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This article elaborates on the main achievements and progress in the research of alkaloid components in the Dactylicapnos at home and abroad, and introduces the research status and characteristics of this field at home and abroad. By comparing domestic and foreign studies, this article found that there are some hot and difficult issues in the research field of Dactylicapnos alkaloid components, mainly manifested in the imbalance of alkaloid research among different species in Dactylicapnos, the narrow scope of alkaloid components and pharmacological activity research in this genus. Finally, this article provides a review of the efficacy, chemical composition, biosynthetic pathways, and pharmacological activities of Dactylicapnos, pointing out the shortcomings of current research and proposing future research directions and possible development trends. This article aims to provide reference for researchers on Dactylicapnos alkaloids and provide insights and suggestions for subsequent investigations., authors=LI Ruixue, PAN Yingni, LIU Xiaoqiu, WANG Xianrui, JING Wenguang, CHEN Jia, YANG Jianbo, DUAN Baozhong, CHENG Xianlong, LIN Yongqiang, WEI Feng, authorsList=LI Ruixue, PAN Yingni, LIU Xiaoqiu, WANG Xianrui, JING Wenguang, CHEN Jia, YANG Jianbo, DUAN Baozhong, CHENG Xianlong, LIN Yongqiang, WEI Feng, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388107000902499, articleId=1304388106661163873, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=紫金龙属生物碱类成分、生源合成途径及药理活性研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=随着中药活性成分研究的不断深入,紫金龙属生物碱类成分在植物化学与创新药物研发领域中扮演着越来越重要的角色。首先,详细阐述了国内外在紫金龙属生物碱成分研究方面的主要成果和进展,介绍了国内外在该领域的研究现状和特点。通过比较国内外研究,发现目前紫金龙属生物碱成分研究领域存在一些热点和难点问题,主要表现在对紫金龙属内不同物种间生物碱研究不平衡、该属生物碱成分以及药理活性研究范围较窄等方面。最后,对紫金龙属药用植物功效、化学成分、生源合成途径以及药理活性进行综述,指出了现阶段研究的不足之处,并提出了未来研究方向和可能的发展趋势。旨在为紫金龙属生物碱类成分研究提供参考,并为后续研究提供思路和建议。, authors=李瑞雪1, 潘英妮1, 刘晓秋1, 王献瑞2, 荆文光2, 陈佳2, 杨建波2, 段宝忠3, 程显隆2, 林永强2, 魏锋2, authorsList=李瑞雪, 潘英妮, 刘晓秋, 王献瑞, 荆文光, 陈佳, 杨建波, 段宝忠, 程显隆, 林永强, 魏锋, authorCompany=1 沈阳药科大学中药学院, 辽宁 沈阳 110016;
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Wang X, Dong H J, Yang B, et al. Preparative isolation of alkaloids from Dactylicapnos scandens using pH-zone-refining counter-current chromatography by changing the length of the separation column [J]. J Chromatogr B, 2011, 879(31): 3767-3770.
Jiang H, Hou T, Cao C Y, et al. An integrated strategy for the discovery of quality marker of Dactylicapnos scandens based on phytochemical analysis, network pharmacology and activity screening [J]. J Pharm Biomed Anal, 2024, 241: 115969.
Bao M F, Yang X N, Wu J, et al. Discovery and biological evaluation of a new type of dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase from ethnomedicinal plant Dactylicapnos scandens [J]. Phytochemistry, 2023, 214: 113794.
Wu Q, Hu R X, Han Y R, et al. Four new alkaloids from the roots of Dactylicapnos scandens [J]. J Asian Nat Prod Res, 2024, 26(2): 248-258.
Wang B, Yang Z F, Zhao Y L, et al. Anti-inflammatory isoquinoline with bis-seco-aporphine skeleton from Dactylicapnos scandens [J]. Org Lett, 2018, 20(6): 1647-1650.
曾韦丹. 民族药丽江紫金龙资源开发的化学基础研究[D]. 昆明: 云南中医药大学, 2022.
Rücker G, Breitmaier E, Zhang G L, et al. Alkaloids from Dactylicapnos torulosa [J]. Phytochemistry, 1994, 36(2): 519-523.
Rücker G, Breitmaier E, Zhang G L, et al. Alkaloids from Dactylicapnos torulosa [J]. Phytochemistry, 1994, 36(2): 519-523.
Wang B, Hu B, Pan X B, et al. A new benzophenanthridines derivative from Dactylicapnos scandens and its chemotaxonomic significance [J]. Biochem Syst Ecol, 2025, 119: 104948.
