Article(id=1304388198961009135, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388049975137100, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.11.020, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1760976000000, receivedDateStr=2025-10-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788919980992, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788919980992, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788919980992, creator=13701087609, updateTime=1788919980992, updator=13701087609, issue=Issue{id=1304388049975137100, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='11', pageStart='4089', pageEnd='4508', issueExtLink='null', onlineDate='null', pubDate='1781193600000', pubDateStr='2026-06-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788919945471, creator='13701087609', updateTime=1788923432386, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304402675202805770, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388049975137100, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304402675207000075, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388049975137100, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=4319, endPage=4338, ext={EN=ArticleExt(id=1304388200932332018, articleId=1304388198961009135, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Research progress on yin-nourishing traditional Chinese medicines in prevention and treatment of tumor based on bibliometrics, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To conduct a bibliometric analysis of the relevant literature on traditional Chinese medicine with nourishing-yin properties for tumor prevention and treatment published both domestically and internationally over the past 20 years, with the intention of providing references for the pharmacological effects and scientific connotations of such traditional Chinese medicine in tumor prevention and treatment. Methods The relevant literature was obtained from the databases of China National Knowledge Infrastructure (CNKI), Wanfang Data, and Web of Science (WOS). Using bibliometrics and visualization research tools such as NoteExpress, CiteSpace, VOSviewer, and Gephi, the publication volume, countries, institutions, authors, and keywords of the selected literature were analyzed to form visualization results and analyze the current research status, hotspots, and trends. Results The analysis of publication volume shows that the research on yin-nourishing traditional Chinese medicine in tumor prevention and treatment has been increasing year by year. Currently, Chinese literature is the main body of research literature in this field. Maidong (Ophiopogonis Radix), Shihu (Dendrobii Caulis), and Gouqizi (Lycii Fructus) are the most frequently studied yin-nourishing traditional Chinese medicines in this field. The analysis of the countries and institutions that published papers indicates that the country with the most research publications in this field is China, and the dominant forces are Chinese medical colleges and hospital units. The analysis of authors’ publications shows that there is no core author group formed between domestic and international authors, and the research force in this field presents a diversified situation. The keyword analysis indicates that the research in this field mainly focuses on lung cancer, active ingredients, pharmacological effects, etc., while the medication pattern, data mining, mechanism of action, cell cycle regulation, and Lycium barbarum polysaccharides are the research hotspots in recent years. Conclusion Research on the prevention and treatment of tumors with yin-nourishing traditional Chinese medicine is still in an upward development stage at present. The research focus is on the study of the material basis and mechanism of action of yin-nourishing traditional Chinese medicines in preventing and treating tumors, as well as the research on clinical application experience and innovation in research methods., authors=YAO Ziheng, WEN Xiaoli, MING Liangshan, FAN Qimeng, LIU Hongning, authorsList=YAO Ziheng, WEN Xiaoli, MING Liangshan, FAN Qimeng, LIU Hongning, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388199313330672, articleId=1304388198961009135, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于文献计量学的滋阴中药防治肿瘤作用研究进展, columnId=1304140194819629763, journalTitle=中草药, columnName=数据挖掘与循证医学, runingTitle=null, highlight=null, articleAbstract=目的 对近20年国内外滋阴中药防治肿瘤相关文献进行计量学分析,为滋阴中药防治肿瘤的药理作用和科学内涵提供参考。方法 通过检索中国知网(CNKI)、万方数据库(Wanfang Data)和Web of Science(WOS)数据库获取相关文献信息,利用NoteExpress、CiteSpace、VOSviewer、Gephi等文献计量学和可视化研究工具对筛选后文献的发文量、国家、机构、作者、关键词等进行分析,形成可视化图表结果,分析其研究现状、热点及趋势。结果 滋阴中药防治肿瘤的研究呈现逐年递增趋势,目前中文文献是该领域研究文献的主体,麦冬、石斛、枸杞子是该领域研究最多的滋阴中药。该领域研究发文量最多的国家为中国,主导力量是中国的医药类院校和医院单位。国内外作者之间均未形成核心作者群,领域研究力量呈现多元化现状。该领域研究主要集中在肺癌、有效成分、药理作用等方向,而用药规律、数据挖掘、作用机制、细胞周期调控、枸杞多糖等是近年来的研究热点。结论 滋阴中药防治肿瘤领域研究目前仍处于上升发展阶段,研究前沿聚焦于滋阴中药防治肿瘤的物质基础及作用机制、临床用药经验和方法创新等方面。, authors=姚子恒1, 温晓梨1, 明良山2, 樊启猛2, 刘红宁1,2, authorsList=姚子恒, 温晓梨, 明良山, 樊启猛, 刘红宁, authorCompany=1 江西中医药大学 江西省中医病因学重点实验室&中医基础理论分化发展研究中心, 江西 南昌 330004; 2 江西中医药大学高等研究院, 江西 南昌 330004, correspAuthors=刘红宁, authorNote=姚子恒: 姚子恒,硕士研究生,从事中药药理研究。