯类化合物(67)。分别鉴定为异香豆素F1(1)、阿魏酸(2)、evofolin A(3)、对羟基苯甲酸(4)、4-羟基苯甲醛(5)、异黑麦草内酯(6)和黑麦草内酯(7)。结论 化合物17均为首次从三七中分离得到,其中化合物1为新的异香豆素,命名为异香豆素F1;化合物2有较强的DPPH自由基清除能力。, authors=杨平1,2, 王新欣2, 尚佳欢2, 朱宏涛2, 赵平1, 朱国磊1, 张颖君2, authorsList=杨平, 王新欣, 尚佳欢, 朱宏涛, 赵平, 朱国磊, 张颖君, authorCompany=1 西南林业大学 西南地区林业生物质资源高效利用国家林业和草原局重点实验室, 云南 昆明 650224;
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王宁,刘聪毅,丁颖,等.杜仲雄花-三七花药对改善2型糖尿病糖脂代谢的机制研究[J]. 北京中医药大学学报, 2025, 48(10):1-16.
李欣馨,王新欣,廖彭莹,等.三七花中1个新的多烯炔型大环内酯[J]. 中草药, 2024, 55(14):4643-4649.
韦献雅,殷丽琴,钟成,等. DPPH法评价抗氧化活性研究进展[J]. 食品科学, 2014, 35(9):317-322.
俞雅芮.金桂的化学成分和生物活性研究[D]. 成都:四川大学, 2022.
马小龙,王宪,冯娟.一氧化氮对适应性免疫系统功能的调控及在相关疾病中的作用[J]. 生理科学进展,2020, 51(6):415-421.
Reif D W, McCreedy S A. N-Nitro-L-arginine and Nmonomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases[J]. Arch Biochem Biophys, 1995, 320(1):170-176.
Krohn K, Kock I, Elsässer B, et al. Bioactive natural products from the endophytic fungus Ascochyta sp. from Meliotus dentatus-configurational assignment by solidstate CD and TDDFT calculations[J]. Eur J Org Chem,2007, 2007(7):1123-1129.
李娜,赵斌,余娅芳,等.白花败酱抗炎作用化学成分研究[J]. 中药材, 2008, 31(1):51-53.
余小红,李盼盼,耿圆圆,等.小远志化学成分研究[J]. 林产化学与工业, 2017, 37(1):149-154.
孟令杰,刘百联,张英,等.地骨皮化学成分研究[J]. 中草药, 2014, 45(15):2139-2142.
李浩华,周燕燕,陈玉婵,等.紫玉盘内生真菌节菱孢中1个新的异香豆素类化合物[J]. 中草药, 2016,47(3):369-373.
Park K E, Kim Y A, Jung H A, et al. Three norisoprenoids from the brown Alga Sargassum thunbergii[J]. J Korean Chem Soc, 2004, 48(4):394-398.
张旋,侴桂新.黄花败酱化学成分研究[J]. 天然产物研究与开发, 2020, 32(5):783-791.
霍志鹏,高文庆,王晴,等.阿魏酸抗氧化作用的量子化学密度泛函理论研究[J]. 现代药物与临床, 2025,40(6):1383-1388.)
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中草药 | 化学成分 2026,57(1): 39-44
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中草药 |化学成分 2026 , 57 (1) : 39 -44
三七花中1个新异香豆素
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杨平1,2, 王新欣2, 尚佳欢2, 朱宏涛2, 赵平1, 朱国磊1, 张颖君2
作者信息
    1 西南林业大学 西南地区林业生物质资源高效利用国家林业和草原局重点实验室, 云南 昆明 650224;
    2 中国科学院昆明植物研究所 植物化学与天然药物全国重点实验室, 云南 昆明 650201
通讯作者:
朱国磊
作者简介:
杨平: 杨平,女,硕士研究生,研究方向为天然产物化学。E-mail:yangping@mail.kib.ac.cn 王新欣: 王新欣,女,硕士研究生,研究方向为天然产物化学。E-mail:861504428@qq.com
A new isocoumarin isolated from flower buds of Panax notoginseng
  • YANG Ping, WANG Xinxin, SHANG Jiahuan, ZHU Hongtao, ZHAO Ping, ZHU Guolei, ZHANG Yingjun
  • Affiliations
    doi: 10.7501/j.issn.0253-2670.2026.01.005
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    目的 研究三七Panax notoginseng花中的非皂苷类化学成分及其抗氧化和抗炎活性。方法 采用65%乙醇水溶液热回流提取,石油醚、醋酸乙酯与正丁醇萃取,通过RP-18、硅胶、MCI gel CHP20P、Sephadex LH-20等柱色谱及半制备液相色谱等方法进行化合物的分离及纯化,综合运用核磁共振谱、高分辨质谱、紫外、计算ECD等技术进行结构鉴定,并对部分化合物进行初步的抗氧化活性和抗炎活性评价。结果 从三七花醋酸乙酯部分分离纯化得到7个非皂苷类化合物,包括1个异香豆素类(1)、4个简单酚类(25)和2个黑麦草内酯类化合物(67)。分别鉴定为异香豆素F1(1)、阿魏酸(2)、evofolin A(3)、对羟基苯甲酸(4)、4-羟基苯甲醛(5)、异黑麦草内酯(6)和黑麦草内酯(7)。结论 化合物17均为首次从三七中分离得到,其中化合物1为新的异香豆素,命名为异香豆素F1;化合物2有较强的DPPH自由基清除能力。
    三七花  /  异香豆素类  /  简单酚类  /  抗氧化  /  抗炎  /  异香豆素F1  /  阿魏酸  /  4-羟基苯甲醛  /  黑麦草内酯
    Objective To study the non-saponin chemical constituents of the flower buds of Panax notoginseng and evaluate their antioxidant and anti-inflammatory activities. Methods The extraction was performed by refluxing with 65% aqueous ethanol, followed by successive liquid-liquid extraction with petroleum ether, ethyl acetate (EtOAc) and n-butanol. The compounds were isolated and purified using RP-18, silica gel, MCI gel CHP20P, Sephadex LH-20 column chromatography and semi-preparative liquid chromatography. Structural identification was carried out by comprehensive analysis of nuclear magnetic resonance (NMR) spectroscopy, high-resolution mass spectrometry (HR-MS), ultraviolet (UV) spectroscopy, and computational electronic circular dichroism (ECD) spectroscopy. Some purified compounds were evaluated for preliminary antioxidant activity and anti-inflammatory activity. Results A total of seven non-saponin components were isolated from the EtOAc fraction of P. notoginseng flower buds, including one isocoumarin (1), four simple phenols (25), and two loliolides (6, 7), were obtained from the EtOAc fraction. These were identified as isocoumarin F1 (1), ferulic acid (2), evofolin A (3), p-hydroxybenzoic acid (4), 4-hydroxybenzaldehyde (5), (+)-epiloliolide (6), and (-)-loliolide (7), respectively. Conclusion All compounds (17) were isolated from P. notoginseng for the first time. Of which, compound 1 is a new isocoumarin and named isocoumarin F1, while compound 2 exhibited obvious DPPH radical scavenging ability.
