Article(id=1319981933250064957, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1319981498787279574, articleNumber=PA20260909_dmWlt823, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.16.034, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1774886400000, receivedDateStr=2026-03-31, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792637816965, onlineDateStr=2026-10-22, pubDate=1787846400000, pubDateStr=2026-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792637816964, onlineIssueDateStr=2026-10-22, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792637816964, creator=admin, updateTime=1792637816964, updator=admin, issue=Issue{id=1319981498787279574, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='16', pageStart='6209', pageEnd='6660', issueExtLink='null', onlineDate='null', pubDate='1787846400000', pubDateStr='2026-08-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792637713380, creator='ztmeta', updateTime=1792637713380, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=6647, endPage=6660, ext={EN=ArticleExt(id=1319981936060248639, articleId=1319981933250064957, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Advances in toxicity risk control and modern research of highly toxic traditional Chinese medicinal materials, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=The toxicity of traditional Chinese medicines (TCMs), along with the four natures and five flavors, ascending, descending, floating, and sinking, and channel tropism, belongs to the category of pharmacological theory and together constitutes the fundamental principles guiding clinical TCM practices. However, the complex composition of highly toxic medicinal materials makes it difficult to fully elucidate their toxic components and mechanisms of action. Additionally, the diversity of clinical medication regimens and significant individual differences pose considerable challenges to related research. Based on the characteristics of highly toxic medicinal materials, this study systematically reviews the highly toxic medicinal materials included in the 2025 edition of the Chinese Pharmacopoeia. By integrating herbal textual research with modern pharmacological studies, this paper provides an in-depth analysis from multiple perspectives, including common toxic components and pathways, the bidirectional relationship between toxicity and efficacy, and strategies for reducing toxicity while preserving efficacy.Furthermore, it reviews the current application of modern analytical detection techniques in the quality control of these medicinal materials and discusses other potentially toxic substances in TCMs along with risk management strategies. This review aims to serve as a reference for promoting safe and rational clinical use of highly toxic medicinal materials and strengthening the prevention and control of toxicity risks., authors=DENG Lulu¹, ZHAO Zhigao¹, WU Shuyu¹, JIA Lei¹, TAN Rui¹, authorsList=DENG Lulu, ZHAO Zhigao, WU Shuyu, JIA Lei, TAN Rui, authorCompany=1 School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319981935972168254, articleId=1319981933250064957, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=大毒药材毒性风险控制及现代研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=中药的毒性与四气五味、升降浮沉、归经同属药性理论范畴，共同构成指导中医临床用药的基本原则。然而，大毒药材成分复杂，其毒性成分与作用机制难以完全阐明；加之临床用药方案多样及个体差异显著，亦为相关研究带来诸多挑战。基于大毒药材的特性，系统梳理了《中国药典》2025年版所收录的大毒药材。通过本草典籍溯源与现代药理研究相结合的研究路径，从共性毒性成分与通路、毒-效双向规律及减毒存效策略等多维度进行深入分析，综述了现代分析检测技术在大毒药材质量控制中的应用现状，并对其可能存在的其他有毒物质及其风险管控策略进行了阐述，为促进大毒药材临床安全合理应用及加强毒性风险防控提供参考依据。, authors=邓露露¹, 赵志高¹, 吴姝谕¹, 贾磊¹, 谭睿¹, authorsList=邓露露, 赵志高, 吴姝谕, 贾磊, 谭睿, authorCompany=1 西南交通大学生命科学与工程学院, 四川成都 610031, correspAuthors=谭睿, authorNote=邓露露: 邓露露,硕士研究生,研究方向为药物分析。E-mail:1523438846@qq.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=https://oss.bj-dx-dzqywjd-hlw-icp.inspurcloudoss.com:6063/cast-journal-prod/2097521198041731073/excel/pdfs/3b40eae6b6cc48d49fedb5749b903b6d.pdf?response-content-disposition=attachment%3B%20filename%3D%2220261634.pdf%22&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20261022T025348Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=NjRlNmUzOGMtM2Y3OC00MDQ3LThkMmYtN2JkODRmYmI3MTgw%2F20261022%2Fbj-dx-dzqywjd-hlw-icp%2Fs3%2Faws4_request&X-Amz-Signature=dbb3592c7767f861362a6715928ae684f443806e079d9f8e6db2da0fed2e1f93, pdf=kXitTt3lxYs+bqlPKFYf8Q==, pdfFileSize=1240809, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=四川省中医药管理局科学技术专项 (2024zd033); 四川省中医药管理局中医药科研专项 (25ZDAZX012))}, authors=[Author(id=1319981936341267012, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=邓露露, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981936408375878, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, authorId=1319981936341267012, language=CN, stringName=邓露露, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=²西南交通大学生命科学与工程学院, 四川成都 610031, bio=邓露露: 邓露露,硕士研究生,研究方向为药物分析。E-mail:1523438846@qq.com, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981936257380930, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, xref=2^*, ext=[AuthorCompanyExt(id=1319981936269963843, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, companyId=1319981936257380930, language=CN, country=null, province=null, city=null, postcode=null, companyName=西南交通大学生命科学与工程学院, 四川成都 610031, departmentName=null, remark=^2.西南交通大学生命科学与工程学院, 四川成都 610031)])]), Author(id=1319981936479679047, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=赵志高, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981936563565129, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, authorId=1319981936479679047, language=CN, stringName=赵志高, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=²西南交通大学生命科学与工程学院, 四川成都 610031, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981936257380930, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, xref=2^*, ext=[AuthorCompanyExt(id=1319981936269963843, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, companyId=1319981936257380930, language=CN, country=null, province=null, city=null, postcode=null, companyName=西南交通大学生命科学与工程学院, 四川成都 610031, departmentName=null, remark=^2.西南交通大学生命科学与工程学院, 四川成都 610031)])]), Author(id=1319981936626479690, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=吴姝谕, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981936697782860, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, authorId=1319981936626479690, language=CN, stringName=吴姝谕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=²西南交通大学生命科学与工程学院, 四川成都 610031, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981936257380930, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, xref=2^*, ext=[AuthorCompanyExt(id=1319981936269963843, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, companyId=1319981936257380930, language=CN, country=null, province=null, city=null, postcode=null, companyName=西南交通大学生命科学与工程学院, 四川成都 610031, departmentName=null, remark=^2.