E-mail:yaoziheng213@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=RoU+mjn42p9zTKBGu6P0Gg==, pdfFileSize=2203857, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=中央本级重大增减支项目 (2060302); 国家中医药管理局科技项目 (GZY-KJS-2023-021); 江西中医药大学重大项目培育项目 (2023ZDPY002); 江西中医药大学2025年大学生创新创业训练计划项目 (202510412255))}, authors=[Author(id=1307432473290367617, tenantId=1146029695717560320, journalId=null, articleId=1304388198961009135, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={EN=AuthorExt(id=null, tenantId=null, journalId=1302319053441957962, articleId=1304388198961009135, authorId=1307432473290367617, language=EN, stringName=YAO Ziheng, WEN Xiaoli, MING Liangshan, FAN Qimeng, LIU Hongning, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=null, tenantId=null, journalId=1302319053441957962, articleId=1304388198961009135, authorId=1307432473290367617, language=CN, stringName=姚子恒, 温晓梨, 明良山, 樊启猛, 刘红宁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=null)], keywords=[Keyword(id=1304401358778561206, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=CN, orderNo=1, keyword=滋阴中药), Keyword(id=1304401358849864375, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=CN, orderNo=2, keyword=肿瘤防治), Keyword(id=1304401358904390328, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=CN, orderNo=3, keyword=文献计量学), Keyword(id=1304401358979887801, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=CN, orderNo=4, keyword=用药规律), Keyword(id=1304401359072162490, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=CN, orderNo=5, keyword=麦冬), Keyword(id=1304401359135077051, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=CN, orderNo=6, keyword=石斛), Keyword(id=1304401359227351740, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=CN, orderNo=7, keyword=枸杞子), Keyword(id=1304401359399318205, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=EN, orderNo=1, keyword=yin-nourishing traditional Chinese medicines), Keyword(id=1304401359474815678, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=EN, orderNo=2, keyword=tumor prevention and treatment), Keyword(id=1304401359537730239, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=EN, orderNo=3, keyword=bibliometrics), Keyword(id=1304401359600644800, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=EN, orderNo=4, keyword=medication rules), Keyword(id=1304401359680336577, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=EN, orderNo=5, keyword=Ophiopogonis Radix), Keyword(id=1304401359768416962, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=EN, orderNo=6, keyword=Dendrobii Caulis), Keyword(id=1304401359852303043, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388198961009135, language=EN, orderNo=7, keyword=Lycii Fructus)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.11.020, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.11.020, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.11.020, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.11.020, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788919980992, fullTextJson=null, articleText=null, reference=Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2024, 74(3): 229-263. 樊启猛, 贺嫣然, 明良山, 等. 滋阴中药活性成分抗肿瘤作用及机制研究进展[J]. 中国实验方剂学杂志, 2025, 31(20): 252-265. 饶斌, 余功, 谢斌, 等. 肿瘤的发病特点及其阴虚病机归属初探[J]. 时珍国医国药, 2015, 26(6): 1435-1437. Lai W W, Ning Q, Wang G H, et al. Antitumor activity of Polygonatum sibiricum polysaccharides [J]. Arch Pharmacal Res, 2024, 47(8): 696-708. Wang H Y, Ge J C, Zhang F Y, et al. Dendrobium officinale polysaccharide promotes M1 polarization of TAMs to inhibit tumor growth by targeting TLR2[J]. Carbohydr Polym, 2022, 292: 119683. Liu Q, Lu J J, Hong H J, et al. Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms [J]. Phytomedicine, 2023, 113: 154718. Ma W J, Zhou Y B, Lou W J, et al. Mechanism regulating the inhibition of lung cancer A549 cell proliferation and structural analysis of the polysaccharide Lycium barbarum [J]. Food Biosci, 2022, 47: 101664. 郑里翔, 张玉仁, 邓科穗, 等. 二至汤对阴虚阳虚荷瘤小鼠肿瘤生长的影响[J]. 陕西中医, 2008, 29(12): 1678-1680. 余文燕, 王国娟, 王桦影, 等. 二至丸对结肠癌细胞增殖及凋亡作用的实验研究[J]. 中药药理与临床, 2018, 34(4): 11-15. Yin D, Li M, Xiang P. Mapping research performance and hotspots on nanoparticles in cardiovascular diseases [J]. Medicine, 2023, 102(15): e33520. Jia N, Zhang H Y, Gao H S, et al. Research hotspots and frontier prospects in the field of agroforestry picking robots in China: Cite space bibliographic analysis [J]. Forests, 2023, 14(9): 1874. 钟赣生, 杨柏灿. 中药学[M]. 第5版. 北京: 中国中医药出版社, 2021: 390-402. 中国药典[S]. 一部. 2025. Luo X M, Wu Y D, Niu L N, et al. Bibliometric analysis of health technology research: 1990—2020[J]. Int J Environ Res Public Health, 2022, 19(15): 9044. Li J, Xue E Y, Liu B Y, et al. Impact of COVID-19 on the psychological and behavioral health of college students worldwide: A knowledge mapping approach [J]. Humanit Soc Sci Commun, 2024, 11: 1353. 萧子健, 涂依如, 钟惠米, 等. 基于文献计量学的挥发油薄膜包装研究进展可视化分析[J]. 包装工程, 2025, 46(7): 224-233. You Y P, Shou X T, Zhang X S, et al. Psycho-cardiological disease: A bibliometric review from 2001 to 2021[J]. Front Cardiovasc Med, 2022, 9: 890329. Pei Z R, Chen S T, Ding L Q, et al. Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis [J]. J Control Release, 2022, 352: 211-241. Rejeb A, Abdollahi A, Rejeb K, et al. Drones in agriculture: A review and bibliometric analysis [J]. Comput Electron Agric, 2022, 198: 107017. 黄海港, 何利华. 退役锂电池回收知识图谱分析[J]. 中国有色金属学报, 2021, 31(7): 1965-1978. 吕丽婷, 于霞, 张金梅, 等. 脑衰老与外泌体研究进程及现状的文献计量学分析[J]. 中国组织工程研究, 2025, 29(7): 1457-1465. 陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253. 