Article(id=1319981749438886722, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1319981498787279574, articleNumber=PA20260909_N7Cw1KKe, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.16.020, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1778860800000, receivedDateStr=2026-05-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792637773141, onlineDateStr=2026-10-22, pubDate=1787846400000, pubDateStr=2026-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792637773140, onlineIssueDateStr=2026-10-22, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792637773140, creator=admin, updateTime=1792637773140, updator=admin, issue=Issue{id=1319981498787279574, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='16', pageStart='6209', pageEnd='6660', issueExtLink='null', onlineDate='null', pubDate='1787846400000', pubDateStr='2026-08-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792637713380, creator='ztmeta', updateTime=1792637713380, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=6459, endPage=6481, ext={EN=ArticleExt(id=1319981753645773636, articleId=1319981749438886722, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Visualization analysis of knowledge graph on regulation of mitochondrial reactive oxygen species by traditional Chinese medicine based on CiteSpace and VOSviewer, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To apply bibliometric methods to review the research progress, hotspots and frontiers of traditional Chinese medicine (TCM) in regulating mitochondrial reactive oxygen species (mtROS), summarize the regulatory mechanisms, and provide data support and directional guidance for subsequent research and research planning. Methods Relevant Chinese and English literature were retrieved from CNKI, Wanfang, VIP and Web of Science Core Collection using TCM and mtROS as search terms or keywords, with the search period covering from database inception to March 31, 2026. CiteSpace, VOSviewer and Bibliometrix were applied to complete the visualization presentation and construction of the knowledge graph. Statistical analyses were performed on annual publication volumes, countries, institutions, authors, journals and keywords. Scientific research collaboration networks, co-occurrence clustering and keyword burst detection analyses were also carried out. Results A total of 1 026 Chinese articles and 649 English articles were included. Knowledge maps showed a sustained growth in annual publication output. China dominated this research field, while domestic and international cooperation networks were not well-developed. Core research institutions included Heilongjiang University of Chinese Medicine, Henan University of Chinese Medicine and Guangxi University of Chinese Medicine. The most productive journals were Chinese Journal of Experimental Traditional Medical Formulae and Journal of Ethnopharmacology. The top five keywords in Chinese literature were oxidative stress, mitochondria, TCM, Chinese herbal medicine and mechanisms of action; the top five keywords in English literature were oxidative stress, apoptosis, activation, TCM and reactive oxygen species. Keyword burst analysis indicated that the research frontier is shifting from basic antioxidant mechanisms toward precise mechanisms such as network pharmacology, molecular docking and ferroptosis. Conclusion Research on TCM regulating mtROS has become a growing research hotspot in recent years and will draw more academic attention, while interdisciplinary cooperation needs to be further strengthened. The combined application of network pharmacology and molecular docking is gradually becoming an emerging trend in this field., authors=XIE Chunfang¹, XIAO Ruixuan¹, CHEN Guiyan¹, LI Hong¹, ZHANG Tian'e^1,2, authorsList=XIE Chunfang, XIAO Ruixuan, CHEN Guiyan, LI Hong, ZHANG Tian'e, authorCompany=1 Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;
2 Academic Inheritance Center of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319981753280869187, articleId=1319981749438886722, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于CiteSpace和VOSviewer的中医药调控线粒体活性氧研究知识图谱可视化分析, columnId=1304140194819629763, journalTitle=中草药, columnName=数据挖掘与循证医学, runingTitle=null, highlight=null, articleAbstract=目的 运用文献计量学方法，梳理中医药调控线粒体活性氧（mitochondrial reactive oxygen species，mtROS）研究的历程、热点与前沿，总结调控机制，为后续研究与科研布局提供数据支撑和方向指导。方法 以中医药、线粒体活性氧等为主题词或关键词，检索中国知网、万方、维普及Web of Science核心合集数据库，检索时限为建库至2026年3月31日，获得中英文相关文献。应用CiteSpace、VOSviewer、Bibliometrix等工具，完成知识图谱的可视化呈现与图谱构建，对年度发文量、国家、机构、作者、期刊及关键词进行统计分析，并展开科研合作网络、共现聚类、突现检测分析。结果 共纳入中文文献1 026篇、英文文献649篇。图谱显示该领域年发文量呈持续增长趋势。中国在该领域占据主导地位，但国内、国际合作网络尚不紧密。本领域的核心研究机构有黑龙江中医药大学、河南中医药大学、广西中医药大学等。中、英文发文最多的期刊分别是《中国实验方剂学杂志》和Journal of Ethnopharmacology。中文文献关键词排名前5的是氧化应激、线粒体、中医药、中药、作用机制；英文文献关键词排名前5的是oxidative stress（氧化应激）、apoptosis（凋亡）、activation（激活）、traditional Chinese medicine（中医药）、reactive oxygen species（活性氧）。关键词突现分析显示，当前研究前沿正由基础抗氧化机制朝着网络药理学、分子对接、铁死亡等精准机制的方向深入。结论 中医药调控mtROS研究是近年的热点趋势，未来会受到更多学者关注，但后续还需进一步加强跨领域的合作交流。网络药理学与分子对接技术相结合正逐渐成为这一领域的新兴趋势。, authors=谢春芳¹, 肖瑞宣¹, 陈桂燕¹, 李红¹, 张天娥^1,2, authorsList=谢春芳, 肖瑞宣, 陈桂燕, 李红, 张天娥, authorCompany=1 成都中医药大学, 四川成都 611137;
2 成都中医药大学 中医药学术传承中心, 四川成都 611137, correspAuthors=张天娥, authorNote=谢春芳: 谢春芳,女,硕士研究生,从事藏象生物学基础与临床研究。E-mail:xiechunfang@stu.cdutcm.edu.cn, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=https://oss.bj-dx-dzqywjd-hlw-icp.inspurcloudoss.com:6063/cast-journal-prod/2097521198041731073/excel/pdfs/9b89c53b5e864967ac8d098d49b6db94.pdf?response-content-disposition=attachment%3B%20filename%3D%2220261620.pdf%22&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20261022T025340Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=NjRlNmUzOGMtM2Y3OC00MDQ3LThkMmYtN2JkODRmYmI3MTgw%2F20261022%2Fbj-dx-dzqywjd-hlw-icp%2Fs3%2Faws4_request&X-Amz-Signature=504a42f7237e83b560a6ce5e935a768452f5f57d101f07a41753329790ff810f, pdf=zmACJ83eruAqw5BYYGGcCw==, pdfFileSize=2195866, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目 (82104732); 四川省科技厅重点研发计划项目 (2023YFS0333); 四川省中医药管理局专项研究项目 (2024MS039); 院校联合创新基金项目 (LH202402017); 成都中医药大学基础增厚项目 (2023003))}, authors=[Author(id=1319981754224587595, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=谢春芳, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981756153967437, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, authorId=1319981754224587595, language=CN, stringName=谢春芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=³成都中医药大学, 四川成都 611137, bio=谢春芳: 谢春芳,女,硕士研究生,从事藏象生物学基础与临床研究。E-mail:xiechunfang@stu.cdutcm.edu.cn, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981754123924297, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=3^*, ext=[AuthorCompanyExt(id=1319981754128118602, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981754123924297, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学, 四川成都 611137, departmentName=null, remark=^3.