西南交通大学生命科学与工程学院, 四川成都 610031)])]), Author(id=1319981936756503117, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=贾磊, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981936823611983, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, authorId=1319981936756503117, language=CN, stringName=贾磊, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=²西南交通大学生命科学与工程学院, 四川成都 610031, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981936257380930, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, xref=2^*, ext=[AuthorCompanyExt(id=1319981936269963843, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, companyId=1319981936257380930, language=CN, country=null, province=null, city=null, postcode=null, companyName=西南交通大学生命科学与工程学院, 四川成都 610031, departmentName=null, remark=^2.西南交通大学生命科学与工程学院, 四川成都 610031)])]), Author(id=1319981936886526544, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=谭睿, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981936966218322, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, authorId=1319981936886526544, language=CN, stringName=谭睿, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=²西南交通大学生命科学与工程学院, 四川成都 610031, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981936257380930, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, xref=2^*, ext=[AuthorCompanyExt(id=1319981936269963843, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, companyId=1319981936257380930, language=CN, country=null, province=null, city=null, postcode=null, companyName=西南交通大学生命科学与工程学院, 四川成都 610031, departmentName=null, remark=^2.西南交通大学生命科学与工程学院, 四川成都 610031)])])], keywords=[Keyword(id=1322633194453709775, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=CN, orderNo=1, keyword=大毒药材), Keyword(id=1322633194508235728, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=CN, orderNo=2, keyword=共性毒性成分与通路), Keyword(id=1322633194571150289, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=CN, orderNo=3, keyword=毒-效双向规律), Keyword(id=1322633194629870546, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=CN, orderNo=4, keyword=减毒存效), Keyword(id=1322633194688590803, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=CN, orderNo=5, keyword=质量控制), Keyword(id=1322633194860557268, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=EN, orderNo=1, keyword=highly toxic traditional Chinese medicinal materials), Keyword(id=1322633194923471829, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=EN, orderNo=2, keyword=common toxic components and pathways), Keyword(id=1322633194986386390, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=EN, orderNo=3, keyword=bidirectional relationship between toxicity and efficacy), Keyword(id=1322633195045106647, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=EN, orderNo=4, keyword=reducing toxicity while preserving efficacy), Keyword(id=1322633195112215512, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, language=EN, orderNo=5, keyword=quality control)], refs=[Reference(id=1319981937956074079, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=1, rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=魏湘萍, 白莉, 苗明三. 毒性中药分级变化的思考[J]. 中华中医药杂志, 2021, 36(4):2158-2161., articleTitle=null, refAbstract=null), Reference(id=1319981937956074080, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=2, rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=邓德红, 胡菊. 狼毒药材HPLC指纹图谱研究[J]. 国际检验医学杂志, 2016, 37(4): 447-448., articleTitle=null, refAbstract=null), Reference(id=1319981937956074081, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=3, rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=刘天宇, 宋歌, 杨瑞琴, 等. 乌头属植物中生物碱毒素检验方法及溯源研究进展[J]. 药学学报, 2024, 59(4):899-907., articleTitle=null, refAbstract=null), Reference(id=1319981937956074082, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=4, rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=韩莹, 董辉, 孙晖, 等. 基于方证代谢组学的云南白药配伍环境中草乌活血化瘀作用的药效物质基础研究[J]. 中草药, 2025, 56(8):2678-2686., articleTitle=null, refAbstract=null), Reference(id=1319981937956074083, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=5, rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=宋玲玲, 张天柱, 纪丽婕, 等. 熟地黄汁制法炮制降低雷公藤生殖毒的减毒作用及机制研究[J]. 中国中药杂志, 2025, 50(20):5762-5770., articleTitle=null, refAbstract=null), Reference(id=1319981937956074084, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=6, rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=邹利, 郑茜, 钟辉云, 等. 何首乌炮制减毒机制研究进展[J]. 保健医学研究与实践, 2024, 21(12): 147-152., articleTitle=null, refAbstract=null), Reference(id=1319981937956074085, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=7, rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=隋怡, 冯果, 刘刚, 等. 远志配伍对砂烫马钱子的减毒增效作用研究[J]. 中国药房, 2025, 36(10): 1197-1201., articleTitle=null, refAbstract=null), Reference(id=1319981937956074086, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=8, rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=李林, 李晗, 陈腾飞, 等. 诃子、甘草与制草乌配伍对小鼠急性毒性的影响[J]. 世界中医药, 2024, 19(24):3754-3760., articleTitle=null, refAbstract=null), Reference(id=1319981937956074087, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=9, rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=徐麟, 颜冬梅, 聂鹤云, 等. 基于2020年版中国药典毒性药材标准现状对中药毒性分级标准的思考与探讨[J]. 中药材, 2021, 44(5): 1041-1045., articleTitle=null, refAbstract=null), Reference(id=1319981937960268384, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=10, rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=周跃华, 徐增莱, 路金才. 我国大毒药材质量标准的质控现状及相关问题探讨[J]. 中国新药杂志, 2015, 24(21): 2425-2433., articleTitle=null, refAbstract=null), Reference(id=1319981937960268385, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=11, rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=范建华. 《中国药典》2010年版毒性药材对特殊人群使用说明的归类分析[J]. 中国民族民间医药, 2011, 20(24): 708., articleTitle=null, refAbstract=null), Reference(id=1319981937960268386, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=12, rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=李春巧. 植物生川乌的药用价值探究[J]. 核农学报, 2020, 34(9):I0009., articleTitle=null, refAbstract=null), Reference(id=1319981937960268387, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=13, rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=陈良妮, 程雪梅, 陈勇, 等. 川乌药理作用、毒性、质量控制方法研究进展[J]. 中成药, 2021, 43(3):722-729., articleTitle=null, refAbstract=null), Reference(id=1319981937960268388, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=14, rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=李宁, 苗明三, 白莉. 大毒中药临床毒性机制与解救措施[J]. 中华中医药杂志, 2022, 37(2):659-664., articleTitle=null, refAbstract=null), Reference(id=1319981937960268389, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=15, rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=秦贝贝, 贾泽菲, 王佳莉, 等. 马钱子化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测分析[J]. 