Article(id=1304388215901811049, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388157621948709, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.15.019, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1773244800000, receivedDateStr=2026-03-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788919985031, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788919985031, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788919985031, creator=13701087609, updateTime=1788919985031, updator=13701087609, issue=Issue{id=1304388157621948709, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='15', pageStart='5789', pageEnd='6208', issueExtLink='null', onlineDate='null', pubDate='1786464000000', pubDateStr='2026-08-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1788919971137, creator='13701087609', updateTime=1788923514106, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304403017982300207, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388157621948709, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304403017982300208, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388157621948709, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=6015, endPage=6036, ext={EN=ArticleExt(id=1304388216342212973, articleId=1304388215901811049, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Analysis of research hotspots and prospective trends in Croton tiglium based on knowledge graphs and global patent layout, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective A comprehensive analysis of the research hotspots and prospective trends of Croton tiglium from the perspectives of knowledge graphs and global patents is conducted to provide theoretical basis and reference direction for clinical practice and subsequent in-depth exploration of C. tiglium. Methods C. tiglium was used as the keyword to search four databases: CNKI, Wanfang, VIP, and Web of Science (WOS), and the literature was imported into the NoteExpress literature management software for duplication checking and screening. Excel, CiteSpace, VOSviewer and other softwares were used to conduct a visual analysis of the current status and development trends of C. tiglium research at home and abroad from the dimensions of publication trends, publishing countries, institutions, authors, and keywords. The Incopat patent database was used to search and analyze C. tiglium-related global patent applications from aspects such as patent application trends, global geographical distribution, patent applicants and patent technology fields. Results A total of 1 320 Chinese literature and 1 528 English literature that met the criteria were retrieved. After a preliminary search, a total of 11 004 patents were obtained in the Incopat patent database. After the merger process, 5 196 patents were finally retained. Among them, there are 2 346 domestic patents, accounting for 45.15% of the total, occupying a leading position. In general, the research heat in the field of C. tiglium continues to rise, the number of Chinese and English publications is comparable, and the academic influence at home and abroad is balanced. Among them, the United States has the highest number of publication volume in the world, and China is in the forefront, which are important research force in this field. In terms of scientific research cooperation, Chinese medicine colleges and affiliated medical institutions are the main body at home, with a single research structure and loose institutional cooperation, and there are obvious research barriers. International research relies on transnational scientific research subjects, with close cooperation networks and mature collaboration systems. In terms of research content, the domestic focus is on the traditional pharmacology and clinical application of C. tiglium, with an emphasis on the inheritance of traditional medicinal properties. The international focus is on fundamental and cutting-edge research such as active ingredients and mechanisms of action On the whole, C. tiglium research continues to break through the traditional category, relying on multidisciplinary cross to achieve innovative development, forming a development trend of inheritance and innovation. Conclusion Research in the field of C. tiglium is constantly expanding and deepening. Its research paradigm is undergoing a significant transformation, gradually shifting from the application of traditional Chinese medicine to multi-disciplinary interdisciplinary research and in-depth analysis of molecular mechanisms. China dominates the patent layout among various countries in the C. tiglium field. However, its patent system has significant