Article(id=1304735421913654183, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.14.022, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1775577600000, receivedDateStr=2026-04-08, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1789002765396, onlineDateStr=2026-09-10, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789002765396, onlineIssueDateStr=2026-09-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789002765396, creator=13701087609, updateTime=1789002765396, updator=13701087609, issue=Issue{id=1304735403429356361, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='14', pageStart='5353', pageEnd='5788', issueExtLink='null', onlineDate='null', pubDate='1785168000000', pubDateStr='2026-07-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789002760989, creator='13701087609', updateTime=1789002916821, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304736057073889492, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304736057073889493, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304735403429356361, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=5613, endPage=5627, ext={EN=ArticleExt(id=1304735422240809897, articleId=1304735421913654183, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Evidence evaluation of five commonly-used Chinese patent medicines in treatment of knee osteoarthritis based on Eff-iEC and GRADE, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective An evidence assessment was conducted on five commonly used traditional Chinese patent medicines for the treatment of knee osteoarthritis (KOA), using the integrated evidence chain-based efficacy evaluation of traditional Chinese medicine (Eff-iEC) method and the grading of recommendations assessment,development and evaluation (GRADE) system. Methods The internationally recognized GRADE system and Eff-iEC method, which aligns with the characteristics of TCM, were applied in parallel to evaluate the evidence for five high-frequency recommended CPMs from clinical guidelines and expert consensuses. Simultaneously, a Meta-analysis was performed to evaluate their clinical efficacy and safety, using the clinical effective rate as a core indicator for evidence determination. Results GRADE assessment showed that, due to limitations in randomized controlled trials (RCTs) such as blinding and publication bias, among the five Chinese patent medicines, Jintiange Capsules and Biqi Capsules were rated as Grade C (low-quality evidence), while the rest were rated as Grade B (moderate-quality evidence). In contrast, the Eff-iEC method provided different evidence stratification: Jintiange Capsules (AA+B+), Zhuangguguanjie Capsules (BAA), and Biqi Capsules (AA+B+) were identified as high-level evidence. Wangbi Tablets/Capsules (BA+B+), Xianling Gubao Capsules (BA+B+) were identified as moderatelevel evidence. The Meta-analysis showed that CPMs combined with conventional Western medical therapy significantly improved the overall clinical effective rate (RR range 1.15—1.26, all P < 0.05). Notably, Wangbi Tablets/Capsules (RR = 0.41), Xianling Gubao Capsules (RR = 0.57), significantly reduced the risk of adverse reactions, demonstrating efficacy enhancement and toxicity reduction effects. Conclusion The Eff-iEC system and GRADE each have their own advantages in evidence evaluation. The Eff-iEC evaluation system can more comprehensively assess the efficacy