Article(id=1322631224246518292, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631195876242221, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.17.031, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1782662400000, receivedDateStr=2026-06-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793269457159, onlineDateStr=2026-10-29, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793269457159, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793269457159, creator=13701087609, updateTime=1793269457159, updator=13701087609, issue=Issue{id=1322631195876242221, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='17', pageStart='6661', pageEnd='7072', issueExtLink='null', onlineDate='null', pubDate='1789142400000', pubDateStr='2026-09-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793269450396, creator='13701087609', updateTime=1793269538381, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322631565008556693, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631195876242221, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322631565008556694, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631195876242221, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=7023, endPage=7032, ext={EN=ArticleExt(id=1322631224552702486, articleId=1322631224246518292, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Mechanism and research progress of Qishen Yiqi Dropping Pills in treatment of coronary heart disease, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Coronary heart disease (CHD) is characterized by a high incidence rate and a substantial disease burden. Although conventional Western medicine can effectively manage cardiovascular risk factors and achieve coronary revascularization, it often fails to adequately address microcirculation disturbance, residual inflammatory risk, and the lack of holistic systemic regulation. In traditional Chinese medicine (TCM), CHD falls under the categories of “Xiongbi” (chest obstruction) and “Xintong” (cardiac pain), with “qi deficiency and blood stasis” identified as the core pathogenesis. This concept aligns closely with the modern pathological network of “vascular injury-inflammatory immune response-metabolic dysregulation”. Qishen Yiqi Dripping Pills (芪参益气滴丸, QSYQ), a Chinese patent medicine composed of Huangqi (Astragali Radix), Danshen (Salviae Miltiorrhizae Radix et Rhizoma), Sanqi (Notoginseng Radix et Rhizoma), and Jiangxiang (Dalbergiae Odoriferae Lignum), strictly adheres to the therapeutic principle of supplementing qi and activating blood, offering distinct advantages in multi-target systemic regulation. Centered on the theme of systemic regulation and precise intervention, this review first elucidates the scientific connotation of qi deficiency and blood stasis and maps its correlation with modern pathological networks. It then establishes a three-tiered mechanistic framework spanning “molecular events-signaling pathways-biological effects” to systematically decode the synergistic regulatory networks of QSYQ in anti-inflammation, anti-oxidation, anti-apoptosis, angiogenesis promotion, and energy metabolism optimization. Furthermore, a hierarchical clinical evidence evaluation system is constructed to summarize the therapeutic value of QSYQ in alleviating symptoms, improving cardiac function, enhancing long-term prognosis, and managing special patient populations. Future research should leverage multi-omics technologies and real-world evidence studies to further elucidate the underlying mechanisms of action. Additionally, high-quality evidence-based studies should be conducted to standardize evaluation criteria and optimize individualized medication regimens, ultimately promoting the standardized clinical application of QSYQ in the integrative traditional Chinese and Western medicine treatment of coronary heart disease., authors=ZHAO Boxuan¹, YIN Yixuan^2,3, WANG Xinxin², WANG Ziqi², HAN Yu², ZHAO Ning⁴, LI Chunjie³, authorsList=ZHAO Boxuan, YIN Yixuan, WANG Xinxin, WANG Ziqi, HAN Yu, ZHAO Ning, LI Chunjie, authorCompany=1 Tasly Zhijiao Pharmaceutical Co., Ltd., Tianjin 300410, China;
