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Methods The isolates were isolated and purified by silica gel, Sephadex gel, reversed-phase C₁₈ column chromatography, and semi-preparative high-performance liquid chromatography (HPLC). The structures of the obtained compounds were elucidated by spectroscopic methods such as nuclear magnetic resonance (NMR) and mass spectrometry (MS). Finally, all compounds were subjected to MTT assays to evaluate their anti-tumor activities. Results Two new diphenyl ethers were obtained from C. rotundus, specifically as 2,3′-dihydroxy-5,2′,5′-trimethoxy diphenyl ether (1) and 2,3′-dihydroxy-4,2′,5′-trimethoxy diphenyl ether (2). Both compounds exhibited moderate inhibitory effects on human colon cancer cell line HCT116, with median inhibition concentration (IC₅₀) values of (24.20 ± 0.77) and (25.26 ± 0.65) μmol/L, respectively. Conclusion Compounds 1 and 2 are new compounds with anti-tumor potential, named cydipethers A (1) and B (2). Diphenyl ethers were identified from C. rotundus for the first time., authors=HU Yali, LIU Qingyun, WANG Ruyuan, authorsList=HU Yali, LIU Qingyun, WANG Ruyuan, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388247820460883, articleId=1304388247577191250, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=香附中2个新的二苯醚类化合物, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究香附Cyperus rotundus的化学成分及其抗肿瘤活性。方法 采用硅胶柱色谱、反相C₁₈柱色谱、凝胶柱色谱、半制备高效液相色谱等技术进行分离纯化，再通过核磁共振、质谱等波谱学手段鉴定结构，最后通过MTT法对分离的化合物进行抗肿瘤细胞毒性测定。结果 从中药香附中分离得到了2个新的二苯醚类化合物，分别鉴定为2,3′-二羟基-5,2′,5′-三甲氧基二苯醚（1）和2,3′-二羟基-4,2′,5′-三甲氧基二苯醚（2）；二者对人源结肠癌细胞HCT116表现出一定的抑制作用，半数抑制浓度（median inhibition concentration，IC₅₀）值分别为（24.20±0.77）μmol/L和（25.26±0.65）μmol/L。结论 化合物1和2均为新化合物，分别命名为香附二苯醚A（1）和香附二苯醚B（2），并具有一定的抗肿瘤潜力。二苯醚类为首次从香附中分离得到的新结构类群化合物。, authors=胡雅丽¹, 刘青云¹, 汪汝渊¹, authorsList=胡雅丽, 刘青云, 汪汝渊, authorCompany=1 云南大学附属医院, 云南昆明 650021, correspAuthors=null, authorNote=胡雅丽: 胡雅丽（1993—），女，博士，主管药师，研究方向为天然药物化学。E-mail:807478014@qq.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=2Vd0xJeMVgGlBQNmkA2KAw==, pdfFileSize=825992, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=云南省教育厅科学研究基金项目-青年人才基础研究专项 (2025J0009); 云南大学医学科研基金-青年项目 (YDYXJJ2024-0050))}, authors=null, keywords=[Keyword(id=1304401943279988741, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388247577191250, language=CN, orderNo=1, keyword=莎草科), Keyword(id=1304401943376457734, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388247577191250, language=CN, orderNo=2, keyword=香附), Keyword(id=1304401943456149511, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388247577191250, language=CN, orderNo=3, keyword=二苯醚), Keyword(id=1304401943531646984, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388247577191250, language=CN, orderNo=4, keyword=抗肿瘤), Keyword(id=1304401943615533065, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388247577191250, language=CN, orderNo=5, keyword=香附二苯醚A), Keyword(id=1304401943678447626, tenantId=1146029695717560320, 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