evidence of traditional Chinese medicine compared to the GRADE system, avoiding underestimation of value due to flaws in trial design. However, high-quality RCTs are still needed in the future to further strengthen the certainty of the evidence., authors=SUN Aolin, WEI Guangcheng, LI Xiaolong, GU Jinguang, MA Qiming, QIN Weikai, authorsList=SUN Aolin, WEI Guangcheng, LI Xiaolong, GU Jinguang, MA Qiming, QIN Weikai, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304735422144340904, articleId=1304735421913654183, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于整合证据链和GRADE系统的5种常用中成药治疗膝骨关节炎证据评价, columnId=1304140194819629763, journalTitle=中草药, columnName=数据挖掘与循证医学, runingTitle=null, highlight=null, articleAbstract=目的 对临床常用治疗膝骨关节炎（knee Osteoarthritis，KOA）的5种中成药使用中药有效性评价整合证据链法（integrated evidence chain-based efficacy evaluation of traditional Chinese medicine，Eff-iEC）和推荐分级的评估、制订和评价系统（grading of recommendations assessment,development and evaluation，GRADE）进行证据评价。方法 并行采用国际通用的GRADE系统与符合中医药特点的Eff-iEC，对指南/共识高频推荐的5种中成药开展双体系证据评价。同时运用Meta分析评价其临床有效性及安全性，并以临床有效率等核心指标进行证据判别。结果 GRADE评价显示，受限于随机对照试验（randomized controlled trial，RCT）在盲法及发表偏倚等瑕疵，5种中成药中金天格胶囊、痹祺胶囊被评价为C级（低级证据），其余均为B级（中级证据）。Eff-iEC法则实现了不同的证据分层：金天格胶囊（AA＋B＋）、壮骨关节胶囊（BAA）及痹祺胶囊（AA＋B＋）评价为“高级证据”；尪痹片/胶囊（BA＋B＋）、仙灵骨葆胶囊（BA＋B＋）评价为“中级证据”。Meta分析显示，中成药联合西医常规治疗可显著提升KOA临床总有效率（RR：1.15～1.26，均P＜0.05）。尪痹片/胶囊（RR＝0.41）、仙灵骨葆（RR＝0.57）等能显著降低不良反应风险，体现了明确的“增效减毒”价值。结论 Eff-iEC体系与GRADE在证据评价方面各有优势，Eff-iEC评价体系较GRADE系统能更全面地评价中医药的有效性证据，避免了因试验设计瑕疵导致的价值低估，但未来仍需开展高质量RCT进一步夯实证据的确定性。, authors=孙奥林¹, 魏光成¹, 李小龙¹, 顾金光¹, 麻启明¹, 秦伟凯¹, authorsList=孙奥林, 魏光成, 李小龙, 顾金光, 麻启明, 秦伟凯, authorCompany=1 中国中医科学院望京医院, 北京 100102, correspAuthors=秦伟凯, authorNote=孙奥林: 孙奥林，硕士研究生，研究方向为中医骨伤。E-mail:sunaolin2025@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=EH2XVjxSkyDIXH5eEJNKhg==, pdfFileSize=1667346, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=中国中医科学院科技创新工程 (CI2026A02018); 北京市中医药科技发展资金项目 (BJZYYB-2025-18); 北京中医药薪火传承“新3＋3”工程尚天裕“三名”传承工作室建设项目)}, authors=[Author(id=1307444570715869746, tenantId=1146029695717560320, journalId=null, articleId=1304735421913654183, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={EN=AuthorExt(id=null, tenantId=null, 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submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.14.022, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.14.022, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.14.022, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.14.022, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1789002765396, fullTextJson=null, articleText=null, reference=廖婕, 吴琼瑶, 吴功华, 等. 1990—2023年中国膝骨关节炎疾病负担现状及趋势分析[J]. 中国修复重建外科杂志, 2025, 39(11): 1381-1387.
朱治龙, 黄国鑫, 艾金伟, 等. 全球膝关节骨性关节炎发病率和患病率分析与趋势预测[J]. 湖北医药学院学报, 2023, 42(6): 647-654.
苏奇, 张文贤, 王斌, 等. 膝骨关节炎的中医治疗进展[J]. 甘肃科技, 2022, 38(8): 128-131.
赵岩, 薛志鹏, 李泰贤, 等. 基于文献计量学分析中成药治疗膝骨关节炎研究现状[J]. 世界中西医结合杂志, 2020, 15(3): 449-453.
国务院办公厅. 关于加快中医药特色发展的若干政策措施[EB/OL]. (2021-01-22) [2026-02-27]. http://www.natcm.gov.cn/bangongshi/gongzuodongtai/2021-02-09/20090.html.
肖小河, 罗烨, 赵旭, 等. 中药有效性评价新策略、新方法: 整合证据链法[J]. 中国中药杂志, 2024, 49(19): 5113-5124.
Luo Y, Zhao X, Wang R L, et al. Integrated evidence chain-based effectiveness evaluation of traditional Chinese medicines (Eff-iEC): A demonstration study [J]. Acta Pharm Sin B, 2025, 15(2): 909-918.
魏光成, 张智龙, 张馨文, 等. 基于整合证据链和GRADE的12种常用中成药治疗骨质疏松症证据评价[J]. 中国中药杂志, 2025, 50(15): 4372-4385.
