Article(id=1304388157416435771, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388108988997783, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.12.002, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1772985600000, receivedDateStr=2026-03-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788919971087, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788919971087, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788919971087, creator=13701087609, updateTime=1788919971087, updator=13701087609, issue=Issue{id=1304388108988997783, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='12', pageStart='4509', pageEnd='4948', issueExtLink='null', onlineDate='null', pubDate='1782576000000', pubDateStr='2026-06-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788919959542, creator='13701087609', updateTime=1788923461082, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304402795579330582, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388108988997783, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304402795579330583, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388108988997783, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=4522, endPage=4527, ext={EN=ArticleExt(id=1304388157735202877, articleId=1304388157416435771, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=A new furanocoumarin dimer from Angelica dahurica var. formosana , columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To investigate the trace amounts of furanocoumarin dimers from Angelica dahurica var. formosana . Methods Using an LC-MS guided separation method, the furanocoumarin dimers were isolated by silica gel, Sephadex LH-20 column chromatography, and semi-preparative HPLC. The structures of the isolated dimeric coumarins were identified by NMR spectroscopy, and their preliminarily acetylcholinesterase (AChE) inhibitory activities were evaluated. Results Three furanocoumarin dimers were isolated from the ethyl acetate fraction of the ethanol extract of A. dahurica var. formosana , namely 9-{[4-(3-methylbut-2-en-1-yl)-7-oxo-7H -furo[3,2-g]chromen-9-yl]oxy}-4-[(2-methylbut-3-en-2-yl)oxy]-7H -furo[3,2-g]chromen-7-one (1 ), dahuribiethrin E (2 ) and dahuribiethrin B (3 ). Conclusion Compound 1 is a new compound, namely dahuribiscoumarin A. Compounds 2 and 3 are isolated from A. dahurica var. formosana for the first time. Compound 2 exhibits acetylcholinesterase inhibitory activity with a median inhibition concentration (IC50 ) value of (71.37 ± 1.26) μmol/L., authors=LING Geyu, WEN Jianniu, WANG Yang, FAN Jiangping, HOU Jie, ZHANG Yulu, SHI Shepo, authorsList=LING Geyu, WEN Jianniu, WANG Yang, FAN Jiangping, HOU Jie, ZHANG Yulu, SHI Shepo, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388157651316796, articleId=1304388157416435771, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=杭白芷中1个新的呋喃香豆素二聚体, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究杭白芷Angelica dahurica var. formosana 中微量的呋喃香豆素二聚体类化学成分。方法 以LC-MS分析为导向,利用硅胶柱色谱、葡聚糖凝胶柱色谱及半制备液相色谱等进行分离纯化,结合NMR等谱学技术对分离得到的香豆素二聚体进行结构鉴定,并对分离得到的化合物进行乙酰胆碱酯酶抑制活性筛选。结果 从杭白芷乙醇提取物的醋酸乙酯萃取部位分离得到3个香豆素二聚体,分别为9-{[4-(3-甲基丁-2-烯-1-基)-7-氧代-7H -呋喃并[3,2-g]色烯-9-基]氧基}-4-[(2-甲基丁-3-烯-2-基)氧基]-7H -呋喃并[3,2-g]色烯-7-酮(1 )、dahuribiethrin E(2 )、dahuribiethrin B(3 )。结论 化合物1 为新化合物,命名为白芷双香豆素A;化合物2 和3 为首次从杭白芷中分离得到,化合物2 对乙酰胆碱酯酶具有抑制活性,半数抑制浓度(median inhibition concentration,IC₅₀)值为(71.37±1.26)µmol/L。, authors=凌鸽雨1,2 , 温建牛1,2 , 王阳1,2 , 樊江平1,2 , 侯婕1,2 , 张雨路1,2 , 史社坡1,2 , authorsList=凌鸽雨, 温建牛, 王阳, 樊江平, 侯婕, 张雨路, 史社坡, authorCompany=1 北京中医药大学,北京中医药研究院,中药现代研究中心,北京 102488; 2 北京中医药大学中药学院,北京 102488, correspAuthors=史社坡, authorNote=凌鸽雨: 凌鸽雨,硕士研究生,研究方向为中药活性成分的发现及生物合成研究。