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This review retrieved literature from PubMed, Web of Science, China national knowledge infrastructure (CNKI), and Wanfang databases using keywords including “wine-processing” “medicinal properties” and “efficacy-enhancing mechanisms”. Findings indicate that traditional wine-processing predominantly utilizes HuangJiu, with distinctive techniques such as wine rinsing, wine stir-frying and wine steaming remaining in current practice. Modern processing technology emphasizes optimization of critical parameters. Wine-processing facilitates component transformation through physical dissolution, enhanced cellular permeability, and synergistic enzymatic/non-enzymatic reactions. Mechanisms involving multi-target networks and microbiota-targeted metabolic regulation, enable directional modulation of herbal cold/hot properties alongside efficacy enhancement and toxicity reduction. Future research should prioritize establishing digitalized process quality control standards, conduct interdisciplinary investigations into wine-processing effects on efficacy-related component groups, and elucidate directional regulation mechanisms of medicinal properties. These advancements are anticipated to promote standardization and modernization of wine-processing techniques while scientifically interpreting the theoretical foundations of TCM processing., authors=GAO Qingqi, ZHENG Lingling, GUO Tong, YE Qitao, WANG Yiwen, TONG Chaoying, ZOU Li, SHOU Dan, authorsList=GAO Qingqi, ZHENG Lingling, GUO Tong, YE Qitao, WANG Yiwen, TONG Chaoying, ZOU Li, SHOU Dan, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388165196861761, articleId=1304388163405893951, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=酒制对中药寒热药性的定向调控及增效减毒机制研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=酒制作为中药炮制的经典方法，通常用于中药的减毒存性、增效改性或定向引导药效。通过以酒制、药性、增效机制等关键词，检索PubMed、Web of Science、中国知网及万方等数据库文献，发现传统酒制采用的酒种以黄酒为主；酒洗、酒炒、酒蒸等酒制方法特色鲜明，沿用至今；现代炮制工艺聚焦关键参数的优化。酒制通过物理溶解与促进细胞渗透、酶促反应与非酶促反应的协同使中药成分转化。以多靶点网络与微生物群的靶向代谢调控等机制，实现中药寒热药性的定向调控及增效减毒。未来研究应关注数字化的工艺质控标准，跨学科深入解析酒制对于药效成分群的影响及寒热药性定向调控机制，期望为酒制工艺的标准化、现代化发展及中药炮制理论科学内涵阐释提供参考。, authors=高晴琪¹, 郑灵玲¹, 郭彤¹, 叶琪涛¹, 王依雯¹, 童超英¹, 邹莉¹, 寿旦¹, authorsList=高晴琪, 郑灵玲, 郭彤, 叶琪涛, 王依雯, 童超英, 邹莉, 寿旦, authorCompany=1 浙江中医药大学药学院,浙江杭州 310053, correspAuthors=寿旦, authorNote=高晴琪: 高晴琪，硕士研究生，研究方向为药物分析学。E-mail:gqq09292024@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=ycATIsZI7q4vfZcUF8IJfA==, pdfFileSize=1661086, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, 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detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.12.029, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.12.029, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.12.029, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788919972515, fullTextJson=null, articleText=null, reference=杨冰, 祝丹丹, 于欣茗, 等. 新世纪20年: 守正创新背景下创新炮制技术探索与实践[J]. 中草药, 2024, 55(2): 357-365.
钮敏洁, 蔡皓, 曹岗. 中药酒制及其机理研究概述[J]. 中药材, 2020, 43(11): 2838-2842.
许慎. 说文解字[M]. 上海: 上海古籍出版社, 2007: 746.
刘慧敏, 刘雪梅, 江雨柔, 等. 酒在中药制药与用药过程中的古今研究进展[J]. 中草药, 2022, 53(11): 3538-3549.
Li J B, Sun C, Hou A J, et al. Exploring wine-processing: A distinctive classic technique in TCM [J]. RSC Adv, 2025, 15(53): 45157-45176.
李文丽, 刘红宁, 张高传. 中医药用酒史述要[J]. 中医药文化, 2024, 19(2): 141-151.
戴冰, 黄雍, 张嘉妮, 等. 中药炮制辅料黄酒的现代研究概况[J]. 中医药导报, 2018, 24(20): 114-116.
马王堆汉墓帛书整理小组. 五十二病方[M]. 北京: 文物出版社, 1979: 38-39.