黄旭铭, 吴娜, 陈嘉琪, 等. 基于GRADE系统和Eff-iEC法的常用中成药治疗溃疡性结肠炎证据评价[J/OL]. 中国实验方剂学杂志, (2025-10-21) [2026-02-27]. https://doi.org/10.13422/j.cnki.syfjx.20251416.
周永梅, 房德敏, 高颖. 虎骨代用品制剂金天格胶囊治疗骨关节炎文献综述[J]. 中国医院药学杂志, 2012, 32(17): 1391-1393.
武义钞, 张盛庭, 郭澳, 等. 人工虎骨粉通过Wnt/β-catenin通路治疗膝骨关节炎的疗效[J]. 中国现代医生, 2025, 63(16): 62-68.
侯小丽, 赵林涛, 宋延平. 金天格胶囊对骨关节炎大鼠病理形态的影响[J]. 中国实验方剂学杂志, 2013, 19(6): 287-290.
Zhuang C Y, Wang Z X, Chen W, et al. Jintiange Capsules ameliorate osteoarthritis by modulating subchondral bone remodeling and protecting cartilage against degradation [J]. Front Pharmacol, 2021, 12: 762543.
Zhongying C, ZHANG X, ZHANG X, et al. Transcriptome sequencing-based study on the mechanism of action of Jintiange Capsules (金天格胶囊) in regulating synovial mesenchymal stem cells exosomal miRNA and articular chondrocytes mRNA for the treatment of osteoarthritis[J]. Journal of Traditional Chinese Medicine, 2024, 44(6): 1153.
车涛, 陈永强, 戴琪萍, 等. 金天格胶囊治疗膝关节骨性关节炎的临床观察[J]. 中国中医骨伤科杂志, 2012, 20(10): 43-44.
林剑, 王胜. 从P38丝裂原活化蛋白激酶信号通路探讨金天格胶囊防治膝骨关节炎临床研究[J]. 中国骨质疏松杂志, 2014, 20(8): 936-939.
麻存柱, 王晓东. 金天格胶囊联合玻璃酸钠治疗膝骨关节炎的临床研究[J]. 山西医药杂志, 2015, 44(7): 791-792.
曹建刚, 王天仪, 王磊, 等. 金天格胶囊治疗膝骨关节炎的临床研究[J]. 中国骨质疏松杂志, 2015, 21(1): 84-87.
赵双利, 王世轩, 李洪涛, 等. 中药热熨配合金天格胶囊治疗早中期膝骨关节炎的临床研究[J]. 中国骨质疏松杂志, 2015, 21(6): 723-725.
李蓉, 殷芳霞, 钱康. 金天格胶囊联合西药治疗膝骨关节炎的疗效观察及其对IL-1β、MMP-1表达的影响[J]. 中国中医药科技, 2016, 23(3): 253-255.
包芸, 高小明, 包毅敏. 金天格胶囊联合美洛昔康治疗膝骨关节炎的疗效观察[J]. 现代药物与临床, 2017, 32(12): 2434-2437.
彭杰威, 黄子奇, 黄伟彦, 等. 金天格胶囊对膝骨关节炎患者关节软骨及膝关节功能的作用及机制[J]. 中国老年学杂志, 2018, 38(2): 393-395.
肖东伟. 金天格胶囊治疗45例膝骨性关节炎疗效观察[J]. 中国实用医药, 2018, 13(3): 106-107.
黄斌, 许锦煌, 周镇威. 金天格胶囊与透明质酸注射治疗老年膝骨关节炎的效果分析[J]. 医药前沿, 2020, 10(34): 85-86.
涂大华, 刘学东, 黄思聪, 等. 金天格胶囊配合中药封包治疗膝骨性关节炎的疗效观察[J]. 当代临床医刊, 2020, 33(2): 185-186.
常增伟, 高彩霞. 金天格胶囊与玻璃酸钠联合治疗膝骨关节炎的效果分析[J]. 医学食疗与健康, 2020, 18(15): 31.