    flower buds of Panax notoginseng  /  isocoumarin  /  phenolics  /  antioxidant activity  /  anti-inflammatory  /  isocoumarin F1  /  ferulic acid  /  4-hydroxybenzaldehyde  /  (-)-loliolide
    杨平, 王新欣, 尚佳欢, 朱宏涛, 赵平, 朱国磊, 张颖君. 三七花中1个新异香豆素. 中草药, 2026 , 57 (1) : 39 -44 . DOI: 10.7501/j.issn.0253-2670.2026.01.005
    YANG Ping, WANG Xinxin, SHANG Jiahuan, ZHU Hongtao, ZHAO Ping, ZHU Guolei, ZHANG Yingjun. A new isocoumarin isolated from flower buds of Panax notoginseng[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (1) : 39 -44 . DOI: 10.7501/j.issn.0253-2670.2026.01.005

      云南省科技厅重点研发计划 (202203AC100008); 植物化学与西部植物资源持续利用国家重点实验室课题 (P2022-KF15)

    参考文献 引证文献
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    Li Y, Hei J Y, Wang B, et al. Unraveling the molecular mechanisms of flavonoid biosynthesis in Panax notoginseng flowers across planting patterns and developmental stages using integrated metabolomics and transcriptomics analyses[J]. Sci Hortic, 2024, 335:113362.
    周定婷,陈晓彤,张华峰,等.人参花、三七花的化学组成及多糖提取物抗氧化、抑制血糖相关酶活性的比较研究[J]. 特产研究, 2025, 44(7):1-9.
    王宁,刘聪毅,丁颖,等.杜仲雄花-三七花药对改善2型糖尿病糖脂代谢的机制研究[J]. 北京中医药大学学报, 2025, 48(10):1-16.
    李欣馨,王新欣,廖彭莹,等.三七花中1个新的多烯炔型大环内酯[J]. 中草药, 2024, 55(14):4643-4649.
    韦献雅,殷丽琴,钟成,等. DPPH法评价抗氧化活性研究进展[J]. 食品科学, 2014, 35(9):317-322.
    俞雅芮.金桂的化学成分和生物活性研究[D]. 成都:四川大学, 2022.
    马小龙,王宪,冯娟.一氧化氮对适应性免疫系统功能的调控及在相关疾病中的作用[J]. 生理科学进展,2020, 51(6):415-421.
    Reif D W, McCreedy S A. N-Nitro-L-arginine and Nmonomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases[J]. Arch Biochem Biophys, 1995, 320(1):170-176.
    Krohn K, Kock I, Elsässer B, et al. Bioactive natural products from the endophytic fungus Ascochyta sp. from Meliotus dentatus-configurational assignment by solidstate CD and TDDFT calculations[J]. Eur J Org Chem,2007, 2007(7):1123-1129.
    李娜,赵斌,余娅芳,等.白花败酱抗炎作用化学成分研究[J]. 中药材, 2008, 31(1):51-53.
    余小红,李盼盼,耿圆圆,等.小远志化学成分研究[J]. 林产化学与工业, 2017, 37(1):149-154.
    孟令杰,刘百联,张英,等.地骨皮化学成分研究[J]. 中草药, 2014, 45(15):2139-2142.
    李浩华,周燕燕,陈玉婵,等.紫玉盘内生真菌节菱孢中1个新的异香豆素类化合物[J]. 中草药, 2016,47(3):369-373.
    Park K E, Kim Y A, Jung H A, et al. Three norisoprenoids from the brown Alga Sargassum thunbergii[J]. J Korean Chem Soc, 2004, 48(4):394-398.
    张旋,侴桂新.黄花败酱化学成分研究[J]. 天然产物研究与开发, 2020, 32(5):783-791.
    霍志鹏,高文庆,王晴,等.阿魏酸抗氧化作用的量子化学密度泛函理论研究[J]. 现代药物与临床, 2025,40(6):1383-1388.
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    doi: 10.7501/j.issn.0253-2670.2026.01.005
    • 接收时间:2025-11-07
    • 首发时间:2026-09-09
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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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