weaknesses, mainly manifested in the premature expiration of a large number of patents, low technology industrialization, and insufficient commercial expansion capabilities. The research hotspots in Chinese literature focus on the anti-inflammatory pharmacological effects and processing techniques for reducing toxicity of C. tiglium, gradually extending to agricultural applications. Meanwhile, English research hotspots are concentrated on antioxidant activity, chemical taxonomy, and natural product chemistry, with antioxidant research showing significant growth in recent years., authors=JI Tingting, LIN Hehua, CHENG Nuoxi, ZHAO Junyi, XUE Wenxuan, SHI Zheng, WANG Xiaoding, authorsList=JI Tingting, LIN Hehua, CHENG Nuoxi, ZHAO Junyi, XUE Wenxuan, SHI Zheng, WANG Xiaoding, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388216258326892, articleId=1304388215901811049, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于知识图谱与全球专利布局分析巴豆的研究热点及前瞻趋势, columnId=1304140194819629763, journalTitle=中草药, columnName=数据挖掘与循证医学, runingTitle=null, highlight=null, articleAbstract=目的 从知识图谱和全球专利角度对巴豆Croton tiglium的研究热点与前沿领域进行全面分析，为巴豆的临床实践及后续的深入探索提供理论依据和参考方向。方法 以巴豆为关键词检索中国知网（CNKI）、万方（Wanfang）、维普（VIP）、Web of Science（WOS）4个数据库，将文献导入NoteExpress文献管理软件中进行查重和筛选。利用Excel、CiteSpace、VOSviewer等软件，从发文趋势、发文国家、机构、作者、关键词等维度对国内外的巴豆研究现状与发展趋势进行可视化分析。通过Incopat专利数据库从专利申请趋势、全球地域分布、专利申请人及专利技术领域等方面检索并分析巴豆相关全球专利申请情况。结果 共检索到符合标准的中文文献1 320篇，英文文献1 528篇。总体上，巴豆领域研究热度持续上升，中英文发文量相当，国内外学术影响力均衡，其中美国发文量全球最高，中国位居前列，是该领域重要研究力量。科研合作方面，国内以中医药院校及附属医疗机构为主体，研究结构单一、机构协作松散，存在明显研究壁垒；国际研究依托跨国科研主体，合作网络紧密、协作体系成熟。研究内容方面，国内侧重于巴豆传统药理与临床应用等方面，注重传统药用传承；国际聚焦于活性成分、作用机制等基础前沿研究方面。整体而言，巴豆研究不断突破传统范畴，依托多学科交叉实现创新发展，形成了传承与创新并举的发展态势。经初步检索，在Incopat专利数据库中共获得巴豆相关专利11 004件。进行同族合并处理后，最终保留专利5 196件。其中，国内专利2 346项，占总数的45.15%，处于主导地位。结论 巴豆领域的研究正不断拓展和深入，其研究范式正发生显著转变，逐渐由以传统应用为主导演进至多学科交叉融合、分子机制深入阐释的新格局。中国主导了巴豆领域各个国家间的专利布局，然而其专利体系存在显著弱点，主要表现为大量专利过早失效、技术产业化程度不高以及商业化拓展能力不足等。中文研究热点侧重于巴豆的抗炎药理作用及其炮制减毒工艺等方面，并逐步向农业应用领域延伸；而英文研究热点则集中在抗氧化活性、化学分类学及天然产物化学等方向，其中抗氧化研究在近几年表现出显著的增长势头。, authors=计婷婷¹, 林合华², 程锘溪¹, 赵君谊³, 薛文轩³, 施铮³, 王小丁⁴, authorsList=计婷婷, 林合华, 程锘溪, 赵君谊, 薛文轩, 施铮, 王小丁, authorCompany=1 南京中医药大学药学院, 江苏 南京 210023;
2 南京中医药大学中医文化研究院, 江苏 南京 210023;
3 南京中医药大学中医药文献研究院, 江苏 南京 210023;
4 西藏藏医药大学基础部, 西藏 拉萨 850000, correspAuthors=施铮, authorNote=计婷婷: 计婷婷，本科生，研究方向为中医药文献与临床药学。E-mail:orchidting29@126.com 林合华: 林合华，博士，副教授，研究方向为中医药国际传播。E-mail:linhhwhu@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=Wo2ZicTX+kLXvSErR0O9ug==, pdfFileSize=2152033, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目 (81904322))}, authors=null, keywords=[Keyword(id=1304402050016637193, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=CN, orderNo=1, keyword=巴豆), Keyword(id=1304402050092134666, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=CN, orderNo=2, keyword=CiteSpace), Keyword(id=1304402050171826443, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=CN, orderNo=3, keyword=VOSviewer), Keyword(id=1304402050264101132, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=CN, orderNo=4, keyword=知识图谱), Keyword(id=1304402050339598605, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=CN, orderNo=5, keyword=专利布局), Keyword(id=1304402050410901774, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=CN, orderNo=6, keyword=炮制减毒), Keyword(id=1304402050486399247, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=CN, orderNo=7, keyword=抗炎), Keyword(id=1304402050666754320, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=EN, orderNo=1, keyword=Croton tiglium L.), Keyword(id=1304402050742251793, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=EN, orderNo=2, keyword=CiteSpace), Keyword(id=1304402050830332178, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=EN, orderNo=3, keyword=VOSviewer), Keyword(id=1304402050897441043, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=EN, orderNo=4, keyword=knowledge graph), Keyword(id=1304402050977132820, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=EN, orderNo=5, keyword=patent layout), Keyword(id=1304402051048435989, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=EN, orderNo=6, keyword=processing to reduce toxicity), Keyword(id=1304402051111350550, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388215901811049, language=EN, orderNo=7, keyword=anti-inflammatory)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.15.019, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.15.019, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.15.019, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.15.019, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788919985031, fullTextJson=null, articleText=null, reference=吴普. 神农本草经[M]. 南宁: 广西科学技术出版社, 2016: 139.
