Article(id=1304388074482459595, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.10.014, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1768233600000, receivedDateStr=2026-01-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788919951314, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788919951314, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788919951314, creator=13701087609, updateTime=1788919951314, updator=13701087609, issue=Issue{id=1304388047747969563, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='10', pageStart='3685', pageEnd='4088', issueExtLink='null', onlineDate='null', pubDate='1779897600000', pubDateStr='2026-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788919944940, creator='13701087609', updateTime=1788923403989, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304402556332037104, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304402556332037105, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3831, endPage=3847, ext={EN=ArticleExt(id=1304388074834781133, articleId=1304388074482459595, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Phase separation of classic prescription Baoyuan Decoction and screening of effective phases for alleviating exercise-induced fatigue in rats, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To split the classic prescription Baoyuan Decoction (保元汤) into different phases, study the relieving effects of different phases on exercise fatigue in rats, and screen for their effective phases. Methods The gradient centrifugation dialysis method was used to separate Baoyuan Decoction into the nano phase (BD nano phase, BD-N), precipitation phase (BD-P) and solution phase (BD-S). The appearance was physically characterized and contents of main ingredients was determined. A rat swimming fatigue model was established, control group, model group, positive control (Dazhu Hongjingtian Capsule) group, Baoyuan Decoction group, BD-N group and BD-P group were set up, active phases was screened by measuring behavioral indicators, organ indices, serum biochemical indicators, and pathological changes in liver and muscle tissues. Based on combined analysis of gut microbiome, metabolomics and transcriptomics, the potential mechanism of Baoyuan Decoction and its effective phase in alleviating exercise fatigue in rats was explored. Four differentially expressed genes (Gck, Ackr3, Pde4b, Ppp1r3b) were randomly selected for qRT-PCR validation. Results The particle morphology of BD-N was spherical and Tyndall effect was significant. The particle size was in the order of BD-P > Baoyuan Decoction > BD-N. The polydispersity index (PDI) of each phase was in the order of Baoyuan Decoction > BD-N > BD-P. The absolute value of zeta potential for each phase was BD-P > BD-N > Baoyuan Decoction. Ginsenoside Rb₁, calycosin-7- O-β-D-glucoside, liquiritin, ammonium glycyrrhizinate, cinnamic acid, cinnamaldehyde and 6-gingerol were mainly distributed in BD-N. The comprehensive efficacy ranking was Baoyuan Decoction ≈ positive control drug > BD-N > BD-P. The ability of BD-N in regulating the abundance of gut microbiota, increasing the level of Lactobacillus genus and regulating 45 differential metabolites related to fatigue was similar to Baoyuan Decoction. The qRT-PCR results showed that the regulatory trends of BD-N and Baoyuan Decoction on four genes were consistent with the transcriptome sequencing results. Conclusion From the perspective of physics, chemistry and pharmacological effects, the effective phase of Baoyuan Decoction in relieving fatigue is screened, and BD-N is the effective phase of Baoyuan Decoction in relieving fatigue., authors=LI Chunyu, CHAI Yuankun, HAN Xinran, HAO Xinyang, LI Junge, QIU Zhidong, JIA Ailing, authorsList=LI Chunyu, CHAI Yuankun, HAN Xinran, HAO Xinyang, LI Junge, QIU Zhidong, JIA Ailing, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388074759283660, articleId=1304388074482459595, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=经典名方保元汤相态拆分及其对大鼠运动性疲劳缓解作用的有效相态筛选, columnId=1304140191707456168, journalTitle=中草药, columnName=药理与临床, runingTitle=null, highlight=null, articleAbstract=目的 对经典名方保元汤进行相态拆分，研究不同相态对大鼠运动性疲劳的缓解作用，筛选其有效相态。方法 采用梯度离心-透析法将保元汤拆分为纳米相态（BD nano phase，BD-N）、沉淀相态（BD precipitation phase，BD-P）及真溶液相态（BD solution phase，BD-S），对其外观进行物理学表征，并进行含量测定。建立大鼠游泳疲劳模型，设置对照组、模型组、阳性对照（大株红景天胶囊）组、保元汤组、BD-N组和BD-P组，通过测定行为学指标、脏器指数、血清生化指标及肝组织、肌肉组织病理学变化筛选活性相态。基于肠道微生物组学、代谢组学、转录组学联合分析探讨保元汤及有效相态缓解大鼠运动性疲劳的潜在作用机制，并随机选取其中4个差异表达基因（Gck、Ackr3、Pde4b、Ppp1r3b）进行qRT-PCR验证。结果 BD-N粒子形态呈圆球形且丁达尔效应明显，粒径排序为BD-P＞保元汤＞BD-N；各相态的多分散指数（polydispersity index，PDI）排序为保元汤＞BD-N＞BD-P；各相态ζ电位绝对值排序为BD-P＞BD-N＞保元汤。