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However, the underlying dynamic mechanism governing the selection of regulatory direction cannot be adequately explained through the static “component-target” paradigm of modern pharmacology or the empirical induction of traditional “pattern-effect” relationships. To address this theoretical bottleneck, this study, grounded in the intrinsic logic of TCM thinking, introduces and elaborates on the theoretical concept of “dynamic tendency”, constructing a dynamic explanatory framework that organically integrates “body state”, “medicinal properties”, and “effect direction”. This study proposes the basic approach of “discerning the dynamic tendency to clarify the mechanism, and following the dynamic tendency to regulate accordingly”. It innovatively defines three core categories—“disease tendency”, “tendency towards homeostasis”, and “herbal tendency” and, based on the principle of “guiding according to the tendency”, constructs a ternary dynamic response model of “disease tendency-tendency towards homeostasis-herbal tendency”. This model redefines the essence of bidirectional regulation in TCM as follows: within the context of a specific “disease tendency”, the body's inherent self-balancing trend—the “homeostatic tendency” is activated yet lacks the conditions to restore equilibrium. The “herbal tendency”, as an exogenous intervention with a consistent directional property, precisely coordinates with and stimulates this “homeostatic tendency”, thereby guiding the system back to dynamic balance from various states of deviation. Furthermore, the paper analyzes the bidirectional regulatory mechanisms of single herbs (such as Dahuang-Cijili), herb pairs (such as Chaihu-Huangqin), and compound formulas (such as Guizhi Tang) through the lens of the “disease tendency-homeostatic tendency-herbal tendency” framework. Extending the “tendency” theory to the level of clinical diagnosis and treatment, this study aims to provide a new perspective and theoretical foundation for deepening TCM clinical thinking from “pattern differentiation” toward “tendency differentiation and mechanism discernment”, and from “formula selection” toward “precise tendency alignment”. This is intended to promote the modern interpretation and development of “tendency-based” theory in TCM., authors=ZHANG Sai1 , HU Jinpeng1 , CHEN Li1 , YU Sijia1 , FAN Mingyuan1 , YUAN Jiushu1 , YAO Qiyuan1,2,3 , XIE Hongyan1,2,3 , YUAN Haipo1,2,3 , XIE Chunguang1,2,3 , GAO Hong1,2,3 , authorsList=ZHANG Sai, HU Jinpeng, CHEN Li, YU Sijia, FAN Mingyuan, YUAN Jiushu, YAO Qiyuan, XIE Hongyan, YUAN Haipo, XIE Chunguang, GAO Hong, authorCompany=1 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China; 1 , 胡锦鹏1 , 陈莉1 , 余思佳1 , 樊明媛1 , 袁久术1 , 姚淇元1,2,3 , 谢红艳1,2,3 , 袁海泼1,2,3 , 谢春光1,2,3 , 高泓1,2,3 , authorsList=张赛, 胡锦鹏, 陈莉, 余思佳, 樊明媛, 袁久术, 姚淇元, 谢红艳, 袁海泼, 谢春光, 高泓, authorCompany=1 成都中医药大学附属医院, 四川成都 610072;
中草药
|综述
2026
, 57
(17) :
7033
-7045
基于“因势利导”探讨中药双向调节作用的“势”学理论内涵
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张赛, 胡锦鹏, 陈莉, 余思佳, 樊明媛, 袁久术, 姚淇元, 谢红艳, 袁海泼, 谢春光, 高泓
作者信息
通讯作者:
高泓
作者简介:
张赛: 张赛，博士研究生，研究方向为中医药防治内分泌代谢疾病的临床与基础。E-mail:1565147579@qq.com
Exploring theoretical connotation of “potential” in bidirectional regulatory effects of traditional Chinese medicine based on “guiding according to trends”
ZHANG Sai, HU Jinpeng, CHEN Li, YU Sijia, FAN Mingyuan, YUAN Jiushu, YAO Qiyuan, XIE Hongyan, YUAN Haipo, XIE Chunguang, GAO Hong
Affiliations
1 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China;
doi: 10.7501/j.issn.0253-2670.2026.17.032
文章导航
中药“双向调节”现象作为中医特色效应之一，体现了“以平为期”的治疗宗旨，然而其背后的动态方向选择机制难以通过现代药理学“成分-靶点”的静态分析范式或传统“证-效”关系的经验归纳中得到充分阐释。针对这一理论瓶颈，立足中医本体思维，引入并深化“势”的理论范畴，构建一个能够有机贯通“机体状态-药物特性-效应方向”的动态解释框架。提出“察势以明机，顺势以为调”的基本思路，创新性地界定了“病势”“趋和之势”与“药势”3个核心范畴，并以“因势利导”为基础构建了“病势-趋和之势-药势”三元动态响应模型。该模型将中药双向调节的本质重新界定：在特定“病势”背景下，机体固有的自我平衡趋势，即“趋和之势”被激活且缺乏恢复平衡的条件，而具有恒定趋向的“药势”作为一种外源性干预工具，通过精准协同与激发“趋和之势”，从而引导系统从不同失衡方向回归动态平衡的过程。进一步从“病势-趋和之势-药势”角度解析了单味药如大黄和刺蒺藜、柴胡-黄芩药对、桂枝汤复方等中药的双向调节机制。并将“势”学机制延伸至临床辨治层面，旨在为中医临床从“辨证”向“辨势察机”、从“选方”向“精准择势”的思维深化提供新的视角与理论支点，以期推动“势”学中医理论的现代诠释发展。