吴克亮, 肖庆华, 张震, 等. PRP联合金天格胶囊对人膝骨关节炎关节液IL-1β、IL-6及TNF-α水平的影响[J]. 中国老年学杂志, 2021, 41(10): 2110-2114.
隋聪, 武义钞. 金天格胶囊与氨基葡萄糖对原发性膝骨性关节炎的治疗效果分析[J]. 淮海医药, 2022, 40(2): 174-177.
赵海波, 李晓林, 沈晨啸. 金天格胶囊联合氨基葡萄糖治疗膝骨关节炎临床研究[J]. 新中医, 2023, 55(24): 91-95.
蒋建新, 郑宪友, 王骁, 等. 人工虎骨粉与玻璃酸钠联合治疗肝肾亏虚型膝骨关节炎的效果分析[J]. 同济大学学报: 医学版, 2024, 45(4): 536-542.
李书良, 黄永华. 富血小板血浆联合金天格胶囊治疗膝骨关节炎患者的临床效果[J]. 深圳中西医结合杂志, 2025, 35(6): 14-16.
赵岩. 基于GRADE系统方法学的尪痹片治疗膝骨关节炎临床应用专家共识研究[D]. 北京: 中国中医科学院, 2024.
贺蓉, 杨依霏, 徐启华, 等. 尪痹片对骨性关节炎模型动物膝关节组织形态学的影响[J]. 中国实验方剂学杂志, 2018, 24(5): 142-148.
杰索尔·居来提, 梁鹏飞, 郭奕彤, 等. 尪痹胶囊治疗碘乙酸钠致膝关节炎软骨降解的药效学研究[J]. 解剖科学进展, 2022, 28(6): 751-754.
柯胜兰, 钱平, 曹卓然, 等. 尪痹胶囊对膝关节炎大鼠的药效学研究及机制探讨[J]. 解剖科学进展, 2025, 31(3): 364-368.
Cui H, Shu H Y, Fan D C, et al. Wang-Bi Capsule alleviates the joint inflammation and bone destruction in mice with collagen-induced arthritis [J]. Evid Based Complementary Altern Med, 2020, 2020: 1015083.
Li H, You Y, Jiang B, et al. Wang-Bi Tablet ameliorates DMM-induced knee osteoarthritis through suppressing the activation of p38-MAPK and NF-κB signaling pathways in mice [J]. Evid Based Complementary Altern Med, 2021, 2021: 3930826.
Wu S S, Hao L J, Shi Y Y, et al. Network pharmacology-based analysis on the effects and mechanism of the Wang-Bi Capsule for rheumatoid arthritis and osteoarthritis [J]. ACS Omega, 2022, 7(9): 7825-7836.
康信忠, 吴启富, 接红宇, 等. 尪痹片治疗膝骨关节炎的临床研究[J]. 中国中西医结合杂志, 2011, 31(9): 1205-1208.
刘冬梅, 杨丽丽, 薛红霞. 尪痹片治疗膝骨关节炎的疗效[J]. 实用药物与临床, 2012, 15(6): 380-381.
高明利, 岳月. 尪痹片治疗膝骨关节炎疗效观察[A] // 中华中医药学会. 中华中医药学会第十六届全国风湿病学术大会论文集[C]. 沈阳: 辽宁中医药大学附属医院, 2012: 258-259.
吴廷换, 周辉, 陈兴恺. 清宫正骨手法联合尪痹片治疗膝关节骨性关节炎疗效观察[J]. 中国中医骨伤科杂志, 2017, 25(1): 38-41.
李异龙, 刘满仓, 许小真. 尪痹片对膝骨关节炎临床症状及血清炎症因子水平的影响[J]. 中外医学研究, 2017, 15(26): 22-24.
陈璐, 阎小萍, 鄢泽然, 等. 尪痹片治疗膝骨性关节炎有效性及安全性的临床研究[J]. 中华中医药杂志, 2018, 33(8): 3366-3369.
王华建, 刘灵晓. 尪痹胶囊对膝骨关节炎治疗疗效分析[J]. 中国农村卫生, 2018, 10(4): 34-35.