凌金忠, 李珊珊, 朱国旗, 等. 人参的文献计量学研究: 热点与趋势分析[J]. 中草药, 2024, 55(17): 5952-5963. 李杰, 陈超美. CiteSpace: 科技文本挖掘及可视化[M]. 第3版. 北京: 首都经济贸易大学出版社, 2022: 86. 沈元良, 章继民. 吴良村教授从组方规律论治恶性肿瘤经验探析[J]. 中华中医药学刊, 2011, 29(8): 1720-1721. 王文成. 吴良村教授治疗肺癌常用药对[J]. 中华中医药杂志, 2015, 30(4): 1121-1123. 李烨, 孙磊涛, 沈敏鹤. 吴良村教授治疗脑肿瘤常用药对[J]. 时珍国医国药, 2020, 31(2): 461-463. 王文成, 王彬彬. 吴良村应用“肝体阴而用阳”理论治疗原发性肝癌经验[J]. 辽宁中医杂志, 2015, 42(7): 1195-1197. 王颖, 吴群, 欧阳思露, 等. 国医大师刘尚义教授临证治疗恶性肿瘤常用药对研究[J]. 中华中医药学刊, 2021, 39(12): 42-45. 黄雯琪, 杨兵, 王镜辉, 等. 基于疡科与中医肿瘤的联系浅析国医大师刘尚义“从膜论治,引疡入瘤”理论[J]. 辽宁中医杂志, 2024, 51(1): 19-22. 唐东昕, 杨柱, 刘尚义. 刘尚义“引疡入瘤、从膜论治”学术观点在肿瘤诊治中的应用[J]. 中医杂志, 2016, 57(20): 1732-1734. 黄雯琪, 龙奉玺, 罗莉, 等. 探析国医大师刘尚义“从膜论治”学术思想理论来源及发展轨迹[J]. 辽宁中医杂志, 2019, 46(2): 282-283. 刘声, 吴洁, 王逊, 等. 孙桂芝病证结合辨证在肿瘤治疗中的应用[J]. 世界中医药, 2024, 19(9): 1307-1311. 顾恪波, 王逊, 何立丽, 等. 孙桂芝教授从六气化火说探讨恶性肿瘤病因病机[J]. 中华中医药杂志, 2013, 28(3): 709-711. 王振华, 孙桂芝. 孙桂芝治疗肺癌经验[J]. 辽宁中医杂志, 2010, 37(5): 791-793. 李柳, 程海波, 叶放, 等. 从病机辨证探析国医大师周仲瑛复法组方辨治肿瘤的经验[J]. 南京中医药大学学报, 2021, 37(5): 765-768. 王松, 李正钧, 杨涛, 等. 国医大师周仲瑛辨治肺癌的中医药本体构建研究[J]. 世界科学技术—中医药现代化, 2022, 24(2): 495-501. 周奎龙, 史锁芳. 国医大师周仲瑛复法大方治疗恶性肿瘤经验[J]. 中华中医药杂志, 2016, 31(12): 5061-5064. 赵延华, 周仲瑛, 吴勉华, 等. 基于癌毒理论探讨“抗癌解毒药”[J]. 中华中医药杂志, 2022, 37(12): 7146-7149. 补娟娟, 豆晓云, 孙萌, 等. 基于复合病机论探讨国医大师周仲瑛原发性肝癌辨治思路[J]. 中华中医药学刊, 2025, 43(2): 80-83. 许海柱, 徐振晔, 陈佩晶. 基于数据挖掘探析徐振晔教授治疗肺癌脾肾两虚证的用药规律[J]. 世界科学技术-中医药现代化, 2023, 25(4): 1217-1223. 徐琪玥, 徐振晔, 顾贤. 基于徐振晔教授“脾虚精亏”理论治疗肠癌术后腹泻临床诊治思维[J]. 世界科学技术-中医药现代化, 2023, 25(4): 1211-1216. 周卫东, 韩丹. 数据挖掘徐振晔治疗非小细胞肺癌病案证型特点及用药规律[J]. 辽宁中医杂志, 2014, 41(7): 1398-1402. 饶志璟, 王中奇, 邓海滨, 等. 徐振晔教授经方辨治恶性肿瘤验案撷英[J]. 世界科学技术-中医药现代化, 2023, 25(4): 1205-1210. 胡凤山, 张青. 基于“治未病”理论的“肿瘤内虚学说” [J]. 中医杂志, 2011, 52(19): 1630-1632. 马云飞, 孙旭, 杨永, 等. 名老中医郁仁存治疗原发性肝癌经验拾萃[J]. 辽宁中医杂志, 2017, 44(12): 2505-2506. 富琦, 张青. 郁仁存应用清热解毒药物治疗肿瘤经验[J]. 中医杂志, 2014, 55(21): 1815-1817. 唐武军, 王笑民. 郁仁存治疗肿瘤“内虚学说”初探[J]. 北京中医药, 2011, 30(3): 186-188. 田建辉, 席志超, 罗斌, 等. “扶正治癌”理论的科学内涵[J]. 世界科学技术—中医药现代化, 2019, 21(5): 943-948. 余永鑫, 孙明瑜. 国医大师刘嘉湘运用中气理论辨治肿瘤临证撷菁[J]. 中华中医药杂志, 2023, 38(9): 4171-4175. 田建辉, 刘嘉湘. 刘嘉湘恶性肿瘤攻邪法度探讨[J]. 中医杂志, 2017, 58(2): 104-107. 顾军花, 刘嘉湘. 刘嘉湘教授“扶正治癌”理论核心及运用方法[J]. 中国中西医结合杂志, 2017, 37(4): 495-499. 姜晓晨, 张传龙, 刘福栋, 等. 朴炳奎病证结合诊治肺癌经验撷要[J]. 中华中医药杂志, 2023, 38(12): 5865-5870. 王桂彬, 庞博, 潘雪, 等. 朴炳奎肺癌诊治方药心法纵论[J]. 中华中医药杂志, 2024, 39(7): 3455-3461. 张孝刚, 胡帅航, 田培裕, 等. 朴炳奎治疗肿瘤常用药组探析[J]. 中医杂志, 2021, 62(16): 1395-1399. 王常松. 朴炳奎治疗肿瘤学术思想浅析[J]. 中华中医药杂志, 2021, 36(1): 221-223. 刘福栋, 姜晓晨, 李奕, 等. 全国名中医朴炳奎诊治肺癌辨证体系构建[J]. 世界中医药, 2025, 20(4): 665-670. Yang X M, Sun J L, Wen B, et al. Biejiajian Pill promotes the infiltration of CD8+ T cells in hepatocellular carcinoma by regulating the expression of CCL5[J]. Front Pharmacol, 2021, 12: 771046. 文彬, 孙海涛, 贺松其, 等. 鳖甲煎丸对Wnt信号通路中β-catenin/TCF4复合物活性及信号分子cyclin D1、MMP-2的影响[J]. 南方医科大学学报, 2014, 34(12): 1758-1762. 张荣花, 李尹凡, 李以恒, 等. 鳖甲煎丸通过PI3K/AKT通路对胰腺癌细胞增殖、迁移及侵袭能力的影响[J]. 郑州大学学报: 医学版, 2025, 60(4): 509-514. 孙阳, 吴勃岩, 车艳新, 等. 鳖甲煎丸诱导肝癌细胞凋亡及对STAT信号通路的影响[J]. 时珍国医国药, 2016, 27(4): 849-851. Wu H, Sun W, Zeng Z Y, et al. Baihe Gujin Decoction attenuates idiopathic pulmonary fibrosis via regulating proline metabolism [J]. J Ethnopharmacol, 2025, 349: 119934. 赵晶磊, 闫琪. 百合固金汤联合化疗治疗晚期非小细胞肺癌肺肾阴虚证临床研究[J]. 新中医, 2024, 56(17): 160-165. 李洪智, 高娴, 曹小九, 等. 加味百合固金汤对利福平敏感肺阴亏虚型肺结核CD4+ T细胞亚群及预后的影响分析[J]. 中华中医药学刊, 2025, 43(10): 37-40. Zheng Y Y, Yang S C, Si J C, et al. Shashen-Maidong Decoction inhibited cancer growth under intermittent hypoxia conditions by suppressing oxidative stress and inflammation [J]. J Ethnopharmacol, 2022, 299: 115654. 余霖, 周燕萍, 周姝含, 等. 沙参麦冬汤对Lewis肺癌模型肾损伤小鼠氧化应激、炎症、凋亡的影响[J]. 时珍国医国药, 2023, 34(2): 317-320. 杨忠光, 梁鑫, 赵远桥. 沙参麦冬汤联合化疗对气阴两虚型肺癌患者免疫功能及炎性反应的影响[J]. 中国实验方剂学杂志, 2017, 23(16): 158-163. 祝宏江, 庞立健, 王天娇, 等. 沙参麦冬汤治疗肺系疾病研究进展及其质量标志物(Q-marker)预测分析[J]. 中华中医药学刊, 2025, 43(8): 149-158. 王红兵, 蒲志忠, 邓彬, 等. 青蒿鳖甲汤对肺癌骨转移患者细胞因子的影响[J]. 世界中医药, 2018, 13(3): 665-668. 成欣, 韩鑫龙, 谭晓梅, 等. 青蒿鳖甲汤对肝癌模型小鼠代谢的影响[J]. 世界科学技术—中医药现代化, 2021, 23(3): 662-670. 陈竹, 黄礼明, 唐志宇, 等. 青蒿鳖甲汤含药血清对AML-CR患者CD34+细胞源DC诱导过程中TNF-α的影响[J]. 时珍国医国药, 2015, 26(1): 7-8. 张洁, 梁平, 李建波, 等. 青蒿鳖甲汤加减治疗癌性发热疗效及对NF-κB p65蛋白、IL-6、IL-10、TNF-α的影响[J]. 中华中医药学刊, 2023, 41(5): 220-223. Zhang Z P, Liu S H, Yao W, et al. Maimendong Decoction inhibits lung cancer metastasis by increasing the proportion and killing activity of NK cells [J]. J Ethnopharmacol, 2025, 338: 119127. 杨晓慧, 臧海洋, 顾小侠, 等. 麦门冬汤基于调节肿瘤相关巨噬细胞表型抑制肺癌增殖转移的机制研究[J]. 辽宁中医杂志, 2022, 49(9): 148-151. 方芳, 吴万垠, 杨春旭, 等. 麦门冬汤加减方联合顺铂对Lewis肺癌移植瘤模型小鼠的抑瘤作用及机制研究[J]. 中国药房, 2019, 30(9): 1226-1230. 蒋时红, 孙超龙, 刘燕, 等. 麦门冬汤诱导人肺腺癌A549细胞凋亡作用及其机制[J]. 中华中医药杂志, 2015, 30(4): 1236-1238. 李春杰, 孙建立, 刘苓霜, 等. 益气养阴方对C57小鼠Lewis肺癌ERα及CyclinD1表达的影响[J]. 中华中医药杂志, 2010, 25(4): 578-581. 祝龙, 詹其林, 王飞娟, 等. 益气养阴方灌胃在白血病大鼠中的作用机制及对白血病抑制因子影响的研究[J]. 中华中医药学刊, 2020, 38(5): 212-214. 张树森, 徐瑞荣, 王兆华, 等. 益气养阴方及其拆方对急性髓系白血病细胞细胞凋亡及Cyt-C, Apaf-1, Smac/Diablo, AIF表达的影响[J]. 中国实验方剂学杂志, 2017, 23(5): 95-100. 乔志安. 益气养阴方联合放疗对晚期肺癌患者肿瘤负荷及抗肿瘤免疫应答的影响[J]. 海南医学院学报, 2018, 24(1): 75-78. Fang Z R, Xue Y J, Leng Y Z, et al. Erzhi pills reverse PD-L1-mediated immunosuppression in melanoma microenvironment [J]. Heliyon, 2024, 10(3): e24988. Qi Y, Li P, Li B Q, et al. Integrating of serum pharmacochemistry, metabolomics, and experimental validation to explore the mechanism of Erzhi Pill against triple-negative breast cancer [J]. J Ethnopharmacol, 2025, 353: 120287. 尚广彬, 曾莉萍, 赵益, 等. 二至丸对诱发性乳腺癌组织中VEGF和MMP-9表达的影响[J]. 