中草药

橙皮素防治消化系统疾病的药理作用及机制研究进展

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中草药 | 综述 2026,57(11): 4457-4466

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中草药 |综述 2026 , 57 (11) : 4457 -4466

橙皮素防治消化系统疾病的药理作用及机制研究进展

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晏雨露¹, 黄菲菲¹, 邱思梦¹, 刘馨雅¹, 刘曾阳¹, 陈婷婷¹, 蒋欣雨¹, 龚普阳¹

作者信息

通讯作者:

龚普阳

作者简介:

晏雨露: 晏雨露，硕士研究生，研究方向为中药药理学。E-mail:isyanyulu@163.com

Research progress on pharmacological effects and mechanisms of hesperetin in prevention and treatment of digestive system diseases

YAN Yulu, HUANG Feifei, QIU Simeng, LIU Xinya, LIU Zengyang, CHEN Tingting, JIANG Xinyu, GONG Puyang

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doi: 10.7501/j.issn.0253-2670.2026.11.031

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消化系统疾病临床发病率高且病机复杂，安全有效的治疗药物开发需求迫切。橙皮素是一种广泛存在于芸香科植物中的类黄酮化合物，也是中药陈皮、枳壳及青皮防治消化系统功能紊乱的主要药效物质基础。现代药理研究证实橙皮素可通过抑制炎症反应、抗氧化应激、改善脂质代谢、调节肠道菌群、调控线粒体自噬、抗肿瘤等途径对非酒精性脂肪肝、肝纤维化、溃疡性结肠炎、胃癌、结直肠癌等消化系统疾病发挥潜在治疗作用。通过归纳分析近30年国内外相关研究报道，系统综述了橙皮素在治疗消化系统疾病中的药效作用及其分子机制，为其新药创制及大健康产品开发提供一定的理论依据和科学参考。

关键词

橙皮素 / 消化系统疾病 / 非酒精性脂肪肝 / 肝损伤 / 胃癌 / 结直肠癌 / 溃疡性结肠炎

Abstract

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Digestive system diseases exhibit high clinical incidence rates and complex pathogenesis, creating an urgent need for the development of safe and effective therapeutic agents. Hesperetin is a flavonoid compound widely presented in Rutaceae plants, and serves as the primary effective component of traditional Chinese medicines such as Chenpi (Citri Reticulatae Pericarpium), Zhiqiao (Aurantii Fructus) and Qingpi (Citri Reticulatae Pericarpium Viride) in preventing and treating digestive system dysfunction. Modern pharmacological studies have confirmed that hesperetin could exert potential therapeutic effects on digestive system diseases such as non-alcoholic fatty liver disease, liver fibrosis, ulcerative colitis, gastric cancer, and colorectal cancer through multiple pathways including inhibiting inflammatory responses, antioxidative stress, improving lipid metabolism, regulating intestinal flora, regulating mitochondrial autophagy, antitumor, etc. This article summarizes and analyzes the relevant research reports at home and abroad in the past 30 years, systematically reviews the pharmacological effects and molecular mechanisms of hesperetin in treatment of digestive system diseases, and provides theoretical basis and scientific reference for the development of new drugs and health products.

Key words

hesperetin / digestive system disorders / non-alcoholic fatty liver disease / liver injury / gastric cancer / colorectal cancer / ulcerative colitis

引用本文

晏雨露, 黄菲菲, 邱思梦, 刘馨雅, 刘曾阳, 陈婷婷, 蒋欣雨, 龚普阳. 橙皮素防治消化系统疾病的药理作用及机制研究进展. 中草药, 2026 , 57 (11) : 4457 -4466 . DOI: 10.7501/j.issn.0253-2670.2026.11.031

YAN Yulu, HUANG Feifei, QIU Simeng, LIU Xinya, LIU Zengyang, CHEN Tingting, JIANG Xinyu, GONG Puyang. Research progress on pharmacological effects and mechanisms of hesperetin in prevention and treatment of digestive system diseases[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (11) : 4457 -4466 . DOI: 10.7501/j.issn.0253-2670.2026.11.031

基金

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国家自然科学基金资助项目 (82004069); 四川省重点研发计划 (2024YFFK0183); 西南民族大学中央高校基本科研业务费专项 (ZYN2024035)

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2026年第57卷第11期

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doi: 10.7501/j.issn.0253-2670.2026.11.031

接收时间：2026-01-12
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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