张机. 金匮要略方论: 三卷[M]. 影印本. 北京: 人民卫生出版社, 1956: 50-56.
雷敩. 雷公炮制论[M]. 北京: 中医古籍出版社, 1999: 4.
苏敬. 唐·新修本草: 辑复本[M]. 尚志钧辑校. 合肥: 安徽科学技术出版社, 1981: 447-448.
太平惠民和剂局. 太平惠民和剂局方[M]. 刘景源, 整理. 北京: 人民卫生出版社, 2023.
童立英.《汤液本草》评述[J]. 四川中医, 1990, 8(1): 6-8.
李时珍. 本草纲目-第二册: 校点本[M]. 北京: 人民卫生出版社, 1977: 1890-1892.
李明, 丁艳亭, 陶晓华. 宋本《伤寒论》中大黄“酒洗”考辨[J]. 中医杂志, 2023, 64(16): 1627-1631.
翁倩倩, 赵佳琛, 金艳, 等. 酒及经典名方中酒制方法的考证与梳理[J]. 中国现代中药, 2021, 23(2): 202-217.
解旺洋, 张雪, 裴科, 等. 焦苍术炮制工艺优化及其性状-成分关联性与抗氧化活性变化研究[J]. 中草药, 2025, 56(22): 8162-8174.
Zhang Y H, Ge J M, Wu C L, et al. Integrated multidimensional technology for optimized extraction, chemometric quantification, and mechanistic evaluation of anti-oral squamous cell carcinoma effects of aglycones from Scutellaria baicalensis Georgi [J]. J Pharm Biomed Anal, 2026, 269: 117234.
邓戈宇, 蒋鑫, 孙慧娟, 等. 酒制白鲜皮饮片炮制工艺及其急性毒性实验研究[J]. 中药材, 2025, 48(4): 872-878.
张玉波, 陈绪军, 贾子乐, 等. 基于免疫调节作用的黄精酒制新工艺研究[J]. 中国医药导报, 2025, 22(5): 24-28.
Wang Y H, Qin W H, Yang Y J, et al. A study on the processing technology for Rhizoma Coptidis [J]. BMC Biotechnol, 2022, 22(1): 3.
Papachristou I, Nazarova N, Wüstner R, et al. Biphasic lipid extraction from microalgae after PEF-treatment reduces the energy demand of the downstream process [J]. Biotechnol Biofuels Bioprod, 2025, 18(1): 12.
DiLeo M R, Hall R E, Vellers H L, et al. Alcohol alters skeletal muscle bioenergetic function: A scoping review [J]. Int J Mol Sci, 2024, 25(22): 12280.
Shi R X, Yang S M, Zeng S T, et al. Effect of structural changes of Rehmannia glutinosa polysaccharide before and after processing on anti-aging activity [J]. Int J Biol Macromol, 2025, 309: 143168.
秦聪聪, 张诗敏, 李玉清. 龙胆炮制历史沿革及化学成分、药理作用研究[J]. 中华中医药学刊, 2026, 44(1): 133-139.
杜亚朋, 王美, 李璐遥, 等. 基于化合物稳定性探讨炮制对含环烯醚萜类成分中药药性及功效影响的研究进展[J]. 中草药, 2021, 52(16): 5039-5051.
Zhang L Q, Feng L, Jia Q, et al. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2(COX-2) in vitro [J]. Bioorg Med Chem, 2011, 19(16): 4882-4886.
魏桃英. 浅析绍兴黄酒生产中的美拉德反应[J]. 江苏调味副食品, 2011, 28(1): 30-32.
Zhao X, Duan C Q, Li S Y, et al. Non-enzymatic browning of wine induced by monomeric flavan-3-ols: A review [J]. Food Chem, 2023, 425: 136420.
Kertsch A L, Wagner J, Henle T. Selected Maillard reaction products and their yeast metabolites in commercial wines [J]. J Agric Food Chem, 2023, 71(32): 12300-12310.
郭舒臣, 李得天, 梁士魁, 等. 新世纪20年: 现代生物体系下的中药炮制机制的研究技术与方法[J]. 中国中药杂志, 2022, 47(5): 1170-1176.
裴科, 宁燕, 蔡皓, 等. 基于UHPLC-Q-Orbitrap HRMS和整合网络药理学的川芎酒制后增强抗脑缺血损伤作用机制分析[J]. 中国实验方剂学杂志, 2022, 28(12): 164-173.
