Article(id=1304140201320796775, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.03.020, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1760371200000, receivedDateStr=2025-10-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788860853748, onlineDateStr=2026-09-08, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788860853748, onlineIssueDateStr=2026-09-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788860853748, creator=13701087609, updateTime=1788860853748, updator=13701087609, issue=Issue{id=1304140186485543391, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='3', pageStart='789', pageEnd='1208', issueExtLink='null', onlineDate='null', pubDate='1770825600000', pubDateStr='2026-02-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788860850211, creator='13701087609', updateTime=1788860942564, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304140573955351430, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304140573955351431, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1032, endPage=1040, ext={EN=ArticleExt(id=1304140201668924009, articleId=1304140201320796775, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Analysis of global patent situation in drug development of berberine and its derivatives, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To systematically analyze the global patent landscape of berberine and its major derivatives, including berberine hydrochloride, dihydroberberine, and tetrahydroberberine, to identify technological development trends and research hotspots and provide references for innovative drug development, strategic patent layout, and the modernization of traditional Chinese medicine. Methods Based on global patent databases, patents related to berberine and its derivatives were retrieved and expanded by patent families. Keyword extraction and clustering analysis were applied to analyze diversified technological themes, application areas, and geographical distributions of different categories of berberine-related patent families. Results A total of 1 155 berberine, 494 berberine hydrochloride, and 65 dihydroberberine or tetrahydroberberine patent families were identified. China was the primary market for research and application. Patents mainly focused on pharmaceutical preparations and covered multiple indications, including metabolic syndrome, liver diseases, and neurodegenerative disorders. Conclusion Technological innovation in berberine and its derivatives remains active, with research hotspots concentrated on formulation optimization, expansion of therapeutic indications, and improvement of safety. Some enterprises have actively deployed patents in cocrystals, liposomes, nanoformulations, and compound preparations, indicating a continuous expansion from traditional active components of Chinese medicine toward modern pharmaceutical technologies and international applications., authors=SUN Minghan, WANG Tianwei, ZHU Xiuzhu, ZHANG Dong, authorsList=SUN Minghan, WANG Tianwei, ZHU Xiuzhu, ZHANG Dong, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304140201538900584, articleId=1304140201320796775, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=小檗碱及其衍生物药物开发的全球专利态势分析, columnId=1304140194819629763, journalTitle=中草药, columnName=数据挖掘与循证医学, runingTitle=null, highlight=null, articleAbstract=目的 系统分析小檗碱及其主要衍生物（盐酸小檗碱、二氢小檗碱和四氢小檗碱）的全球专利布局特征，揭示其技术发展趋势与研发热点，为创新药物开发、产业专利布局和中药现代化提供参考。方法 基于全球专利数据库，对小檗碱及其衍生物相关专利进行检索与同族扩展，并通过主题词抽取与聚类分析方法，对不同类型小檗碱专利家族的多元化技术主题、应用领域和区域分布进行系统分析。结果 共识别出1 155个原小檗碱、494个盐酸小檗碱以及65个二氢或四氢小檗碱专利家族。中国是该领域最主要的研发与应用市场。各类小檗碱专利均以药物制备为核心，涉及代谢综合征、肝病、神经退行性疾病等多种适应症。结论 小檗碱及其衍生物领域技术创新活跃，研发热点主要集中在制剂优化、适应证拓展及安全性提升等方面。部分企业在共晶物、脂质体、纳米制剂及复方药物等方向积极布局，体现了该领域正由传统中药活性成分向现代药物工艺和国际化应用方向持续拓展的趋势。, authors=孙明汉1,2 , 王天炜1 , 朱秀珠2 , 张栋1 , authorsList=孙明汉, 王天炜, 朱秀珠, 张栋, authorCompany=1 南京理工大学知识产权学院, 江苏南京 210094; et al . Berberine: A review of its pharmacokinetics properties and therapeutic potentials in diverse vascular diseases [J]. Front Pharmacol , 2021, 12: 762654.et al . Multivariate patent analysis: Using chemometrics to analyze collections of chemical and pharmaceutical patents [J]. J Chemom , 2020, 34(1): e3041.