2 Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;
3 Tianjin Chest Hospital, Tianjin 300222, China;
4 Tianjin University, Tianjin 300072, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322631224485593621, articleId=1322631224246518292, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=芪参益气滴丸治疗冠心病的作用机制与研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=冠状动脉粥样硬化性心脏病发病率高、疾病负担沉重。西医常规治疗虽可有效控制危险因素、重建冠脉血运，但难以解决微循环障碍、残余炎症及整体功能调节缺失等问题。中医认为冠心病属“胸痹”“心痛”范畴，以“气虚血瘀”为核心病机，与现代医学“血管损伤-炎症免疫-代谢失衡”的病理网络深度契合。芪参益气滴丸由黄芪、丹参、三七、降香配伍而成，紧扣益气活血治则，兼具多靶点系统调控优势。以系统调控与精准干预为主线，首先厘清气虚血瘀病机的科学内涵及其与现代病理网络的关联，进而通过“分子事件-信号通路-生物效应”3层级的机制挖掘，系统阐释芪参益气滴丸抗炎、抗氧化、抗凋亡、促血管新生及改善能量代谢的协同调控网络。通过临床证据分层评价体系，总结该药在症状改善、心功能提升、远期预后及特殊人群中的应用价值，并提出未来研究可依托多组学技术、真实世界研究等方法，深化芪参益气滴丸作用机制的探索，开展高质量临床循证研究，建立统一的疗效评价体系，优化个体化用药方案，进一步推动该药物在冠心病中西医结合诊疗中的规范化应用。, authors=赵泊萱¹, 尹艺璇^2,3, 王欣鑫², 王梓旗², 韩雨², 赵宁⁴, 李春洁³, authorsList=赵泊萱, 尹艺璇, 王欣鑫, 王梓旗, 韩雨, 赵宁, 李春洁, authorCompany=1 天士力之骄药业有限公司, 天津 300410;
2 天津中医药大学研究生院, 天津 301617;
3 天津市胸科医院, 天津 300222;
4 天津大学, 天津 300072, correspAuthors=李春洁, authorNote=赵泊萱: 赵泊萱，硕士，研究方向为中药学。E-mail:2586570305@qq.com 尹艺璇: 尹艺璇，博士，研究方向为中医内科学。E-mail:yinyixuan0329@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=3sGFm/9fXyGIp4jsVMcC7w==, pdfFileSize=1662276, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=天津市自然科学基金重点项目 (23JCZDJC00930); 现代中医药海河实验室2023年度第二批“揭榜挂帅”科技项目 (24HHZYSS00016); 天津市生物医药科技重大专项项目 (25ZXSWSY00190); 天津市卫生健康委员会中医药重点领域科研项目 (A0104); 国家中西医协同旗舰科室建设项目)}, authors=null, keywords=[Keyword(id=1322634623465669099, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631224246518292, language=CN, orderNo=1, keyword=冠心病), Keyword(id=1322634623545360876, tenantId=1146029695717560320, 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detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.17.031, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.17.031, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.17.031, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1789142400000, fullTextJson=null, articleText=null, reference=国家心血管病中心. 中国心血管健康与疾病报告-2024[M]. 北京: 中国协和医科大学出版社, 2025.
刘明波, 何新叶, 杨晓红, 等.《中国心血管健康与疾病报告2024》要点解读[J]. 实用医学杂志, 2025, 41(14): 2111-2131.
中国心血管病风险评估和管理指南编写联合委员会. 中国心血管病风险评估和管理指南[J]. 中华健康管理学杂志, 2019, 13(1): 7-29.
田泽祥, 王坚, 刘志平.《冠心病诊断与治疗》出版: 冠状动脉旁路移植术与经皮冠状动脉介入术治疗老年复杂冠状动脉病变临床差异分析[J]. 介入放射学杂志, 2023, 32(8): 后插3.
中华医学会, 中华医学会临床药学分会, 中华医学会杂志社, 等. 心脏骤停基层合理用药指南[J]. 中华全科医师杂志, 2021, 20(3): 307-310.
贾硕, 程功, 关蕾, 等. 单电子发射计算机断层成像技术在经皮冠状动脉支架植入术后患者冠脉微循环障碍中的诊断性能研究[J]. 中国全科医学, 2025, 28(9): 1122-1127.
艾纯颖, 米金霞, 谢燕. 中药复方治疗痰瘀互结型冠心病的研究进展[J]. 上海中医药大学学报, 2024, 38(4): 92-101.
王肖龙, 毛威, 杨天伦. 芪参益气滴丸临床应用专家共识[J]. 药物评价研究, 2025, 48(6): 1386-1402.
Tan Y Q, Chen H W, Li J. Astragaloside IV: An effective drug for the treatment of cardiovascular diseases [J]. Drug Des Dev Ther, 2020, 14: 3731-3746.
张婧懿, 李晓, 黄晓莹, 等. 丹参化学成分及药理作用研究进展[J]. 中医药信息, 2026, 43(2): 92-97.
杨春昆, 姜春云, 王雪娇, 等. 人参皂苷对血管的保护机制[J]. 世界中西医结合杂志, 2022, 17(8): 1685-1690.
何欣, 杨云, 赵祥升, 等. 降香化学成分及药理作用研究进展[J]. 中国现代中药, 2022, 24(6): 1149-1166.
孙沁瑜, 邓毅凡, 方震, 等. 基于网络药理学和分子对接技术探讨芪参益气滴丸治疗冠心病合并心力衰竭的作用机制[J]. 中国老年保健医学, 2025, 23(3): 37-44.
Schade D S, Blankenship J C, Gonzales K, et al. A new paradigm to reduce cardiovascular disease based on the pathogenesis of atherosclerosis [J]. Am J Med, 2026, 139(3): 276-282.