宋寿龙, 刘超. 旭痹胶囊联合硫酸氨基葡萄糖胶囊治疗膝骨关节炎[J]. 中医药临床杂志, 2020, 32(5): 952-954.
邓彦俊, 焦长庚, 赵斌, 等. 尪痹片联合双醋瑞因治疗膝骨关节炎的临床研究[J]. 现代药物与临床, 2021, 36(7): 1435-1439.
陶江涛, 马玉, 张敏. 尪痹片联合美洛昔康治疗膝骨关节炎临床研究[J]. 新中医, 2021, 53(11): 85-87.
邓亚男. 膝骨性关节炎患者血清与关节液中炎症指标水平差异及尪痹片的治疗作用研究[J]. 临床研究, 2022, 30(11): 127-130.
王飞. 尪痹片治疗膝骨关节炎的临床疗效分析[J]. 国际临床研究杂志, 2022, 6(10): 34-35.
黄鹏飞, 徐小兰, 张文波, 等. 尪痹片对膝骨关节炎39例疼痛程度及WOMAC评分的影响[J]. 药品评价, 2023, 20(12): 1527-1529.
廖琳, 黄小燕, 徐水明, 等. 尪痹片联合艾瑞昔布治疗膝骨性关节炎临床观察[J]. 光明中医, 2023, 38(4): 724-726.
周祝建, 程越生, 王涤非. 尪痹片联合塞来昔布胶囊治疗膝骨关节炎的临床疗效[J]. 临床合理用药, 2024, 17(12): 104-107.
林福万. 尪痹片联合塞来昔布胶囊治疗膝骨关节炎的临床效果[J]. 临床合理用药, 2025, 18(35): 123-126.
黄希娇, 黄剑云, 叶小芳. 塞来昔布联合尪痹片治疗膝骨性关节炎的临床效果及对炎症因子水平的影响[J]. 中国医药科学, 2025, 15(18): 127-132.
李丹. 尪痹片联合塞来昔布治疗膝关节骨性关节炎临床观察[J]. 实用中医药杂志, 2025, 41(1): 100-102.
上海医药大学附属曙光医院, 上海医科大学附属华山医院, 上海医科大学附属中山医院. 仙灵骨葆胶囊临床验证总结[J]. 首都医药, 1999(1): 33.
童静玲, 朱让腾, 罗利飞. 仙灵骨葆联合康复运动对大鼠骨关节炎炎性因子mRNA表达的影响[J]. 新中医, 2017, 49(11): 9-11.
张奇先, 丁爽, 吴前. 仙灵骨葆胶囊对大鼠膝骨关节炎的治疗作用及机制[J]. 解剖科学进展, 2022, 28(1): 100-103.
蔡振华, 肖木洲, 罗恒, 等. 富血小板血浆联合仙灵骨葆胶囊治疗大鼠膝骨关节炎的应用研究[J]. 重庆医科大学学报, 2025, 50(5): 623-629.
Hou J Y, Li Y B, Zhang Y, et al. Integrated network pharmacology reveals the mechanism of action of Xianlinggubao prescription for inflammation in osteoarthritis [J]. BMC Complementary Med Ther, 2025, 25(1): 190.
Wu X W, Sun S, Wu X Y, et al. Multitech-based study on medicinal material basis and action mechanism of herbal formula Xian-Ling-Gu-Bao Capsule in treatment of osteoarthritis [J]. Evid Based Complementary Altern Med, 2022, 2022: 6986372.
Ma Q J, Ma X H, Hua X J, et al. Unveiling the therapeutic targets and active components of Xianlinggubao Capsule in osteoarthritis and osteoporosis through network pharmacology and bioinformatics analysis [J]. Curr Pharm Des, 2025, 32: 2244-2256.
Zeng J W, Li C, Gu Z C. A network pharmacological study to unveil the mechanisms of Xianlinggubao Capsule in the treatment of osteoarthritis and osteoporosis [J]. Arch Med Sci, 2020, 20(2): 557.
