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Methods The constituents were isolated from non-polysaccharide fractions of the aqueous extract of Astragalus membranaceus var. mongholicus by employing multiple chromatographic techniques including silica gel, Sephadex LH-20 and ODS. Their structures were identified based on the physicochemical properties as well as spectroscopic and spectrometric data. Their protective activities against renal injury were evaluated by detecting the cell viability of human renal proximal tubular epithelial (HK-2) cells injured by cisplatin. Results Four cycloartane triterpenoids were isolated from Astragalus membranaceus var. mongholicus and identified as 12-carboxy-20,24,25-trihydroxy-3-(β-D-xylopyranosyloxy)-6-(β-D-glucopyra- nosyloxy)-7(8)-ene-9,10-secocycloartane (1), astragaloside II (2), astragaloside Ⅳ (3) and astragaloside Ⅰ (4). Additionally, compounds 2 and 3 could significantly improve the decreased cell viability induced by cisplatin (P < 0.05). Conclusion Compound 1 is a novel homocycloartane triterpenoid named homoastragaloside A, and compounds 2 and 3 exhibit protective effects against renal injury., authors=ZHANG Yixin, FAN Chunyu, GUO Hui, MA Jiantong, DING Liqin, authorsList=ZHANG Yixin, FAN Chunyu, GUO Hui, MA Jiantong, DING Liqin, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388057025770045, articleId=1304388056765723196, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=蒙古黄芪环阿屯烷型三萜类化合物及其肾损伤保护作用研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究蒙古黄芪Astragalus membranaceus var. mongholicus环阿屯烷型三萜类化学成分及其顺铂所致肾损伤保护活性。方法 采用硅胶、Sephadex LH-20、ODS等多种色谱分离技术对蒙古黄芪水提物的非多糖组分进行分离纯化，根据其理化性质和光谱、波谱数据鉴定其结构；并采用顺铂诱导人肾皮质近曲小管上皮细胞（HK-2细胞）损伤模型，评价了其肾保护活性。结果 从蒙古黄芪中共分离得到4个环阿屯烷型三萜，分别鉴定为12-carboxy-20,24,25-trihydroxy-3-(β-D-xylopyranosyloxy)-6-(β-D-glucopyranosyloxy)-7(8)-ene-9,10-secocycloartane（1）、黄芪皂苷Ⅱ（2）、黄芪甲苷（3）、黄芪皂苷Ⅰ（4）。体外活性评价结果显示，化合物2、3能够显著改善顺铂所造成的细胞活力下降（P＜0.05）。结论 化合物1为新的高环阿屯烷型三萜，命名为高环黄芪皂苷A，化合物2、3具有肾损伤保护作用。, authors=张一鑫^1,2,3, 范春雨^4,2,3, 郭慧^1,2,3, 马建彤^4,2,3, 丁丽琴^1,2,3, authorsList=张一鑫, 范春雨, 郭慧, 马建彤, 丁丽琴, authorCompany=1 天津中医药大学中医药研究院, 天津 301617;
2 天津市中药功效物质重点实验室, 天津 301617;
3 现代中药创制全国重点实验室, 天津 301617;
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