Article(id=1322631214364741816, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631195876242221, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.17.025, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1771171200000, receivedDateStr=2026-02-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793269454803, onlineDateStr=2026-10-29, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793269454803, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793269454803, creator=13701087609, updateTime=1793269454803, updator=13701087609, issue=Issue{id=1322631195876242221, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='17', pageStart='6661', pageEnd='7072', issueExtLink='null', onlineDate='null', pubDate='1789142400000', pubDateStr='2026-09-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793269450396, creator='13701087609', updateTime=1793269538381, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322631565008556693, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631195876242221, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322631565008556694, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631195876242221, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=6955, endPage=6964, ext={EN=ArticleExt(id=1322631214754812090, articleId=1322631214364741816, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Quality difference evaluation of multi-index quantitative determination combined with chemometrics and TOPSIS-GRA model of Limonium bicolor from different producing areas, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To establish a multi-index quantitative determination method for Limonium bicolor from different habitats, and to evaluate the quality of L. bicolor from different habitats by combining chemometrics and integratedTOPSIS-GRA method. Methods HPLC was performed on a Prep Scalar C₁₈ (250 mm × 4.6 mm, 5 μm) column. Detection wavelength: 273, 254, 360 and 210 nm; acetonitrile-0.2% phosphoric acid was used as the mobile phase for gradient elution. The injection volume was 10 μL, the flow rate was 1.0 mL/min, and the column temperature was 30 ℃. The contents of gallic acid, vanillic acid, myricitrin, eriodictyol, rutin, luteolin, quercetin, kaempferol, isorhamnetin, naringenin, β-sitosterol, daucosterol in 20 batches of L. bicolor were determined simultaneously. The extractives, total ash and acid-insoluble ash of samples were examined. Utilize SPSS 26.0 and SIMCA 14.1 statistical software to perform chemometric analysis on detection data to group 20 batches of L. bicolor from different habitats, and the quality difference markers were screened, and then the TOPSIS-GRA method fusion model was constructed to sort the quality. Results The results of the established multi-index quantitative methodology were good. Under the same chromatographic conditions, gallic acid, vanillic acid, myricitrin, eriodictyol, rutin, luteolin, quercetin, kaempferol, isorhamnetin, naringenin, β-sitosterol, daucosterol were effectively separated. There were differences in the content of each component. The results of chemometrics analysis showed that the clustering of 20 batches of L. bicolor was obvious, and luteolin, gallic acid, β-sitosterol, rutin, isorhamnetin, quercetin, eriodictyol and myricitrin were the dominant components of origin difference. The results of TOPSIS-GRA analysis showed that there were differences in the comprehensive relative closeness of 20 batches of samples, and the comprehensive relative closeness of S16, S18, S15, S17, S19, S20 was larger, which was 0.642 1, 0.634 2, 0.626 1, 0.614 8, 0.595 4 and 0.593 0, respectively. Conclusion The established multi-index quantitative method can reflect the quality differences of L. bicolor rutin from different habitats. The fusion model combining chemometrics with weighted TOPSIS and GRA comprehensively evaluated the quality characteristics of from different origins, which established a foundation for the quality analysis and evaluation of L. bicolor., authors=TANG Zhihua^1,2, WU Fang³, ZHANG Ke², YU Lushan¹, authorsList=TANG Zhihua, WU Fang, ZHANG Ke, YU Lushan, authorCompany=1 Institute of Drug Metabolism and Pharmaceutical Analysis, School of Pharmacy, Zhejiang University, Hangzhou 310058, China;
