中草药

心肌梗死后心肌纤维化的病理机制及其中医药防治研究

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中草药 | 综述 2026,57(12): 4889-4900

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中草药 |综述 2026 , 57 (12) : 4889 -4900

心肌梗死后心肌纤维化的病理机制及其中医药防治研究

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靳雅惠¹, 刘星雨¹, 折煜轩¹, 陈语涵¹, 刘博¹, 张博¹, 高枫¹, 陆晨曦¹

作者信息

通讯作者:

高枫

作者简介:

靳雅惠: 靳雅惠，博士，硕士生导师，从事中药药效物质筛选与评价研究。E-mail:sxyajyh@126.com

Myocardial fibrosis after myocardial infarction: Pathological mechanisms and therapeutic potential of traditional Chinese medicine

JIN Yahui, LIU Xingyu, SHE Yuxuan, CHEN Yuhan, LIU Bo, ZHANG Bo, GAO Feng, LU Chenxi

Affiliations

doi: 10.7501/j.issn.0253-2670.2026.12.030

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摘要

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心肌纤维化（myocardial fibrosis，MF）是心肌梗死后的病理特征之一，可导致心肌僵硬，泵血能力减退，进一步诱发心律失常、心力衰竭、心脏破裂等症。目前，化学药、手术等手段在心肌梗死后MF的治疗中发挥了重要作用，但仍存在预后不理想、费用高昂等局限。同时，中医药凭借整体调节、多靶点作用的优势，在该领域也展现出了潜在价值。系统综述了心肌梗死后MF的病理机制及其中医药防治策略，为其临床研究与药物开发提供帮助。

关键词

心肌纤维化 / 心肌梗死 / 信号通路 / 中医药 / 作用机制

Abstract

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Myocardial fibrosis (MF) is a key pathological feature following myocardial infarction (MI). This condition leads to myocardial stiffening and impaired cardiac pumping, ultimately resulting in complications including arrhythmias, heart failure, and cardiac rupture. Currently, interventions such as chemical drugs and surgery play an important role in the treatment of post-MI MF. However, they are still limited by suboptimal prognoses and high medical costs. Meanwhile, traditional Chinese medicine (TCM) has demonstrated potential value in this area, owing to its holistic regulation and multi-target therapeutic effects. This review provides a systematic overview of the pathological mechanisms underlying MF after MI and the preventive and therapeutic strategies of TCM for this disease. It aims to provide references for future clinical research and guide drug development efforts.

Key words

myocardial fibrosis / myocardial infarction / signal pathway / traditional Chinese medicine / mechanism of action

引用本文

靳雅惠, 刘星雨, 折煜轩, 陈语涵, 刘博, 张博, 高枫, 陆晨曦. 心肌梗死后心肌纤维化的病理机制及其中医药防治研究. 中草药, 2026 , 57 (12) : 4889 -4900 . DOI: 10.7501/j.issn.0253-2670.2026.12.030

JIN Yahui, LIU Xingyu, SHE Yuxuan, CHEN Yuhan, LIU Bo, ZHANG Bo, GAO Feng, LU Chenxi. Myocardial fibrosis after myocardial infarction: Pathological mechanisms and therapeutic potential of traditional Chinese medicine[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (12) : 4889 -4900 . DOI: 10.7501/j.issn.0253-2670.2026.12.030

基金

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国家自然科学基金资助项目 (82460765); 陕西省教育厅一般项目 (24JK0730,25JK0747); 陕西省秦创原“科学家＋工程师”队伍建设项目 (2025QCY-KXJ-185); 陕西省自然科学基础研究计划项目 (2025JC-YBMS-1027); 延安大学博士科研启动项目 (YDBK2023-75); 国家级大学生创新创业计划训练项目 (202410719011)

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2026年第57卷第12期

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doi: 10.7501/j.issn.0253-2670.2026.12.030

接收时间：2025-10-31
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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