中草药, 2022, 53(18): 5920-5933., articleTitle=null, refAbstract=null), Reference(id=1319981937960268390, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=16, rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=田家璇, 谢义松, 李金颖, 等. 马钱子本草再考证及其功效和临床应用进展[J]. 中药材, 2024, 47(6):1566-1573., articleTitle=null, refAbstract=null), Reference(id=1319981937960268391, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=17, rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=李艳, 高粉粉, 谈利红, 等. 马钱子减毒增效途径及机制研究进展[J]. 中国医药科学, 2024, 14(6): 39-42., articleTitle=null, refAbstract=null), Reference(id=1319981937960268392, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=18, rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=戴晓雁, 柴艳冬, 许颖, 等. 《中国药典》2020版收载含马钱子中成药质量标准分析[J]. 甘肃医药, 2024, 43(2): 157-159., articleTitle=null, refAbstract=null), Reference(id=1319981937960268393, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=19, rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=何石燕, 王孝勋. 马钱子研究进展[J]. 壮瑶药研究, 2023(2):325-328., articleTitle=null, refAbstract=null), Reference(id=1319981937960268394, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=20, rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=李时珍. 本草纲目(下) [M]. 北京:中国文史出版社, 2003: 338., articleTitle=null, refAbstract=null), Reference(id=1319981937960268395, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=21, rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=马钱子粉[J]. 光明中医, 2016, 31(3):432., articleTitle=null, refAbstract=null), Reference(id=1319981937960268396, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=22, rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=张梦田, 王俊香, 梁晓东, 等. 天仙子化学成分及药理作用研究进展[J]. 中成药, 2024, 46(7):2321-2326., articleTitle=null, refAbstract=null), Reference(id=1319981937960268397, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=23, rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=商国懋, 卢文可. 剧毒良药: 巴豆[J]. 首都食品与医药, 2017, 24(3):54., articleTitle=null, refAbstract=null), Reference(id=1319981937960268398, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=24, rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=单雪莲. 不同炮制方法制备巴豆霜对巴豆蛋白毒性的影响[D]. 南京: 南京中医药大学, 2019., articleTitle=null, refAbstract=null), Reference(id=1319981937960268399, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=25, rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=中国药典[S]. 一部. 2025: 56., articleTitle=null, refAbstract=null), Reference(id=1319981937960268400, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=26, rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=何佳, 金艳, 赵玉洋, 等. 有毒中草药炮制减毒方法研究进展[J]. 中国药物警戒, 2023, 20(9):1064-1070., articleTitle=null, refAbstract=null), Reference(id=1319981937960268401, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=27, rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=Chung J Y, Lee S J, Lee H J, et al. Aconitine neurotoxicity according to administration methods [J]. J Clin Med, 2021, 10(10): 2149., articleTitle=null, refAbstract=null), Reference(id=1319981937960268402, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=28, rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=Zhang Y R, Chen S Y, Fan F F, et al. Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry [J]. J Pharm Anal, 2023, 13(1):88-98., articleTitle=null, refAbstract=null), Reference(id=1319981937960268403, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=29, rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=Yoda S, Onimaru H, Izumizaki M. Effects of aconitine on the respiratory activity of brainstem-spinal cord preparations isolated from newborn rats [J]. Pflügers Arch Eur J Physiol, 2023, 475(11): 1301-1314., articleTitle=null, refAbstract=null), Reference(id=1319981937960268404, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=30, rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=孙凤姣, 张译丹, 吴锦, 等. 生川乌醇提物致心、脑毒性的表现及其对血管内皮的影响[J]. 中草药, 2017, 48(6):1178-1182., articleTitle=null, refAbstract=null), Reference(id=1319981937960268405, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=31, rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=张韶华, 牛家宽, 宋梦依, 等. 乌头碱诱发心律失常的新机制[J]. 临床心血管病杂志, 2026, 42(3):183-190., articleTitle=null, refAbstract=null), Reference(id=1319981937960268406, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=32, rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=李志勇. 附子成分次乌头碱心脏毒性及中毒机制研究[D]. 北京: 北京中医药大学, 2008., articleTitle=null, refAbstract=null), Reference(id=1319981937960268407, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=33, rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=王金华, 李莉, 杜冠华. 中药天仙子的历史认识与评价[J]. 中药药理与临床, 2018, 34(5):163-165., articleTitle=null, refAbstract=null), Reference(id=1319981937964462689, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=34, rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=Yin Y H, Qi Y P, Zhang K, et al. Integrating metabolomics and network toxicology to reveal the mechanism of hypoaconitine-induced hepatotoxicity in mice [J]. Pestic Biochem Physiol, 2024, 202: 105950., articleTitle=null, refAbstract=null), Reference(id=1319981937964462690, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=35, rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=Zhao C J, Li E W, Wang Z Y, et al. Nux Vomica exposure triggered liver injury and metabolic disturbance in zebrafish larvae [J]. Zebrafish, 2018, 15(6): 610-628., articleTitle=null, refAbstract=null), Reference(id=1319981937964462691, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=36, rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=王晓烨, 林瑞超, 董世芬, 等. 含汞矿物药的毒性研究进展[J]. 中国中药杂志, 2017, 42(7):1258-1264., articleTitle=null, refAbstract=null), Reference(id=1319981937964462692, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=37, rfOrder=36, authorNames=null, journalName=null, refType=null, unstructuredReference=张文平, 朱培芳, 马雅鸽, 等. 马钱子的毒理学及安全性研究进展[J]. 中国民族民间医药, 2012, 21(8):53-54., articleTitle=null, refAbstract=null), Reference(id=1319981937964462693, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=38, rfOrder=37, authorNames=null, journalName=null, refType=null, unstructuredReference=Xu T, Wu Z N, Yao H R, et al. Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device [J]. Chem Commun, 2024, 60(37):4898-4901., articleTitle=null, refAbstract=null), Reference(id=1319981937964462694, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=39, rfOrder=38, authorNames=null, journalName=null, refType=null, unstructuredReference=段肖彤, 李晓飞, 张建永. 基于PP2A亚型探索斑蝥素致肝细胞毒性的作用机制研究[A] // 中国毒理学会第十一次全国毒理学大会论文集[C]. 