吴信华, 瞿慧, 曹园, 等. 基于网络药理学的山茱萸酒制科学内涵探究[J]. 中华中医药学刊, 2021, 39(5): 81-85.
Yang H, Zhao S H, Li Z K, et al. Comparative study of hypoglycemic effects and mechanisms of crude and wine-processed polysaccharides from Polygonatum sibiricum [J]. Food Sci Nutr, 2025, 13(12): e71216.
Tian R, Wang W X, Bai Y Y, et al. Effect of Coptidis Rhizoma on gastrointestinal system before and after processing with wine based on gut microbiota and short chain fatty acids [J]. Front Pharmacol, 2024, 15: 1492047.
Bai Y Y, Tian R, Qian Y, et al. Integrated gut microbiota and serum pharmacochemistry reveal the mechanisms of wine steaming in alleviating rhubarb diarrhea [J]. Phytomedicine, 2024, 135: 156105.
Ni Z X, Zhou W, Gao Y. A social-architecture perspective on gut microbiota dynamics and host physiology [J]. Front Immunol, 2025, 16: 1642080.
贾天柱. 中药炮制药性变化论[J]. 中成药, 2019, 41(2): 470-471.
杨锦妮, 刘新月, 张艳. 中药“酒制升提”炮制理论的研究进展与探讨[J]. 中草药, 2023, 54(18): 6139-6149.
陈高源, 韩一凡, 韩羽亭, 等.“酒制升提”炮制理论在“寒性”中药中的应用及研究进展[J]. 湖北中医药大学学报, 2024, 26(4): 120-124.
徐超. 基于“成分-效应”关联的酒白芍活血化瘀增效炮制机理研究[D]. 合肥: 安徽中医药大学, 2021.
Zhang Z K, Zheng Y J, Zhang B X, et al. Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of Zingiberis Rhizoma Recens-/Euodiae Fructus-processed Coptidis Rhizoma on gastric ulcer rats [J]. J Ethnopharmacol, 2024, 332: 118376.
陈昺伃, 刘轲, 王彦华, 等.“苦寒败胃”的中医内涵及生物学基础[J]. 中医学报, 2023, 38(1): 43-47.
白亚亚, 张桥, 程鸿俊, 等. 酒制对“寒性”中药影响的研究进展[J]. 中草药, 2023, 54(17): 5773-5785.
徐珊, 张凡, 刘蓬蓬, 等. 基于大鼠物质、能量代谢研究炮制对黄柏药性的影响[J]. 中药材, 2015, 38(9): 1835-1841.
欧则民, 李新健, 张冰冰, 等. 中药酒制法的研究现状及展望[J]. 中华中医药学刊, 2021, 39(12): 28-32.
Huang P, Tan S Z, Zhang Y X, et al. The effects of wine-processing on ascending and descending: The distribution of flavonoids in rat tissues after oral administration of crude and wine-processed Radix scutellariae [J]. J Ethnopharmacol, 2014, 155(1): 649-664.
谭鹏, 郝露. 基于蒽醌转化-异位分布-免疫应激调节研究大黄“酒制升提”清上焦热的生物学机制[Z]. 四川: 四川省中医药科学院, 2024.
Zhang W, Ding Y F, Li P F, et al. An integrated serum pharmacochemistry, network pharmacology, and metabolomics strategy: A study on raw and wine-processed Paeoniae Radix Alba in promoting blood circulation to alleviate blood stasis [J]. Fitoterapia, 2025, 182: 106449.
武艳雪, 陈天丽, 侯晓琳, 等. 酒赤芍炮制工艺优化及其体外抗凝血作用考察[J]. 中国药房, 2021, 32(21): 2613-2618.
徐婷婷. 酒丹参质量标志物及活血化瘀功效评价研究[D]. 哈尔滨: 黑龙江省中医药科学院, 2024.
张桥, 陈艳琰, 乐世俊, 等. 大黄及其不同炮制品中16种化学成分的含量变化研究[J]. 中华中医药杂志, 2022, 37(2): 1036-1040.
龙成燕, 杨炀, 黄思行, 等. 基于高分辨质谱数据库的黄连炮制前后生物碱变化规律[J]. 中草药, 2022, 53(19): 5972-5979.
Hu L Q, Xiong Y, Zou Z R, et al. Identifying the chemical markers in raw and wine-processed Scutellaria baicalensis by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry coupled with multiple statistical strategies [J]. Biomed Chromatogr, 2020, 34(8): e4849.