成都中医药大学, 四川成都 611137)])]), Author(id=1319981756233659214, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=肖瑞宣, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981756309156688, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, authorId=1319981756233659214, language=CN, stringName=肖瑞宣, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=³成都中医药大学, 四川成都 611137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981754123924297, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=3^*, ext=[AuthorCompanyExt(id=1319981754128118602, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981754123924297, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学, 四川成都 611137, departmentName=null, remark=^3.成都中医药大学, 四川成都 611137)])]), Author(id=1319981756577592145, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=陈桂燕, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981756648895315, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, authorId=1319981756577592145, language=CN, stringName=陈桂燕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=³成都中医药大学, 四川成都 611137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981754123924297, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=3^*, ext=[AuthorCompanyExt(id=1319981754128118602, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981754123924297, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学, 四川成都 611137, departmentName=null, remark=^3.成都中医药大学, 四川成都 611137)])]), Author(id=1319981756732781396, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=李红, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981756984439638, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, authorId=1319981756732781396, language=CN, stringName=李红, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=³成都中医药大学, 四川成都 611137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981754123924297, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=3^*, ext=[AuthorCompanyExt(id=1319981754128118602, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981754123924297, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学, 四川成都 611137, departmentName=null, remark=^3.成都中医药大学, 四川成都 611137)])]), Author(id=1319981757051548503, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=张天娥, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1319981757139628890, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, authorId=1319981757051548503, language=CN, stringName=张天娥, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=²,¹,, address=^2.成都中医药大学 中医药学术传承中心, 四川成都 611137,³成都中医药大学 中医药学术传承中心, 四川成都 611137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319981753821934407, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=2^*, ext=[AuthorCompanyExt(id=1319981754044232520, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981753821934407, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学 中医药学术传承中心, 四川成都 611137, departmentName=null, remark=^2.成都中医药大学 中医药学术传承中心, 四川成都 611137)]), AuthorCompany(id=1319981754123924297, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=3^*, ext=[AuthorCompanyExt(id=1319981754128118602, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981754123924297, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学, 四川成都 611137, departmentName=null, remark=^3.成都中医药大学, 四川成都 611137)])])], keywords=[Keyword(id=1322633181031945146, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=CN, orderNo=1, keyword=中医药), Keyword(id=1322633181094859707, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=CN, orderNo=2, keyword=线粒体活性氧), Keyword(id=1322633181161968572, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=CN, orderNo=3, keyword=氧化应激), Keyword(id=1322633181233271741, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=CN, orderNo=4, keyword=文献计量学), Keyword(id=1322633181325546430, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=CN, orderNo=5, keyword=铁死亡), Keyword(id=1322633181442986943, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=CN, orderNo=6, keyword=网络药理学), Keyword(id=1322633181505901504, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=CN, orderNo=7, keyword=分子对接), Keyword(id=1322633181640119233, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=EN, orderNo=1, keyword=traditional Chinese medicine), Keyword(id=1322633181736588226, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=EN, orderNo=2, keyword=mitochondrial reactive oxygen species), Keyword(id=1322633181837251523, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=EN, orderNo=3, keyword=oxidative stress), Keyword(id=1322633181912748996, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=EN, orderNo=4, keyword=bibliometrics), Keyword(id=1322633181975663557, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=EN, orderNo=5, keyword=ferroptosis), Keyword(id=1322633182034383814, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=EN, orderNo=6, keyword=network pharmacology), Keyword(id=1322633182105686983, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, language=EN, orderNo=7, keyword=molecular docking)], refs=[Reference(id=1319981758913819502, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=1, rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=Zhao L L, Zou X T, Deng J Q, et al. hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under mitochondrial stress [J]. Cell Death Differ, 2025, 32(1): 118-133., articleTitle=null, refAbstract=null), Reference(id=1319981758913819503, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=2, rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=Ősz F, Nazir A, Takács-Vellai K, et al. Mutations of the electron transport chain affect lifespan and ROS levels in C. elegans [J]. Antioxidants, 2025, 14(1): 76., articleTitle=null, refAbstract=null), Reference(id=1319981758913819504, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=3, rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=Nolfi-Donegan D, Braganza A, Shiva S. Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement [J]. Redox Biol, 2020, 37: 101674., articleTitle=null, refAbstract=null), Reference(id=1319981758913819505, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=4, rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=Bochkova Z V, Baizhumanov A A, Yusipovich A I, et al. The flexible chain: Regulation of structure and activity of ETC complexes defines rate of ATP synthesis and sites of superoxide generation [J]. Biophys Rev, 2025, 17(1): 55-88., articleTitle=null, refAbstract=null), Reference(id=1319981758913819506, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=5, rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=Mihanovic I, Marinovic J, Bulat C, et al. Mitochondrial ROS production at complexes I and III in human myocardium and skeletal muscle: A distinct pattern compared with rat tissue [J]. Cells, 2026, 15(9): 830., articleTitle=null, refAbstract=null), Reference(id=1319981758918013807, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=6, rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=Giordano L, Ware S A, Lagranha C J, et al. Mitochondrial DNA signals driving immune responses: Why, How, Where? [J]. Cell Commun Signal, 2025, 23(1): 192., articleTitle=null, refAbstract=null), Reference(id=1319981758918013808, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=7, rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=Belosludtsev K N, Dubinin M V, Belosludtseva N V. Ca²⁺-dependent mitochondrial permeability transition pore: Structure, properties, and role in cellular pathophysiology [J]. Biochem Moscow, 2025, 90(12): 1789-1810., articleTitle=null, refAbstract=null), Reference(id=1319981758918013809, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=8, rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=Huan H, Lyamzaev K G, Panteleeva A A, et al. Mitochondrial lipid peroxidation is necessary but not sufficient for induction of ferroptosis [J]. Front Cell Dev Biol, 2024, 12: 1452824., articleTitle=null, refAbstract=null), Reference(id=1319981758918013810, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=9, rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=Jiang X J, Stockwell B R, Conrad M. Ferroptosis: Mechanisms, biology and role in disease [J]. Nat Rev Mol Cell Biol, 2021, 22(4): 266-282., articleTitle=null, refAbstract=null), Reference(id=1319981758918013811, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=10, rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=Xu X Y, Pang Y, Fan X Q. Mitochondria in oxidative stress, inflammation and aging: From mechanisms to therapeutic advances [J]. Signal Transduct Target Ther, 2025, 10: 190., articleTitle=null, refAbstract=null), Reference(id=1319981758918013812, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=11, rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=Fiorani M, Guidarelli A, Cantoni O. Mitochondrial reactive oxygen species: The effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants [J]. Int J Radiat Biol, 2021, 97(8):1055-1062., articleTitle=null, refAbstract=null), Reference(id=1319981758918013813, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=12, rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=Banerjee P, Saha I, Sarkar D, et al. Contributions and limitations of mitochondria-targeted and non-targeted antioxidants in the treatment of Parkinsonism: An updated review [J]. Neurotox Res, 2022, 40(3): 847-873., articleTitle=null, refAbstract=null), Reference(id=1319981758918013814, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=13, rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=Fields M, Marcuzzi A, Gonelli A, et al. Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: Perspectives and limitations [J]. Int J Mol Sci, 2023, 24(4): 3739., articleTitle=null, refAbstract=null), Reference(id=1319981758918013815, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=14, rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=Lei R J, Zhou C Q. The role of reactive oxygen species-mitophagy regulation in the treatment of osteoarthritis by active Chinese herbal medicine monomers: A review [J]. Front Med, 2025, 12: 1686190., articleTitle=null, refAbstract=null), Reference(id=1319981758918013816, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=15, rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=吕瑞龙, 窦芬瑜, 柴梦娜, 等. 中药调控线粒体自噬抗肿瘤作用机制研究进展[J]. 中草药, 2025, 56(8): 3005-3013., articleTitle=null, refAbstract=null), Reference(id=1319981758918013817, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=16, rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=Zhang Y Y, Su F Z, Zhu E L, et al. A systematical review on traditional Chinese medicine treating chronic diseases via regulating ferroptosis from the perspective of experimental evidence and clinical application [J]. Chin Herb Med, 2025, 17(2): 246-260., articleTitle=null, refAbstract=null), Reference(id=1319981758918013818, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=17, rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=时慧, 徐闪闪, 邱建利, 等. 铁死亡在肝纤维化中的作用及中医药干预的研究进展[J]. 中国现代应用药学, 2025, 42(12):2142-2149., articleTitle=null, refAbstract=null), Reference(id=1319981758918013819, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=18, rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=陶奕臻, 王雪婧, 郑帏蔗, 等. 基于文献计量学和全球专利的知识图谱技术在中医药领域研究进展与趋势可视化分析[J]. 中草药, 2026, 57(12): 4760-4779., articleTitle=null, refAbstract=null), Reference(id=1319981758918013820, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=19, rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=Moral-Muñoz J A, Herrera-Viedma E, Santisteban-Espejo A, et al. Software tools for conducting bibliometric analysis in science: An up-to-date review [J]. El Profesion Inform, 2020, 29(1): e290103., articleTitle=null, refAbstract=null), Reference(id=1319981758918013821, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=20, rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=赵小晗, 高洁, 谭宇, 等. 基于文献计量学对中医药干预氧化应激的可视化分析[J]. 天津中医药, 2023, 40(6): 715-725., articleTitle=null, refAbstract=null), Reference(id=1319981758918013822, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=21, rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=Zorov D B, Juhaszova M, Sollott S J. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release [J]. Physiol Rev, 2014, 94(3):909-950., articleTitle=null, refAbstract=null), Reference(id=1319981758918013823, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=22, rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=Dixon S J, Lemberg K M, Lamprecht M R, et al. Ferroptosis: An iron-dependent form of nonapoptotic cell death [J]. Cell, 2012, 149(5):1060-1072., articleTitle=null, refAbstract=null), Reference(id=1319981758918013824, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=23, rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=Elmore S. Apoptosis: A review of programmed cell death [J]. Toxicol Pathol, 2007, 35(4): 495-516., articleTitle=null, refAbstract=null), Reference(id=1319981758918013825, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=24, rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=Sung H, Ferlay J, Siegel R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2021, 71(3): 209-249., articleTitle=null, refAbstract=null), Reference(id=1319981758918013826, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=25, rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=Zhou R B, Yazdi A S, Menu P, et al. A role for mitochondria in NLRP3 inflammasome activation [J]. Nature, 2011, 469(7329): 221-225., articleTitle=null, refAbstract=null), Reference(id=1319981758918013827, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=26, rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=Ru J L, Li P, Wang J N, et al. TCMSP: A database of systems pharmacology for drug discovery from herbal medicines [J]. J Cheminf, 2014, 6(1): 13., articleTitle=null, refAbstract=null), Reference(id=1319981758918013828, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=27, rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=张子婷, 郑彦宁, 袁芳. 