Article(id=1304406857787921087, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406828071281069, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.02.014, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758038400000, receivedDateStr=2025-09-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788924429604, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788924429604, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788924429604, creator=13701087609, updateTime=1788924429604, updator=13701087609, issue=Issue{id=1304406828071281069, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='2', pageStart='393', pageEnd='788', issueExtLink='null', onlineDate='null', pubDate='1769529600000', pubDateStr='2026-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788924422518, creator='13701087609', updateTime=1788924652596, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304407793138688830, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406828071281069, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304407793138688831, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406828071281069, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=541, endPage=552, ext={EN=ArticleExt(id=1304406858064745153, articleId=1304406857787921087, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Ginseng polysaccharide-chitosan oligosaccharide nanoparticles combined with radiotherapy promote NK cells differentiation and enhance antitumor efficacy via IFN-I-mediated JAK3/STAT5 pathway, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To construct Ginseng polysaccharide-chitosan oligosaccharide nanoparticles (GP-NPs) and investigate whether their combination with radiotherapy could promote the differentiation of natural killer (NK) cells into highly cytotoxic subsets by activating interferon-I (IFN-I)-mediated Janus kinase 3 (JAK3)/signal transducer and activator of transcription 5 (STAT5) signaling pathway, thereby enhancing the antitumor immune response against non-small cell lung cancer (NSCLC). Methods GP-NPs were prepared via the ionic cross-linking method, and their particle size, dispersibility and stability were characterized. A subcutaneous xenograft model of A549 lung cancer cells in nude mice was established, and the mice were divided into PBS group, radiotherapy alone group and GP-NPs combined with radiotherapy group. The antitumor efficacy and mechanism of GP-NPs combined with radiotherapy were comprehensively evaluated by measuring tumor volume, detecting levels of cytokines in serum via ELISA, analyzing NK cells subsets by flow cytometry, detecting the protein expressions of JAK3/STAT5 pathway through Western blotting and performing histopathological analysis. Results GP-NPs combined with radiotherapy significantly inhibited tumor growth, and the effect was significantly better than that of the simple radiotherapy group (P < 0.01). The levels of interferon-γ (IFN-γ), interleukin-15 (IL-15), granzyme and perforin in serum of combined treatment group were significantly increased (P < 0.01). Flow cytometry showed an increase in the proportion of NK cells infiltration within the tumor (P < 0.01), and a significant increase in the proportion of mature cytotoxic subgroups (CD27^-CD11b⁺) (P < 0.01). Western blotting results showed that the combination therapy significantly activated the JAK3/STAT5 signaling pathway (P < 0.01). Organizational analysis showed that the combination therapy group had increased tumor cell apoptosis, aggravated DNA damage and enhanced NK cell infiltration, with no significant toxicity observed in major organs. Conclusion GP-NPs combined with radiotherapy promote the differentiation of NK cells into highly cytotoxic subsets and enhance their antitumor function by activating IFN-I-mediated JAK3/STAT5 signaling pathway. This combination strategy not only significantly improves the efficacy of radiotherapy but also has good biosafety, providing new experimental evidence and strategic directions for the immunocombination therapy of NSCLC., authors=WANG Haojie, HU Zheming, YU Xingtai, CHEN Zhijun, WU Tianxin, FAN Jiayi, WANG Wenyi, ZHANG Liqun, LIU Xiaoyang, LU Yang, authorsList=WANG Haojie, HU Zheming, YU