Liu X Y, Wu J, Wei F, et al. Four new alkaloids from Dactylicapnos grandifoliolata [J]. J Asian Nat Prod Res, 2026, 28(4): 542-552.
罗建蓉, 钱金栿, 周浓. 紫金龙脂溶性化学成分的研究[J]. 西北药学杂志, 2010, 25(1): 19-20.
Jiang H, Hou T, Han Y, et al. Preparation and identification of isoquinoline alkaloids with ATP citrate lyase inhibitory activity from Dactylicapnos scandens [J]. Fitoterapia, 2023, 165: 105397.
张国林, 潘维恩, 彭树林, 等. 小藤铃儿草的生物碱成分[J]. 药学学报, 1990, 25(8): 604-607.
董璐. 宽果紫金龙和淡红忍冬的化学成分研究[D]. 昆明: 云南中医学院, 2013.
严田青, 艾铁民. 紫金龙化学成分的研究[J]. 中草药, 2004, 35(8): 861-862.
Manske R H F. The alkaloids of fumariaceous plants: Xxxvii. Dactylicapnos macrocapnos Hutchinson [J]. Can J Res, 1943, 21b(6): 117-118.
Guo C C, Jiang Y, Li L, et al. Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of Dactylicapnos scandens in rats [J]. J Pharm Biomed Anal, 2013, 74: 92-100.
吴颖瑞, 赵友兴, 刘玉清, 等. 紫金龙的生物碱成分研究[J]. 天然产物研究与开发, 2008, 20(4): 622-626.
He Q B, Li X B, Wang X L, et al. Chemical constituents of Dactylicapnos torulosa and their antithrombotic activities [J]. Phytochem Lett, 2022, 49: 12-20.
陆丽萍, 王宗玉, 吴大刚. 紫金龙的生物碱成分[J]. 云南植物研究, 1987, 9(3): 367-368.
Wang B, Zhao Y J, Zhao Y L, et al. Exploring aporphine as anti-inflammatory and analgesic lead from Dactylicapnos scandens [J]. Org Lett, 2020, 22(1): 257-260.
Qing Z X, Cheng P, Liu X B, et al. Systematic identification of alkaloids in Macleaya microcarpa fruits by liquid chromatography tandem mass spectrometry combined with the isoquinoline alkaloids biosynthetic pathway [J]. J Pharm Biomed Anal, 2015, 103: 26-34.
He S M, Song W L, Cong K, et al. Identification of candidate genes involved in isoquinoline alkaloids biosynthesis in Dactylicapnos scandens by transcriptome analysis [J]. Sci Rep, 2017, 7: 9119.
Iwasa K, Moriyasu M, Wiegrebe W. Some contributions to the application of LC-NMR, LC-MS, and LC-CD to the biosynthesis of isoquinoline alkaloids using callus cultures [J]. Pharmazie, 2012, 67: 571-585.
Beaudoin G A W, Facchini P J. Benzylisoquinoline alkaloid biosynthesis in opium poppy [J]. Planta, 2014, 240(1): 19-32.
Kamigauchi M, Yoshida M, Noda Y, et al. Difference between enzymatic and chemical N-methylations of protoberberine-type alkaloid, dependent on the stereoisomer of (-)-N-methyl-7, 8, 13, 13a-tetrahydroberberinium salt [J]. Bull Chem Soc Jpn, 2003, 76(3): 587-593.
丁福荣, 陈宇琼, 黄火强. 紫金龙脂溶性化学成分的研究及进展[J]. 中医临床研究, 2012, 4(20): 29-31.
吴勐, 王银叶, 艾铁民. 紫金龙总生物碱的镇痛作用及其机制初探[J]. 中草药, 2003, 34(11): 1022-1025.
李明, 郭瑞华. 《中华本草》收载止痛中药药性规律研究[J]. 山东中医药大学学报, 2011, 35(6): 487-488.
Lu P, Sun H F, Zhang L X, et al. Isocorydine targets the drug-resistant cellular side population through PDCD4-related apoptosis in hepatocellular carcinoma [J]. Mol Med, 2012, 18(7): 1136-1146.
Song L, Zhao F, Liu Y, et al. Effects of 8-amino-isocorydine, a derivative of isocorydine, on gastric carcinoma cell proliferation and apoptosis [J]. Curr Ther Res, 2021, 94: 100624.