E-mail:lgy031144@yeah.net, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=SeypqmanYIeM4fAGurzRzw==, pdfFileSize=2123346, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=北京市自然科学基金资助项目 (7202125))}, authors=null, keywords=[Keyword(id=1304401907594842392, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388157416435771, language=CN, orderNo=1, keyword=杭白芷), Keyword(id=1304401907670339865, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388157416435771, language=CN, orderNo=2, keyword=呋喃香豆素), Keyword(id=1304401907724865818, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388157416435771, language=CN, orderNo=3, keyword=香豆素二聚体), Keyword(id=1304401907808751899, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388157416435771, language=CN, orderNo=4, keyword=LC-MS), Keyword(id=1304401907884249372, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388157416435771, language=CN, orderNo=5, keyword=乙酰胆碱酯酶抑制活性), Keyword(id=1304401907972329757, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388157416435771, language=CN, orderNo=6, keyword=白芷双香豆素A), Keyword(id=1304401908043632926, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388157416435771, language=CN, orderNo=7, keyword=dahuribiethrin E), Keyword(id=1304401908173656351, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304388157416435771, language=EN, orderNo=1, keyword=Angelica dahurica (Fisch. ex Hoffm.) 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orderTime=1788919971087, fullTextJson=null, articleText=null, reference=中国药典[S]. 一部. 2025: 109. 薛艳萍, 秦旭华, 胡黄婉莹, 等. 白芷总香豆素和挥发油镇痛抗炎作用的比较研究[J]. 中国民族民间医药, 2016, 25(8): 20-22. 杨诗雨, 高欣阳, 张庆芬, 等. 鲜白芷挥发油提取工艺优化及其成分与抗氧化活性研究[J]. 中国调味品, 2026, 51(1): 234-243. 王阳, 石璠钰, 卢姿含, 等. 白芷中非香豆素类成分研究[J]. 天然产物研究与开发, 2023, 35(10): 1724-1731. 康学军, 曲见松, 顾忠泽. 白芷多糖的分析[J]. 分析化学, 2006, 34(4): 533-535. Qi B W, Yang W Q, Ding N, et al. Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica [J]. J Nat Med, 2019, 73(4): 769-776. 袁英豪, 赖谦, 向卓亚, 等. 白芷研究现状及发展态势分析[J]. 四川农业科技, 2025(9): 85-89. Wu F Z, Liu J, Cao Z T, et al. Molecular mechanism of the Saposhnikovia divaricata-Angelica dahurica herb pair in migraine therapy based on network pharmacology and molecular docking [J]. Evid Based Complementary Altern Med, 2022, 2022(1): 1994575. 雷雨恬, 黄婷, 陈文莉, 等. 不同等级川白芷有效成分含量及抗炎镇痛作用对比研究[J]. 中药药理与临床, 2021, 37(1): 105-110. Adakudugu E A, Obiri D D, Ameyaw E O, et al. Bergapten modulates ovalbumin-induced asthma [J]. Sci Afr, 2020, 8: e00457. 苏琳, 邬宗周, 余茜, 等. 基于“肺主皮毛”理论在历代古方中挖掘最具美白祛斑潜力中药“二白一辛” [J]. 中药新药与临床药理, 2024, 35(1): 35-45. Lu X, Yuan Z Y, Yan X J, et al. Effects of Angelica dahurica on obesity and fatty liver in mice [J]. Chin J Nat Med, 2016, 14(9): 641-652. Kozioł E, Skalicka-Woźniak K. Imperatorin-pharmacological meaning and analytical clues: Profound investigation [J]. Phytochem Rev, 2016, 15(4): 627-649. 蒋桂华, 张绿明, 马逾英, 等. 白芷综合开发利用研究进展及展望[J]. 时珍国医国药, 2008, 19(11): 2718-2720. Wang Y, Shi F Y, Lu Z H, et al. Seven new 3,4-dihydro-furanocoumarin derivatives from Angelica dahurica [J]. Chin Herb Med, 2023, 15(3): 457-462. 温建牛, 石璠钰, 杨万青, 等. 白芷中香豆素类成分研究[J]. 中草药, 2024, 55(19): 6465-6473. Yang W Q, Zhu Z X, Song Y L, et al. Dimeric furanocoumarins from the roots of Angelica dahurica [J]. Nat Prod Res, 2017, 31(8): 870-877. Yang W Q, Song Y L, Zhu Z X, et al. Anti-inflammatory dimeric furanocoumarins from the roots of Angelica dahurica [J]. Fitoterapia, 2015, 105: 187-193. Fan J P, et al. Characterization and synthesis of alkaloidal butenolides with seed germination stimulating properties from Angelica dahurica [J]. J Agric Food Chem, 2025, 73(13): 7822-7832. 赵爱红, 杨秀伟, 杨鑫宝, 等. 祁白芷根中新的天然产物[J]. 中国中药杂志, 2012, 37(16): 2400-2407.)