苏州:中国毒理协会, 2024: 61-62., articleTitle=null, refAbstract=null), Reference(id=1319981937964462695, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=40, rfOrder=39, authorNames=null, journalName=null, refType=null, unstructuredReference=Ruyani A, Sinta B D, Emilia, et al. Preliminary studies on therapeutic effect of ethanolic extract of Tylophora Villosa leaves against paracetamol-induced hepatotoxicity in mice [J]. J Tradit Complementary Med, 2019, 9(4): 285-296., articleTitle=null, refAbstract=null), Reference(id=1319981937964462696, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=41, rfOrder=40, authorNames=null, journalName=null, refType=null, unstructuredReference=Guan H F, Xu Y, Ma C, et al. Pharmacology, toxicology, and rational application of cinnabar, realgar, and their formulations [J]. Evid Based Complement Altern Med ECAM, 2022, 2022: 6369150., articleTitle=null, refAbstract=null), Reference(id=1319981937964462697, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=42, rfOrder=41, authorNames=null, journalName=null, refType=null, unstructuredReference=方莲花, 杜冠华. 中药斑蝥毒的历史认识与评价[J]. 中药药理与临床, 2018(5):150-152., articleTitle=null, refAbstract=null), Reference(id=1319981937964462698, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=43, rfOrder=42, authorNames=null, journalName=null, refType=null, unstructuredReference=刘璟贤. 基于功能代谢组学的斑蝥素致肾毒性研究[D]. 遵义: 遵义医科大学, 2022., articleTitle=null, refAbstract=null), Reference(id=1319981937964462699, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=44, rfOrder=43, authorNames=null, journalName=null, refType=null, unstructuredReference=Tian W Y, Li Y L, Liu F Z, et al. Strychni Semen and two alkaloidal components cause apoptosis in HK-2 cells through TRADD-MAPK/NF-κB pathway [J]. Toxicon, 2025, 256:108224., articleTitle=null, refAbstract=null), Reference(id=1319981937964462700, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=45, rfOrder=44, authorNames=null, journalName=null, refType=null, unstructuredReference=Lei Y Y, Hou F Q, Wu X Y, et al. Brucine-induced neurotoxicity by targeting Caspase 3: Involvement of PPARγ/NF-κB/apoptosis signaling pathway [J]. Neurotox Res, 2022, 40(6):2117-2131., articleTitle=null, refAbstract=null), Reference(id=1319981937964462701, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=46, rfOrder=45, authorNames=null, journalName=null, refType=null, unstructuredReference=翟兴英, 杨文博, 李洋, 等. 乌头碱、新乌头碱和次乌头碱代谢产物研究进展[J]. 江西中医药, 2024, 55(6):71-75., articleTitle=null, refAbstract=null), Reference(id=1319981937964462702, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=47, rfOrder=46, authorNames=null, journalName=null, refType=null, unstructuredReference=郭姿璇, 吕德彪, 万昌丽，等. 巴豆药理和毒性研究进展[J/OL]. 中华中医药学刊, (2025-11-12) [2026-05-14]. https://link.cnki.net/urlid/21.1546.R.20251112.1131. 036., articleTitle=null, refAbstract=null), Reference(id=1319981937964462703, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=48, rfOrder=47, authorNames=null, journalName=null, refType=null, unstructuredReference=叶日贵, 包勒朝鲁, 红梅, 等. 药用植物北乌头研究进展[J]. 中国民族医药杂志, 2026, 32(1):112-116., articleTitle=null, refAbstract=null), Reference(id=1319981937964462704, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=49, rfOrder=48, authorNames=null, journalName=null, refType=null, unstructuredReference=Clarkson T W, Magos L. The toxicology of mercury and its chemical compounds [J]. Crit Rev Toxicol, 2006, 36(8): 609-662., articleTitle=null, refAbstract=null), Reference(id=1319981937964462705, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=50, rfOrder=49, authorNames=null, journalName=null, refType=null, unstructuredReference=萨日娜, 美丽, 陈格歌, 等. 基于网络毒理学探讨草乌致心脏毒性的作用机制[J]. 中国民族医药杂志, 2026, 32(3):105-109., articleTitle=null, refAbstract=null), Reference(id=1319981937964462706, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=51, rfOrder=50, authorNames=null, journalName=null, refType=null, unstructuredReference=古剑辉, 曾浩, 廖凌晨, 等. 基于网络毒理学与分子对接探析马钱子碱诱导神经毒性的作用机制[J]. 亚太传统医药, 2026, 22(8):175-181., articleTitle=null, refAbstract=null), Reference(id=1319981937964462707, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=52, rfOrder=51, authorNames=null, journalName=null, refType=null, unstructuredReference=郭小红, 黄孟军, 王立娟, 等. 基于血清代谢组学和网络毒理学研究闹羊花毒性作用机制[J]. 中国中药杂志, 2022, 47(7): 1932-1941., articleTitle=null, refAbstract=null), Reference(id=1319981937964462708, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=53, rfOrder=52, authorNames=null, journalName=null, refType=null, unstructuredReference=林芳花, 罗平静, 梁梦丹, 等. 有毒中草药的药性分析[J]. 惠州学院学报, 2017, 37(3):56-60., articleTitle=null, refAbstract=null), Reference(id=1319981937964462709, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=54, rfOrder=53, authorNames=null, journalName=null, refType=null, unstructuredReference=陈双燕, 段恬筱, 翁健. 一起误饮川乌药酒致乌头碱中毒事件调查[J]. 预防医学, 2021, 33(11): 1170-1171., articleTitle=null, refAbstract=null), Reference(id=1319981937964462710, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=55, rfOrder=54, authorNames=null, journalName=null, refType=null, unstructuredReference=滑成龙, 陈颖, 米文静, 等. 重构本草: 马钱子[J]. 长春中医药大学学报, 2025, 41(7):728-731., articleTitle=null, refAbstract=null), Reference(id=1319981937964462711, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=56, rfOrder=55, authorNames=null, journalName=null, refType=null, unstructuredReference=刘艾林, 张莉, 杜冠华. 闹羊花毒之历史认识与评价[J]. 中药药理与临床, 2018, 34(5):161-163., articleTitle=null, refAbstract=null), Reference(id=1319981937964462712, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=57, rfOrder=56, authorNames=null, journalName=null, refType=null, unstructuredReference=孙立艳, 刘鹏辉, 窦国义, 等. 巴豆炮制历史沿革考证[J]. 中国医药导报, 2023, 20(32):160-163., articleTitle=null, refAbstract=null), Reference(id=1319981937964462713, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=58, rfOrder=57, authorNames=null, journalName=null, refType=null, unstructuredReference=郭小红, 冯靖雯, 王耀登, 等. 闹羊花的本草考证及炮制历史沿革分析[J]. 中国实验方剂学杂志, 2021, 27(22):172-180., articleTitle=null, refAbstract=null), Reference(id=1319981937964462714, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=59, rfOrder=58, authorNames=null, journalName=null, refType=null, unstructuredReference=蒋一帆, 高建超, 田春华, 等. 毒性药材天仙子的文献研究及风险探讨[J]. 中国药物警戒, 2016, 13(3):165-168., articleTitle=null, refAbstract=null), Reference(id=1319981937968656994, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=60, rfOrder=59, authorNames=null, journalName=null, refType=null, unstructuredReference=陈珺怡, 江科, 董梦婷, 等. 红升丹的医史文献研究与安全性思考[J]. 中国民间疗法, 2026, 34(6):8-13., articleTitle=null, refAbstract=null), Reference(id=1319981937968656995, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=61, rfOrder=60, authorNames=null, journalName=null, refType=null, unstructuredReference=王芳静, 金传山, 张伟, 等. 产业化生产中川乌不同炮制品的“减毒-存效”研究[J]. 时珍国医国药, 2021, 32(7):1643-1646., articleTitle=null, refAbstract=null), Reference(id=1319981937968656996, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=62, rfOrder=61, authorNames=null, journalName=null, refType=null, unstructuredReference=黄琦, 韩秉辰, 陈丹丹, 等. 不同炮制方法对川乌毒性成分的影响及其质量评价[J]. 