Xu L F, Chu W J, Qing X Y, et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models [J]. Neuropharmacology, 2006, 50(8): 934-940.
Perviz S, Khan H, Pervaiz A. Plant alkaloids as an emerging therapeutic alternative for the treatment of depression [J]. Front Pharmacol, 2016, 7: 28.
Rezaie A, Pezeshki A, Zadfattah B, et al. Study of sedation, pre-anesthetic and anti-anxiety effects of celandine extract compared with diazepam in rats [J]. J Anim Vet Adv, 2012, 11(12): 2143-2147.
Wang Y Y, Tai Y L, Zhao D, et al. Berberine prevents disease progression of nonalcoholic steatohepatitis through modulating multiple pathways [J]. Cells, 2021, 10(2): 210.
Gao L L, Wei N, Yang G P, et al. Ethnomedicine study on traditional medicinal plants in the Wuliang Mountains of Jingdong, Yunnan, China [J]. J Ethnobiol Ethnomed, 2019, 15(1): 41.
Xu J, Yang X W. LC-MS-based metabolomics reveals the mechanism of protection of berberine against indomethacin-induced gastric injury in rats [J]. Molecules, 2024, 29(5): 1055.
陈植和, 王懋德, 黄润, 等. 异紫堇定急性和亚急性毒性研究[J]. 昆明医学院学报, 1984, 5(3): 15-16.
Hu W J, Yang F, Liu W X, et al. Potential toxicity evaluation of protopine in Macleaya cordata (Willd.) R. Br.-a bioactivity guided approach [J]. Front Vet Sci, 2021, 8: 752767.)
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紫金龙属生物碱类成分、生源合成途径及药理活性研究进展
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中草药 |综述 2026 , 57 (11) : 4467 -4482
紫金龙属生物碱类成分、生源合成途径及药理活性研究进展
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李瑞雪1, 潘英妮1, 刘晓秋1, 王献瑞2, 荆文光2, 陈佳2, 杨建波2, 段宝忠3, 程显隆2, 林永强2, 魏锋2
作者信息
    1 沈阳药科大学中药学院, 辽宁 沈阳 110016;
    2 中国食品药品检定研究院, 北京 100050;
    3 大理大学药学院, 云南 大理 671000
通讯作者:
刘晓秋
作者简介:
李瑞雪: 李瑞雪,硕士研究生,研究方向为中药民族药质量控制。E-mail:lrx021230@126.com
Research progress on alkaloid components in plants from Dactylicapnos and their biosynthetic pathways and pharmacological activities
  • LI Ruixue, PAN Yingni, LIU Xiaoqiu, WANG Xianrui, JING Wenguang, CHEN Jia, YANG Jianbo, DUAN Baozhong, CHENG Xianlong, LIN Yongqiang, WEI Feng
  • Affiliations
    doi: 10.7501/j.issn.0253-2670.2026.11.032
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    随着中药活性成分研究的不断深入,紫金龙属生物碱类成分在植物化学与创新药物研发领域中扮演着越来越重要的角色。首先,详细阐述了国内外在紫金龙属生物碱成分研究方面的主要成果和进展,介绍了国内外在该领域的研究现状和特点。通过比较国内外研究,发现目前紫金龙属生物碱成分研究领域存在一些热点和难点问题,主要表现在对紫金龙属内不同物种间生物碱研究不平衡、该属生物碱成分以及药理活性研究范围较窄等方面。最后,对紫金龙属药用植物功效、化学成分、生源合成途径以及药理活性进行综述,指出了现阶段研究的不足之处,并提出了未来研究方向和可能的发展趋势。旨在为紫金龙属生物碱类成分研究提供参考,并为后续研究提供思路和建议。
    罂粟科  /  紫金龙属  /  生物碱  /  生物合成途径  /  异喹啉类生物碱
    With the continuous deepening of research on active ingredients in traditional Chinese medicine, Dactylicapnos alkaloids play an increasingly important role in the fields of plant chemistry and innovative drug development. This article elaborates on the main achievements and progress in the research of alkaloid components in the Dactylicapnos at home and abroad, and introduces the research status and characteristics of this field at home and abroad. By comparing domestic and foreign studies, this article found that there are some hot and difficult issues in the research field of Dactylicapnos alkaloid components, mainly manifested in the imbalance of alkaloid research among different species in Dactylicapnos, the narrow scope of alkaloid components and pharmacological activity research in this genus. Finally, this article provides a review of the efficacy, chemical composition, biosynthetic pathways, and pharmacological activities of Dactylicapnos, pointing out the shortcomings of current research and proposing future research directions and possible development trends. This article aims to provide reference for researchers on Dactylicapnos alkaloids and provide insights and suggestions for subsequent investigations.