势
/
因势利导
/
双向调节
/
稳态
/
中医理论
/
调控系统
The phenomenon of “bidirectional regulation” in traditional Chinese medicine (TCM), as one of its characteristic therapeutic effects, embodies the treatment principle of “achieving equilibrium as the therapeutic goal”. However, the underlying dynamic mechanism governing the selection of regulatory direction cannot be adequately explained through the static “component-target” paradigm of modern pharmacology or the empirical induction of traditional “pattern-effect” relationships. To address this theoretical bottleneck, this study, grounded in the intrinsic logic of TCM thinking, introduces and elaborates on the theoretical concept of “dynamic tendency”, constructing a dynamic explanatory framework that organically integrates “body state”, “medicinal properties”, and “effect direction”. This study proposes the basic approach of “discerning the dynamic tendency to clarify the mechanism, and following the dynamic tendency to regulate accordingly”. It innovatively defines three core categories—“disease tendency”, “tendency towards homeostasis”, and “herbal tendency” and, based on the principle of “guiding according to the tendency”, constructs a ternary dynamic response model of “disease tendency-tendency towards homeostasis-herbal tendency”. This model redefines the essence of bidirectional regulation in TCM as follows: within the context of a specific “disease tendency”, the body's inherent self-balancing trend—the “homeostatic tendency” is activated yet lacks the conditions to restore equilibrium. The “herbal tendency”, as an exogenous intervention with a consistent directional property, precisely coordinates with and stimulates this “homeostatic tendency”, thereby guiding the system back to dynamic balance from various states of deviation. Furthermore, the paper analyzes the bidirectional regulatory mechanisms of single herbs (such as Dahuang-Cijili), herb pairs (such as Chaihu-Huangqin), and compound formulas (such as Guizhi Tang) through the lens of the “disease tendency-homeostatic tendency-herbal tendency” framework. Extending the “tendency” theory to the level of clinical diagnosis and treatment, this study aims to provide a new perspective and theoretical foundation for deepening TCM clinical thinking from “pattern differentiation” toward “tendency differentiation and mechanism discernment”, and from “formula selection” toward “precise tendency alignment”. This is intended to promote the modern interpretation and development of “tendency-based” theory in TCM.
potential
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guiding according to the tendency
/
bidirectional regulation
/
homeostasis
/
traditional Chinese medicine theory
/
regulatory system
张赛, 胡锦鹏, 陈莉, 余思佳, 樊明媛, 袁久术, 姚淇元, 谢红艳, 袁海泼, 谢春光, 高泓.
基于“因势利导”探讨中药双向调节作用的“势”学理论内涵.
中草药,
2026
, 57
(17)
: 7033
-7045
.
DOI: 10.7501/j.issn.0253-2670.2026.17.032
ZHANG Sai, HU Jinpeng, CHEN Li, YU Sijia, FAN Mingyuan, YUAN Jiushu, YAO Qiyuan, XIE Hongyan, YUAN Haipo, XIE Chunguang, GAO Hong.
Exploring theoretical connotation of “potential” in bidirectional regulatory effects of traditional Chinese medicine based on “guiding according to trends”[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(17)
: 7033
-7045
.
DOI: 10.7501/j.issn.0253-2670.2026.17.032
四川省自然科学基金重点项目 (25ZDIZX025); 国家自然科学基金面上项目 (82574995); 第六批四川省名中医传承工作室建设项目——四川省名中医高泓传承工作室 (川中医药办发 [2023] 36号); 成都中医药大学附属医院省重点实验室专项基金 (23SZ03,23SZ05,23SZ06)
参考文献
引证文献
吴垠莲, 陈西平, 叶静, 等. 浅析邓中甲教授“双向调节”诊治思维[J]. 四川中医, 2024, 42(9): 15-18.
2026年第57卷第17期
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doi: 10.7501/j.issn.0253-2670.2026.17.032
接收时间：2026-05-19
首发时间：2026-10-29
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.17.032
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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