中国实验方剂学杂志, 2013, 19(13): 270-273. Liu M Q, Bao C J, Liang X F, et al. Specific molecular weight of Lycium barbarum polysaccharide for robust breast cancer regression by repolarizing tumor-associated macrophages [J]. Int J Biol Macromol, 2024, 261: 129674. Zhang K, Zhou X T, Wang J Q, et al. Dendrobium officinale polysaccharide triggers mitochondrial disorder to induce colon cancer cell death via ROS-AMPK-autophagy pathway [J]. Carbohydr Polym, 2021, 264: 118018. Li M, Liu Y M, Zhang H N, et al. Anti-cancer potential of polysaccharide extracted from Polygonatum sibiricum on HepG2 cells via cell cycle arrest and apoptosis [J]. Front Nutr, 2022, 9: 938290. Lu M K, Chang C C, Chao C H, et al. Structural changes, and anti-inflammatory, anti-cancer potential of polysaccharides from multiple processing of Rehmannia glutinosa [J]. Int J Biol Macromol, 2022, 206: 621-632. Li S S, Li Y, Sun H J, et al. Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepato-carcinogenesis in vivo: The roles of cell apoptosis and inflammation [J]. Bioengineered, 2021, 12(2): 11599-11611. Liu W H, Li K X, Zhang H, et al. An antitumor Arabinan from Glehnia littoralis activates immunity and inhibits angiogenesis [J]. Int J Biol Macromol, 2024, 263: 130242. Liu Z W, Cao Y F, Guo X H, et al. The potential role of timosaponin-AIII in cancer prevention and treatment [J]. Molecules, 2023, 28(14): 5500. Li X L, Ma R H, Ni Z J, et al. Dioscin from Polygonatum sibiricum induces apoptosis and autophagy in Ishikawa human endometrial cancer cell and in vivo [J]. Food Sci Hum Wellness, 2024, 13(5): 2601-2616. Zhang F, Zhang X X, Zhang J G, et al. Asparanin A exerts cytotoxicity on human endometrial cancer Ishikawa cells via regulating miR-6236-p5_4 expression [J]. Food Chem Toxicol, 2023, 178: 113900. Zhang F, Zhang Y Y, Ma R H, et al. Multi-omics reveals the anticancer mechanism of Asparagus saponin-asparanin A on endometrial cancer Ishikawa cells [J]. Food Funct, 2021, 12(2): 614-632. Li M, Yu X X, Liu Y J, et al. KRAS/ABHD17C/A LOX15B axis promotes pancreatic cancer progression via ferroptosis evasion [J]. Adv Sci, 2025, 12(35): e04470. Chen P, Wu Q B, Feng J, et al. Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis [J]. Signal Transduct Target Ther, 2020, 5: 51. Ma X, Hu X L, Zhu Y J, et al. Sesamol inhibits proliferation, migration and invasion of triple negative breast cancer via inactivating Wnt/β-catenin signaling [J]. Biochem Pharmacol, 2022, 206: 115299. Jiang H, Niu C Q, Guo Y Q, et al. Wedelolactone induces apoptosis and pyroptosis in retinoblastoma through promoting ROS generation [J]. Int Immunopharmacol, 2022, 111: 108855. Huang H P, Chang Y C, Wu C H, et al. Anthocyanin-rich mulberry extract inhibit the gastric cancer cell growth in vitro and xenograft mice by inducing signals of p38/p53 and c-Jun [J]. Food Chem, 2011, 129(4): 1703-1709. Huang H P, Shih Y W, Chang Y C, et al. Chemoinhibitory effect of mulberry anthocyanins on melanoma metastasis involved in the Ras/PI3K pathway [J]. J Agric Food Chem, 2008, 56(19): 9286-9293. Jung J S, Jung K, Kim D H, et al. Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: Involvement of PI3K/Akt and MAPK signaling pathways [J]. Pharmacol Res, 2012, 66(1): 95-103. Tsai A C, Pan S L, Lai C, et al. The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling [J]. J Nutr Biochem, 2011, 22(7): 625-633. Laurindo L F, Rodrigues V D, Guiguer E L, et al. Catalpol: An iridoid glycoside with potential in combating cancer development and progression: A comprehensive review [J]. Phytother Res, 2025, 39(10): 4950-4971. Yu H, Xu H, Yang X Y, et al. Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase [J]. J Pharm Anal, 2023, 13(9): 1024-1040. Liu B, Cheng Y, Bian H J, et al. Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells [J]. Autophagy, 2009, 5(2): 253-255. Zhang Z T, Peng H, Li C Y, et al. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin [J]. Phytomedicine, 2010, 18(1): 25-31. Ouyang L, Chen Y, Wang X Y, et al. Polygonatum odoratum lectin induces apoptosis and autophagy via targeting EGFR-mediated Ras-Raf-MEK-ERK pathway in human MCF-7 breast cancer cells [J]. Phytomedicine, 2014, 21(12): 1658-1665. Song T H, Chen X X, Lee C K, et al. Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo [J]. Phytomedicine, 2019, 53: 18-27. Kongtawelert P, Wudtiwai B, Shwe T H, et al. Inhibition of programmed death ligand 1(PD-L1) expression in breast cancer cells by sesamin [J]. Int Immunopharmacol, 2020, 86: 106759. Liang J, Li H L, Chen J Q, et al. Dendrobium officinale polysaccharides alleviate colon tumorigenesis via restoring intestinal barrier function and enhancing anti-tumor immune response [J]. Pharmacol Res, 2019, 148: 104417. Wang Z H, Hu Z S. Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice [J]. Biomed Pharmacother, 2018, 103: 1708-1719. Deng Y, Zhong L, Zhao Y, et al. A Dendrobium chrysotoxum extract erianin induce AML cells death by activating PPARɑ and downregulating PI3K/AKT signaling pathways [J]. Toxicon, 2025, 261: 108371. Zhang H, Du X, Sun T T, et al. Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2[J]. Oncol Rep, 2017, 37(3): 1765-1771. Zhang Q N, Qiu M H, Liu J P, et al. Erianin induces apoptosis and pyroptosis via MAPK/ERK and PI3K/Akt pathways and synergizes with anlotinib in anaplastic thyroid carcinoma [J]. Front Pharmacol, 2025, 16: 1596873.)