Zhang J, Chang J, Chen V, et al. Oxidized LDL stimulates PKM2-mediated mtROS production and phagocytosis [J]. J Lipid Res, 2025, 66(5): 100809.
赵旻炅, 陈铃芳, 胡苗清, 等. 免疫细胞调控心肌缺血损伤后再生的研究进展[J]. 上海交通大学学报: 医学版, 2026, 46(3): 368-376.
Gronda E, Sacchi S, Benincasa G, et al. Unresolved issues in left ventricular postischemic remodeling and progression to heart failure [J]. J Cardiovasc Med, 2019, 20(10): 640-649.
韩晶岩. 心气虚血瘀的科学内涵和芪参益气滴丸补气活血的作用机理[J]. 世界科学技术—中医药现代化, 2019, 21(2): 139-147.
王阶, 董艳, 熊兴江, 等. 活血化瘀治疗冠脉微循环障碍的研究进展[J]. 中国科学基金, 2024, 38(4): 677-686.
Ross R. Atherosclerosis: An inflammatory disease [J]. N Engl J Med, 1999, 340(2): 115-126.
胡武明, 施振华, 叶士勇, 等. 芪参益气滴丸通过TRPC1/STIM1通路调节Ca²⁺稳态发挥抗动脉粥样硬化作用[J]. 中国病理生理杂志, 2019, 35(4): 686-691.
燕芳芳, 刘艳, 刘运芳, 等. 芪参益气滴丸对实验性动脉粥样硬化超敏C反应蛋白的影响[J]. 上海中医药杂志, 2007, 41(2): 59-60.
彭立, 沈佳成, 王亚东, 等. 芪参益气滴丸对ApoE基因敲除小鼠动脉粥样硬化中调节性T细胞的影响[J]. 中华中医药杂志, 2018, 33(3): 907-910.
张博承, 彭立, 许滔, 等. 芪参益气滴丸对AopE基因敲除小鼠动脉粥样硬化中Th17细胞的作用及其网络药理学靶点分析[J]. 世界科学技术—中医药现代化, 2022, 24(5): 2003-2013.
Tseng A H H, Shieh S S, Wang D L. SIRT3 deacetylates FoxO3 to protect mitochondria against oxidative damage [J]. Free Radic Biol Med, 2013, 63: 222-234.
Wang C R, Wo D, Huang Y, et al. Qishen Yiqi Dropping Pills protect against myocardial infarction in mice via activating SIRT3/FoxO3a signaling pathway [J]. Pharmaceuticals, 2026, 19(3): 489.
Zhou R B, Tardivel A, Thorens B, et al. Thioredoxin-interacting protein links oxidative stress to inflammasome activation [J]. Nat Immunol, 2010, 11(2): 136-140.
吕李飞, 朱婷婷, 丁帆, 等. 芪参益气滴丸调节肠道菌群和ROS/TXNIP/NLRP3信号通路改善慢性心力衰竭大鼠的作用机制[J]. 北京中医药大学学报, 2025, 48(3): 354-369.
Xu Z J, Meng F, Yang H J, et al. Bak and Bax: Therapeutic targets for acute myocardial infarction and myocardial ischemia-reperfusion injury [J]. Biology, 2026, 15(1): 81.
王静, 刘桂华, 王爱玲. 芪参益气滴丸对急性心肌梗死大鼠心肌细胞凋亡及心功能的影响[J]. 中国老年学杂志, 2013, 33(12): 2847-2848.
龚燚婷, 李彦萍, 程亚茹, 等. 基于HIF-1信号通路研究芪参益气滴丸治疗心肌缺血的分子机制[J]. 中国中药杂志, 2021, 46(15): 3949-3959.
Kaur G, Roy B. Decoding tumor angiogenesis for therapeutic advancements: Mechanistic insights [J]. Biomedicines, 2024, 12(4): 827.
Zhang L, Wang Y, Yu L Y, et al. QI-SHEN-YI-QI accelerates angiogenesis after myocardial infarction in rats [J]. Int J Cardiol, 2010, 143(1): 105-109.
Dai G H, Liu N, Zhu J W, et al. Qi-Shen-Yi-Qi Dripping Pills promote angiogenesis of ischemic cardiac microvascular endothelial cells by regulating microRNA-223-3p expression [J]. Evid Based Complementary Altern Med, 2016, 2016: 5057328.
张玲. 芪参益气方促血管新生机制及抗心肌缺血作用研究[D]. 杭州: 浙江大学, 2011.