Xingtai, CHEN Zhijun, WU Tianxin, FAN Jiayi, WANG Wenyi, ZHANG Liqun, LIU Xiaoyang, LU Yang, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304406858001830592, articleId=1304406857787921087, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=人参多糖-壳寡糖纳米粒联合放疗通过IFN-I介导的JAK3/STAT5通路促进NK细胞分化增强抗肿瘤效应, columnId=1304140191707456168, journalTitle=中草药, columnName=药理与临床, runingTitle=null, highlight=null, articleAbstract=目的 构建人参多糖-壳寡糖纳米粒（Ginseng polysaccharide-chitosan oligosaccharide nanoparticles，GP-NPs），并探究其联合放疗能否通过激活I型干扰素（interferon-I，IFN-I）介导的Janus激酶3（Janus kinase 3，JAK3）/信号转导和转录激活蛋白5（signal transducer and activator of transcription 5，STAT5）信号通路，促进自然杀伤（natural killer，NK）细胞向高细胞毒性亚群分化，从而增强对非小细胞肺癌的抗肿瘤免疫应答。方法 通过离子交联法制备GP-NPs，并对其粒径、分散性及稳定性进行表征。建立A549肺癌细胞皮下荷瘤裸鼠模型，将小鼠分为PBS组、单纯放疗组和GP-NPs联合放疗组。通过测量肿瘤体积、ELISA检测血清细胞因子水平、流式细胞术分析NK细胞亚群、Western blotting检测JAK3/STAT5通路蛋白表达，以及组织病理学分析，综合评价GP-NPs联合放疗的抗肿瘤效果与机制。结果 GP-NPs联合放疗显著抑制肿瘤生长，且效果显著优于单纯放疗组（P＜0.01）。联合治疗组血清中γ干扰素（interferon-γ，IFN-γ）、白细胞介素-15（interleukin-15，IL-15）、颗粒酶和穿孔素水平显著升高（P＜0.01）。流式细胞术显示肿瘤内NK细胞浸润比例增加（P＜0.01），且成熟细胞毒亚群（CD27⁻CD11b⁺）比例显著上升（P＜0.01）。Western blotting结果表明联合治疗显著激活JAK3/STAT5信号通路（P＜0.01）。组织学分析显示联合治疗组肿瘤细胞凋亡增加、DNA损伤加重、NK细胞浸润增强，且主要脏器未见明显毒性。结论 GP-NPs联合放疗通过激活IFN-I介导的JAK3/STAT5信号通路，促进NK细胞向高细胞毒性亚群分化，增强其抗肿瘤功能。该联合策略不仅显著提升放疗的疗效，还具有良好的生物安全性，为非小细胞肺癌的免疫联合治疗提供了新的实验依据和策略方向。, authors=王浩捷¹, 胡哲铭¹, 于兴泰¹, 陈祉君¹, 吴湉昕¹, 樊家怡¹, 王文艺¹, 张丽群¹, 刘笑洋¹, 陆洋¹, authorsList=王浩捷, 胡哲铭, 于兴泰, 陈祉君, 吴湉昕, 樊家怡, 王文艺, 张丽群, 刘笑洋, 陆洋, authorCompany=1 北京中医药大学中药学院, 北京 102488, correspAuthors=陆洋, authorNote=王浩捷: 王浩捷，男，硕士研究生，研究方向为中药新剂型与新技术。E-mail: hjwang47@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=iWRzGCMazx+Cukpye4wvrw==, pdfFileSize=2437353, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=北京市科技新星计划 (20240484544); 中国原子能科学研究院稳定性支持经费科研项目 (CNNCWZ-2023002))}, authors=null, keywords=[Keyword(id=1304406858203157186, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=CN, orderNo=1, keyword=人参多糖), Keyword(id=1304406858274460355, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=CN, orderNo=2, keyword=壳寡糖), Keyword(id=1304406858337374916, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=CN, orderNo=3, keyword=纳米粒), Keyword(id=1304406858400289477, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=CN, orderNo=4, keyword=免疫调节), Keyword(id=1304406858492564166, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=CN, orderNo=5, keyword=NK细胞), Keyword(id=1304406858551284423, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=CN, orderNo=6, keyword=放射治疗), Keyword(id=1304406858643559112, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=CN, orderNo=7, keyword=JAK3/STAT5信号通路), Keyword(id=1304406858740028105, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=EN, orderNo=1, keyword=Ginseng polysaccharide), Keyword(id=1304406858798748362, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=EN, orderNo=2, keyword=chitosan oligosaccharide), Keyword(id=1304406858870051531, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=EN, orderNo=3, keyword=nanoparticles), Keyword(id=1304406858937160396, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=EN, orderNo=4, keyword=immunomodulation), Keyword(id=1304406859016852173, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=EN, orderNo=5, keyword=NK cells), Keyword(id=1304406859092349646, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=EN, orderNo=6, keyword=radiotherapy), Keyword(id=1304406859163652815, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304406857787921087, language=EN, orderNo=7, keyword=JAK3/STAT5 signaling pathway)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.02.014, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.02.014, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.02.014, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.02.014, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788924429604, fullTextJson=null, articleText=null, reference=李思苒, 刘荣衡, 张炳松. 1992-2021年中国育龄期人群肺癌发病和死亡趋势及年龄-时期-队列分析[J]. 中华肿瘤防治杂志, 2025, 32(17):1033-1040.
李洁莹. PD-1单抗为基础的联合策略在晚期头颈鳞癌治疗中的临床评价[D]. 青岛:青岛大学, 2023.
金少华, 张晓青, 马纯正, 等. 铁死亡及其在胶质母细胞瘤放化疗中的作用机制及研究进展[J]. 现代肿瘤医学, 2024, 32(17):3335-3341.
单莉平, 刘倩, 宋琼, 等. 放射治疗与肿瘤疫苗联合在肿瘤治疗中的应用研究进展[J]. 陕西医学杂志, 2025, 54(8):1141-1144.