缪希雍. 神农本草经疏[M]. 郑金生, 校注. 北京: 中医古籍出版社, 2002: 373.
清·汪讱庵. 本草易读[M]. 北京: 人民卫生出版社, 1987: 304.
倪朱谟. 本草汇言[M]. 戴慎，陈仁寿，虞舜, 点校. 上海: 上海科学技术出版社, 2005: 617.
陈琼如, 夏清青, 张宇锋, 等. 基于知识图谱和全球专利的贝母属植物研究现状与发展趋势的可视化分析[J]. 中草药, 2025, 56(22): 8296-8314.
Genomatica Incorporated. Microorganisms for producing butadiene and related methods: USA, US20190127764A1[P]. 2019-05-02.
Genomatica Incorporated. Microorganisms and biosynthetic methods of butadiene: Australia, AU2019204872A1[P]. 2019-07-25.
Genomatica Incorporated. Phosphoketolase variants and methods of use: USA, US20240218346A1[P]. 2024-07-04.
Hoechst Aktiengesellschaft. N-phenyl-2-cyano-3-hydroxycrotonamide derivatives and their use as medicaments with immunomodulatory properties: South Africa, ZA928159A, [P]. 1993-08-04.
Hoechst Aktiengesellschaft. Crotonate-containing copolymers, preparation method thereof and use thereof: Japan, JP08030101B2[P]. 1996-03-27.
Hoechst Aktiengesellschaft. Isoxazole and crotonamide derivatives for use in medical treatment of cancer diseases: Japan, JP09165336A [P]. 1997-06-24.
Hoechst Aktiengesellschaft. Medicaments for the treatment of skin diseases: Germany, DE69419954D1[P]. 1999-09-16.
Global Bioenergies. Improved process for producing isobutene from 3-methylcrotonic acid: WIPO, WO2022136207A1[P]. 2022-06-30.
Global Bioenergies. Acyl-CoA hydrolase variants: EPO, EP4448779A1[P]. 2024-10-23.
Global Bioenergies. 3-methylcrotonic acid decarboxylase (MDC) variants: USA, US11293016B2[P]. 2022-04-05.
Global Bioenergies. Biogenic isododecane-based cosmetic compositions and preparation method thereof: EPO, EP4149413A1[P]. 2023-03-22.
曾凤. 《金匮要略》九痛丸文献考证[J]. 北京中医药大学学报, 2021, 44(8): 700-703.
楚毓博, 濮文渊, 杨青青, 等. 基于网络药理学探究三物白散治疗胃癌的机制[J]. 中成药, 2020, 42(10): 2778-2785.
周祖兵, 刘毅, 刘兰, 等. 五积丸治疗腹部肿瘤的可行性分析[J]. 中华中医药杂志, 2017, 32(7): 3263-3265.
赖冬梅, 张晓轩, 欧阳惠欣, 等. 基于古籍整理的巴豆外用治疗咽痛研究[J]. 中国中医药信息杂志, 2016, 23(12): 38-40.
郭仲魁, 郭利东. 三物小白散治疗肠不全梗阻2例[J]. 新中医, 2009, 41(7): 57.
唐晓龙, 金庆江, 王瑞平, 等. 基于反向分子对接和网络药理学预测木兰花碱抗肿瘤的潜在作用机制[J]. 世界科学技术—中医药现代化, 2021, 23(4): 1108-1118.
王廷旭, 张原, 黄陈. 新型蛋白质翻译后修饰在胃肠肿瘤中的作用及分子机制[J]. 中国生物化学与分子生物学报, 2026, 42(3): 370-378.
袁超, 姜佳辰, 孔思琪, 等. 基于网络药理学和动物实验探讨桔梗白散治疗肺腺癌作用机制[J]. 中国中医药信息杂志, 2024, 31(9): 33-40.
许群, 方轶萍, 赵小迎. 巴豆生物碱诱导Hela细胞凋亡及其作用机制[J]. 中国生化药物杂志, 2010, 31(6): 392-395.
周咏明, 黄炜祺, 江高峰, 等. IKKα和IKKβ信号通路在肿瘤中的作用机制及其相关药物研究进展[J]. 中国新药杂志, 2020, 29(20): 2321-2330.
李文儒, 时庆欣, 胡家豪, 等. 巴豆烷型二萜及该类化合物抗HIV活性的构效关系和作用机制研究进展[J]. 药学学报, 2025, 60(5): 1354-1365.