人参皂苷Rb₁、毛蕊异黄酮-7-O-葡萄糖苷、甘草苷、甘草酸铵、肉桂酸、桂皮醛及6-姜酚均主要分布于BD-N中，综合药效排序为保元汤≈阳性对照药＞BD-N＞BD-P。BD-N调节肠道菌群丰度并增加乳杆菌属水平及其对与疲劳相关的45个差异代谢物的调控能力与保元汤相近；qRT-PCR结果显示，BD-N与保元汤对4个基因的调控趋势与转录组测序结果一致。结论 从物理-化学-药效角度筛选保元汤缓解疲劳作用的有效相态，BD-N为保元汤缓解疲劳的有效相态。, authors=李春雨¹, 柴渊鲲¹, 韩欣燃¹, 郝鑫洋¹, 李军鸽¹, 邱智东¹, 贾艾玲¹, authorsList=李春雨, 柴渊鲲, 韩欣燃, 郝鑫洋, 李军鸽, 邱智东, 贾艾玲, authorCompany=1 长春中医药大学药学院, 吉林长春 130117, correspAuthors=邱智东, authorNote=李春雨: 李春雨(2001—),女,硕士研究生,从事中药制剂与新药开发研究。E-mail:13766011812@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=apgECyzXsv8aJWDM9we12Q==, pdfFileSize=2325630, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=吉林省发改委项目 (2022C41-7); 吉林省科技发展计划项目 (YDZJ202402034CXJD))}, authors=null, keywords=[Keyword(id=1304401288125505601, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=1, keyword=保元汤), Keyword(id=1304401288268111938, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=2, keyword=相态), Keyword(id=1304401288360386627, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=3, keyword=运动性疲劳), Keyword(id=1304401288435884100, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=4, keyword=肠道菌群), Keyword(id=1304401290113605701, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=5, keyword=代谢组学), Keyword(id=1304401290218463302, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=6, keyword=转录组学), Keyword(id=1304401290344292423, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=7, keyword=人参皂苷Rb₁), Keyword(id=1304401290449150024, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=8, keyword=毛蕊异黄酮-7-O-葡萄糖苷), Keyword(id=1304401290579173449, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=9, keyword=甘草苷), Keyword(id=1304401290692419658, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=10, keyword=甘草酸铵), Keyword(id=1304401290780500043, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=11, keyword=肉桂酸), Keyword(id=1304401290851803212, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=12, keyword=桂皮醛), Keyword(id=1304401290960855117, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=CN, orderNo=13, keyword=6-姜酚), Keyword(id=1304401291187347534, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=1, keyword=Baoyuan Decoction), Keyword(id=1304401291254456399, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=2, keyword=phase state), Keyword(id=1304401291342536784, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=3, keyword=exercise-induced fatigue), Keyword(id=1304401291426422865, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=4, keyword=gut microbiota), Keyword(id=1304401291514503250, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=5, keyword=metabolomics), Keyword(id=1304401291602583635, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=6, keyword=transcriptomics), Keyword(id=1304401291682275412, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=7, keyword=ginsenoside Rb₁), Keyword(id=1304401291761967189, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=8, keyword=calycosin-7-O-β-D-glucoside), Keyword(id=1304401291845853270, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=9, keyword=liquiritin), Keyword(id=1304401291925545047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=10, keyword=ammonium glycyrrhizinate), Keyword(id=1304401291992653912, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=11, keyword=cinnamic acid), Keyword(id=1304401292063957081, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=12, keyword=cinnamaldehyde), Keyword(id=1304401292135260250, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388074482459595, language=EN, orderNo=13, keyword=6-gingerol)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.10.014, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.10.014, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.10.014, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.10.014, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788919951314, fullTextJson=null, articleText=null, reference=杨言言, 李惠珍, 艾志福, 等. 中药防治疲劳作用机制的研究进展[J]. 中草药, 2023, 54(7): 2309-2318.
玄其文, 沈诞, 杜娟, 等. 具有抗疲劳作用的补益类中药研究进展[J]. 现代中西医结合杂志, 2023, 32(2): 275-280.
陈利平, 吴整军, 仝战旗, 等. 慢性疲劳综合征中医病因病机及治疗探悉[J]. 中华中医药学刊, 2010, 28(12): 2533-2534.
余格, 梁慧慧, 文雯, 等. 保元汤的研究进展及其质量标志物的预测分析[J]. 中草药, 2021, 52(2): 567-577.
Wu Z, Wang L X, Yin Z Y, et al. Baoyuan Decoction inhibits atherosclerosis progression through suppression peroxidized fatty acid and Src/MKK4/JNK pathway-mediated CD36 expression [J]. Phytomedicine, 2024, 130: 155668.
李淑慧, 王雅, 田军, 等. 古代经典名方保元汤的药效物质基础及其分子水平机制的研究[J]. 中草药, 2023, 54(21): 6971-6987.
李双钰, 万博雅, 杨艳, 等. 保元汤的化学成分、药理作用和临床应用的研究进展[J/OL]. 吉林医药学院学报(2025-12-22) [2026-04-28]. https://doi.org/10.13845/ j.cnki.issn1673-2995.20251222.001.