Research progress on yin-nourishing traditional Chinese medicines in prevention and treatment of tumor based on bibliometrics
YAO Ziheng, WEN Xiaoli, MING Liangshan, FAN Qimeng, LIU Hongning
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.11.020
文章导航
摘要
收起
目的 对近20年国内外滋阴中药防治肿瘤相关文献进行计量学分析,为滋阴中药防治肿瘤的药理作用和科学内涵提供参考。方法 通过检索中国知网(CNKI)、万方数据库(Wanfang Data)和Web of Science(WOS)数据库获取相关文献信息,利用NoteExpress、CiteSpace、VOSviewer、Gephi等文献计量学和可视化研究工具对筛选后文献的发文量、国家、机构、作者、关键词等进行分析,形成可视化图表结果,分析其研究现状、热点及趋势。结果 滋阴中药防治肿瘤的研究呈现逐年递增趋势,目前中文文献是该领域研究文献的主体,麦冬、石斛、枸杞子是该领域研究最多的滋阴中药。该领域研究发文量最多的国家为中国,主导力量是中国的医药类院校和医院单位。国内外作者之间均未形成核心作者群,领域研究力量呈现多元化现状。该领域研究主要集中在肺癌、有效成分、药理作用等方向,而用药规律、数据挖掘、作用机制、细胞周期调控、枸杞多糖等是近年来的研究热点。结论 滋阴中药防治肿瘤领域研究目前仍处于上升发展阶段,研究前沿聚焦于滋阴中药防治肿瘤的物质基础及作用机制、临床用药经验和方法创新等方面。
关键词
滋阴中药
/
肿瘤防治
/
文献计量学
/
用药规律
/
麦冬
/
石斛
/
枸杞子
Abstract
收起
Objective To conduct a bibliometric analysis of the relevant literature on traditional Chinese medicine with nourishing-yin properties for tumor prevention and treatment published both domestically and internationally over the past 20 years, with the intention of providing references for the pharmacological effects and scientific connotations of such traditional Chinese medicine in tumor prevention and treatment. Methods The relevant literature was obtained from the databases of China National Knowledge Infrastructure (CNKI), Wanfang Data, and Web of Science (WOS). Using bibliometrics and visualization research tools such as NoteExpress, CiteSpace, VOSviewer, and Gephi, the publication volume, countries, institutions, authors, and keywords of the selected literature were analyzed to form visualization results and analyze the current research status, hotspots, and trends. Results The analysis of publication volume shows that the research on yin-nourishing traditional Chinese medicine in tumor prevention and treatment has been increasing year by year. Currently, Chinese literature is the main body of research literature in this field. Maidong (Ophiopogonis Radix), Shihu (Dendrobii Caulis), and Gouqizi (Lycii Fructus) are the most frequently studied yin-nourishing traditional Chinese medicines in this field. The analysis of the countries and institutions that published papers indicates that the country with the most research publications in this field is China, and the dominant forces are Chinese medical colleges and hospital units. The analysis of authors’ publications shows that there is no core author group formed between domestic and international authors, and the research force in this field presents a diversified situation. The keyword analysis indicates that the research in this field mainly focuses on lung cancer, active ingredients, pharmacological effects, etc., while the medication pattern, data mining, mechanism of action, cell cycle regulation, and Lycium barbarum polysaccharides are the research hotspots in recent years. Conclusion Research on the prevention and treatment of tumors with yin-nourishing traditional Chinese medicine is still in an upward development stage at present. The research focus is on the study of the material basis and mechanism of action of yin-nourishing traditional Chinese medicines in preventing and treating tumors, as well as the research on clinical application experience and innovation in research methods.
Key words
yin-nourishing traditional Chinese medicines
/
tumor prevention and treatment
/
bibliometrics
/
medication rules
/
Ophiopogonis Radix
/
Dendrobii Caulis
/
Lycii Fructus
YAO Ziheng, WEN Xiaoli, MING Liangshan, FAN Qimeng, LIU Hongning.
Research progress on yin-nourishing traditional Chinese medicines in prevention and treatment of tumor based on bibliometrics[J].
Chinese Traditional and Herbal Drugs,
2026
, 57
(11)
: 4319
-4338
.