中国民族民间医药, 2023, 32(16):25-32., articleTitle=null, refAbstract=null), Reference(id=1319981937968656997, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=63, rfOrder=62, authorNames=null, journalName=null, refType=null, unstructuredReference=Zheng Y, Wei N N, Lu C, et al. Mechanistic insights into honey-boiled detoxification of Chuanwu: A study on alkaloid transformation and supramolecular aggregation [J]. J Pharm Anal, 2025, 15(9): 101205., articleTitle=null, refAbstract=null), Reference(id=1319981937968656998, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=64, rfOrder=63, authorNames=null, journalName=null, refType=null, unstructuredReference=李艳, 高粉粉, 谈利红, 等. 马钱子减毒增效途径及机制研究进展[J]. 中国医药科学, 2024, 14(6):39-42., articleTitle=null, refAbstract=null), Reference(id=1319981937968656999, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=65, rfOrder=64, authorNames=null, journalName=null, refType=null, unstructuredReference=李永康, 陈智. 斑蝥的炮制历史沿革、化学成分及药理作用研究进展[J]. 中华中医药学刊, 2025, 43(5):202-209., articleTitle=null, refAbstract=null), Reference(id=1319981937968657000, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=66, rfOrder=65, authorNames=null, journalName=null, refType=null, unstructuredReference=张贵鑫, 宋凤瑞, 朱禹奇, 等. 蒙药草乌炮制减毒及质量标准的研究进展[J]. 世界科学技术—中医药现代化, 2022, 24(6):2418-2425., articleTitle=null, refAbstract=null), Reference(id=1319981937968657001, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=67, rfOrder=66, authorNames=null, journalName=null, refType=null, unstructuredReference=Wu J F, Duan R, Deng H R, et al. The effect of compatibility of Aconiti Radix and honey on the pharmacokinetics of five Aconitum alkaloids in rat plasma [J]. Biomed Chromatogr, 2022, 36(11): e5453., articleTitle=null, refAbstract=null), Reference(id=1319981937968657002, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=68, rfOrder=67, authorNames=null, journalName=null, refType=null, unstructuredReference=邰通芝, 陈桃香, 何席呈, 等. 川乌与地榆配伍减毒的长期毒性研究[J]. 时珍国医国药, 2025, 36(3):448-452., articleTitle=null, refAbstract=null), Reference(id=1319981937968657003, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=69, rfOrder=68, authorNames=null, journalName=null, refType=null, unstructuredReference=霍旺, 李晗, 李林, 等. 诃子、甘草与制草乌配伍调控CYP450系统减轻肝毒性研究[J]. 中国中药杂志, 2022, 47(6): 1618-1624., articleTitle=null, refAbstract=null), Reference(id=1319981937968657004, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=70, rfOrder=69, authorNames=null, journalName=null, refType=null, unstructuredReference=李晗, 宋玲, 高云航, 等. 诃子、甘草与制草乌合用调控心脏代谢酶CYP2J3减毒机制[J]. 中国实验方剂学杂志, 2023, 29(17): 88-95., articleTitle=null, refAbstract=null), Reference(id=1319981937968657005, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=71, rfOrder=70, authorNames=null, journalName=null, refType=null, unstructuredReference=董辉, 李太平, 孙晖. 川乌配伍白芍减毒增效作用研究进展[J]. 中国医药导报, 2020, 17(4):32-35., articleTitle=null, refAbstract=null), Reference(id=1319981937968657006, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=72, rfOrder=71, authorNames=null, journalName=null, refType=null, unstructuredReference=刘蔚然. 白术内酯II缓解马钱子碱对HK-2细胞毒性的代谢组学及机制研究[D]. 济南:山东中医药大学, 2024., articleTitle=null, refAbstract=null), Reference(id=1319981937968657007, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=73, rfOrder=72, authorNames=null, journalName=null, refType=null, unstructuredReference=李瑶, 郭盛, 陶伟伟, 等. 基于小鼠胃肠道系统毒性及利尿效应的大枣与巴豆霜配伍减毒机制研究[J]. 药学学报, 2019, 54(1):95-103., articleTitle=null, refAbstract=null), Reference(id=1319981937968657008, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=74, rfOrder=73, authorNames=null, journalName=null, refType=null, unstructuredReference=闫静, 甄晓宇, 刘志强, 等. 配伍延胡索对马钱子毒性影响的实验研究[J]. 中华中医药杂志, 2020, 35(7):3690-3694., articleTitle=null, refAbstract=null), Reference(id=1319981937968657009, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=75, rfOrder=74, authorNames=null, journalName=null, refType=null, unstructuredReference=郭玉岩, 高滔, 李春城, 等. 酸碱药对甘草-马钱子配伍汤液沉积相态释放特性研究[J]. 中草药, 2022, 53(10):3000-3005., articleTitle=null, refAbstract=null), Reference(id=1319981937968657010, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=76, rfOrder=75, authorNames=null, journalName=null, refType=null, unstructuredReference=郭玉岩, 李春成, 孙爽, 等. “甘草-马钱子”配伍前后及其拆分相态指纹图谱对比研究[J]. 中医药学报, 2020, 48(10):1-6., articleTitle=null, refAbstract=null), Reference(id=1319981937968657011, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=77, rfOrder=76, authorNames=null, journalName=null, refType=null, unstructuredReference=胡亚. 基于MDCK-MDR1细胞模型的马钱子活性成分配伍白芍活性成分的转运机制研究及对P-糖蛋白表达的影响[D]. 南昌: 江西中医药大学, 2019., articleTitle=null, refAbstract=null), Reference(id=1319981937968657012, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=78, rfOrder=77, authorNames=null, journalName=null, refType=null, unstructuredReference=王淑静, 娄玉钤. 制马钱子配伍赤芍桂枝汤的抗炎镇痛实验研究[J]. 风湿病与关节炎, 2020, 9(5):6-9., articleTitle=null, refAbstract=null), Reference(id=1319981937968657013, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=79, rfOrder=78, authorNames=null, journalName=null, refType=null, unstructuredReference=郭传杰. 巴豆配伍甘草治疗急性髓系白血病的增效减毒作用机制研究[D]. 成都: 成都中医药大学, 2021., articleTitle=null, refAbstract=null), Reference(id=1319981937968657014, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=80, rfOrder=79, authorNames=null, journalName=null, refType=null, unstructuredReference=徐启华, 彭博, 贺蓉, 等.炉甘石对生肌散中红粉所致肾损伤的保护作用[A] // 中国毒理学会中药与天然药物毒理专业委员会第一次（2016年）学术交流大会论文集[C]. 北京: 中国中医科学院中药研究所, 2016: 71., articleTitle=null, refAbstract=null), Reference(id=1319981937968657015, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=81, rfOrder=80, authorNames=null, journalName=null, refType=null, unstructuredReference=Liu G X, Zuo W Q, Zhang Z, et al. Nucleolin inhibits α-synuclein to attenuate aconitine’s neurotoxicity [J]. Phytomedicine, 2025, 144: 156932., articleTitle=null, refAbstract=null), Reference(id=1319981937968657016, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=82, rfOrder=81, authorNames=null, journalName=null, refType=null, unstructuredReference=Wang M, Wang R Y, Sun H, et al. Ginsenoside Rb₁ ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis [J]. Phytomedicine, 2021, 83: 153468., articleTitle=null, refAbstract=null), Reference(id=1319981937972851299, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=83, rfOrder=82, authorNames=null, journalName=null, refType=null, unstructuredReference=Xu X, Xie X F, Dong Y H, et al. Ginsenoside Rg₁ reduces cardiotoxicity while increases cardiotonic effect of aconitine in vitro [J]. Chin J Integr Med, 2022, 28(8): 693-701., articleTitle=null, refAbstract=null), Reference(id=1319981937972851300, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=84, rfOrder=83, authorNames=null, journalName=null, refType=null, unstructuredReference=李艳, 高粉粉, 谈利红, 等. 马钱子减毒增效途径及机制研究进展[J]. 