朱诗塔, 雷鹏, 李新中, 等. 掌叶大黄不同炮制品泻下、止血作用的比较研究[J]. 中药材, 2008, 31(2): 199-201.
李燕, 闫美娟, 隋峰, 等. 大黄不同炮制品醇提物解热作用及机制的比对研究[J]. 中药材, 2012, 35(8): 1224-1227.
张晴, 王云, 贾哲, 等. 基于热分析技术、指纹图谱及含量测定的不同产地酒黄芩质量评价[J]. 中国实验方剂学杂志, 2024, 30(19): 170-179.
柴冲冲. 基于颜色-滋味-成分-代谢的黄芩酒炙前后药性变化的科学内涵研究[D]. 北京: 北京中医药大学, 2020.
胡恋琪, 孙豪杰, 熊优, 等. 基于“成分-靶点-代谢”预测分析黄芩酒炙前后质量标志物[J]. 中草药, 2020, 51(10): 2618-2626.
Lu F, Zhang W J, Zhai S, et al. Anti-migraine effect of wine-processed Radix scutellariae: Pharmacodynamic verification in nitroglycerin-induced rats and correlation study between compounds dissolution and the fractal dimension [J]. J Ethnopharmacol, 2020, 263: 113131.
贺素容, 杜远东, 王晶, 等. 黄芩酒炙工艺的优化及其抗炎活性[J]. 中成药, 2020, 42(7): 1681-1687.
白而力. 不同辅料炮制对黄连生物碱类成分含量的影响[J]. 亚太传统医药, 2016, 12(13): 38-39.
Qian X C, Zhang L, Tao Y, et al. Simultaneous determination of ten alkaloids of crude and wine-processed Rhizoma Coptidis aqueous extracts in rat plasma by UHPLC-ESI-MS/MS and its application to a comparative pharmacokinetic study [J]. J Pharm Biomed Anal, 2015, 105: 64-73.
王亚, 杨军辉, 芮天奇, 等. 酒炙前后对上焦病症及肝脏能量代谢酶活性的影响[J]. 南京中医药大学学报, 2014, 30(4): 335-339.
周巧, 张智慧, 张学兰, 等. 基于谱效相关法探究酒炙丹参增强抗凝血活性的物质基础[J]. 中成药, 2021, 43(4): 954-958.
崔伟亮, 李慧芬, 宋梦晗, 等. 丹参酒炙前后HPLC指纹图谱色谱峰归属比较[J]. 辽宁中医杂志, 2019, 46(8): 1707-1709.
李鹏飞, 岳倩侠, 孙叶芬, 等. 基于指纹图谱与化学计量学的白芍酒炙前后差异性标志物研究[J]. 中草药, 2023, 54(8): 2398-2407.
刘烨, 马向慧, 姜恒丽, 等. 基于指纹图谱探讨白芍不同炮制品成分的差异[J]. 天津药学, 2022, 34(3): 6-12.
Zhang L, Yu J, Wang C, et al. The effects of total glucosides of paeony (TGP) and paeoniflorin (Pae) on inflammatory-immune responses in rheumatoid arthritis (RA) [J]. Funct Plant Biol, 2019, 46(2): 107-117.
杨艳玲, 刘彩凤, 黄嘉怡, 等. 基于HPLC指纹图谱的白芍及酒白芍比较分析[J]. 中国现代中药, 2021, 23(8): 1374-1379.
Sun S L, Chen Y P, Zhang Y, et al. A novel comprehensive strategy for research on wine-processed mechanism of Corni Fructus guided by variation in the chemical components and network analysis [J]. BMC Complementary Med Ther, 2025, 25(1): 312.
刘蓬蓬, 刘婷婷, 高慧, 等.“中药炮制化学生物学”驱动的炮制前后中药性能变化科学内涵探析[J]. 药学学报, 2026, 61(1): 29-36.
张亚柯, 张宏伟, 张振凌, 等. 炮制对加味拱辰浓缩丸化学成分的影响[J]. 中成药, 2024, 46(3): 755-765.
张婷婷. 川芎及酒川芎饮片质量评价和药效学研究[D]. 成都: 成都中医药大学, 2018.
钟宇晨, 匡海学, 王秋红. 酒炙前后当归多糖对血瘀证大鼠的作用研究及机制探讨[J]. 中药新药与临床药理, 2020, 31(5): 495-501.
钟立甲. 基于代谢组学的生当归、当归炭、酒当归活血化瘀作用机制研究[D]. 兰州: 甘肃农业大学, 2016.