DOI: 10.7501/j.issn.0253-2670.2026.11.020
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2024, 74(3): 229-263. 樊启猛, 贺嫣然, 明良山, 等. 滋阴中药活性成分抗肿瘤作用及机制研究进展[J]. 中国实验方剂学杂志, 2025, 31(20): 252-265. 饶斌, 余功, 谢斌, 等. 肿瘤的发病特点及其阴虚病机归属初探[J]. 时珍国医国药, 2015, 26(6): 1435-1437. Lai W W, Ning Q, Wang G H, et al. Antitumor activity of Polygonatum sibiricum polysaccharides [J]. Arch Pharmacal Res, 2024, 47(8): 696-708. Wang H Y, Ge J C, Zhang F Y, et al. Dendrobium officinale polysaccharide promotes M1 polarization of TAMs to inhibit tumor growth by targeting TLR2[J]. Carbohydr Polym, 2022, 292: 119683. Liu Q, Lu J J, Hong H J, et al. Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms [J]. Phytomedicine, 2023, 113: 154718. Ma W J, Zhou Y B, Lou W J, et al. Mechanism regulating the inhibition of lung cancer A549 cell proliferation and structural analysis of the polysaccharide Lycium barbarum [J]. Food Biosci, 2022, 47: 101664. 郑里翔, 张玉仁, 邓科穗, 等. 二至汤对阴虚阳虚荷瘤小鼠肿瘤生长的影响[J]. 陕西中医, 2008, 29(12): 1678-1680. 余文燕, 王国娟, 王桦影, 等. 二至丸对结肠癌细胞增殖及凋亡作用的实验研究[J]. 中药药理与临床, 2018, 34(4): 11-15. Yin D, Li M, Xiang P. Mapping research performance and hotspots on nanoparticles in cardiovascular diseases [J]. Medicine, 2023, 102(15): e33520. Jia N, Zhang H Y, Gao H S, et al. Research hotspots and frontier prospects in the field of agroforestry picking robots in China: Cite space bibliographic analysis [J]. Forests, 2023, 14(9): 1874. 钟赣生, 杨柏灿. 中药学[M]. 第5版. 北京: 中国中医药出版社, 2021: 390-402. 中国药典[S]. 一部. 2025. Luo X M, Wu Y D, Niu L N, et al. Bibliometric analysis of health technology research: 1990—2020[J]. Int J Environ Res Public Health, 2022, 19(15): 9044. Li J, Xue E Y, Liu B Y, et al. Impact of COVID-19 on the psychological and behavioral health of college students worldwide: A knowledge mapping approach [J]. Humanit Soc Sci Commun, 2024, 11: 1353. 萧子健, 涂依如, 钟惠米, 等. 基于文献计量学的挥发油薄膜包装研究进展可视化分析[J]. 包装工程, 2025, 46(7): 224-233. You Y P, Shou X T, Zhang X S, et al. Psycho-cardiological disease: A bibliometric review from 2001 to 2021[J]. Front Cardiovasc Med, 2022, 9: 890329. Pei Z R, Chen S T, Ding L Q, et al. Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis [J]. J Control Release, 2022, 352: 211-241. Rejeb A, Abdollahi A, Rejeb K, et al. Drones in agriculture: A review and bibliometric analysis [J]. Comput Electron Agric, 2022, 198: 107017. 黄海港, 何利华. 退役锂电池回收知识图谱分析[J]. 中国有色金属学报, 2021, 31(7): 1965-1978. 吕丽婷, 于霞, 张金梅, 等. 脑衰老与外泌体研究进程及现状的文献计量学分析[J]. 中国组织工程研究, 2025, 29(7): 1457-1465. 陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253. 凌金忠, 李珊珊, 朱国旗, 等. 人参的文献计量学研究: 热点与趋势分析[J]. 中草药, 2024, 55(17): 5952-5963. 李杰, 陈超美. CiteSpace: 科技文本挖掘及可视化[M]. 第3版. 北京: 首都经济贸易大学出版社, 2022: 86. 沈元良, 章继民. 吴良村教授从组方规律论治恶性肿瘤经验探析[J]. 中华中医药学刊, 2011, 29(8): 1720-1721. 王文成. 吴良村教授治疗肺癌常用药对[J]. 中华中医药杂志, 2015, 30(4): 1121-1123. 李烨, 孙磊涛, 沈敏鹤. 吴良村教授治疗脑肿瘤常用药对[J]. 时珍国医国药, 2020, 31(2): 461-463. 王文成, 王彬彬. 吴良村应用“肝体阴而用阳”理论治疗原发性肝癌经验[J]. 辽宁中医杂志, 2015, 42(7): 1195-1197. 王颖, 吴群, 欧阳思露, 等. 国医大师刘尚义教授临证治疗恶性肿瘤常用药对研究[J]. 中华中医药学刊, 2021, 39(12): 42-45. 黄雯琪, 杨兵, 王镜辉, 等. 基于疡科与中医肿瘤的联系浅析国医大师刘尚义“从膜论治,引疡入瘤”理论[J]. 辽宁中医杂志, 2024, 51(1): 19-22. 唐东昕, 杨柱, 刘尚义. 刘尚义“引疡入瘤、从膜论治”学术观点在肿瘤诊治中的应用[J]. 中医杂志, 2016, 57(20): 1732-1734. 黄雯琪, 龙奉玺, 罗莉, 等. 探析国医大师刘尚义“从膜论治”学术思想理论来源及发展轨迹[J]. 辽宁中医杂志, 2019, 46(2): 282-283. 刘声, 吴洁, 王逊, 等. 孙桂芝病证结合辨证在肿瘤治疗中的应用[J]. 世界中医药, 2024, 19(9): 1307-1311. 顾恪波, 王逊, 何立丽, 等. 孙桂芝教授从六气化火说探讨恶性肿瘤病因病机[J]. 中华中医药杂志, 2013, 28(3): 709-711. 王振华, 孙桂芝. 孙桂芝治疗肺癌经验[J]. 辽宁中医杂志, 2010, 37(5): 791-793. 李柳, 程海波, 叶放, 等. 从病机辨证探析国医大师周仲瑛复法组方辨治肿瘤的经验[J]. 南京中医药大学学报, 2021, 37(5): 765-768. 王松, 李正钧, 杨涛, 等. 国医大师周仲瑛辨治肺癌的中医药本体构建研究[J]. 世界科学技术—中医药现代化, 2022, 24(2): 495-501. 周奎龙, 史锁芳. 国医大师周仲瑛复法大方治疗恶性肿瘤经验[J]. 中华中医药杂志, 2016, 31(12): 5061-5064. 赵延华, 周仲瑛, 吴勉华, 等. 基于癌毒理论探讨“抗癌解毒药”[J]. 中华中医药杂志, 2022, 37(12): 7146-7149. 补娟娟, 豆晓云, 孙萌, 等. 基于复合病机论探讨国医大师周仲瑛原发性肝癌辨治思路[J]. 中华中医药学刊, 2025, 43(2): 80-83. 许海柱, 徐振晔, 陈佩晶. 基于数据挖掘探析徐振晔教授治疗肺癌脾肾两虚证的用药规律[J]. 世界科学技术-中医药现代化, 2023, 25(4): 1217-1223. 徐琪玥, 徐振晔, 顾贤. 基于徐振晔教授“脾虚精亏”理论治疗肠癌术后腹泻临床诊治思维[J]. 世界科学技术-中医药现代化, 2023, 25(4): 1211-1216. 周卫东, 韩丹. 数据挖掘徐振晔治疗非小细胞肺癌病案证型特点及用药规律[J]. 辽宁中医杂志, 2014, 41(7): 1398-1402. 饶志璟, 王中奇, 邓海滨, 等. 徐振晔教授经方辨治恶性肿瘤验案撷英[J]. 世界科学技术-中医药现代化, 2023, 25(4): 1205-1210. 胡凤山, 张青. 基于“治未病”理论的“肿瘤内虚学说” [J]. 中医杂志, 2011, 52(19): 1630-1632. 马云飞, 孙旭, 杨永, 等. 名老中医郁仁存治疗原发性肝癌经验拾萃[J]. 辽宁中医杂志, 2017, 44(12): 2505-2506. 富琦, 张青. 郁仁存应用清热解毒药物治疗肿瘤经验[J]. 中医杂志, 2014, 55(21): 1815-1817. 唐武军, 王笑民. 郁仁存治疗肿瘤“内虚学说”初探[J]. 北京中医药, 2011, 30(3): 186-188. 