多指标核心作者识别方法研究[J]. 现代情报, 2020, 40(7): 144-151., articleTitle=null, refAbstract=null), Reference(id=1319981758918013829, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=28, rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253., articleTitle=null, refAbstract=null), Reference(id=1319981758918013830, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=29, rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=余佳蓓, 林沐萱, 仝心如, 等. 基于CiteSpace和VOSviewer的中医药治疗儿童遗尿症可视化分析[J]. 中医药导报, 2025, 31(9): 171-177., articleTitle=null, refAbstract=null), Reference(id=1319981758918013831, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=30, rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=刘成娟, 黄盛洁, 杜瑞姣, 等. 基于CiteSpace对红景天研究进展的可视化分析[J]. 中南药学, 2022, 20(5): 1192-1197., articleTitle=null, refAbstract=null), Reference(id=1319981758918013832, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=31, rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=Abudalo R A, Alqudah A M, Roarty C, et al. Oxidative stress and inflammation in COVID-19: Potential application of GLP-1 receptor agonists [J]. Eur Rev Med Pharmacol Sci, 2023, 27(13): 6459-6471., articleTitle=null, refAbstract=null), Reference(id=1319981758918013833, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=32, rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=Murphy M P. How mitochondria produce reactive oxygen species [J]. Biochem J, 2009, 417(1): 1-13., articleTitle=null, refAbstract=null), Reference(id=1319981758918013834, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=33, rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=Zou X L, Liu X N, Qu W J, et al. Astragaloside IV relieves mitochondrial oxidative stress damage and dysfunction in diabetic mice endothelial progenitor cells by regulating the GSK-3β/Nrf2 axis [J]. Appl Biochem Biotechnol, 2025, 197(6): 3964-3981., articleTitle=null, refAbstract=null), Reference(id=1319981758922208112, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=34, rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=Gote S, Dubey S, Nargund S L, et al. A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders [J]. Inflammopharmacology, 2025, 33(9):5097-5111., articleTitle=null, refAbstract=null), Reference(id=1319981758922208113, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=35, rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=孙兴华, 曲阳, 刘冬雪, 等. 中药天然产物调控Nrf2信号通路防治阿尔茨海默病的研究进展[J]. 药物评价研究, 2024, 47(12): 2924-2936., articleTitle=null, refAbstract=null), Reference(id=1319981758922208114, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=36, rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=Wang J J, Ye W L, Zou J M, et al. Targeting the smooth muscle cell Keap1-Nrf2-GSDMD-pyroptosis axis by cryptotanshinone prevents abdominal aortic aneurysm formation [J]. Theranostics, 2024, 14(17): 6516-6542., articleTitle=null, refAbstract=null), Reference(id=1319981758922208115, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=37, rfOrder=36, authorNames=null, journalName=null, refType=null, unstructuredReference=凌鑫萍, 晏伟, 杨芬, 等. 绿原酸改善炎症性疾病的研究进展[J]. 中南大学学报: 医学版, 2023, 48(10): 1611-1620., articleTitle=null, refAbstract=null), Reference(id=1319981758922208116, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=38, rfOrder=37, authorNames=null, journalName=null, refType=null, unstructuredReference=栾博, 栾梅, 邱雅慧. 葛根素激活Nrf2通路减轻心力衰竭大鼠氧化应激损伤的研究[J]. 现代预防医学, 2019, 46(10): 1852-1856., articleTitle=null, refAbstract=null), Reference(id=1319981758922208117, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=39, rfOrder=38, authorNames=null, journalName=null, refType=null, unstructuredReference=何信用, 王俊岩, 宋囡, 等. 基于网络药理学的葛根素治疗动脉粥样硬化潜在分子机制研究[J]. 中华中医药学刊, 2020, 38(9):116-120., articleTitle=null, refAbstract=null), Reference(id=1319981758922208118, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=40, rfOrder=39, authorNames=null, journalName=null, refType=null, unstructuredReference=李彩虹, 崔亚萌, 曾超, 等. 六味地黄丸对顺铂诱导大鼠急性肾损伤的保护作用[J]. 现代药物与临床, 2019, 34(1): 15-19., articleTitle=null, refAbstract=null), Reference(id=1319981758922208119, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=41, rfOrder=40, authorNames=null, journalName=null, refType=null, unstructuredReference=殷贝, 毕艺鸣, 黄锦珠, 等. 基于网络药理学和分子对接探讨六味地黄丸治疗糖尿病肾病的作用机制研究[J]. 中国现代应用药学, 2021, 38(17): 2060-2069., articleTitle=null, refAbstract=null), Reference(id=1319981758922208120, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=42, rfOrder=41, authorNames=null, journalName=null, refType=null, unstructuredReference=冯小霞, 陈晨, 邱静, 等. 黄连解毒汤调控FBXL5/IRP2改善VaD小鼠脑铁代谢紊乱、髓鞘损伤及激越攻击行为[J]. 中国实验方剂学杂志, 2024, 30(24): 1-9., articleTitle=null, refAbstract=null), Reference(id=1319981758922208121, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=43, rfOrder=42, authorNames=null, journalName=null, refType=null, unstructuredReference=孙亦轩, 王俊力, 刘欣, 等. 基于Nrf2信号通路探讨黄连解毒汤对阿尔茨海默病小鼠学习记忆的改善作用[J]. 中成药, 2024, 46(7): 2371-2375., articleTitle=null, refAbstract=null), Reference(id=1319981758922208122, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=44, rfOrder=43, authorNames=null, journalName=null, refType=null, unstructuredReference=Pickles S, Vigié P, Youle R J. Mitophagy and quality control mechanisms in mitochondrial maintenance [J]. Curr Biol, 2018, 28(4):R170-R185., articleTitle=null, refAbstract=null), Reference(id=1319981758922208123, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=45, rfOrder=44, authorNames=null, journalName=null, refType=null, unstructuredReference=Scarpulla R C. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network [J]. Biochim Biophys Acta BBA Mol Cell Res, 2011, 1813(7): 1269-1278., articleTitle=null, refAbstract=null), Reference(id=1319981758922208124, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=46, rfOrder=45, authorNames=null, journalName=null, refType=null, unstructuredReference=韩雪, 白巧云, 申林, 等. 人参皂苷Rb₁通过AMPK/ SIRT1/PGC-1α轴调节线粒体裂变融合缓解哮喘气道炎症[J]. 中国药理学通报, 2024, 40(4): 798-799., articleTitle=null, refAbstract=null), Reference(id=1319981758922208125, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=47, rfOrder=46, authorNames=null, journalName=null, refType=null, unstructuredReference=谢月敏, 韩爱子, 陈乾, 等. 人参皂苷Rg₁调节SIRT1/AMPK/PGC1α信号通路对阿霉素心肌损伤大鼠的影响[J]. 