中国医药科学, 2024, 14(6): 39-42., articleTitle=null, refAbstract=null), Reference(id=1319981937972851301, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=85, rfOrder=84, authorNames=null, journalName=null, refType=null, unstructuredReference=Shan Q Y, Yu W, Xu Q F, et al. Detoxification and underlying mechanisms towards toxic alkaloids by traditional Chinese medicine processing: A comprehensive review [J]. Phytomedicine, 2024, 129: 155623., articleTitle=null, refAbstract=null), Reference(id=1319981937972851302, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=86, rfOrder=85, authorNames=null, journalName=null, refType=null, unstructuredReference=戴冠苹, 符锋, 张梓豪, 等. 直接进样测汞法检测粮食中汞含量[J]. 食品安全质量检测学报, 2025, 16(3):203-207., articleTitle=null, refAbstract=null), Reference(id=1319981937972851303, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=87, rfOrder=86, authorNames=null, journalName=null, refType=null, unstructuredReference=冯靖雯, 郭小红, 李丹, 等. HPLC-CAD法测定不同产地和花期闹羊花中闹羊花毒素II、III、V [J]. 中草药, 2021, 52(24): 7624-7629., articleTitle=null, refAbstract=null), Reference(id=1319981937972851304, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=88, rfOrder=87, authorNames=null, journalName=null, refType=null, unstructuredReference=Anger E E, Yu F, Li J. Aristolochic acid-induced nephrotoxicity: Molecular mechanisms and potential protective approaches [J]. Int J Mol Sci, 2020, 21(3): 1157., articleTitle=null, refAbstract=null), Reference(id=1319981937972851305, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=89, rfOrder=88, authorNames=null, journalName=null, refType=null, unstructuredReference=Chen X M, Ma J, He Y S, et al. Characterization of liver injury induced by a pyrrolizidine alkaloid in rats [J]. Phytomedicine, 2021, 89: 153595., articleTitle=null, refAbstract=null), Reference(id=1319981937972851306, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=90, rfOrder=89, authorNames=null, journalName=null, refType=null, unstructuredReference=Han C Y, Pei H Y, Sheng Y J, et al. Toxicological mechanism of triptolide-induced liver injury:Caspase3-GSDME-mediated pyroptosis of Kupffer cell [J]. Ecotoxicol Environ Saf, 2023, 258: 114963., articleTitle=null, refAbstract=null), Reference(id=1319981937972851307, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=91, rfOrder=90, authorNames=null, journalName=null, refType=null, unstructuredReference=杜选香, 王自梁, 杨碧娟, 等. 中药材重金属超标概况[J]. 云南民族大学学报: 自然科学版, 2025, 34(3): 303-312., articleTitle=null, refAbstract=null), Reference(id=1319981937972851308, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=92, rfOrder=91, authorNames=null, journalName=null, refType=null, unstructuredReference=Bratu M M, Birghila S, Birghila C, et al. Correlation between toxic elements and pesticide residues in medicinal herbs available in pharmaceutical market [J]. Biol Trace Elem Res, 2023, 201(12): 5848-5860., articleTitle=null, refAbstract=null), Reference(id=1319981937972851309, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=93, rfOrder=92, authorNames=null, journalName=null, refType=null, unstructuredReference=Wei G F, Guo X T, Liang Y C, et al. Occurrence of fungi and mycotoxins in herbal medicines and rapid detection of toxin-producing fungi [J]. Environ Pollut, 2023, 333:122082., articleTitle=null, refAbstract=null), Reference(id=1319981937972851310, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=94, rfOrder=93, authorNames=null, journalName=null, refType=null, unstructuredReference=叶日贵, 包勒朝鲁, 红梅, 等. 药用植物北乌头研究进展[J]. 中国民族医药杂志, 2026, 32(1):112-116., articleTitle=null, refAbstract=null), Reference(id=1319981937972851311, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=95, rfOrder=94, authorNames=null, journalName=null, refType=null, unstructuredReference=党文浩, 肖云峰, 吕玮等. 中药毒性风险的“三要素”框架：化学成分异质性、机体特异性与用药可控性[A] // 中国毒理学会中药与天然药物毒理专业委员会第五次（2025年）学术交流大会暨2025年（第一届）大湾区中药与天然药物产业创新发展论坛[C]. 广州:中国毒理学会中药与天然药物毒理专业委员会, 2025: 223-224., articleTitle=null, refAbstract=null)], funds=[Fund(id=1319981937750553181, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, awardId=2097522030921453571, language=CN, fundingSource=四川省中医药管理局科学技术专项, fundOrder=null, country=null), Fund(id=1319981937817662046, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, awardId=2097522030921453574, language=CN, fundingSource=四川省中医药管理局中医药科研专项, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1319981936177689152, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, xref=1, ext=[AuthorCompanyExt(id=1319981936186077761, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, companyId=1319981936177689152, language=CN, country=null, province=null, city=null, postcode=null, companyName=西南交通大学生命科学与工程学院, 四川成都 610031, departmentName=null, remark=^1.西南交通大学生命科学与工程学院, 四川成都 610031)]), AuthorCompany(id=1319981936257380930, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, xref=2^*, ext=[AuthorCompanyExt(id=1319981936269963843, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981933250064957, companyId=1319981936257380930, language=CN, country=null, province=null, city=null, postcode=null, companyName=西南交通大学生命科学与工程学院, 四川成都 610031, departmentName=null, remark=^2.西南交通大学生命科学与工程学院, 四川成都 610031)])], figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.16.034, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.16.034, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.16.034, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.16.034, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1787846400000, fullTextJson=null, articleText=null, reference=魏湘萍, 白莉, 苗明三. 毒性中药分级变化的思考[J]. 中华中医药杂志, 2021, 36(4):2158-2161.
邓德红, 胡菊. 狼毒药材HPLC指纹图谱研究[J]. 国际检验医学杂志, 2016, 37(4): 447-448.
刘天宇, 宋歌, 杨瑞琴, 等. 乌头属植物中生物碱毒素检验方法及溯源研究进展[J]. 药学学报, 2024, 59(4):899-907.
韩莹, 董辉, 孙晖, 等. 基于方证代谢组学的云南白药配伍环境中草乌活血化瘀作用的药效物质基础研究[J]. 中草药, 2025, 56(8):2678-2686.
宋玲玲, 张天柱, 纪丽婕, 等. 熟地黄汁制法炮制降低雷公藤生殖毒的减毒作用及机制研究[J]. 中国中药杂志, 2025, 50(20):5762-5770.
邹利, 郑茜, 钟辉云, 等. 何首乌炮制减毒机制研究进展[J]. 保健医学研究与实践, 2024, 21(12): 147-152.
隋怡, 冯果, 刘刚, 等. 远志配伍对砂烫马钱子的减毒增效作用研究[J]. 中国药房, 2025, 36(10): 1197-1201.
李林, 李晗, 陈腾飞, 等. 诃子、甘草与制草乌配伍对小鼠急性毒性的影响[J]. 世界中医药, 2024, 19(24):3754-3760.
徐麟, 颜冬梅, 聂鹤云, 等. 基于2020年版中国药典毒性药材标准现状对中药毒性分级标准的思考与探讨[J]. 中药材, 2021, 44(5): 1041-1045.
周跃华, 徐增莱, 路金才. 我国大毒药材质量标准的质控现状及相关问题探讨[J]. 中国新药杂志, 2015, 24(21): 2425-2433.
范建华. 《中国药典》2010年版毒性药材对特殊人群使用说明的归类分析[J]. 中国民族民间医药, 2011, 20(24): 708.
李春巧. 植物生川乌的药用价值探究[J]. 核农学报, 2020, 34(9):I0009.
陈良妮, 程雪梅, 陈勇, 等. 川乌药理作用、毒性、质量控制方法研究进展[J]. 中成药, 2021, 43(3):722-729.
李宁, 苗明三, 白莉. 大毒中药临床毒性机制与解救措施[J]. 中华中医药杂志, 2022, 37(2):659-664.
秦贝贝, 贾泽菲, 王佳莉, 等. 马钱子化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测分析[J]. 中草药, 2022, 53(18): 5920-5933.
田家璇, 谢义松, 李金颖, 等. 马钱子本草再考证及其功效和临床应用进展[J]. 中药材, 2024, 47(6):1566-1573.
李艳, 高粉粉, 谈利红, 等. 马钱子减毒增效途径及机制研究进展[J]. 中国医药科学, 2024, 14(6): 39-42.
戴晓雁, 柴艳冬, 许颖, 等. 《中国药典》2020版收载含马钱子中成药质量标准分析[J]. 甘肃医药, 2024, 43(2): 157-159.