Li X Y, Zhou L, Jiang Z H, et al. Integrated toxicology of Aconitum carmichaelii Debx.: Bridging traditional toxicity-efficacy understanding and modern toxicology [J]. Front Pharmacol, 2025, 16: 1667059.
王文通, 江汉美, 张智婧. HS-SPME-GC-MS分析仙茅及酒仙茅的挥发性成分[J]. 湖北农业科学, 2020, 59(13): 137-139.
陈娟, 郭小红, 张小琼, 等. 仙茅化学成分、药理与毒理作用研究进展[J]. 中华中医药杂志, 2021, 36(7): 4151-4158.
陈智伟, 杨建波, 陈子涵, 等. 何首乌中顺式(反式)-大黄素-大黄素二蒽酮肝保护活性研究[J]. 药学学报, 2023, 58(3): 711-720.
方思, 程琳, 田秀娟, 等. 中药炮制辅料黄酒的应用历史沿革及其现代研究[J]. 药学前沿, 2025, 29(2): 334-344.
Gandhi H J, Chandnani S, Jena A, et al. A rare cause of acute on chronic liver failure (ACLF): Bakuchi-induced liver injury [J]. J Clin Exp Hepatol, 2024, 14(1): 101267.
Zhang C, Zhao J Q, Sun J X, et al. Psoralen and isopsoralen from Psoraleae Fructus aroused hepatotoxicity via induction of aryl hydrocarbon receptor-mediated CYP1A2 expression [J]. J Ethnopharmacol, 2022, 297: 115577.
宋迪, 陈帅帅, 李朋彦, 等. 补骨脂潜在肝毒性的修制减毒方法研究: 酒浸水漂法[J]. 药学学报, 2020, 55(2): 276-282.
张一美, 王巍, 李利华, 等. 仙茅酒蒸炮制工艺研究[J]. 中国现代中药, 2024, 26(1): 113-119.
王晓平. 当归不同炮制方法对多糖含量的影响分析[J]. 内蒙古中医药, 2017, 36(8): 134-135.
覃祖玲, 钟凌云, 王艳, 等. 不同炮制技术对当归药性及临床作用的影响[J]. 中草药, 2025, 56(17): 6416-6429.
孙雪豪, 陈家璇, 尹佳鑫, 等. 基于HS-GC-IMS、HS-SPME-GC-MS和UPLC-Q-Orbitrap-MS结合化学计量学探讨当归酒炙前后化学成分差异[J]. 中国中药杂志, 2025, 50(14): 3909-3917.
黄丽, 靳庆霞. 当归炮制品及有效成分变化[J]. 陕西中医, 2010, 31(5): 597-598.
李玟玲, 于子涵, 裴科, 等. 综合UHPLC-Q-Exactive Orbitrap MS和GC-MS技术探究不同类型黄酒炮制对川芎化学成分的影响[J]. 中国医院药学杂志, 2025, 45(14): 1608-1619.
张秀如, 于明, 崔雅晴, 等. 基于UPLC指纹图谱的菟丝子酒炙前后化学模式识别及多成分定量测定[J]. 中草药, 2023, 54(9): 2733-2740.
张文, 郑鹏, 张江山, 等. 基于电子鼻和HS-GC-MS分析茶芎酒制前后挥发性成分变化[J]. 中国实验方剂学杂志, 2025, 31(2): 173-181.
李媛媛, 王巍, 鞠成国, 等. 酒仙茅的微波炮制工艺建立及与传统炮制法的比较[J]. 中国药房, 2021, 32(18): 2223-2229.
刘芳, 祝宇, 魏娟, 等. 不同炮制法对仙茅中仙茅苷含量的影响[J]. 中国药师, 2018, 21(12): 2284-2286.
刘霞, 吴文辉, 郭小红, 等. 仙茅酒炙前后对骨质疏松小鼠股骨组织中OPG及RANKL表达的影响[J]. 中药药理与临床, 2022, 38(1): 98-103.
李佳妍, 刘欣欣, 宁青, 等. 基于斑马鱼模型的补骨脂毒性相关成分群的高效辨识研究[J]. 中草药, 2021, 52(1): 129-136.
梁丽金, 刘权震, 覃柳莹, 等. 盐补骨脂与酒补骨脂的炮制工艺优选及补骨脂生品与炮制品的差异研究[J]. 广东药科大学学报, 2023, 39(6): 54-64.)