    Papaveraceae  /  Dactylicapnos Wall.  /  alkaloids  /  synthetic pathway  /  isoquinoline alkaloids
    李瑞雪, 潘英妮, 刘晓秋, 王献瑞, 荆文光, 陈佳, 杨建波, 段宝忠, 程显隆, 林永强, 魏锋. 紫金龙属生物碱类成分、生源合成途径及药理活性研究进展. 中草药, 2026 , 57 (11) : 4467 -4482 . DOI: 10.7501/j.issn.0253-2670.2026.11.032
    LI Ruixue, PAN Yingni, LIU Xiaoqiu, WANG Xianrui, JING Wenguang, CHEN Jia, YANG Jianbo, DUAN Baozhong, CHENG Xianlong, LIN Yongqiang, WEI Feng. Research progress on alkaloid components in plants from Dactylicapnos and their biosynthetic pathways and pharmacological activities[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (11) : 4467 -4482 . DOI: 10.7501/j.issn.0253-2670.2026.11.032

      新疆维吾尔自治区重点研发任务专项 (2023B03001-2,2024B02023-2)

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    Jiang H, Hou T, Cao C Y, et al. An integrated strategy for the discovery of quality marker of Dactylicapnos scandens based on phytochemical analysis, network pharmacology and activity screening [J]. J Pharm Biomed Anal, 2024, 241: 115969.
    Bao M F, Yang X N, Wu J, et al. Discovery and biological evaluation of a new type of dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase from ethnomedicinal plant Dactylicapnos scandens [J]. Phytochemistry, 2023, 214: 113794.
    Wu Q, Hu R X, Han Y R, et al. Four new alkaloids from the roots of Dactylicapnos scandens [J]. J Asian Nat Prod Res, 2024, 26(2): 248-258.
    Wang B, Yang Z F, Zhao Y L, et al. Anti-inflammatory isoquinoline with bis-seco-aporphine skeleton from Dactylicapnos scandens [J]. Org Lett, 2018, 20(6): 1647-1650.
    曾韦丹. 民族药丽江紫金龙资源开发的化学基础研究[D]. 昆明: 云南中医药大学, 2022.
    Rücker G, Breitmaier E, Zhang G L, et al. Alkaloids from Dactylicapnos torulosa [J]. Phytochemistry, 1994, 36(2): 519-523.
    Rücker G, Breitmaier E, Zhang G L, et al. Alkaloids from Dactylicapnos torulosa [J]. Phytochemistry, 1994, 36(2): 519-523.
    Wang B, Hu B, Pan X B, et al. A new benzophenanthridines derivative from Dactylicapnos scandens and its chemotaxonomic significance [J]. Biochem Syst Ecol, 2025, 119: 104948.
    Liu X Y, Wu J, Wei F, et al. Four new alkaloids from Dactylicapnos grandifoliolata [J]. J Asian Nat Prod Res, 2026, 28(4): 542-552.
    罗建蓉, 钱金栿, 周浓. 紫金龙脂溶性化学成分的研究[J]. 西北药学杂志, 2010, 25(1): 19-20.
    Jiang H, Hou T, Han Y, et al. Preparation and identification of isoquinoline alkaloids with ATP citrate lyase inhibitory activity from Dactylicapnos scandens [J]. Fitoterapia, 2023, 165: 105397.
    张国林, 潘维恩, 彭树林, 等. 小藤铃儿草的生物碱成分[J]. 药学学报, 1990, 25(8): 604-607.
    董璐. 宽果紫金龙和淡红忍冬的化学成分研究[D]. 昆明: 云南中医学院, 2013.
    严田青, 艾铁民. 紫金龙化学成分的研究[J]. 中草药, 2004, 35(8): 861-862.
    Manske R H F. The alkaloids of fumariaceous plants: Xxxvii. Dactylicapnos macrocapnos Hutchinson [J]. Can J Res, 1943, 21b(6): 117-118.
    Guo C C, Jiang Y, Li L, et al. Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of Dactylicapnos scandens in rats [J]. J Pharm Biomed Anal, 2013, 74: 92-100.
    吴颖瑞, 赵友兴, 刘玉清, 等. 紫金龙的生物碱成分研究[J]. 天然产物研究与开发, 2008, 20(4): 622-626.