何石燕, 王孝勋. 马钱子研究进展[J]. 壮瑶药研究, 2023(2):325-328.
李时珍. 本草纲目(下) [M]. 北京:中国文史出版社, 2003: 338.
马钱子粉[J]. 光明中医, 2016, 31(3):432.
张梦田, 王俊香, 梁晓东, 等. 天仙子化学成分及药理作用研究进展[J]. 中成药, 2024, 46(7):2321-2326.
商国懋, 卢文可. 剧毒良药: 巴豆[J]. 首都食品与医药, 2017, 24(3):54.
单雪莲. 不同炮制方法制备巴豆霜对巴豆蛋白毒性的影响[D]. 南京: 南京中医药大学, 2019.
中国药典[S]. 一部. 2025: 56.
何佳, 金艳, 赵玉洋, 等. 有毒中草药炮制减毒方法研究进展[J]. 中国药物警戒, 2023, 20(9):1064-1070.
Chung J Y, Lee S J, Lee H J, et al. Aconitine neurotoxicity according to administration methods [J]. J Clin Med, 2021, 10(10): 2149.
Zhang Y R, Chen S Y, Fan F F, et al. Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry [J]. J Pharm Anal, 2023, 13(1):88-98.
Yoda S, Onimaru H, Izumizaki M. Effects of aconitine on the respiratory activity of brainstem-spinal cord preparations isolated from newborn rats [J]. Pflügers Arch Eur J Physiol, 2023, 475(11): 1301-1314.
孙凤姣, 张译丹, 吴锦, 等. 生川乌醇提物致心、脑毒性的表现及其对血管内皮的影响[J]. 中草药, 2017, 48(6):1178-1182.
张韶华, 牛家宽, 宋梦依, 等. 乌头碱诱发心律失常的新机制[J]. 临床心血管病杂志, 2026, 42(3):183-190.
李志勇. 附子成分次乌头碱心脏毒性及中毒机制研究[D]. 北京: 北京中医药大学, 2008.
王金华, 李莉, 杜冠华. 中药天仙子的历史认识与评价[J]. 中药药理与临床, 2018, 34(5):163-165.
Yin Y H, Qi Y P, Zhang K, et al. Integrating metabolomics and network toxicology to reveal the mechanism of hypoaconitine-induced hepatotoxicity in mice [J]. Pestic Biochem Physiol, 2024, 202: 105950.
Zhao C J, Li E W, Wang Z Y, et al. Nux Vomica exposure triggered liver injury and metabolic disturbance in zebrafish larvae [J]. Zebrafish, 2018, 15(6): 610-628.
王晓烨, 林瑞超, 董世芬, 等. 含汞矿物药的毒性研究进展[J]. 中国中药杂志, 2017, 42(7):1258-1264.
张文平, 朱培芳, 马雅鸽, 等. 马钱子的毒理学及安全性研究进展[J]. 中国民族民间医药, 2012, 21(8):53-54.
Xu T, Wu Z N, Yao H R, et al. Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device [J]. Chem Commun, 2024, 60(37):4898-4901.
段肖彤, 李晓飞, 张建永. 基于PP2A亚型探索斑蝥素致肝细胞毒性的作用机制研究[A] // 中国毒理学会第十一次全国毒理学大会论文集[C]. 苏州:中国毒理协会, 2024: 61-62.
Ruyani A, Sinta B D, Emilia, et al. Preliminary studies on therapeutic effect of ethanolic extract of Tylophora Villosa leaves against paracetamol-induced hepatotoxicity in mice [J]. J Tradit Complementary Med, 2019, 9(4): 285-296.
Guan H F, Xu Y, Ma C, et al. Pharmacology, toxicology, and rational application of cinnabar, realgar, and their formulations [J]. Evid Based Complement Altern Med ECAM, 2022, 2022: 6369150.
方莲花, 杜冠华. 中药斑蝥毒的历史认识与评价[J]. 中药药理与临床, 2018(5):150-152.
刘璟贤. 基于功能代谢组学的斑蝥素致肾毒性研究[D]. 遵义: 遵义医科大学, 2022.
Tian W Y, Li Y L, Liu F Z, et al. Strychni Semen and two alkaloidal components cause apoptosis in HK-2 cells through TRADD-MAPK/NF-κB pathway [J]. Toxicon, 2025, 256:108224.
Lei Y Y, Hou F Q, Wu X Y, et al. Brucine-induced neurotoxicity by targeting Caspase 3: Involvement of PPARγ/NF-κB/apoptosis signaling pathway [J]. Neurotox Res, 2022, 40(6):2117-2131.
翟兴英, 杨文博, 李洋, 等. 乌头碱、新乌头碱和次乌头碱代谢产物研究进展[J]. 江西中医药, 2024, 55(6):71-75.
郭姿璇, 吕德彪, 万昌丽，等. 巴豆药理和毒性研究进展[J/OL]. 中华中医药学刊, (2025-11-12) [2026-05-14]. https://link.cnki.net/urlid/21.1546.R.20251112.1131. 036.
叶日贵, 包勒朝鲁, 红梅, 等. 药用植物北乌头研究进展[J]. 中国民族医药杂志, 2026, 32(1):112-116.
Clarkson T W, Magos L. The toxicology of mercury and its chemical compounds [J]. Crit Rev Toxicol, 2006, 36(8): 609-662.
萨日娜, 美丽, 陈格歌, 等. 基于网络毒理学探讨草乌致心脏毒性的作用机制[J]. 中国民族医药杂志, 2026, 32(3):105-109.
古剑辉, 曾浩, 廖凌晨, 等. 基于网络毒理学与分子对接探析马钱子碱诱导神经毒性的作用机制[J]. 亚太传统医药, 2026, 22(8):175-181.
郭小红, 黄孟军, 王立娟, 等. 基于血清代谢组学和网络毒理学研究闹羊花毒性作用机制[J]. 中国中药杂志, 2022, 47(7): 1932-1941.
林芳花, 罗平静, 梁梦丹, 等. 有毒中草药的药性分析[J]. 惠州学院学报, 2017, 37(3):56-60.
陈双燕, 段恬筱, 翁健. 一起误饮川乌药酒致乌头碱中毒事件调查[J]. 预防医学, 2021, 33(11): 1170-1171.
滑成龙, 陈颖, 米文静, 等. 重构本草: 马钱子[J]. 长春中医药大学学报, 2025, 41(7):728-731.
刘艾林, 张莉, 杜冠华. 闹羊花毒之历史认识与评价[J]. 中药药理与临床, 2018, 34(5):161-163.
孙立艳, 刘鹏辉, 窦国义, 等. 巴豆炮制历史沿革考证[J]. 中国医药导报, 2023, 20(32):160-163.
郭小红, 冯靖雯, 王耀登, 等. 闹羊花的本草考证及炮制历史沿革分析[J]. 中国实验方剂学杂志, 2021, 27(22):172-180.
蒋一帆, 高建超, 田春华, 等. 毒性药材天仙子的文献研究及风险探讨[J]. 中国药物警戒, 2016, 13(3):165-168.
陈珺怡, 江科, 董梦婷, 等. 红升丹的医史文献研究与安全性思考[J]. 中国民间疗法, 2026, 34(6):8-13.