何贵新, 肖婷, 秦伟彬, 等. 芪参益气滴丸联合骨髓间充质干细胞移植对心肌梗死小鼠血管新生及心功能的影响研究[J]. 海南医学院学报, 2021, 27(5): 321-326.
Chen J R, Wei J, Wang L Y, et al. Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill^® via ameliorate of multiple mitochondrial dysfunctions [J]. Drug Des Dev Ther, 2015: 3051.
Chau K Y, Taanman J W, Schapira A H V. Small-scale protocols to characterize mitochondrial complex V activity and assembly in peripheral blood mononuclear cells [J]. PLoS One, 2025, 20(5): e0323136.
Cui Y C, Yan L, Pan C S, et al. The contribution of different components in QiShenYiQi Pills^® to its potential to modulate energy metabolism in protection of ischemic myocardial injury [J]. Front Physiol, 2018, 9: 389.
史子法. 芪参益气滴丸联合新四联治疗冠心病合并慢性心功能不全患者的疗效及对血清hs-CRP及NT-proBNP水平的影响[J]. 中国药学药品知识仓库, 2025, 23(6): 64-68.
赖沛伦, 李锦锋, 袁圣亮, 等. 芪参益气滴丸联合沙库巴曲缬沙坦对HFrEF患者的临床效果及循环外泌体miR-92b-5p、miR-208a水平的影响[J]. 分子诊断与治疗杂志, 2025, 17(10): 1925-1928.
王芮, 迪力热巴·沙依提江. 芪参益气滴丸联合尼可地尔对冠心病心绞痛患者临床指标及炎性因子的影响[J]. 中国医药指南, 2025, 23(18): 146-149.
王静, 黄容, 方宁, 等. 芪参益气滴丸对急性心肌梗死患者PCI术后血流动力学、心室重构的影响[J]. 临床和实验医学杂志, 2026, 25(6): 576-580.
韩晓娟, 闫占光, 侯海文. 芪参益气滴丸联合达格列净、沙库巴曲缬沙坦对慢性心力衰竭患者的治疗效果[J]. 中华中医药学刊, 2026, 44(6): 219-222.
沈秀张, 蒋广恩. 芪参益气滴丸联合沙库巴曲缬沙坦治疗慢性心力衰竭的疗效及其对心率变异性的影响[J]. 中西医结合心脑血管病杂志, 2025, 23(24): 3780-3784.
张玉辉, 宋颖. 芪参益气滴丸联合曲美他嗪治疗老年慢性心力衰竭患者的疗效及对C反应蛋白的影响研究[J]. 内蒙古中医药, 2025, 44(3): 9-11.
张力俨, 宋付凯, 杨东慧, 等. 芪参益气滴丸辅助治疗对冠心病心力衰竭患者心肌酶谱和血管内皮功能的影响[J]. 河南医学研究, 2026, 35(3): 530-533.
李警卓, 王佩, 翟蒙恩. 芪参益气滴丸对冠心病急性心肌缺血病人心肌细胞铁死亡的调节机制[J]. 中西医结合心脑血管病杂志, 2025, 23(17): 2645-2649.
于燕乔, 杨芙蓉, 崔卓睿, 等. 芪参益气滴丸干预非ST段抬高型急性冠脉综合征患者经皮冠状动脉介入后前瞻性队列研究[J]. 中国中西医结合杂志, 2025, 45(5): 538-546.
杨芙蓉, 杨严凯, 崔卓睿, 等. 芪参益气滴丸治疗急性冠脉综合征PCI术后气虚血瘀证女性患者的临床预后研究[J]. 天津中医药, 2025, 42(9): 1096-1105.
涂华燕, 周红英, 梁勇. 芪参益气滴丸对慢性心力衰竭患者心肌保护作用及主要不良心血管事件的防治[J]. 实用中西医结合临床, 2025, 25(11): 12-14.
张军芳. 芪参益气滴丸辅治糖尿病伴冠心病临床观察[J]. 实用中医药杂志, 2025, 41(12): 2387-2389.
王瑶, 吴玉, 程姗姗, 等. 芪参益气滴丸治疗糖尿病心肌病的临床疗效[J]. 江西中医药, 2026, 57(2): 37-41.
杨玫, 刘莹, 李佳, 等. 芪参益气滴丸对接受AC-TH方案化疗的HER-2阳性高危乳腺癌患者肿瘤治疗相关心血管毒性的一级预防作用[J]. 临床心血管病杂志, 2026, 42(4): 280-284.
李慧平, 钟成梁, 李梅芳, 等. 芪参益气滴丸治疗慢性心力衰竭的安全性I期临床试验[J]. 长春中医药大学学报, 2026, 42(3): 314-318.)