中草药

荧光探针在中药材二氧化硫残留分析中的应用与进展

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中草药 | 综述 2026,57(13): 5273-5286

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中草药 |综述 2026 , 57 (13) : 5273 -5286

荧光探针在中药材二氧化硫残留分析中的应用与进展

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邢成¹, 张明童², 靳婉君², 张生杰², 姚立琼^1,3, 乌丹^1,3

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通讯作者:

姚立琼

作者简介:

邢成: 邢成，研究方向为中药学、药物分析技术与检测新技术开发。E-mail:hsingcheng@126.com 张明童: 张明童，副主任中药师，从事中药材检测研究。E-mail:519815751@qq.com

Application and research progress of fluorescent probes in detection of sulfur dioxide residues in traditional Chinese medicinal materials

XING Cheng, ZHANG Mingtong, JIN Wanjun, ZHANG Shengjie, YAO Liqiong, WU Dan

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doi: 10.7501/j.issn.0253-2670.2026.13.028

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中药用药安全至关重要。硫熏作为一种传统中药材加工养护工艺，具有贮藏防霉和改善色泽的作用。然而，过量硫熏会导致药材中二氧化硫残留，引发潜在健康风险。目前，二氧化硫残留检测方法存在检测时间长、成本高、操作复杂等缺点，难以满足市场快速检测需求。荧光探针技术凭借其高灵敏度、便携性、制备简便和检测快速等优势，已在医药开发、生物技术及食品安全等领域广泛应用。近年来，利用高选择性、高灵敏度的荧光探针对中药材中二氧化硫残留进行定量或半定量检测已成为研究热点。通过系统总结近年来用于中药材二氧化硫残留检测的荧光探针，依据其识别机制或结构特点进行分类；重点介绍了该类荧光探针在实际检测中的应用进展；分析了当前面临的技术挑战并展望了其未来发展方向。为提升中药材用药安全及质量控制水平提供理论依据与技术参考。

关键词

荧光探针 / 二氧化硫残留量 / 中药 / 定量分析 / 快速检测

Abstract

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The safety of traditional Chinese medicines (TCMs) is of paramount importance. Sulfur fumigation, a traditional processing and preservation technique for TCMs, serves to prevent mold during storage and improve product appearance. However, excessive sulfur fumigation leads to sulfur dioxide (SO₂) residues in the herbs, posing potential health risks. Currently, the SO₂ residue detection methods suffer from limitations including long analysis time, high cost, and operational complexity, making them inadequate for meeting the market demand for rapid testing. Fluorescent probe technology, with its advantages of high sensitivity, portability, simple preparation, and rapid response, has been widely applied in pharmaceutical development, biotechnology, and food safety. In recent years, the use of highly selective and sensitive fluorescent probes for the quantitative or semi-quantitative detection of SO₂ residues in TCMs has emerged as a significant research focus. This review systematically summarizes fluorescent probes developed in recent years for detecting SO₂ residues in TCMs, categorizing them based on their recognition mechanisms or structural features. It focuses on application progress of these probes in practical detection scenarios, analyzes the current technical challenges, and discusses future development directions. This review aims to provide theoretical foundations and technical references for enhancing the medicinal safety and quality control of TCMs.

Key words

fluorescent probes / sulfur dioxide residues / traditional Chinese medicine / quantitative analysis / rapid detection

引用本文

邢成, 张明童, 靳婉君, 张生杰, 姚立琼, 乌丹. 荧光探针在中药材二氧化硫残留分析中的应用与进展. 中草药, 2026 , 57 (13) : 5273 -5286 . DOI: 10.7501/j.issn.0253-2670.2026.13.028

XING Cheng, ZHANG Mingtong, JIN Wanjun, ZHANG Shengjie, YAO Liqiong, WU Dan. Application and research progress of fluorescent probes in detection of sulfur dioxide residues in traditional Chinese medicinal materials[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (13) : 5273 -5286 . DOI: 10.7501/j.issn.0253-2670.2026.13.028

基金

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国家重点研发计划中医药现代化专项 (2023YFC3504103); 甘肃省卫生健康行业科研项目 (GSWSKY2024-45); 甘肃省兰州大学大学生省级创新创业训练计划项目 (20240060176); 兰州大学第一医院院内基金 (ldyyyn2025-281)

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2026年第57卷第13期

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doi: 10.7501/j.issn.0253-2670.2026.13.028

接收时间：2026-01-15
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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