王芳静, 金传山, 张伟, 等. 产业化生产中川乌不同炮制品的“减毒-存效”研究[J]. 时珍国医国药, 2021, 32(7):1643-1646.
黄琦, 韩秉辰, 陈丹丹, 等. 不同炮制方法对川乌毒性成分的影响及其质量评价[J]. 中国民族民间医药, 2023, 32(16):25-32.
Zheng Y, Wei N N, Lu C, et al. Mechanistic insights into honey-boiled detoxification of Chuanwu: A study on alkaloid transformation and supramolecular aggregation [J]. J Pharm Anal, 2025, 15(9): 101205.
李艳, 高粉粉, 谈利红, 等. 马钱子减毒增效途径及机制研究进展[J]. 中国医药科学, 2024, 14(6):39-42.
李永康, 陈智. 斑蝥的炮制历史沿革、化学成分及药理作用研究进展[J]. 中华中医药学刊, 2025, 43(5):202-209.
张贵鑫, 宋凤瑞, 朱禹奇, 等. 蒙药草乌炮制减毒及质量标准的研究进展[J]. 世界科学技术—中医药现代化, 2022, 24(6):2418-2425.
Wu J F, Duan R, Deng H R, et al. The effect of compatibility of Aconiti Radix and honey on the pharmacokinetics of five Aconitum alkaloids in rat plasma [J]. Biomed Chromatogr, 2022, 36(11): e5453.
邰通芝, 陈桃香, 何席呈, 等. 川乌与地榆配伍减毒的长期毒性研究[J]. 时珍国医国药, 2025, 36(3):448-452.
霍旺, 李晗, 李林, 等. 诃子、甘草与制草乌配伍调控CYP450系统减轻肝毒性研究[J]. 中国中药杂志, 2022, 47(6): 1618-1624.
李晗, 宋玲, 高云航, 等. 诃子、甘草与制草乌合用调控心脏代谢酶CYP2J3减毒机制[J]. 中国实验方剂学杂志, 2023, 29(17): 88-95.
董辉, 李太平, 孙晖. 川乌配伍白芍减毒增效作用研究进展[J]. 中国医药导报, 2020, 17(4):32-35.
刘蔚然. 白术内酯II缓解马钱子碱对HK-2细胞毒性的代谢组学及机制研究[D]. 济南:山东中医药大学, 2024.
李瑶, 郭盛, 陶伟伟, 等. 基于小鼠胃肠道系统毒性及利尿效应的大枣与巴豆霜配伍减毒机制研究[J]. 药学学报, 2019, 54(1):95-103.
闫静, 甄晓宇, 刘志强, 等. 配伍延胡索对马钱子毒性影响的实验研究[J]. 中华中医药杂志, 2020, 35(7):3690-3694.
郭玉岩, 高滔, 李春城, 等. 酸碱药对甘草-马钱子配伍汤液沉积相态释放特性研究[J]. 中草药, 2022, 53(10):3000-3005.
郭玉岩, 李春成, 孙爽, 等. “甘草-马钱子”配伍前后及其拆分相态指纹图谱对比研究[J]. 中医药学报, 2020, 48(10):1-6.
胡亚. 基于MDCK-MDR1细胞模型的马钱子活性成分配伍白芍活性成分的转运机制研究及对P-糖蛋白表达的影响[D]. 南昌: 江西中医药大学, 2019.
王淑静, 娄玉钤. 制马钱子配伍赤芍桂枝汤的抗炎镇痛实验研究[J]. 风湿病与关节炎, 2020, 9(5):6-9.
郭传杰. 巴豆配伍甘草治疗急性髓系白血病的增效减毒作用机制研究[D]. 成都: 成都中医药大学, 2021.
徐启华, 彭博, 贺蓉, 等.炉甘石对生肌散中红粉所致肾损伤的保护作用[A] // 中国毒理学会中药与天然药物毒理专业委员会第一次（2016年）学术交流大会论文集[C]. 北京: 中国中医科学院中药研究所, 2016: 71.
Liu G X, Zuo W Q, Zhang Z, et al. Nucleolin inhibits α-synuclein to attenuate aconitine’s neurotoxicity [J]. Phytomedicine, 2025, 144: 156932.
Wang M, Wang R Y, Sun H, et al. Ginsenoside Rb₁ ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis [J]. Phytomedicine, 2021, 83: 153468.
Xu X, Xie X F, Dong Y H, et al. Ginsenoside Rg₁ reduces cardiotoxicity while increases cardiotonic effect of aconitine in vitro [J]. Chin J Integr Med, 2022, 28(8): 693-701.
李艳, 高粉粉, 谈利红, 等. 马钱子减毒增效途径及机制研究进展[J]. 中国医药科学, 2024, 14(6): 39-42.
Shan Q Y, Yu W, Xu Q F, et al. Detoxification and underlying mechanisms towards toxic alkaloids by traditional Chinese medicine processing: A comprehensive review [J]. Phytomedicine, 2024, 129: 155623.
戴冠苹, 符锋, 张梓豪, 等. 直接进样测汞法检测粮食中汞含量[J]. 食品安全质量检测学报, 2025, 16(3):203-207.
冯靖雯, 郭小红, 李丹, 等. HPLC-CAD法测定不同产地和花期闹羊花中闹羊花毒素II、III、V [J]. 中草药, 2021, 52(24): 7624-7629.
Anger E E, Yu F, Li J. Aristolochic acid-induced nephrotoxicity: Molecular mechanisms and potential protective approaches [J]. Int J Mol Sci, 2020, 21(3): 1157.
Chen X M, Ma J, He Y S, et al. Characterization of liver injury induced by a pyrrolizidine alkaloid in rats [J]. Phytomedicine, 2021, 89: 153595.
Han C Y, Pei H Y, Sheng Y J, et al. Toxicological mechanism of triptolide-induced liver injury:Caspase3-GSDME-mediated pyroptosis of Kupffer cell [J]. Ecotoxicol Environ Saf, 2023, 258: 114963.
杜选香, 王自梁, 杨碧娟, 等. 中药材重金属超标概况[J]. 云南民族大学学报: 自然科学版, 2025, 34(3): 303-312.
Bratu M M, Birghila S, Birghila C, et al. Correlation between toxic elements and pesticide residues in medicinal herbs available in pharmaceutical market [J]. Biol Trace Elem Res, 2023, 201(12): 5848-5860.
Wei G F, Guo X T, Liang Y C, et al. Occurrence of fungi and mycotoxins in herbal medicines and rapid detection of toxin-producing fungi [J]. Environ Pollut, 2023, 333:122082.
叶日贵, 包勒朝鲁, 红梅, 等. 药用植物北乌头研究进展[J]. 中国民族医药杂志, 2026, 32(1):112-116.
党文浩, 肖云峰, 吕玮等. 中药毒性风险的“三要素”框架：化学成分异质性、机体特异性与用药可控性[A] // 中国毒理学会中药与天然药物毒理专业委员会第五次（2025年）学术交流大会暨2025年（第一届）大湾区中药与天然药物产业创新发展论坛[C]. 广州:中国毒理学会中药与天然药物毒理专业委员会, 2025: 223-224.)