Article(id=1319981517728756548, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1319981498787279574, articleNumber=PA20260909_km9SmaFD, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.16.003, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1779292800000, receivedDateStr=2026-05-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792637717897, onlineDateStr=2026-10-22, pubDate=1787846400000, pubDateStr=2026-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792637717897, onlineIssueDateStr=2026-10-22, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792637717897, creator=admin, updateTime=1792637717897, updator=admin, issue=Issue{id=1319981498787279574, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='16', pageStart='6209', pageEnd='6660', issueExtLink='null', onlineDate='null', pubDate='1787846400000', pubDateStr='2026-08-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792637713380, creator='ztmeta', updateTime=1792637713380, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=6233, endPage=6241, ext={EN=ArticleExt(id=1319981520970953542, articleId=1319981517728756548, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Two new sesquiterpenoid dimers from Inula japonica and their in vitro anti-hepatocellular carcinoma activity, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To investigate the chemical constituents from the inflorescences of Inula japonica and their in vitro anti-hepatocellular carcinoma activity. Methods The compounds were isolated and purified by multiple chromatographic techniques.. Their structures were identified by HRESIMS, NMR, IR, UV spectroscopic methods, and the absolute configurations of new compounds were determined by calculated NMR and ECD. The inhibitory effects of the compounds on the proliferation of HepG2 cells were evaluated by MTT assay and colony formation assay. Results Six sesquiterpenoid dimers were isolated from the ethyl acetate fraction of the 90% ethanol extract of I. japonica, among which compounds 1 (inujaponolide T) and 3 (inujaponolide U) were identified as new compounds. The bioactivity screening results showed that compounds 1—6exhibited potent cytotoxicity against HepG2 cells, with IC₅₀ values ranging from 2.61 to 13.94 μmol/L. Furthermore, compounds 1 and 3 inhibited the cell viability and reduced the colony formation of HepG2 cells in a dose-dependent manner. Conclusion Compounds 1 and 3 are new sesquiterpenoid dimers with anti-hepatocellular carcinoma activity, and may serve as potential antitumor lead compounds for further in-depth investigation., authors=YU Hang¹, LIU Guiyou², YU Jinzheng^3,4, ZHAO Yongxue¹, HUANG Mingsi¹, JIN Haixiang¹, SU Xuan¹, LI Qianzi¹, CHEN Mingxuan¹, HU Dongbao¹, DONG Wei¹, authorsList=YU Hang, LIU Guiyou, YU Jinzheng, ZHAO Yongxue, HUANG Mingsi, JIN Haixiang, SU Xuan, LI Qianzi, CHEN Mingxuan, HU Dongbao, DONG Wei, authorCompany=1 School of Chemistry and Environmental Engineering of Yuxi Normal University, Yuxi 653100, China;
2 Dehong Vocational College, Mangshi 678400, China;
3 School of Traditional Chinese Materia Medica of Shenyang Pharmaceutical University, Shenyang 110016, China;
4 Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China, correspAuthors=刘贵有: 于金正,男,硕士研究生,研究方向为中药药理学。E-mail:yujinzheng@mail.kib.ac.cn, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319981520899650373, articleId=1319981517728756548, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=旋覆花中2个新倍半萜二聚体成分及体外抗肝癌活性, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究旋覆花Inula japonica花序的化学成分及其体外抗肝癌活性。方法 采用多种色谱技术分离纯化，通过HRESIMS、NMR、IR、UV等波谱学方法及计算NMR和ECD确定新化合物的绝对构型，并采用MTT法和克隆形成实验评价化合物对人肝癌HepG2细胞的增殖抑制作用。结果 从旋覆花90%乙醇提取物的醋酸乙酯部位中分离鉴定出6个倍半萜二聚体，分别鉴定为旋覆花倍半萜二聚体内酯T（1）、双旋覆花内酯E（2）、旋覆花倍半萜二聚体内酯U（3）、双旋覆花内酯D（4）、双旋覆花内酯I（5）和双旋覆花内酯X（6），其中化合物1和3为新化合物。活性结果显示，化合物1～6对HepG2细胞均表现出较强的细胞毒性，半数抑制浓度（median inhibition concentration，IC₅₀）值在2.61～13.94 μmol/L；进一步研究表明，化合物1和3能以剂量相关性方式显著抑制细胞活力并减少集落形成数量。结论 化合物1和3为具有抗肝癌活性的新倍半萜二聚体内酯，可作为潜在的抗肿瘤先导化合物供深入研究。, authors=于航¹, 刘贵有², 于金正^3,4, 赵永雪¹, 黄明思¹, 靳海香¹, 苏璇¹, 李千姿¹, 陈明轩¹, 胡栋宝¹, 董伟¹, authorsList=于航, 刘贵有, 于金正, 赵永雪, 黄明思, 靳海香, 苏璇, 李千姿, 陈明轩, 胡栋宝, 董伟, authorCompany=1 玉溪师范学院化学与环境工程学院, 云南玉溪 653100;
2 德宏职业学院, 云南芒市 678400;
3 沈阳药科大学中药学院, 辽宁沈阳 110016;
4 中国科学院昆明植物研究所, 云南昆明 650201, correspAuthors=刘贵有, authorNote=于航: 于航,学士,研究方向为天然药物化学。E-mail:2023141122@yxnu.edu.cn 刘贵有: 于金正,男,硕士研究生,研究方向为中药药理学。E-mail:yujinzheng@mail.kib.ac.cn, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=https://oss.bj-dx-dzqywjd-hlw-icp.inspurcloudoss.com:6063/cast-journal-prod/2097521198041731073/excel/pdfs/1aab9b597b5e42c4ae8a0974dc01099a.pdf?response-content-disposition=attachment%3B%20filename%3D%2220261603.pdf%22&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20261022T025336Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=NjRlNmUzOGMtM2Y3OC00MDQ3LThkMmYtN2JkODRmYmI3MTgw%2F20261022%2Fbj-dx-dzqywjd-hlw-icp%2Fs3%2Faws4_request&X-Amz-Signature=867018413ebd95069dd548d82d2900dc9e2e72909140578530e6dbde16ed594e, pdf=KsuXqk7zdnMjrgL2KCdXNg==, pdfFileSize=1418570, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=云南省地方高校基础研究专项面上项目 (202301AO070134); 云南省教育厅科学研究基金青年项目 (2024J0889); 省级大学生创新创业训练计划 (S202511390017,S202611390065))}, authors=[Author(id=1319981522585760593, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981517728756548, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=于航, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1319981522682229587, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1319981517728756548, authorId=1319981522585760593, language=CN, stringName=于航, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹,, address=⁵玉溪师范学院化学与环境工程学院, 云南玉溪 653100, bio=于航: 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