2 Department of Pharmacy, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing 312000, China;
3 Department of Chinese Traditional Medicine, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310051, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322631214666731705, articleId=1322631214364741816, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=不同产地二色补血草多指标定量联合化学计量学及TOPSIS-GRA模型的质量差异评价, columnId=1304140203967410414, journalTitle=中草药, columnName=药材与资源, runingTitle=null, highlight=null, articleAbstract=目的 建立不同产地二色补血草Limonium bicolor多指标定量测定方法，联合化学计量学及逼近理想解排序法（technique for order preference by similarity to an ideal solution，TOPSIS）-灰色关联度分析法（grey relational analysis，GRA）评价不同产地二色补血草的质量。方法 采用HPLC法，以Prep Scalar C₁₈（250 mm×4.6 mm，5 μm）为色谱柱；检测波长273、254、360、210 nm；乙腈-0.2%磷酸为流动相，梯度洗脱，进样量10 μL，体积流量1.0 mL/min，柱温30 ℃。同步检测20批二色补血草中没食子酸、香草酸、杨梅苷、圣草酚、芦丁、木犀草素、槲皮素、山柰酚、异鼠李素、柚皮素、β-谷甾醇、胡萝卜苷的含量；并检查浸出物、总灰分和酸不溶性灰分。利用SPSS 26.0、SIMCA 14.1统计软件对检测数据进行化学计量学分析，对20批不同产地二色补血草进行分组，筛选质量差异标志物，进而构建TOPSIS-GRA法融合模型对其质量进行排序。结果 建立的多指标定量方法学考察结果均良好，同一色谱条件下没食子酸、香草酸、杨梅苷、圣草酚、芦丁、木犀草素、槲皮素、山柰酚、异鼠李素、柚皮素、β-谷甾醇、胡萝卜苷均得到有效分离，各成分含量存在产地差异。化学计量学分析结果显示20批二色补血草分组明显，木犀草素、没食子酸、β-谷甾醇、芦丁、异鼠李素、槲皮素、圣草酚和杨梅苷为产地差异的主导成分。TOPSIS-GRA法分析结果显示20批样品的综合相对贴近度存在差异，以S16、S18、S15、S17、S19、S20综合相对贴近度较大，分别为0.642 1、0.634 2、0.626 1、0.614 8、0.595 4、0.593 0。结论 建立的多指标定量方法可以反映不同产地二色补血草的质量差异；化学计量学联合加权TOPSIS与GRA融合模型全面地分析了不同产地二色补血草的质量状况，为二色补血草质量分析和评价奠定基础。, authors=唐志华^1,2, 吴芳³, 张钶², 余露山¹, authorsList=唐志华, 吴芳, 张钶, 余露山, authorCompany=1 浙江大学药学院 药物代谢和药物分析研究所, 浙江杭州 310058;
2 绍兴市人民医院(浙江大学绍兴医院)药学部, 浙江 绍兴 312000;
3 浙江大学医学院附属儿童医院 中医科, 浙江杭州 310051, correspAuthors=余露山, authorNote=唐志华: 唐志华（1975—），男，浙江绍兴人，硕士，主任药师，研究方向为中药质控及药理、智慧药学。Tel:(0575)88509711 E-mail:sxtzh@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=UD0IdATUw875hyNxnSut5w==, pdfFileSize=1847485, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=浙江省“尖兵”“领雁”研发攻关计划项目 (2023C03042))}, authors=[Author(id=1324139477307896451, tenantId=1146029695717560320, journalId=null, articleId=1322631214364741816, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={EN=AuthorExt(id=null, tenantId=null, journalId=1302319053441957962, articleId=1322631214364741816, authorId=1324139477307896451, language=EN, stringName=TANG Zhihua, WU Fang, ZHANG Ke, YU Lushan, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=null, tenantId=null, journalId=1302319053441957962, articleId=1322631214364741816, authorId=1324139477307896451, language=CN, stringName=唐志华, 吴芳, 张钶, 余露山, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=null)], keywords=[Keyword(id=1322634613911048683, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=1, keyword=二色补血草), Keyword(id=1322634613986546156, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=2, keyword=化学计量学), Keyword(id=1322634614066237933, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=3, keyword=逼近理想解排序法), Keyword(id=1322634614145929710, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=4, keyword=灰色关联度分析法), Keyword(id=1322634614225621487, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=5, keyword=质量评价), Keyword(id=1322634614359839216, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=6, keyword=没食子酸), Keyword(id=1322634614431142385, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=7, keyword=香草酸), Keyword(id=1322634614506639858, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=8, keyword=杨梅苷), Keyword(id=1322634614598914547, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=9, keyword=圣草酚), Keyword(id=1322634614682800628, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=10, keyword=木犀草素), Keyword(id=1322634614745715189, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=11, keyword=异鼠李素), Keyword(id=1322634614817018358, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=CN, orderNo=12, keyword=柚皮素), Keyword(id=1322634614955430391, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1322631214364741816, language=EN, orderNo=1, keyword=Limonium bicolor (Bag.) 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