    He Q B, Li X B, Wang X L, et al. Chemical constituents of Dactylicapnos torulosa and their antithrombotic activities [J]. Phytochem Lett, 2022, 49: 12-20.
    陆丽萍, 王宗玉, 吴大刚. 紫金龙的生物碱成分[J]. 云南植物研究, 1987, 9(3): 367-368.
    Wang B, Zhao Y J, Zhao Y L, et al. Exploring aporphine as anti-inflammatory and analgesic lead from Dactylicapnos scandens [J]. Org Lett, 2020, 22(1): 257-260.
    Qing Z X, Cheng P, Liu X B, et al. Systematic identification of alkaloids in Macleaya microcarpa fruits by liquid chromatography tandem mass spectrometry combined with the isoquinoline alkaloids biosynthetic pathway [J]. J Pharm Biomed Anal, 2015, 103: 26-34.
    He S M, Song W L, Cong K, et al. Identification of candidate genes involved in isoquinoline alkaloids biosynthesis in Dactylicapnos scandens by transcriptome analysis [J]. Sci Rep, 2017, 7: 9119.
    Iwasa K, Moriyasu M, Wiegrebe W. Some contributions to the application of LC-NMR, LC-MS, and LC-CD to the biosynthesis of isoquinoline alkaloids using callus cultures [J]. Pharmazie, 2012, 67: 571-585.
    Beaudoin G A W, Facchini P J. Benzylisoquinoline alkaloid biosynthesis in opium poppy [J]. Planta, 2014, 240(1): 19-32.
    Kamigauchi M, Yoshida M, Noda Y, et al. Difference between enzymatic and chemical N-methylations of protoberberine-type alkaloid, dependent on the stereoisomer of (-)-N-methyl-7, 8, 13, 13a-tetrahydroberberinium salt [J]. Bull Chem Soc Jpn, 2003, 76(3): 587-593.
    丁福荣, 陈宇琼, 黄火强. 紫金龙脂溶性化学成分的研究及进展[J]. 中医临床研究, 2012, 4(20): 29-31.
    吴勐, 王银叶, 艾铁民. 紫金龙总生物碱的镇痛作用及其机制初探[J]. 中草药, 2003, 34(11): 1022-1025.
    李明, 郭瑞华. 《中华本草》收载止痛中药药性规律研究[J]. 山东中医药大学学报, 2011, 35(6): 487-488.
    Lu P, Sun H F, Zhang L X, et al. Isocorydine targets the drug-resistant cellular side population through PDCD4-related apoptosis in hepatocellular carcinoma [J]. Mol Med, 2012, 18(7): 1136-1146.
    Song L, Zhao F, Liu Y, et al. Effects of 8-amino-isocorydine, a derivative of isocorydine, on gastric carcinoma cell proliferation and apoptosis [J]. Curr Ther Res, 2021, 94: 100624.
    Xu L F, Chu W J, Qing X Y, et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models [J]. Neuropharmacology, 2006, 50(8): 934-940.
    Perviz S, Khan H, Pervaiz A. Plant alkaloids as an emerging therapeutic alternative for the treatment of depression [J]. Front Pharmacol, 2016, 7: 28.
    Rezaie A, Pezeshki A, Zadfattah B, et al. Study of sedation, pre-anesthetic and anti-anxiety effects of celandine extract compared with diazepam in rats [J]. J Anim Vet Adv, 2012, 11(12): 2143-2147.
    Wang Y Y, Tai Y L, Zhao D, et al. Berberine prevents disease progression of nonalcoholic steatohepatitis through modulating multiple pathways [J]. Cells, 2021, 10(2): 210.
    Gao L L, Wei N, Yang G P, et al. Ethnomedicine study on traditional medicinal plants in the Wuliang Mountains of Jingdong, Yunnan, China [J]. J Ethnobiol Ethnomed, 2019, 15(1): 41.
    Xu J, Yang X W. LC-MS-based metabolomics reveals the mechanism of protection of berberine against indomethacin-induced gastric injury in rats [J]. Molecules, 2024, 29(5): 1055.
    陈植和, 王懋德, 黄润, 等. 异紫堇定急性和亚急性毒性研究[J]. 昆明医学院学报, 1984, 5(3): 15-16.
    Hu W J, Yang F, Liu W X, et al. Potential toxicity evaluation of protopine in Macleaya cordata (Willd.) R. Br.-a bioactivity guided approach [J]. Front Vet Sci, 2021, 8: 752767.
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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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