中草药
|化学成分
2026
, 57
(12) :
4522
-4527
杭白芷中1个新的呋喃香豆素二聚体
全屏
凌鸽雨1,2 , 温建牛1,2 , 王阳1,2 , 樊江平1,2 , 侯婕1,2 , 张雨路1,2 , 史社坡1,2
作者信息
1 北京中医药大学,北京中医药研究院,中药现代研究中心,北京 102488; 2 北京中医药大学中药学院,北京 102488
通讯作者:
史社坡
作者简介:
凌鸽雨: 凌鸽雨,硕士研究生,研究方向为中药活性成分的发现及生物合成研究。E-mail:lgy031144@yeah.net
A new furanocoumarin dimer from Angelica dahurica var. formosana
LING Geyu, WEN Jianniu, WANG Yang, FAN Jiangping, HOU Jie, ZHANG Yulu, SHI Shepo
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.12.002
文章导航
目的 研究杭白芷Angelica dahurica var. formosana 中微量的呋喃香豆素二聚体类化学成分。方法 以LC-MS分析为导向,利用硅胶柱色谱、葡聚糖凝胶柱色谱及半制备液相色谱等进行分离纯化,结合NMR等谱学技术对分离得到的香豆素二聚体进行结构鉴定,并对分离得到的化合物进行乙酰胆碱酯酶抑制活性筛选。结果 从杭白芷乙醇提取物的醋酸乙酯萃取部位分离得到3个香豆素二聚体,分别为9-{[4-(3-甲基丁-2-烯-1-基)-7-氧代-7H -呋喃并[3,2-g]色烯-9-基]氧基}-4-[(2-甲基丁-3-烯-2-基)氧基]-7H -呋喃并[3,2-g]色烯-7-酮(1 )、dahuribiethrin E(2 )、dahuribiethrin B(3 )。结论 化合物1 为新化合物,命名为白芷双香豆素A;化合物2 和3 为首次从杭白芷中分离得到,化合物2 对乙酰胆碱酯酶具有抑制活性,半数抑制浓度(median inhibition concentration,IC₅₀)值为(71.37±1.26)µmol/L。
杭白芷
/
呋喃香豆素
/
香豆素二聚体
/
LC-MS
/
乙酰胆碱酯酶抑制活性
/
白芷双香豆素A
/
dahuribiethrin E
Objective To investigate the trace amounts of furanocoumarin dimers from Angelica dahurica var. formosana . Methods Using an LC-MS guided separation method, the furanocoumarin dimers were isolated by silica gel, Sephadex LH-20 column chromatography, and semi-preparative HPLC. The structures of the isolated dimeric coumarins were identified by NMR spectroscopy, and their preliminarily acetylcholinesterase (AChE) inhibitory activities were evaluated. Results Three furanocoumarin dimers were isolated from the ethyl acetate fraction of the ethanol extract of A. dahurica var. formosana , namely 9-{[4-(3-methylbut-2-en-1-yl)-7-oxo-7H -furo[3,2-g]chromen-9-yl]oxy}-4-[(2-methylbut-3-en-2-yl)oxy]-7H -furo[3,2-g]chromen-7-one (1 ), dahuribiethrin E (2 ) and dahuribiethrin B (3 ). Conclusion Compound 1 is a new compound, namely dahuribiscoumarin A. Compounds 2 and 3 are isolated from A. dahurica var. formosana for the first time. Compound 2 exhibits acetylcholinesterase inhibitory activity with a median inhibition concentration (IC50 ) value of (71.37 ± 1.26) μmol/L.
Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan
/
furanocoumarin
/
coumarin dimer
/
LC-MS
/
acetylcholinesterase inhibitory activity
/
dahuribiscoumarin A
/
dahuribiethrin E
凌鸽雨, 温建牛, 王阳, 樊江平, 侯婕, 张雨路, 史社坡.