李大伦, 唐汉庆. 仙灵骨葆胶囊配合玻璃酸钠治疗早期膝骨性关节炎的疗效观察[J]. 中外妇儿健康, 2011, 19(4): 226.
刘义山, 杜建龙, 黄修鸿. 盐酸氨基葡萄糖片单独使用及与仙灵骨葆胶囊联合治疗膝骨性关节炎的疗效比较[J]. 中国基层医药, 2015, 22(20): 3044-3047.
程良礼, 桂光明. 仙灵骨葆胶囊治疗膝骨性关节炎临床研究[J]. 中医学报, 2015, 30(5): 737-738.
邵亚超. 仙灵骨葆联合玻璃酸钠治疗膝骨性关节炎46例[J]. 中国药业, 2015, 24(4): 88-88.
赵友, 王伟东, 王昌兴. 仙灵骨葆胶囊联合穴位贴敷治疗膝骨性关节炎效果观察[J]. 中国乡村医药, 2016, 23(23): 28-29.
牛玉祥. 仙灵骨葆胶囊联合医用臭氧对膝骨性关节炎患者疼痛及膝关节功能影响[J]. 现代中西医结合杂志, 2016, 25(28): 3168-3170.
侯宝生, 姜婷, 金立, 等. 艾瑞昔布单独应用及与仙灵骨葆胶囊联合治疗膝骨关节炎的疗效比较[J]. 现代医学, 2017, 45(7): 941-945.
邓锡岳, 袁恩梅. 仙灵骨葆胶囊治疗膝骨性关节炎的临床疗效观察[J]. 北方药学, 2017, 14(5): 51.
唐小军. 仙灵骨葆胶囊治疗膝骨性关节炎临床观察[J]. 现代临床医学, 2017, 43(3): 199-200.
陶阳, 邓华, 胡俊. 仙灵骨葆胶囊与玻璃酸钠联用对膝骨性关节炎患者的临床疗效及疼痛改善的影响[J]. 抗感染药学, 2018, 15(6): 1029-1031.
张丽宁. 双氯芬酸钠联合仙灵骨葆治疗膝骨性关节炎的临床效果[J]. 双足与保健, 2019, 28(12): 173-174.
叶小林. 仙灵骨葆胶囊联合臭氧关节内注射治疗膝骨性关节炎临床研究[J]. 新中医, 2020, 52(5): 88-90.
蔡峰, 张杰, 周少杰, 等. 仙灵骨葆胶囊联合硫酸氨基葡萄糖胶囊治疗膝骨性关节炎临床研究[J]. 新中医, 2020, 52(2): 82-84.
肖鸿智, 李乐. 仙灵骨葆胶囊联合西药治疗膝骨关节炎的临床疗效及对血清炎症因子水平的影响[J]. 世界中西医结合杂志, 2022, 17(4): 821-825.
何胜利, 杨宁, 常东军. 仙灵骨葆胶囊联合盐酸氨基葡萄糖治疗膝骨关节炎临床研究[J]. 中国药业, 2022, 31(19): 84-87.
何胜利, 杨宁, 常东军. 盐酸氨基葡萄糖联合仙灵骨葆胶囊治疗膝骨关节炎的临床疗效研究[J]. 中国医院用药评价与分析, 2022, 22(6): 676-679.
吴彩云, 雷霖玲, 饶锦峰. 仙灵骨葆胶囊联合硫酸氨基葡萄糖治疗膝骨关节炎的效果研究[J]. 中国医学创新, 2023, 20(5): 74-77.
秦红安, 杜贵强, 苏海涛. 仙灵骨葆胶囊联合盐酸氨基葡萄糖胶囊治疗膝骨关节炎的效果及对患者炎症因子、生活质量的影响[J]. 药品评价, 2023, 20(10): 1246-1249.
冯洪山, 张涛. 仙灵骨葆胶囊联合塞来昔布胶囊治疗膝骨性关节炎的效果[J]. 临床医学, 2024, 44(3): 120-122.
任远勤, 郑林霞, 彭冬凌. 仙灵骨葆胶囊辅助膝关节封闭治疗退行性膝骨关节炎的效果[J]. 实用中西医结合临床, 2025, 25(7): 71-74.
