Article(id=1304388216828744275, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388135723496407, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.13.004, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1774540800000, receivedDateStr=2026-03-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788919985252, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788919985252, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788919985252, creator=13701087609, updateTime=1788919985252, updator=13701087609, issue=Issue{id=1304388135723496407, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='13', pageStart='4949', pageEnd='5352', issueExtLink='null', onlineDate='null', pubDate='1783785600000', pubDateStr='2026-07-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788919965916, creator='13701087609', updateTime=1788923489765, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304402915871977875, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388135723496407, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304402915871977876, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388135723496407, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=4979, endPage=4986, ext={EN=ArticleExt(id=1304388217160094293, articleId=1304388216828744275, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Chemical constituents of Fissistigma bracteolatum, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To investigate the chemical constituents of Fissistigma bracteolatum. Methods The 95% ethanol extract of F. bracteolatum was successively separated by solvent partitioning, macroporous resin, silica gel, MCI, Sephadex LH-20, ODS column chromatography, and semi-preparative HPLC to obtain individual compounds. Their structures were elucidated using modern spectroscopic techniques such as NMR and MS. An in vitro inflammatory model was established using lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages to evaluate the anti-inflammatory activity of the isolated compounds. Results A total of 22 compounds were isolated from F. bracteolatum, comprising of 12 flavonoids, 8 amides, 1 lignan, and 1 lactone. These were determined as: 5,7-dihydroxy-6,8-dimethoxyflavone (1), 5-hydroxy-7,8-dimethoxyflavone (2), quercetin (3), rutin (4), 5,7,8-trimethoxydihydroflavone (5), 5,6,8-trimethoxy-7-hydroxydihydroflavone (6), 6,7-dimethoxy-8-hydroxydihydroflavone (7), (2S)-7-hydroxy-6,8-dimethoxydihydroflavone (8), dihydroquercetin (9), aromadendrin (10), 4,2',6'-trihydroxy-3',4'-dimethoxy- dihydrochalcone (11), 2',6'-dihydroxy-4'-methoxydihydrochalcone (12), N-trans-sinapoylmethoxytyramine (13), N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-3-phenyl-2-propenamide (14), (E)-3-(4-hydroxy-3-methoxyphenyl)-N-phenethyl-acrylamide (15), N-trans-feruloyltyramine (16), N-trans-p-coumaroyltyramine (17), N-cis-feruloyltyramine (18), cis-N-feruloyl-3-O-methyldopamine (19), cannabisin D (20), 3-caffeoyl-2-methyl-D-erythronic acid-1,4-lactone (21), and (-)-syringaresinol (22). Conclusion Compounds 1, 7, 9—11, 13—15, 17, 19, and 21 were isolated from the genus Fissistigma for the first time.The anti-inflammatory activity results demonstrated that compounds 5 , 9 , 13 , and 16 significantly inhibited the release of nitric oxide in LPS-induced RAW264.7 macrophages., authors=LI Yanjie, YUE Xiaofeng, GUO Xinxin, LIU Yi, FENG Hao, DENG Shiming, CHEN Hui, FENG Weisheng, XUE Jinfeng, XUE Guimin, authorsList=LI Yanjie, YUE Xiaofeng, GUO Xinxin, LIU Yi, FENG Hao, DENG Shiming, CHEN Hui, FENG Weisheng, XUE Jinfeng, XUE Guimin, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388217080402516, articleId=1304388216828744275, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=排骨灵化学成分研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究排骨灵Fissistigma bracteolatum化学成分。方法 排骨灵95%乙醇提取总浸膏经萃取、大孔树脂、硅胶、MCI、凝胶、ODS等柱色谱以及半制备液相进行分离与纯化。利用波谱技术等现代光谱技术对结构进行解析鉴定。并构建脂多糖（lipopolysaccharide，LPS）诱导的RAW264.7细胞体外炎症模型，对分离得到的化合物进行体外抗炎活性评价。结果 从排骨灵中分离得到22个化合物，其中12个黄酮类，8个酰胺类、1个木脂素类和1个内酯类。分别鉴定为5,7-二羟基-6,8-二甲氧基黄酮（1）、5-羟基-7,8-二甲氧基黄酮（2）、槲皮素（3）、芦丁（4）、5,7,8-三甲氧基二氢黄酮（5）、5,6,8-三甲氧基-7-羟基二氢黄酮（6）、6,7-二甲氧基-8-羟基二氢黄酮（7）、2S-7-羟基-6,8-二甲氧基二氢黄酮（8）、双氢槲皮素（9）、香橙素（10）、4,2',6'-三羟基-3',4'-二甲氧基二氢查耳酮（11）、2',6'-二羟基-4'-甲氧基二氢查耳酮（12）、N-trans-sinapoylmethoxytyramine（13）、N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-3-phenyl-2-propenamide（14）、(E)-3-(4-hydroxy-3-methoxyphenyl)-N-phenethyl-acrylamide（15）、Ｎ-反式-阿魏酰基酪胺（16）、N-反式-对香豆酰酪胺（17）、N-cis-feruloyltyramine（18）、cis-N-feruloyl-3-O-methyldopamine（19）、cannabisin D（20）、3-咖啡酸酰基-2-甲基-D-赤藓糖酸-1,4-内酯（21）、(-)-syringaresinol（22）。结论 化合物1、7、9～11、13～15、17、19、21均为首次从瓜馥木属中分离得到。抗炎活性结果表明化合物5、9、13、16能明显抑制LPS诱导的RAW264.7巨噬细胞释放一氧化氮的释放。, authors=李艳洁¹, 岳晓锋¹, 郭鑫鑫¹, 刘艺¹, 冯好¹, 邓世明¹, 陈辉¹, 冯卫生¹, 薛金凤¹, 薛贵民¹, authorsList=李艳洁, 岳晓锋, 郭鑫鑫, 刘艺, 冯好, 邓世明, 陈辉, 冯卫生, 薛金凤, 薛贵民, authorCompany=1 河南中医药大学药学院, 河南 郑州 450046, correspAuthors=薛金凤, authorNote=李艳洁: 李艳洁，女，硕士研究生，从事天然药物活性成分及应用研究。E-mail:l1936581262@163.com, correspAuthorsNote=null, 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