杭白芷中1个新的呋喃香豆素二聚体.
中草药,
2026
, 57
(12)
: 4522
-4527
.
DOI: 10.7501/j.issn.0253-2670.2026.12.002
LING Geyu, WEN Jianniu, WANG Yang, FAN Jiangping, HOU Jie, ZHANG Yulu, SHI Shepo.
A new furanocoumarin dimer from Angelica dahurica var. formosana [J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(12)
: 4522
-4527
.
DOI: 10.7501/j.issn.0253-2670.2026.12.002
参考文献
引证文献
中国药典[S]. 一部. 2025: 109. 薛艳萍, 秦旭华, 胡黄婉莹, 等. 白芷总香豆素和挥发油镇痛抗炎作用的比较研究[J]. 中国民族民间医药, 2016, 25(8): 20-22. 杨诗雨, 高欣阳, 张庆芬, 等. 鲜白芷挥发油提取工艺优化及其成分与抗氧化活性研究[J]. 中国调味品, 2026, 51(1): 234-243. 王阳, 石璠钰, 卢姿含, 等. 白芷中非香豆素类成分研究[J]. 天然产物研究与开发, 2023, 35(10): 1724-1731. 康学军, 曲见松, 顾忠泽. 白芷多糖的分析[J]. 分析化学, 2006, 34(4): 533-535. Qi B W, Yang W Q, Ding N, et al. Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica [J]. J Nat Med, 2019, 73(4): 769-776. 袁英豪, 赖谦, 向卓亚, 等. 白芷研究现状及发展态势分析[J]. 四川农业科技, 2025(9): 85-89. Wu F Z, Liu J, Cao Z T, et al. Molecular mechanism of the Saposhnikovia divaricata-Angelica dahurica herb pair in migraine therapy based on network pharmacology and molecular docking [J]. Evid Based Complementary Altern Med, 2022, 2022(1): 1994575. 雷雨恬, 黄婷, 陈文莉, 等. 不同等级川白芷有效成分含量及抗炎镇痛作用对比研究[J]. 中药药理与临床, 2021, 37(1): 105-110. Adakudugu E A, Obiri D D, Ameyaw E O, et al. Bergapten modulates ovalbumin-induced asthma [J]. Sci Afr, 2020, 8: e00457. 苏琳, 邬宗周, 余茜, 等. 基于“肺主皮毛”理论在历代古方中挖掘最具美白祛斑潜力中药“二白一辛” [J]. 中药新药与临床药理, 2024, 35(1): 35-45. Lu X, Yuan Z Y, Yan X J, et al. Effects of Angelica dahurica on obesity and fatty liver in mice [J]. Chin J Nat Med, 2016, 14(9): 641-652. Kozioł E, Skalicka-Woźniak K. Imperatorin-pharmacological meaning and analytical clues: Profound investigation [J]. Phytochem Rev, 2016, 15(4): 627-649. 蒋桂华, 张绿明, 马逾英, 等. 白芷综合开发利用研究进展及展望[J]. 时珍国医国药, 2008, 19(11): 2718-2720. Wang Y, Shi F Y, Lu Z H, et al. Seven new 3,4-dihydro-furanocoumarin derivatives from Angelica dahurica [J]. Chin Herb Med, 2023, 15(3): 457-462. 温建牛, 石璠钰, 杨万青, 等. 白芷中香豆素类成分研究[J]. 中草药, 2024, 55(19): 6465-6473. Yang W Q, Zhu Z X, Song Y L, et al. Dimeric furanocoumarins from the roots of Angelica dahurica [J]. Nat Prod Res, 2017, 31(8): 870-877. Yang W Q, Song Y L, Zhu Z X, et al. Anti-inflammatory dimeric furanocoumarins from the roots of Angelica dahurica [J]. Fitoterapia, 2015, 105: 187-193. Fan J P, et al. Characterization and synthesis of alkaloidal butenolides with seed germination stimulating properties from Angelica dahurica [J]. J Agric Food Chem, 2025, 73(13): 7822-7832. 赵爱红, 杨秀伟, 杨鑫宝, 等. 祁白芷根中新的天然产物[J]. 中国中药杂志, 2012, 37(16): 2400-2407.
2026年第57卷第12期
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doi: 10.7501/j.issn.0253-2670.2026.12.002
接收时间:2026-03-09
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2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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