赵新先. 三九企业集团南方制药厂[J]. 天然产物研究与开发, 1996(4): 2-117.
马锋, 马敬祖, 巩凡, 等. 壮骨关节胶囊对SD大鼠骨性关节炎并骨质疏松症骨密度和雌激素受体表达的影响[J]. 中国临床研究, 2017, 30(3): 391-394.
Gong G W, Zheng Y Z, Zhou X, et al. Zhuanggu Guanjie herbal formula mitigates osteoarthritis via the NF-κB transduction mechanism [J]. Front Pharmacol, 2022, 13: 896397.
Lu K, Shi T, Li L, et al. Zhuangguguanjie formulation protects articular cartilage from degeneration in joint instability-induced murine knee osteoarthritis [J]. Am J Translat Res, 2018, 10(2): 411.
王志彬, 陈传杰. 壮骨关节胶囊配合透明质酸钠注射液治疗老年膝骨关节炎的疗效[J]. 中国老年学杂志, 2015, 35(7): 1835-1836.
张瑞. 壮骨关节胶囊配合透明质酸钠注射液治疗膝骨关节炎的疗效观察[J]. 临床医药文献电子杂志, 2016, 3(27): 5483-5484.
张金龙, 何延智. 壮骨关节胶囊治疗老年性膝骨关节炎的疗效及安全性研究[J]. 中国老年保健医学, 2019, 17(4): 80-82.
郭会. 壮骨关节胶囊与复方伤痛胶囊分别配伍玻璃酸钠治疗创伤性膝关节炎疗效差异性分析[J]. 新中医, 2019, 51(3): 179-181.
王来福, 侯芳丽. 壮骨关节胶囊治疗膝关节骨性关节炎98例疗效观察[J]. 北方药学, 2019, 16(1): 125-126.
王志强, 许丹, 冯创. 壮骨关节胶囊联合玻璃酸钠治疗膝骨关节炎的临床研究[J]. 现代药物与临床, 2021, 36(1): 126-129.
王晓君. 壮骨关节胶囊促进老年性膝骨关节炎患者康复效果观察[J]. 天津药学, 2024, 36(5): 59-62.
Zhang X L, Yang J, Yang L, et al. Efficacy and safety of zhuanggu joint capsules in combination with celecoxib in knee osteoarthritis: A multi-center, randomized, double-blind, double-dummy, and parallel controlled trial [J]. Chin Med J, 2016, 129(8): 891-897.
胡滨. 壮骨关节胶囊治疗膝关节骨性关节炎60例临床研究[J]. 中国实用医药, 2015, 10(23): 201-202.
刘玉璇, 刘文伟, 赵宇, 等. 近三年痹祺胶囊临床及药理研究进展[J]. 中华中医药杂志, 2011, 26(11): 2651-2653.
柳占彪, 师咏梅, 许放, 等. 痹祺胶囊对大鼠膝骨关节炎软骨组织影响的病理形态观察[J]. 天津中医药, 2010, 27(4): 318-321.
许放, 师咏梅, 柳占彪, 等. 痹祺胶囊对实验性骨关节炎大鼠NO、HYP的影响[J]. 天津中医药, 2011, 28(3): 237-239.
Jia Z Y, Zhang J L, Yang X T, et al. Bioactive components and potential mechanisms of Biqi Capsule in the treatment of osteoarthritis: Based on chondroprotective and anti-inflammatory activity [J]. Front Pharmacol, 2024, 15: 1347970.
梁昊. 痹祺胶囊治疗膝关节骨性关节炎150例临床疗效观察[J]. 中华中医药杂志, 2009, 24(6): 819-820.
刘维, 薛斌. 痹祺胶囊治疗膝骨关节炎临床观察[J]. 辽宁中医杂志, 2011, 38(7): 1254-1255.
李芳, 姚建华, 于织波, 等. 痹祺胶囊治疗膝骨性关节炎的临床疗效研究[A] //基层医疗机构从业人员科技论文写作培训会议论文集[C]. 北京: 中国中药杂志, 2016: 1169.