王晓芳. 黄芪建中汤含药血清联合顺铂对人肺腺癌A549细胞E-cadherin、Snail1表达的影响[D]. 沈阳:辽宁中医药大学, 2020.
任晨晨, 姚立志, 苏肖肖, 等. 人参的化学成分及药理作用研究进展[J]. 广东化工, 2025, 52(16):62-64.
梁贝贝, 李彬, 李佳, 等. 人参总次苷通过改善线粒体能量代谢抑制血管紧张素II诱导的原代心肌细胞肥大[J/OL]. 安徽中医药大学学报, (2025-08-11)[2025-09-03]. https://link.cnki.net/urlid/34.1324.R.20250811.1253.004.
黄鸿才, 余华. 植物源性外泌体样纳米囊泡在癌症治疗中的潜力研究进展[J]. 中国临床新医学, 2025, 18(8):937-942.
刘泳君, 张国华, 林瑞芳, 等. 基于"虚气留滞"理论探讨线粒体动力学介导巨噬细胞焦亡与极化在慢性心力衰竭中的作用及中药防治[J/OL]. 中国免疫学杂志, (2025-09-03)[2025-12-03]. https://link.cnki.net/urlid/22.1126.R.20250912.1546.002.
李艺, 张艳, 牟琪瑞. 基于正邪理论探讨巨噬细胞极化在冠脉微循环障碍中的作用及中药干预[J/OL]. 中华中医药学刊, (2025-09-03)[2025-12-03]. https://link.cnki.net/urlid/21.1546.R.20250912.1346.038.
马文妍, 辛杰, 苗宇航, 等. 植物细胞外囊泡在肿瘤疾病中的研究进展[J]. 中国细胞生物学学报, 2025, 47(8):2084-2094.
Jan P, Nikola M, Liliana T, et al. Microbiota modulate immune cell populations and drive dynamic structural changes in gut-associated lymphoid tissue[J]. Gut Microbes, 2025, 17(1):2543908.
Jang J, He Z L, Huang L, et al. Upregulation of NK cell activity, cytokine expression, and NF-κB pathway by ginsenoside concentrates from Panax ginseng Berries in healthy mice and macrophage cell lines[J]. J Ethnopharmacol, 2024, 335:118681.
Jeevan-Raj B, Gehrig J, Charmoy M, et al. The transcription factor Tcf1 contributes to normal NK cell development and function by limiting the expression of granzymes[J]. Cell Rep, 2017, 20(3):613-626.
史同瑞, 崔宇超, 王丽坤, 等. 壳聚糖-海藻酸钠载药微球制备工艺研究[J]. 中国兽药杂志, 2019, 53(8):56-65.
杨继辰, 邱玲, 林建国. 监测免疫治疗反应的颗粒酶B靶向分子影像探针研究进展[J]. 南京医科大学学报:自然科学版, 2025, 45(9):1267-1275.
李亚丹. CCL17/CCL22-CCR4趋化因子轴对淋巴瘤肿瘤微环境的作用研究[D]. 郑州:郑州大学, 2023.
陈子嫣, 郭紫婵, 陈丽华. 结肠癌皮下荷瘤小鼠体内NK细胞表型检测和分析[J]. 空军军医大学学报, 2025, 16(7):923-930.
Yang F, Li A Q, Zhu Y Y, et al. GATA1-mediated Notch signaling augment antitumor immunity of CD11b⁺CD27⁻ natural killer cells maturation via BCL9/β-catenin signal[J]. Cell Rep, 2025, 44(5):115708.
Zhang Y Z, Guo H. Su1997:Cd11b⁻cd27⁻ NK subsets account for NK-cell dysfunction in patients with inflammatory bowel disease[J]. Gastroenterology, 2025, 169(1):S-924.
Ni M, Zhao P, Kang Q, et al. CD56briCD27⁺CD11b⁺/-NK cells mediated remission of agvhd via immunoregulation[J]. Blood, 2020, 136:28.
汪熙, 张一飞, 滕业方, 等. 受体偏向性白细胞介素-2类似药在肿瘤免疫治疗中的研究进展[J]. 中国新药与临床杂志, 2024, 43(10):743-750.
刘陶霞. 疏水无机纳米晶的环糊精功能化用于肿瘤的诊疗研究[D]. 北京:北京化工大学, 2025.
郑颖城. 原型泡沫病毒Gag蛋白与Alix相互作用引发粒噬的机制与功能研究[D]. 武汉:武汉大学, 2020.
焦雨竹, 李慧杰, 杨青. 乌帕替尼皮肤科超说明书应用进展[J]. 中国麻风皮肤病杂志, 2025, 41(9):692-696.)