河北医学, 2025, 31(8): 1263-1269., articleTitle=null, refAbstract=null), Reference(id=1319981758922208126, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=48, rfOrder=47, authorNames=null, journalName=null, refType=null, unstructuredReference=Wang L, Qin N, Ge S C, et al. Notoginseng leaf triterpenes promotes angiogenesis by activating the Nrf2 pathway and AMPK/SIRT1-mediated PGC-1/ERα axis in ischemic stroke [J]. Fitoterapia, 2024, 176: 106045., articleTitle=null, refAbstract=null), Reference(id=1319981758922208127, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=49, rfOrder=48, authorNames=null, journalName=null, refType=null, unstructuredReference=Rosencrans W M, Lee R W, McGraw L, et al. Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress [J]. Sci Adv, 2025, 11(35): eady0240., articleTitle=null, refAbstract=null), Reference(id=1319981758922208128, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=50, rfOrder=49, authorNames=null, journalName=null, refType=null, unstructuredReference=叶旭星, 杨超, 章义利, 等. 丹参酮II_A通过调节PINK1/Parkin通路改善慢性阻塞性肺疾病大鼠急性肺损伤的机制研究[J]. 浙江中西医结合杂志, 2025, 35(6): 519-524., articleTitle=null, refAbstract=null), Reference(id=1319981758922208129, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=51, rfOrder=50, authorNames=null, journalName=null, refType=null, unstructuredReference=Wu K, Yu C, Li P, Li N. Cardiomyoprotective effect of tanshinone II_A in diabetic cardiomyopathy achieved through enhancing PINK1-Parkin dependent mitophagy [J]. Histol Histopathol, 2026, 41(3): 493-503., articleTitle=null, refAbstract=null), Reference(id=1319981758922208130, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=52, rfOrder=51, authorNames=null, journalName=null, refType=null, unstructuredReference=张伟梁, 刘瑞琦, 周丽娟, 等. 丹参酮II_A对尿酸诱导的肾小管上皮细胞纤维化模型线粒体损伤和相关炎症因子的影响[J]. 中药材, 2023, 46(1): 207-211., articleTitle=null, refAbstract=null), Reference(id=1319981758922208131, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=53, rfOrder=52, authorNames=null, journalName=null, refType=null, unstructuredReference=何小姣, 黄崧, 谢彬, 等. 大黄素恢复自噬减轻脂多糖诱导的急性肝损伤[J]. 中华急诊医学杂志, 2021, 30(5): 545-550., articleTitle=null, refAbstract=null), Reference(id=1319981758922208132, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=54, rfOrder=53, authorNames=null, journalName=null, refType=null, unstructuredReference=赵欣, 姬孟艳, 董强. 补阳还五汤对缺血性脑卒中大鼠神经元自噬的保护作用及机制分析[J]. 临床和实验医学杂志, 2020, 19(9): 910-914., articleTitle=null, refAbstract=null), Reference(id=1319981758922208133, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=55, rfOrder=54, authorNames=null, journalName=null, refType=null, unstructuredReference=王世界, 杨晶, 马贺, 等. 基于线粒体质量控制系统观察六味地黄丸对老龄小鼠的神经保护作用[J]. 中国比较医学杂志, 2023, 33(6): 24-34., articleTitle=null, refAbstract=null), Reference(id=1319981758922208134, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=56, rfOrder=55, authorNames=null, journalName=null, refType=null, unstructuredReference=林鹏展, 田菲, 张林, 等. 中医药干预铁死亡机制的研究进展[J]. 湖南中医药大学学报, 2021, 41(2): 318-322., articleTitle=null, refAbstract=null), Reference(id=1319981758922208135, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=57, rfOrder=56, authorNames=null, journalName=null, refType=null, unstructuredReference=郑恩会, 钟晓琳, 蒋宗哲, 等. 中药及其天然产物通过靶向铁死亡治疗肝癌研究进展[J]. 天然产物研究与开发, 2025, 37(8):1578-1584., articleTitle=null, refAbstract=null), Reference(id=1319981758926402417, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=58, rfOrder=57, authorNames=null, journalName=null, refType=null, unstructuredReference=焦泉慧, 钟凌云, 程子文, 等. 中药及其天然产物通过靶向铁死亡治疗癌症研究进展[J]. 医药导报, 2024, 43(3): 408-413., articleTitle=null, refAbstract=null), Reference(id=1319981758926402418, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=59, rfOrder=58, authorNames=null, journalName=null, refType=null, unstructuredReference=丁瑞, 张艺馨, 程青虹. 穿心莲内酯通过调节铁死亡中SLC7A11/GPX4通路减轻脓毒症急性肾损伤[J/OL]. 海南医科大学学报, (2025-06-27) [2026-04-15]. http:// 10.13210/j.cnki.jhmu.20250627.003., articleTitle=null, refAbstract=null), Reference(id=1319981758926402419, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=60, rfOrder=59, authorNames=null, journalName=null, refType=null, unstructuredReference=吴春阳, 欧阳竞锋. 姜黄素调控铁死亡干预帕金森病的网络药理学研究及实验验证[J]. 海南医科大学学报, 2025, 31(5):360-372., articleTitle=null, refAbstract=null), Reference(id=1319981758926402420, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=61, rfOrder=60, authorNames=null, journalName=null, refType=null, unstructuredReference=Lin X, Zhao X X, Chen Q F, et al. Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis-induced cardiomyopathy [J]. Int J Mol Med, 2023, 52(6): 116., articleTitle=null, refAbstract=null), Reference(id=1319981758926402421, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=62, rfOrder=61, authorNames=null, journalName=null, refType=null, unstructuredReference=周思聪, 杨威, 曾丽, 等. 大黄素对胶原诱导性关节炎大鼠的骨保护作用: 基于抑制铁死亡和降解基质金属蛋白酶[J]. 南方医科大学学报, 2023, 43(10): 1776-1781., articleTitle=null, refAbstract=null), Reference(id=1319981758926402422, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=63, rfOrder=62, authorNames=null, journalName=null, refType=null, unstructuredReference=Bersuker K, Hendricks J M, Li Z P, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis [J]. Nature, 2019, 575(7784): 688-692., articleTitle=null, refAbstract=null), Reference(id=1319981758926402423, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=64, rfOrder=63, authorNames=null, journalName=null, refType=null, unstructuredReference=Ding T, Song M Y, Wu Y S, et al. Schisandrin B ameliorates Alzheimer’s disease by suppressing neuronal ferroptosis and ensuing microglia M1 polarization [J]. Phytomedicine, 2025, 142: 156780., articleTitle=null, refAbstract=null), Reference(id=1319981758926402424, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=65, rfOrder=64, authorNames=null, journalName=null, refType=null, unstructuredReference=Chen J H, Shi Z H, Zhang C L, et al. Oroxin A alleviates early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation [J]. J Neuroinflammation, 2024, 21(1): 116., articleTitle=null, refAbstract=null), Reference(id=1319981758926402425, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=66, rfOrder=65, authorNames=null, journalName=null, refType=null, unstructuredReference=Zhao Y Y, Yang M J, Liang X X. The role of mitochondria in iron overload-induced damage [J]. J Transl Med, 2024, 22(1): 1057., articleTitle=null, refAbstract=null), Reference(id=1319981758926402426, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=67, rfOrder=66, authorNames=null, journalName=null, refType=null, unstructuredReference=Wang Y Y, Wang M, Liu Y S, et al. Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores [J]. Redox Biol, 2022, 55: 102407., articleTitle=null, refAbstract=null), Reference(id=1319981758926402427, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=68, rfOrder=67, authorNames=null, journalName=null, refType=null, unstructuredReference=You R J, Sun B, Luo J, et al. Exploring the role of mitoferrin-1 in ferroptosis and mitochondrial damage in acute ischemic stroke [J]. Int Immunopharmacol, 2025, 155: 114625., articleTitle=null, refAbstract=null), Reference(id=1319981758926402428, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=69, rfOrder=68, authorNames=null, journalName=null, refType=null, unstructuredReference=Cui J X, Chen Y J, Yang Q N, et al. Protosappanin a protects DOX-induced myocardial injury and cardiac dysfunction by targeting ACSL4/FTH1 axis-dependent ferroptosis [J]. Adv Sci, 2024, 11(34): 2310227., articleTitle=null, refAbstract=null), Reference(id=1319981758926402429, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=70, rfOrder=69, authorNames=null, journalName=null, refType=null, unstructuredReference=张栏译, 沈子涵, 苏嘉楠, 等. 