胡静, 秦贝贝, 马琳, 等. 巴豆化学成分、药理作用及其质量标志物预测分析[J]. 中草药, 2021, 52(21): 6743-6754.
陈俊仁, 王代波, 李轶, 等. 巴豆油治疗寒积便秘的“毒-效”关系研究[J]. 世界科学技术—中医药现代化, 2023, 25(9): 3164-3173.
曾宝, 唐君苹, 唐本钦, 等. 巴豆油中佛波醇类成分的HPLC指纹图谱[J]. 中国实验方剂学杂志, 2016, 22(14): 89-92.
牛欣怡, 裴小捷, 陆赛健, 等. 灵芝-巴豆双向发酵产物“灵巴菌质”中1个新的佛波醇化合物[J]. 中国中药杂志, 2026, 51(8): 2240-2248.
杨舜伊, 袁纯红. 巴豆属二萜化学成分和药理活性研究新进展[J]. 中国野生植物资源, 2021, 40(8): 32-40.
孙颂三, 赵燕洁, 袁士琴. 巴豆霜对抗炎、免疫、镇痛及致突变的影响[J]. 中药药理与临床, 1993, 9(3): 36-38.
岳云, 王佩佩, 袁兆鹤, 等. 巴豆霜干预脑缺血再灌注损伤大鼠皮质区JNK/p38 MAPK及神经元凋亡的机制[J]. 中国组织工程研究, 2024, 28(8): 1186-1192.
王利蒙, 李翔, 杨陟华, 等. 巴豆醛诱导人支气管上皮细胞(BEAS-2B)自噬及相关通路的时间效应变化[J]. 烟草科技, 2017, 50(10): 35-41.
张淑曼, 张琦, 张彪, 等. 巴豆醛亚慢性染毒致雄性大鼠肝脏氧化损伤与炎性作用[J]. 中国职业医学, 2020, 47(4): 396-401.
林赓, 李双双, 张志虎, 等. 巴豆醛亚慢性染毒致雄性大鼠肺组织细胞焦亡研究[J]. 中国职业医学, 2019, 46(5): 564-571.
刘兴余, 杨陟华, 潘秀颉, 等. 巴豆醛诱导人支气管上皮细胞凋亡研究[J]. 烟草科技, 2011, 44(1): 36-42.
吕俣颉, 陈惠琴, 王昊, 等. 银叶巴豆枝叶化学成分及其生物活性研究[J]. 中成药, 2025, 47(7): 2249-2254.
王明艳, 瞿融, 许冬青. 巴豆生物碱诱导人胃腺癌SGC-7901细胞凋亡的研究[J]. 南京中医药大学学报, 2010, 26(5): 368-369.
武晓, 谷勤勤, 于淼淼, 等. 巴豆生物碱对Lewis小鼠肺腺癌细胞生长和凋亡的影响及机制研究[J]. 中国现代医学杂志, 2022, 32(15): 59-66.
陈武, 陈鹏英, 刘鹏, 等. 巴豆生物碱对人肝癌SMMC-7721细胞凋亡及Bax, Bcl-2蛋白表达的影响[J]. 中国实验方剂学杂志, 2011, 17(11): 199-201.
赵小迎, 陈俊, 蔡平生. 巴豆生物碱抑制卵巢癌细胞增殖和诱导其凋亡的实验研究[J]. 中国全科医学, 2010, 13(21): 2345-2348.
王莉兰, 徐中驰, 凌云, 等. 三物白散含药血清通过TGF-β/Smad通路抑制TGF-β1诱导的人胃癌SGC-7901细胞上皮间质转化[J]. 中国实验方剂学杂志, 2022, 28(21): 66-73.
徐力, 王明艳, 许冬青, 等. 三物白散加味方癌化学预防作用实验研究[J]. 时珍国医国药, 2005, 16(12): 1226-1227.
徐力, 王明艳, 许冬青, 等. 三物白散加味方对正常细胞突变凋亡及肝功能的影响[J]. 辽宁中医杂志, 2005, 32(10): 1000-1001.
王怡珍, 梁绿圆, 曹佳蕾, 等. 经典名方金铃子散关键信息考证与现代研究进展[J]. 中国实验方剂学杂志, 2024, 30(24): 215-223.
蔡江. 王氏保赤丸在儿科的临床运用[J]. 中医杂志, 2010, 51(S2): 84.
李恩庆, 山艳春, 陈孝银. 《备急千金要方》中小儿癖结胀满证治特色[J]. 四川中医, 2003, 21(11): 8-9.)