中草药
|数据挖掘与循证医学
2026
, 57
(3) :
1032
-1040
小檗碱及其衍生物药物开发的全球专利态势分析
全屏
孙明汉1,2 , 王天炜1 , 朱秀珠2 , 张栋1
作者信息
1 南京理工大学知识产权学院, 江苏南京 210094;
通讯作者:
张栋
作者简介:
孙明汉: 孙明汉，男，博士，南京理工大学知识产权学院讲师，南京大学信息管理学院博士后，研究方向为专利信息分析，知识产权管理。Tel:(025)84303386 E-mail:sunminghan6@njust.edu.cn
Analysis of global patent situation in drug development of berberine and its derivatives
SUN Minghan, WANG Tianwei, ZHU Xiuzhu, ZHANG Dong
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.03.020
文章导航
目的 系统分析小檗碱及其主要衍生物（盐酸小檗碱、二氢小檗碱和四氢小檗碱）的全球专利布局特征，揭示其技术发展趋势与研发热点，为创新药物开发、产业专利布局和中药现代化提供参考。方法 基于全球专利数据库，对小檗碱及其衍生物相关专利进行检索与同族扩展，并通过主题词抽取与聚类分析方法，对不同类型小檗碱专利家族的多元化技术主题、应用领域和区域分布进行系统分析。结果 共识别出1 155个原小檗碱、494个盐酸小檗碱以及65个二氢或四氢小檗碱专利家族。中国是该领域最主要的研发与应用市场。各类小檗碱专利均以药物制备为核心，涉及代谢综合征、肝病、神经退行性疾病等多种适应症。结论 小檗碱及其衍生物领域技术创新活跃，研发热点主要集中在制剂优化、适应证拓展及安全性提升等方面。部分企业在共晶物、脂质体、纳米制剂及复方药物等方向积极布局，体现了该领域正由传统中药活性成分向现代药物工艺和国际化应用方向持续拓展的趋势。
小檗碱
/
盐酸小檗碱
/
二氢小檗碱
/
小檗碱衍生物
/
专利分析
Objective To systematically analyze the global patent landscape of berberine and its major derivatives, including berberine hydrochloride, dihydroberberine, and tetrahydroberberine, to identify technological development trends and research hotspots and provide references for innovative drug development, strategic patent layout, and the modernization of traditional Chinese medicine. Methods Based on global patent databases, patents related to berberine and its derivatives were retrieved and expanded by patent families. Keyword extraction and clustering analysis were applied to analyze diversified technological themes, application areas, and geographical distributions of different categories of berberine-related patent families. Results A total of 1 155 berberine, 494 berberine hydrochloride, and 65 dihydroberberine or tetrahydroberberine patent families were identified. China was the primary market for research and application. Patents mainly focused on pharmaceutical preparations and covered multiple indications, including metabolic syndrome, liver diseases, and neurodegenerative disorders. Conclusion Technological innovation in berberine and its derivatives remains active, with research hotspots concentrated on formulation optimization, expansion of therapeutic indications, and improvement of safety. Some enterprises have actively deployed patents in cocrystals, liposomes, nanoformulations, and compound preparations, indicating a continuous expansion from traditional active components of Chinese medicine toward modern pharmaceutical technologies and international applications.
berberine
/
berberine hydrochloride
/
dihydroberberine
/
berberine derivatives
/
patent analysis
孙明汉, 王天炜, 朱秀珠, 张栋.
小檗碱及其衍生物药物开发的全球专利态势分析.
中草药,
2026
, 57
(3)
: 1032
-1040
.
DOI: 10.7501/j.issn.0253-2670.2026.03.020
SUN Minghan, WANG Tianwei, ZHU Xiuzhu, ZHANG Dong.
Analysis of global patent situation in drug development of berberine and its derivatives[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(3)
: 1032
-1040
.
DOI: 10.7501/j.issn.0253-2670.2026.03.020
参考文献
引证文献
孙吉娜, 汪进林, 谢雄, 等. 小檗碱及其衍生物的研究进展 [J]. 中国科学: 化学, 2025, 55(8): 2331-2360.et al . Berberine: A review of its pharmacokinetics properties and therapeutic potentials in diverse vascular diseases [J]. Front Pharmacol , 2021, 12: 762654.et al . Multivariate patent analysis: Using chemometrics to analyze collections of chemical and pharmaceutical patents [J]. J Chemom , 2020, 34(1): e3041.
2026年第57卷第3期
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doi: 10.7501/j.issn.0253-2670.2026.03.020
接收时间：2025-10-14
首发时间：2026-09-08
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.03.020
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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