基于线粒体MFRN2/ NFS1/ABCB7通路探讨益糖康对抗胰岛β细胞铁死亡作用机制[J]. 辽宁中医药大学学报, 2025, 27(8): 18-22., articleTitle=null, refAbstract=null), Reference(id=1319981758926402430, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=71, rfOrder=70, authorNames=null, journalName=null, refType=null, unstructuredReference=宓伟, 于敏, 李宁, 等. 基于AMPK/SREBP-1c分子通路的山楂原花青素调控脂质代谢机制[J]. 食品科学, 2023, 44(15): 129-136., articleTitle=null, refAbstract=null), Reference(id=1319981758926402431, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=72, rfOrder=71, authorNames=null, journalName=null, refType=null, unstructuredReference=Sheng N, Zhang Z H, Zheng H, et al. Scutellarin rescued mitochondrial damage through ameliorating mitochondrial glucose oxidation via the pdk-pdc axis [J]. Adv Sci, 2023, 10(32): 2303584., articleTitle=null, refAbstract=null), Reference(id=1319981758926402432, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=73, rfOrder=72, authorNames=null, journalName=null, refType=null, unstructuredReference=陈德良, 张磊, 付长其, 等. 线粒体活性氧在氟化钠诱导PC12细胞NF-κB/NLRP3信号通路活化中的作用[J]. 中国兽医学报, 2023, 43(10): 2116-2122., articleTitle=null, refAbstract=null), Reference(id=1319981758926402433, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=74, rfOrder=73, authorNames=null, journalName=null, refType=null, unstructuredReference=Chen F, Jiang G W, Liu H, et al. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop [J]. Bone Res, 2020, 8: 10., articleTitle=null, refAbstract=null), Reference(id=1319981758926402434, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=75, rfOrder=74, authorNames=null, journalName=null, refType=null, unstructuredReference=Wei X H, Chen J, Wu X F, et al. Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3[J]. Phytomedicine, 2025, 136:156260., articleTitle=null, refAbstract=null), Reference(id=1319981758926402435, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=76, rfOrder=75, authorNames=null, journalName=null, refType=null, unstructuredReference=Qiao X, Zhang L, Wang T, et al. Diosgenin ameliorates colitis by inhibiting mitochondrial DNA synthesis in macrophages via STAT2-CMPK2 pathway [J]. Phytomedicine, 2026, 150: 157605., articleTitle=null, refAbstract=null)], funds=[Fund(id=1319981758511166313, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, awardId=2097521963581902850, language=CN, fundingSource=国家自然科学基金项目, fundOrder=null, country=null), Fund(id=1319981758582469482, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, awardId=2097521963586097153, language=CN, fundingSource=四川省科技厅重点研发计划项目, fundOrder=null, country=null), Fund(id=1319981758649578347, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, awardId=2097521963586097154, language=CN, fundingSource=四川省中医药管理局专项研究项目, fundOrder=null, country=null), Fund(id=1319981758725075820, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, awardId=2097521963586097155, language=CN, fundingSource=院校联合创新基金项目, fundOrder=null, country=null), Fund(id=1319981758783796077, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, awardId=2097521963586097156, language=CN, fundingSource=成都中医药大学基础增厚项目, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1319981753746436933, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=1, ext=[AuthorCompanyExt(id=1319981753754825542, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981753746436933, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学, 四川成都 611137, departmentName=null, remark=^1.成都中医药大学, 四川成都 611137)]), AuthorCompany(id=1319981753821934407, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=2^*, ext=[AuthorCompanyExt(id=1319981754044232520, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981753821934407, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学 中医药学术传承中心, 四川成都 611137, departmentName=null, remark=^2.成都中医药大学 中医药学术传承中心, 四川成都 611137)]), AuthorCompany(id=1319981754123924297, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, xref=3^*, ext=[AuthorCompanyExt(id=1319981754128118602, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981749438886722, companyId=1319981754123924297, language=CN, country=null, province=null, city=null, postcode=null, companyName=成都中医药大学, 四川成都 611137, departmentName=null, remark=^3.成都中医药大学, 四川成都 611137)])], figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.16.020, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.16.020, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.16.020, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.16.020, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1787846400000, fullTextJson=null, articleText=null, reference=Zhao L L, Zou X T, Deng J Q, et al. hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under mitochondrial stress [J]. Cell Death Differ, 2025, 32(1): 118-133.
Ősz F, Nazir A, Takács-Vellai K, et al. Mutations of the electron transport chain affect lifespan and ROS levels in C. elegans [J]. Antioxidants, 2025, 14(1): 76.
Nolfi-Donegan D, Braganza A, Shiva S. Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement [J]. Redox Biol, 2020, 37: 101674.
Bochkova Z V, Baizhumanov A A, Yusipovich A I, et al. The flexible chain: Regulation of structure and activity of ETC complexes defines rate of ATP synthesis and sites of superoxide generation [J]. Biophys Rev, 2025, 17(1): 55-88.
Mihanovic I, Marinovic J, Bulat C, et al. Mitochondrial ROS production at complexes I and III in human myocardium and skeletal muscle: A distinct pattern compared with rat tissue [J]. Cells, 2026, 15(9): 830.
Giordano L, Ware S A, Lagranha C J, et al. Mitochondrial DNA signals driving immune responses: Why, How, Where? [J]. Cell Commun Signal, 2025, 23(1): 192.
Belosludtsev K N, Dubinin M V, Belosludtseva N V. Ca²⁺-dependent mitochondrial permeability transition pore: Structure, properties, and role in cellular pathophysiology [J]. Biochem Moscow, 2025, 90(12): 1789-1810.
Huan H, Lyamzaev K G, Panteleeva A A, et al. Mitochondrial lipid peroxidation is necessary but not sufficient for induction of ferroptosis [J]. Front Cell Dev Biol, 2024, 12: 1452824.
Jiang X J, Stockwell B R, Conrad M. Ferroptosis: Mechanisms, biology and role in disease [J]. Nat Rev Mol Cell Biol, 2021, 22(4): 266-282.
Xu X Y, Pang Y, Fan X Q. Mitochondria in oxidative stress, inflammation and aging: From mechanisms to therapeutic advances [J]. Signal Transduct Target Ther, 2025, 10: 190.