李钠, 刁元元, 刘伟朋, 等. 基于特征图谱和量值传递评价经典名方保元汤颗粒剂的关键生产工艺[J]. 中国新药杂志, 2024, 33(14): 1472-1481.
魏吉昌, 林晓钰, 张景怡, 等. 基于相态变化探讨煎煮方式对黄芩-黄连超分子物质基础及配伍“和合”机制的影响[J]. 中草药, 2024, 55(24): 8366-8378.
王琪, 郭小萌, 倪乾坤, 等. 中药水煎液自组装聚集体研究面临的问题初探[J]. 药学学报, 2024, 59(1): 94-104.
张则宽, 王琪, 郭小萌, 等. 基于相态变化探究煎煮方法与纯化工艺对经典名方吴茱萸汤药性传递的影响[J]. 中草药, 2025, 56(2): 430-440.
胡英还, 于舒婷, 李若彤, 等. 基于相态特征的中药质量评价研究进展[J]. 中草药, 2026, 57(1): 314-321.
Zhuang Y, Yan J J, Zhu W, et al. Can the aggregation be a new approach for understanding the mechanism of Traditional Chinese Medicine? [J]. J Ethnopharmacol, 2008, 117(2): 378-384.
Zhou J W, Gao G Z, Chu Q P, et al. Chromatographic isolation of nanoparticles from Ma-Xing-Shi-Gan-Tang decoction and their characterization [J]. J Ethnopharmacol, 2014, 151(3): 1116-1123.
高湘婷, 贺鹏, 谯茹, 等. 补阳还五汤煎煮过程2种相态与成分变化关系研究[J]. 中草药, 2025, 56(22): 8113-8125.
李华健, 叶小风, 柯俏颖, 等. 基于成分互作-物相结构探究防己黄芪汤有效相态部位性质及其抗炎活性[J]. 中华中医药杂志, 2025, 40(11): 5164-5172.
苏贝贝, 卢凯, 张鑫渝, 等. 防己黄芪汤干预脾虚肾性水肿小鼠的药效评价及活性相态筛选[J]. 中草药, 2025, 56(22): 8175-8187.
何沂灿, 申宝德, 沈成英, 等. 黄芩汤相态拆分及其抗皮肤癣菌作用研究[J]. 中草药, 2025, 56(9): 3099-3108.
付佳宁, 赵氏淳, 郝凌烽, 等. 金银花-蒲公英提取液纳米相态凝胶剂制备及对大鼠痤疮模型的药效评价[J]. 中草药, 2024, 55(24): 8416-8424.
Su H B, Lei H, Cao L, et al. Phase preparation of Xiao-Chai-hu Decoction and its pharmacodynamics of acute liver injury [J]. Curr Top Med Chem, 2024, 24(24): 2129-2140.
朱耀萱, 陈伟, 王振中, 等. 麻杏石甘汤抗菌活性的空间异质性及其物理结构基础[J]. 药学学报, 2021, 56(8): 2112-2118.
高文晶, 李珊珊, 向小梅, 等. 基于UPLC-Q-TOF-MS/MS分析经典名方保元汤的物质基础[J]. 中国实验方剂学杂志, 2024, 30(22): 243-248.
吴雪, 冒银苹, 王丹, 等. 苓桂术甘汤活性相态的物质解析及对梗阻肾的保护作用[J]. 药学学报, 2025, 60(7): 2342-2351.
黄保年, 车环宇, 刘雪坤, 等. 疲劳模型的建立及中药抗疲劳作用研究进展[J]. 中草药, 2025, 56(5): 1805-1816.
Nair A, Jacob S. A simple practice guide for dose conversion between animals and human [J]. J Basic Clin Pharma, 2016, 7(2): 27.
崔煦然, 刘清泉. 基于代谢组学与肠道菌群测序探讨苍麻化毒颗粒治疗呼吸道感染的潜在机制[J]. 病毒学报, 2026, 42(1): 101-114.
Chen S F, Zhou Y Q, Chen Y R, et al. Fastp: An ultra-fast all-in-one FASTQ preprocessor [J]. Bioinformatics, 2018, 34(17): i884-i890.
Kim D, Langmead B, Salzberg S L. HISAT: A fast spliced aligner with low memory requirements [J]. Nat Meth, 2015, 12(4): 357-360.
王晓婷. 服用中药汤剂有讲究[J]. 农家之友, 2007(7): 65.
Yuan D, Wang Z L, Li B, et al. Complexation of apigenin and oxymatrine leading to enhanced anti-inflammatory activity [J]. J Nat Prod, 2023, 86(5): 1179-1188.
Tian X H, Wang P L, Li T, et al. Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination [J]. Acta Pharm Sin B, 2020, 10(9): 1784-1795.
Zheng J, Fan R, Wu H Q, et al. Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation [J]. Nat Commun, 2019, 10: 1604.
林岱. 葛根芩连汤药材蛋白自组装行为的研究[D]. 福州: 福州大学, 2013.)