田建辉, 席志超, 罗斌, 等. “扶正治癌”理论的科学内涵[J]. 世界科学技术—中医药现代化, 2019, 21(5): 943-948. 余永鑫, 孙明瑜. 国医大师刘嘉湘运用中气理论辨治肿瘤临证撷菁[J]. 中华中医药杂志, 2023, 38(9): 4171-4175. 田建辉, 刘嘉湘. 刘嘉湘恶性肿瘤攻邪法度探讨[J]. 中医杂志, 2017, 58(2): 104-107. 顾军花, 刘嘉湘. 刘嘉湘教授“扶正治癌”理论核心及运用方法[J]. 中国中西医结合杂志, 2017, 37(4): 495-499. 姜晓晨, 张传龙, 刘福栋, 等. 朴炳奎病证结合诊治肺癌经验撷要[J]. 中华中医药杂志, 2023, 38(12): 5865-5870. 王桂彬, 庞博, 潘雪, 等. 朴炳奎肺癌诊治方药心法纵论[J]. 中华中医药杂志, 2024, 39(7): 3455-3461. 张孝刚, 胡帅航, 田培裕, 等. 朴炳奎治疗肿瘤常用药组探析[J]. 中医杂志, 2021, 62(16): 1395-1399. 王常松. 朴炳奎治疗肿瘤学术思想浅析[J]. 中华中医药杂志, 2021, 36(1): 221-223. 刘福栋, 姜晓晨, 李奕, 等. 全国名中医朴炳奎诊治肺癌辨证体系构建[J]. 世界中医药, 2025, 20(4): 665-670. Yang X M, Sun J L, Wen B, et al. Biejiajian Pill promotes the infiltration of CD8+ T cells in hepatocellular carcinoma by regulating the expression of CCL5[J]. Front Pharmacol, 2021, 12: 771046. 文彬, 孙海涛, 贺松其, 等. 鳖甲煎丸对Wnt信号通路中β-catenin/TCF4复合物活性及信号分子cyclin D1、MMP-2的影响[J]. 南方医科大学学报, 2014, 34(12): 1758-1762. 张荣花, 李尹凡, 李以恒, 等. 鳖甲煎丸通过PI3K/AKT通路对胰腺癌细胞增殖、迁移及侵袭能力的影响[J]. 郑州大学学报: 医学版, 2025, 60(4): 509-514. 孙阳, 吴勃岩, 车艳新, 等. 鳖甲煎丸诱导肝癌细胞凋亡及对STAT信号通路的影响[J]. 时珍国医国药, 2016, 27(4): 849-851. Wu H, Sun W, Zeng Z Y, et al. Baihe Gujin Decoction attenuates idiopathic pulmonary fibrosis via regulating proline metabolism [J]. J Ethnopharmacol, 2025, 349: 119934. 赵晶磊, 闫琪. 百合固金汤联合化疗治疗晚期非小细胞肺癌肺肾阴虚证临床研究[J]. 新中医, 2024, 56(17): 160-165. 李洪智, 高娴, 曹小九, 等. 加味百合固金汤对利福平敏感肺阴亏虚型肺结核CD4+ T细胞亚群及预后的影响分析[J]. 中华中医药学刊, 2025, 43(10): 37-40. Zheng Y Y, Yang S C, Si J C, et al. Shashen-Maidong Decoction inhibited cancer growth under intermittent hypoxia conditions by suppressing oxidative stress and inflammation [J]. J Ethnopharmacol, 2022, 299: 115654. 余霖, 周燕萍, 周姝含, 等. 沙参麦冬汤对Lewis肺癌模型肾损伤小鼠氧化应激、炎症、凋亡的影响[J]. 时珍国医国药, 2023, 34(2): 317-320. 杨忠光, 梁鑫, 赵远桥. 沙参麦冬汤联合化疗对气阴两虚型肺癌患者免疫功能及炎性反应的影响[J]. 中国实验方剂学杂志, 2017, 23(16): 158-163. 祝宏江, 庞立健, 王天娇, 等. 沙参麦冬汤治疗肺系疾病研究进展及其质量标志物(Q-marker)预测分析[J]. 中华中医药学刊, 2025, 43(8): 149-158. 王红兵, 蒲志忠, 邓彬, 等. 青蒿鳖甲汤对肺癌骨转移患者细胞因子的影响[J]. 世界中医药, 2018, 13(3): 665-668. 成欣, 韩鑫龙, 谭晓梅, 等. 青蒿鳖甲汤对肝癌模型小鼠代谢的影响[J]. 世界科学技术—中医药现代化, 2021, 23(3): 662-670. 陈竹, 黄礼明, 唐志宇, 等. 青蒿鳖甲汤含药血清对AML-CR患者CD34+细胞源DC诱导过程中TNF-α的影响[J]. 时珍国医国药, 2015, 26(1): 7-8. 张洁, 梁平, 李建波, 等. 青蒿鳖甲汤加减治疗癌性发热疗效及对NF-κB p65蛋白、IL-6、IL-10、TNF-α的影响[J]. 中华中医药学刊, 2023, 41(5): 220-223. Zhang Z P, Liu S H, Yao W, et al. Maimendong Decoction inhibits lung cancer metastasis by increasing the proportion and killing activity of NK cells [J]. J Ethnopharmacol, 2025, 338: 119127. 杨晓慧, 臧海洋, 顾小侠, 等. 麦门冬汤基于调节肿瘤相关巨噬细胞表型抑制肺癌增殖转移的机制研究[J]. 辽宁中医杂志, 2022, 49(9): 148-151. 方芳, 吴万垠, 杨春旭, 等. 麦门冬汤加减方联合顺铂对Lewis肺癌移植瘤模型小鼠的抑瘤作用及机制研究[J]. 中国药房, 2019, 30(9): 1226-1230. 蒋时红, 孙超龙, 刘燕, 等. 麦门冬汤诱导人肺腺癌A549细胞凋亡作用及其机制[J]. 中华中医药杂志, 2015, 30(4): 1236-1238. 李春杰, 孙建立, 刘苓霜, 等. 益气养阴方对C57小鼠Lewis肺癌ERα及CyclinD1表达的影响[J]. 中华中医药杂志, 2010, 25(4): 578-581. 祝龙, 詹其林, 王飞娟, 等. 益气养阴方灌胃在白血病大鼠中的作用机制及对白血病抑制因子影响的研究[J]. 中华中医药学刊, 2020, 38(5): 212-214. 张树森, 徐瑞荣, 王兆华, 等. 益气养阴方及其拆方对急性髓系白血病细胞细胞凋亡及Cyt-C, Apaf-1, Smac/Diablo, AIF表达的影响[J]. 中国实验方剂学杂志, 2017, 23(5): 95-100. 乔志安. 益气养阴方联合放疗对晚期肺癌患者肿瘤负荷及抗肿瘤免疫应答的影响[J]. 海南医学院学报, 2018, 24(1): 75-78. Fang Z R, Xue Y J, Leng Y Z, et al. Erzhi pills reverse PD-L1-mediated immunosuppression in melanoma microenvironment [J]. Heliyon, 2024, 10(3): e24988. Qi Y, Li P, Li B Q, et al. Integrating of serum pharmacochemistry, metabolomics, and experimental validation to explore the mechanism of Erzhi Pill against triple-negative breast cancer [J]. J Ethnopharmacol, 2025, 353: 120287. 尚广彬, 曾莉萍, 赵益, 等. 二至丸对诱发性乳腺癌组织中VEGF和MMP-9表达的影响[J]. 中国实验方剂学杂志, 2013, 19(13): 270-273. Liu M Q, Bao C J, Liang X F, et al. Specific molecular weight of Lycium barbarum polysaccharide for robust breast cancer regression by repolarizing tumor-associated macrophages [J]. Int J Biol Macromol, 2024, 261: 129674. Zhang K, Zhou X T, Wang J Q, et al. Dendrobium officinale polysaccharide triggers mitochondrial disorder to induce colon cancer cell death via ROS-AMPK-autophagy pathway [J]. Carbohydr Polym, 2021, 264: 118018. Li M, Liu Y M, Zhang H N, et al. Anti-cancer potential of polysaccharide extracted from Polygonatum sibiricum on HepG2 cells via cell cycle arrest and apoptosis [J]. Front Nutr, 2022, 9: 938290. Lu M K, Chang C C, Chao C H, et al. Structural changes, and anti-inflammatory, anti-cancer potential of polysaccharides from multiple processing of Rehmannia glutinosa [J]. Int J Biol Macromol, 2022, 206: 621-632. Li S S, Li Y, Sun H J, et al. Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepato-carcinogenesis in vivo: The roles of cell apoptosis and inflammation [J]. Bioengineered, 2021, 12(2): 11599-11611. Liu W H, Li K X, Zhang H, et al. An antitumor Arabinan from Glehnia littoralis activates immunity and inhibits angiogenesis [J]. Int J Biol Macromol, 2024, 263: 130242. Liu Z W, Cao Y F, Guo X H, et al. The potential role of timosaponin-AIII in cancer prevention and treatment [J]. Molecules, 2023, 28(14): 5500. Li X L, Ma R H, Ni Z J, et al. Dioscin from Polygonatum sibiricum induces apoptosis and autophagy in Ishikawa human endometrial cancer cell and in vivo [J]. Food Sci Hum Wellness, 2024, 13(5): 2601-2616. Zhang F, Zhang X X, Zhang J G, et al. Asparanin A exerts cytotoxicity on human endometrial cancer Ishikawa cells via regulating miR-6236-p5_4 expression [J]. Food Chem Toxicol, 2023, 178: 113900. Zhang F, Zhang Y Y, Ma R H, et al. Multi-omics reveals the anticancer mechanism of Asparagus saponin-asparanin A on endometrial cancer Ishikawa cells [J]. Food Funct, 2021, 12(2): 614-632. Li M, Yu X X, Liu Y J, et al. KRAS/ABHD17C/A LOX15B axis promotes pancreatic cancer progression via ferroptosis evasion [J]. Adv Sci, 2025, 12(35): e04470. Chen P, Wu Q B, Feng J, et al. Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis [J]. Signal Transduct Target Ther, 2020, 5: 51. Ma X, Hu X L, Zhu Y J, et al. Sesamol inhibits proliferation, migration and invasion of triple negative breast cancer via inactivating Wnt/β-catenin signaling [J]. Biochem Pharmacol, 2022, 206: 115299. Jiang H, Niu C Q, Guo Y Q, et al. Wedelolactone induces apoptosis and pyroptosis in retinoblastoma through promoting ROS generation [J]. Int Immunopharmacol, 2022, 111: 108855. Huang H P, Chang Y C, Wu C H, et al. Anthocyanin-rich mulberry extract inhibit the gastric cancer cell growth in vitro and xenograft mice by inducing signals of p38/p53 and c-Jun [J]. Food Chem, 2011, 129(4): 1703-1709. Huang H P, Shih Y W, Chang Y C, et al. Chemoinhibitory effect of mulberry anthocyanins on melanoma metastasis involved in the Ras/PI3K pathway [J]. J Agric Food Chem, 2008, 56(19): 9286-9293. Jung J S, Jung K, Kim D H, et al. Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: Involvement of PI3K/Akt and MAPK signaling pathways [J]. Pharmacol Res, 2012, 66(1): 95-103. Tsai A C, Pan S L, Lai C, et al. The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling [J]. J Nutr Biochem, 2011, 22(7): 625-633. Laurindo L F, Rodrigues V D, Guiguer E L, et al. Catalpol: An iridoid glycoside with potential in combating cancer development and progression: A comprehensive review [J]. Phytother Res, 2025, 39(10): 4950-4971. Yu H, Xu H, Yang X Y, et al. Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase [J]. J Pharm Anal, 2023, 13(9): 1024-1040. Liu B, Cheng Y, Bian H J, et al. Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells [J]. Autophagy, 2009, 5(2): 253-255. Zhang Z T, Peng H, Li C Y, et al. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin [J]. Phytomedicine, 2010, 18(1): 25-31. Ouyang L, Chen Y, Wang X Y, et al. Polygonatum odoratum lectin induces apoptosis and autophagy via targeting EGFR-mediated Ras-Raf-MEK-ERK pathway in human MCF-7 breast cancer cells [J]. Phytomedicine, 2014, 21(12): 1658-1665. Song T H, Chen X X, Lee C K, et al. Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo [J]. Phytomedicine, 2019, 53: 18-27. Kongtawelert P, Wudtiwai B, Shwe T H, et al. Inhibition of programmed death ligand 1(PD-L1) expression in breast cancer cells by sesamin [J]. Int Immunopharmacol, 2020, 86: 106759. Liang J, Li H L, Chen J Q, et al. Dendrobium officinale polysaccharides alleviate colon tumorigenesis via restoring intestinal barrier function and enhancing anti-tumor immune response [J]. Pharmacol Res, 2019, 148: 104417. Wang Z H, Hu Z S. Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice [J]. Biomed Pharmacother, 2018, 103: 1708-1719. Deng Y, Zhong L, Zhao Y, et al. A Dendrobium chrysotoxum extract erianin induce AML cells death by activating PPARɑ and downregulating PI3K/AKT signaling pathways [J]. Toxicon, 2025, 261: 108371. Zhang H, Du X, Sun T T, et al. Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2[J]. Oncol Rep, 2017, 37(3): 1765-1771. Zhang Q N, Qiu M H, Liu J P, et al. Erianin induces apoptosis and pyroptosis via MAPK/ERK and PI3K/Akt pathways and synergizes with anlotinib in anaplastic thyroid carcinoma [J]. Front Pharmacol, 2025, 16: 1596873.