中草药

中药来源核酸成分在肺部疾病中的研究进展

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中草药 | 综述 2026,57(13): 5318-5329

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中草药 |综述 2026 , 57 (13) : 5318 -5329

中药来源核酸成分在肺部疾病中的研究进展

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郭钦华^1,2, 安思静^1,3,2, 冼星辰^1,2, 苗琳^1,3,2, 孙娜^1,3,2

作者信息

通讯作者:

苗琳

作者简介:

郭钦华: 郭钦华，硕士研究生，研究方向为中药学。E-mail:guoqinhua@126.com

Research progress on traditional Chinese medicine-derived nucleic acid components in pulmonary diseases

GUO Qinhua, AN Sijing, XIAN Xingchen, MIAO Lin, SUN Na

Affiliations

doi: 10.7501/j.issn.0253-2670.2026.13.032

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摘要

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肺部疾病发病率与死亡率居高不下，传统疗法面临耐药性、副作用明显等局限，亟需新的治疗策略。核酸类药物凭借其靶向性强、作用持久等优势，为肺部疾病治疗提供了新方向。而传统中药在防治肺部疾病方面具有深厚理论与实践基础，其来源的核酸成分可借助跨界调控机制发挥作用，为肺部疾病干预提供了新思路。探讨了中药来源核酸成分作为一种新兴跨界治疗模式的潜力，系统阐述了其在中医药理论指导下的药物类型、作用机制以及在药物稳定性、递送效率等方面的研究进展和独特优势，进一步介绍了该类潜力药物在慢性阻塞性肺疾病、哮喘、肺炎、肺癌、急性肺损伤、肺纤维化及急性呼吸窘迫综合征等肺部疾病中的应用现状，并讨论了当前面临的挑战与未来的发展前景，以期为该类药物的系统性开发提供理论依据和研究思路。

关键词

中药 / 核酸药物 / 肺部疾病 / 药物递送 / 靶向性

Abstract

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The incidence and mortality of pulmonary diseases remain persistently high. Conventional therapeutic modalities encounter restrictions, including drug resistance and notable side effects, underscoring the urgent need for novel treatment strategies. Nucleic acid drugs, with their strong target specificity and long-lasting effects, provide a promising new direction for treating pulmonary diseases. Meanwhile, traditional Chinese medicine (TCM), with its extensive theoretical and practical foundation the prevention and treatment of pulmonary diseases, offers innovative intervention strategies through its derived nucleic acid components, which can function via trans-kingdom regulatory mechanisms. This paper explores the potential of TCM-derived nucleic acid drugs as an emerging trans-kingdom therapeutic strategy. Guided by TCM theory, it systematically elaborates drug, type, mechanisms of action, and advances in areas such as drug stability and delivery efficiency, as well as the unique advantages of these agents. Furthermore, the article reviews the application status of nucleic acid drugs in various pulmonary diseases, including chronic obstructive pulmonary disease, asthma, pneumonia, lung cancer, acute lung injury, pulmonary fibrosis, and acute respiratory distress syndrome. Finally, the discussion then addresses the current challenges and future prospects to inform the theoretical foundation and research ideas for the systematic development of this drug class.

Key words

traditional Chinese medicine / nucleic acid drugs / pulmonary diseases / drug delivery / targeting specificity

引用本文

郭钦华, 安思静, 冼星辰, 苗琳, 孙娜. 中药来源核酸成分在肺部疾病中的研究进展. 中草药, 2026 , 57 (13) : 5318 -5329 . DOI: 10.7501/j.issn.0253-2670.2026.13.032

GUO Qinhua, AN Sijing, XIAN Xingchen, MIAO Lin, SUN Na. Research progress on traditional Chinese medicine-derived nucleic acid components in pulmonary diseases[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (13) : 5318 -5329 . DOI: 10.7501/j.issn.0253-2670.2026.13.032

基金

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天津市教委科研计划项目 (2023KJ139); 天津中医药大学新教师科研启动项目“雏鹰计划”项目 (XJS2024209)

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2026年第57卷第13期

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doi: 10.7501/j.issn.0253-2670.2026.13.032

接收时间：2026-01-17
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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