李隶. 痹祺胶囊联合尼美舒利片治疗膝骨性关节炎的临床观察[J]. 内蒙古中医药, 2016, 35(13): 84.
张建. 痹祺胶囊联合玻璃酸钠治疗膝骨性关节炎的临床研究[J]. 现代药物与临床, 2017, 32(12): 2438-2441.
陈付艳, 周鑫. 痹祺胶囊联合塞来昔布治疗膝骨性关节炎的临床研究[J]. 现代药物与临床, 2017, 32(7): 1341-1344.
王柏公, 王丽萍, 白人骁. 痹祺胶囊治疗膝骨性关节炎的多中心随机对照临床试验[J]. 中华中医药杂志, 2017, 32(8): 3840-3843.
吴涛. 痹祺胶囊联合依托考昔治疗膝骨性关节炎的临床研究[J]. 现代药物与临床, 2018, 33(5): 1145-1149.
龚韶华, 匡勇, 郑煜新, 等. 痹祺胶囊对老年性膝关节炎的疗效及基质金属酶2/基质金属酶9表达的影响[J]. 世界中医药, 2018, 13(5): 1139-1142.
王琪, 王昊, 王景贵, 等. 痹祺胶囊联合氨基葡萄糖胶囊和玻璃酸钠治疗膝骨关节炎的临床研究[J]. 现代药物与临床, 2019, 34(4): 1147-1152.
龚幼波, 张琥, 杜敏, 等. 痹祺胶囊治疗肝肾亏虚型膝关节炎疗效及对患者红细胞免疫功能变化的影响[J]. 中国中医骨伤科杂志, 2019, 27(8): 15-19.
胡振勇, 成帅, 陈连锁, 等. 痹祺胶囊联合扳机点深压按摩对轻中度膝骨关节炎疼痛患者疗效与生活质量的影响[J]. 中华中医药杂志, 2020, 35(3): 1608-1611.
金钟浦. 痹祺胶囊联合玻璃酸钠关节腔注射对膝骨关节炎患者炎症反应及骨关节炎评分的影响[J]. 药品评价, 2020, 17(18): 31-33.
白卫飞, 柴宏伟, 余向前, 等. 痹祺胶囊治疗中轻度膝骨性关节炎的临床疗效研究[J]. 中华中医药杂志, 2020, 35(2): 1015-1017.
康玉玲, 张江涛, 曹蕾, 等. 痹祺胶囊口服联合透明质酸钠关节腔内注射对膝骨性关节炎患者膝关节功能及血清COX-2、COMP水平的影响[J]. 广东药科大学学报, 2020, 36(6): 886-890.
宋阳春, 吴三兵, 胡谷丰, 等. 痹祺胶囊联合刃针治疗膝骨性关节炎的疗效观察[J]. 中草药, 2021, 52(22): 6923-6927.
黄敦胜, 刘同明, 万能文, 等. 痹祺胶囊联合西药治疗膝骨性关节炎的临床效果[J]. 世界中医药, 2021, 16(17): 2611-2616.
周忠良, 朱俊琛, 苏国宏. 痹祺胶囊联合关节腔内臭氧注射治疗膝骨性关节炎的疗效评价[J]. 中草药, 2023, 54(6): 1879-1885.
李迎春, 汪英杰, 许涛, 等. 痹祺胶囊联合针刀治疗膝骨性关节炎的临床疗效观察[J]. 中草药, 2024, 55(17): 5915-5920.
Meng F, Tao X, Li L, et al. Network pharmacology and molecular docking explore the mechanism of Mubiezi-Yinyanghuo herb pair in the treatment of rheumatoid arthritis [J]. Evid Based Complement Alternat Med, 2023, 2023: 4502994.
Ling H F, Xu J B, Zeng Q H, et al. Fufang Duzhong Jiangu granule (FFDZ) ameliorates osteoarthritis development through maintaining subchondral bone homeostasis [J]. Front Cell Dev Biol, 2025, 13: 1610007.)