Fiorani M, Guidarelli A, Cantoni O. Mitochondrial reactive oxygen species: The effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants [J]. Int J Radiat Biol, 2021, 97(8):1055-1062.
Banerjee P, Saha I, Sarkar D, et al. Contributions and limitations of mitochondria-targeted and non-targeted antioxidants in the treatment of Parkinsonism: An updated review [J]. Neurotox Res, 2022, 40(3): 847-873.
Fields M, Marcuzzi A, Gonelli A, et al. Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: Perspectives and limitations [J]. Int J Mol Sci, 2023, 24(4): 3739.
Lei R J, Zhou C Q. The role of reactive oxygen species-mitophagy regulation in the treatment of osteoarthritis by active Chinese herbal medicine monomers: A review [J]. Front Med, 2025, 12: 1686190.
吕瑞龙, 窦芬瑜, 柴梦娜, 等. 中药调控线粒体自噬抗肿瘤作用机制研究进展[J]. 中草药, 2025, 56(8): 3005-3013.
Zhang Y Y, Su F Z, Zhu E L, et al. A systematical review on traditional Chinese medicine treating chronic diseases via regulating ferroptosis from the perspective of experimental evidence and clinical application [J]. Chin Herb Med, 2025, 17(2): 246-260.
时慧, 徐闪闪, 邱建利, 等. 铁死亡在肝纤维化中的作用及中医药干预的研究进展[J]. 中国现代应用药学, 2025, 42(12):2142-2149.
陶奕臻, 王雪婧, 郑帏蔗, 等. 基于文献计量学和全球专利的知识图谱技术在中医药领域研究进展与趋势可视化分析[J]. 中草药, 2026, 57(12): 4760-4779.
Moral-Muñoz J A, Herrera-Viedma E, Santisteban-Espejo A, et al. Software tools for conducting bibliometric analysis in science: An up-to-date review [J]. El Profesion Inform, 2020, 29(1): e290103.
赵小晗, 高洁, 谭宇, 等. 基于文献计量学对中医药干预氧化应激的可视化分析[J]. 天津中医药, 2023, 40(6): 715-725.
Zorov D B, Juhaszova M, Sollott S J. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release [J]. Physiol Rev, 2014, 94(3):909-950.
Dixon S J, Lemberg K M, Lamprecht M R, et al. Ferroptosis: An iron-dependent form of nonapoptotic cell death [J]. Cell, 2012, 149(5):1060-1072.
Elmore S. Apoptosis: A review of programmed cell death [J]. Toxicol Pathol, 2007, 35(4): 495-516.
Sung H, Ferlay J, Siegel R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2021, 71(3): 209-249.
Zhou R B, Yazdi A S, Menu P, et al. A role for mitochondria in NLRP3 inflammasome activation [J]. Nature, 2011, 469(7329): 221-225.
Ru J L, Li P, Wang J N, et al. TCMSP: A database of systems pharmacology for drug discovery from herbal medicines [J]. J Cheminf, 2014, 6(1): 13.
张子婷, 郑彦宁, 袁芳. 多指标核心作者识别方法研究[J]. 现代情报, 2020, 40(7): 144-151.
陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253.
余佳蓓, 林沐萱, 仝心如, 等. 基于CiteSpace和VOSviewer的中医药治疗儿童遗尿症可视化分析[J]. 中医药导报, 2025, 31(9): 171-177.
刘成娟, 黄盛洁, 杜瑞姣, 等. 基于CiteSpace对红景天研究进展的可视化分析[J]. 中南药学, 2022, 20(5): 1192-1197.
Abudalo R A, Alqudah A M, Roarty C, et al. Oxidative stress and inflammation in COVID-19: Potential application of GLP-1 receptor agonists [J]. Eur Rev Med Pharmacol Sci, 2023, 27(13): 6459-6471.
Murphy M P. How mitochondria produce reactive oxygen species [J]. Biochem J, 2009, 417(1): 1-13.
Zou X L, Liu X N, Qu W J, et al. Astragaloside IV relieves mitochondrial oxidative stress damage and dysfunction in diabetic mice endothelial progenitor cells by regulating the GSK-3β/Nrf2 axis [J]. Appl Biochem Biotechnol, 2025, 197(6): 3964-3981.
Gote S, Dubey S, Nargund S L, et al. A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders [J]. Inflammopharmacology, 2025, 33(9):5097-5111.
孙兴华, 曲阳, 刘冬雪, 等. 中药天然产物调控Nrf2信号通路防治阿尔茨海默病的研究进展[J]. 药物评价研究, 2024, 47(12): 2924-2936.
Wang J J, Ye W L, Zou J M, et al. Targeting the smooth muscle cell Keap1-Nrf2-GSDMD-pyroptosis axis by cryptotanshinone prevents abdominal aortic aneurysm formation [J]. Theranostics, 2024, 14(17): 6516-6542.
凌鑫萍, 晏伟, 杨芬, 等. 绿原酸改善炎症性疾病的研究进展[J]. 中南大学学报: 医学版, 2023, 48(10): 1611-1620.
栾博, 栾梅, 邱雅慧. 葛根素激活Nrf2通路减轻心力衰竭大鼠氧化应激损伤的研究[J]. 现代预防医学, 2019, 46(10): 1852-1856.
何信用, 王俊岩, 宋囡, 等. 基于网络药理学的葛根素治疗动脉粥样硬化潜在分子机制研究[J]. 中华中医药学刊, 2020, 38(9):116-120.
李彩虹, 崔亚萌, 曾超, 等. 六味地黄丸对顺铂诱导大鼠急性肾损伤的保护作用[J]. 现代药物与临床, 2019, 34(1): 15-19.
殷贝, 毕艺鸣, 黄锦珠, 等. 基于网络药理学和分子对接探讨六味地黄丸治疗糖尿病肾病的作用机制研究[J]. 中国现代应用药学, 2021, 38(17): 2060-2069.
冯小霞, 陈晨, 邱静, 等. 黄连解毒汤调控FBXL5/IRP2改善VaD小鼠脑铁代谢紊乱、髓鞘损伤及激越攻击行为[J]. 中国实验方剂学杂志, 2024, 30(24): 1-9.
孙亦轩, 王俊力, 刘欣, 等. 基于Nrf2信号通路探讨黄连解毒汤对阿尔茨海默病小鼠学习记忆的改善作用[J]. 中成药, 2024, 46(7): 2371-2375.
Pickles S, Vigié P, Youle R J. Mitophagy and quality control mechanisms in mitochondrial maintenance [J]. Curr Biol, 2018, 28(4):R170-R185.
Scarpulla R C. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network [J]. Biochim Biophys Acta BBA Mol Cell Res, 2011, 1813(7): 1269-1278.
韩雪, 白巧云, 申林, 等. 人参皂苷Rb₁通过AMPK/ SIRT1/PGC-1α轴调节线粒体裂变融合缓解哮喘气道炎症[J]. 中国药理学通报, 2024, 40(4): 798-799.
谢月敏, 韩爱子, 陈乾, 等. 人参皂苷Rg₁调节SIRT1/AMPK/PGC1α信号通路对阿霉素心肌损伤大鼠的影响[J]. 河北医学, 2025, 31(8): 1263-1269.
Wang L, Qin N, Ge S C, et al. Notoginseng leaf triterpenes promotes angiogenesis by activating the Nrf2 pathway and AMPK/SIRT1-mediated PGC-1/ERα axis in ischemic stroke [J]. Fitoterapia, 2024, 176: 106045.
Rosencrans W M, Lee R W, McGraw L, et al. Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress [J]. Sci Adv, 2025, 11(35): eady0240.
叶旭星, 杨超, 章义利, 等. 丹参酮II_A通过调节PINK1/Parkin通路改善慢性阻塞性肺疾病大鼠急性肺损伤的机制研究[J]. 浙江中西医结合杂志, 2025, 35(6): 519-524.
Wu K, Yu C, Li P, Li N. Cardiomyoprotective effect of tanshinone II_A in diabetic cardiomyopathy achieved through enhancing PINK1-Parkin dependent mitophagy [J]. Histol Histopathol, 2026, 41(3): 493-503.
张伟梁, 刘瑞琦, 周丽娟, 等. 丹参酮II_A对尿酸诱导的肾小管上皮细胞纤维化模型线粒体损伤和相关炎症因子的影响[J]. 中药材, 2023, 46(1): 207-211.
何小姣, 黄崧, 谢彬, 等. 大黄素恢复自噬减轻脂多糖诱导的急性肝损伤[J]. 中华急诊医学杂志, 2021, 30(5): 545-550.
赵欣, 姬孟艳, 董强. 补阳还五汤对缺血性脑卒中大鼠神经元自噬的保护作用及机制分析[J]. 临床和实验医学杂志, 2020, 19(9): 910-914.
王世界, 杨晶, 马贺, 等. 基于线粒体质量控制系统观察六味地黄丸对老龄小鼠的神经保护作用[J]. 中国比较医学杂志, 2023, 33(6): 24-34.
林鹏展, 田菲, 张林, 等. 中医药干预铁死亡机制的研究进展[J]. 湖南中医药大学学报, 2021, 41(2): 318-322.
郑恩会, 钟晓琳, 蒋宗哲, 等. 中药及其天然产物通过靶向铁死亡治疗肝癌研究进展[J]. 天然产物研究与开发, 2025, 37(8):1578-1584.
焦泉慧, 钟凌云, 程子文, 等. 中药及其天然产物通过靶向铁死亡治疗癌症研究进展[J]. 医药导报, 2024, 43(3): 408-413.
丁瑞, 张艺馨, 程青虹. 穿心莲内酯通过调节铁死亡中SLC7A11/GPX4通路减轻脓毒症急性肾损伤[J/OL]. 海南医科大学学报, (2025-06-27) [2026-04-15]. http:// 10.13210/j.cnki.jhmu.20250627.003.
吴春阳, 欧阳竞锋. 姜黄素调控铁死亡干预帕金森病的网络药理学研究及实验验证[J]. 海南医科大学学报, 2025, 31(5):360-372.
Lin X, Zhao X X, Chen Q F, et al. Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis-induced cardiomyopathy [J]. Int J Mol Med, 2023, 52(6): 116.
周思聪, 杨威, 曾丽, 等. 大黄素对胶原诱导性关节炎大鼠的骨保护作用: 基于抑制铁死亡和降解基质金属蛋白酶[J]. 南方医科大学学报, 2023, 43(10): 1776-1781.
Bersuker K, Hendricks J M, Li Z P, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis [J]. Nature, 2019, 575(7784): 688-692.
Ding T, Song M Y, Wu Y S, et al. Schisandrin B ameliorates Alzheimer’s disease by suppressing neuronal ferroptosis and ensuing microglia M1 polarization [J]. Phytomedicine, 2025, 142: 156780.
Chen J H, Shi Z H, Zhang C L, et al. Oroxin A alleviates early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation [J]. J Neuroinflammation, 2024, 21(1): 116.
Zhao Y Y, Yang M J, Liang X X. The role of mitochondria in iron overload-induced damage [J]. J Transl Med, 2024, 22(1): 1057.
Wang Y Y, Wang M, Liu Y S, et al. Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores [J]. Redox Biol, 2022, 55: 102407.
You R J, Sun B, Luo J, et al. Exploring the role of mitoferrin-1 in ferroptosis and mitochondrial damage in acute ischemic stroke [J]. Int Immunopharmacol, 2025, 155: 114625.
Cui J X, Chen Y J, Yang Q N, et al. Protosappanin a protects DOX-induced myocardial injury and cardiac dysfunction by targeting ACSL4/FTH1 axis-dependent ferroptosis [J]. Adv Sci, 2024, 11(34): 2310227.
张栏译, 沈子涵, 苏嘉楠, 等. 基于线粒体MFRN2/ NFS1/ABCB7通路探讨益糖康对抗胰岛β细胞铁死亡作用机制[J]. 辽宁中医药大学学报, 2025, 27(8): 18-22.
宓伟, 于敏, 李宁, 等. 基于AMPK/SREBP-1c分子通路的山楂原花青素调控脂质代谢机制[J]. 食品科学, 2023, 44(15): 129-136.
Sheng N, Zhang Z H, Zheng H, et al. Scutellarin rescued mitochondrial damage through ameliorating mitochondrial glucose oxidation via the pdk-pdc axis [J]. Adv Sci, 2023, 10(32): 2303584.
陈德良, 张磊, 付长其, 等. 线粒体活性氧在氟化钠诱导PC12细胞NF-κB/NLRP3信号通路活化中的作用[J]. 中国兽医学报, 2023, 43(10): 2116-2122.
Chen F, Jiang G W, Liu H, et al. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop [J]. Bone Res, 2020, 8: 10.
Wei X H, Chen J, Wu X F, et al. Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3[J]. Phytomedicine, 2025, 136:156260.
Qiao X, Zhang L, Wang T, et al. Diosgenin ameliorates colitis by inhibiting mitochondrial DNA synthesis in macrophages via STAT2-CMPK2 pathway [J]. Phytomedicine, 2026, 150: 157605.)