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Compared with quercetin and rutin, EMIQ exhibits markedly improved bioavailability. A growing body of research has demonstrated that EMIQ possesses a broad spectrum of pharmacological activities, including antioxidant, anti-inflammatory, anti-allergic, cardiovascular-protective, and muscle-enhancing effects. In addition, EMIQ can precisely regulate glucose and lipid metabolism, primarily through activation of the AMPK signaling pathway. Both animal experiments and clinical studies have confirmed its safety and reliability, and EMIQ has been approved for use as a food additive in Japan and the United States. This article provides a comprehensive review of the structural features, physicochemical properties, preparation methods, pharmacological activities, and safety evaluations of EMIQ, with the aim of offering a solid theoretical foundation and practical guidance for future research and industrial development of this compound., authors=TAN Zhengxi, YUAN Zhi, YU Hongjian, authorsList=TAN Zhengxi, YUAN Zhi, YU Hongjian, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388072133645224, articleId=1304388071768740775, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=酶处理异槲皮苷的研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=酶处理异槲皮苷（enzymatically modified isoquercitrin，EMIQ）是以异槲皮苷为底物经酶促糖基化得到的高水溶性黄酮衍生物，其生物利用度显著高于槲皮素及芦丁。大量研究表明EMIQ具有广泛的药理作用，包括抗氧化、抗炎、抗过敏、心血管保护及促进肌肉生长等作用，还能通过激活AMPK信号通路实现对糖脂代谢的精准调控。动物与临床研究均证实其安全可靠，已被日本和美国批准用于食品添加。系统综述了EMIQ的结构特征、理化性质、制备工艺、药理作用及安全性评价，以期EMIQ的深入研究及产业化发展提供坚实的理论依据与实践指导。, authors=谭正熙1 , 袁志1 , 於洪建1,2 , authorsList=谭正熙, 袁志, 於洪建, authorCompany=1 天津中医药大学, 天津 301617; et al . α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans [J]. Arch Biochem Biophys , 2010, 501(1): 91-97.L -鼠李糖苷酶的挖掘、酶学性质表征与应用[J]. 微生物学报, 2024, 64(9): 3474-3488.et al . Evaluation of the toxicity of enzymatically decomposed rutin with 13-weeks dietary administration to Wistar rats [J]. Food Chem Toxicol , 2004, 42(3): 439-444.L -鼠李糖苷酶的分子和结构生物学研究进展[J]. 生命科学研究, 2015, 19(1): 68-74.L -鼠李糖苷酶酶学性质及其在异槲皮素制备上应用[J]. 食品工业科技, 2018, 39(1): 107-111.l -Rhamnosidase selective for rutin to isoquercitrin transformation from Penicillium griseoroseum MTCC-9224[J]. Bioorg Chem , 2017, 70: 222-228.Pflugers Arch , 2020, 472(9): 1273-1298.et al . Prevention effect of quercetin and its glycosides on obesity and hyperglycemia through activating AMPKα in high-fat diet-fed ICR mice [J]. J Clin Biochem Nutr , 2020, 67(1): 75-83.et al . Single oral administration of quercetin glycosides prevented acute hyperglycemia by promoting GLUT4 translocation in skeletal muscles through the activation of AMPK in mice [J]. J Clin Biochem Nutr , 2024, 74(1): 37-46.Food Res Int , 2013, 50(2): 469-479.et al . Synergistic effects of heat-treated green tea extract and enzymatically-modified isoquercitrin in preventing obesity [J]. Nutrients , 2023, 15(13): 2931.et al . Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease [J]. Br J Nutr , 2020, 123(2): 182-189.et al . Effect of enzymatically modified isoquercitrin in spontaneously hypertensive rats [J]. J Nutr Sci Vitaminol , 2007, 53(1): 68-74.et al . Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice [J]. Nutrition , 2009, 25(4): 421-427.et al . Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis [J]. Allergol Int , 2009, 58(3): 373-382.et al . Influence of lifestyle and dietary habits on the prevalence of food allergies: A scoping review [J]. Foods , 2023, 12(17): 3290.et al . Cilostazol and enzymatically modified isoquercitrin attenuate experimental colitis and colon cancer in mice by inhibiting cell proliferation and inflammation [J]. Food Chem Toxicol , 2017, 100: 103-114.Int Immunopharmacol , 2021, 97: 107735.et al . Enzymatically modified isoquercitrin supplementation intensifies plantaris muscle fiber hypertrophy in functionally overloaded mice [J]. J Int Soc Phys Nutr , 2017, 14(1): 32.et al . Effects of enzymatically modified isoquercitrin in supplementary protein powder on athlete body composition: A randomized, placebo-controlled, double-blind trial [J]. J Int Soc Phys Nutr , 2019, 16(1): 39.et al . Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats [J]. Arch Toxicol , 2010, 84(2): 143-153.et al . Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by β-naphthoflavone [J]. Toxicology , 2010, 268(3): 213-218.et al . Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats [J]. Arch Toxicol , 2011, 85(11): 1475-1484.et al . Ten-day and four-week toxicity and toxicokinetics studies of alpha-glycosyl isoquercitrin in juvenile Göttingen minipigs [J]. Toxicol Res Appl , 2019, 3: 2397847319855087.et al . 13-Week oral toxicity and 4-week recovery study of enzymatically modified isoquercitrin in F344/DuCrj rats [J]. J Food Chem Safety , 2002,8(3):161-167.et al . Lack of carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats [J]. Food Chem Toxicol , 2004, 42(12): 1949-1969.et al . Embryo-fetal developmental toxicity study of alpha-glycosyl isoquercitrin administered orally to New Zealand White rabbits [J]. Toxicol Res Appl , 2020, 4: 2397847320964908.et al . Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential [J]. Food Chem Toxicol , 2018, 113: 218-227.)
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酶处理异槲皮苷的研究进展
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谭正熙, 袁志, 於洪建
作者信息
通讯作者:
於洪建
作者简介:
谭正熙: 谭正熙,硕士研究生,研究方向为天然产物提取分离。E-mail:m13928614381@163.com
Research progress on enzymatically modified isoquercitrin
TAN Zhengxi, YUAN Zhi, YU Hongjian
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.10.034
文章导航
酶处理异槲皮苷（enzymatically modified isoquercitrin，EMIQ）是以异槲皮苷为底物经酶促糖基化得到的高水溶性黄酮衍生物，其生物利用度显著高于槲皮素及芦丁。大量研究表明EMIQ具有广泛的药理作用，包括抗氧化、抗炎、抗过敏、心血管保护及促进肌肉生长等作用，还能通过激活AMPK信号通路实现对糖脂代谢的精准调控。动物与临床研究均证实其安全可靠，已被日本和美国批准用于食品添加。系统综述了EMIQ的结构特征、理化性质、制备工艺、药理作用及安全性评价，以期EMIQ的深入研究及产业化发展提供坚实的理论依据与实践指导。
黄酮类化合物
/
酶处理异槲皮苷
/
糖基化修饰
/
抗氧化
/
抗炎
/
抗过敏
/
心血管保护
/
应用价值
Enzymatically modified isoquercitrin (EMIQ) is a highly water-soluble flavonoid derivative produced through enzymatic glycosylation of isoquercitrin. Compared with quercetin and rutin, EMIQ exhibits markedly improved bioavailability. A growing body of research has demonstrated that EMIQ possesses a broad spectrum of pharmacological activities, including antioxidant, anti-inflammatory, anti-allergic, cardiovascular-protective, and muscle-enhancing effects. In addition, EMIQ can precisely regulate glucose and lipid metabolism, primarily through activation of the AMPK signaling pathway. Both animal experiments and clinical studies have confirmed its safety and reliability, and EMIQ has been approved for use as a food additive in Japan and the United States. This article provides a comprehensive review of the structural features, physicochemical properties, preparation methods, pharmacological activities, and safety evaluations of EMIQ, with the aim of offering a solid theoretical foundation and practical guidance for future research and industrial development of this compound.
flavonoid compounds
/
enzymatically modified isoquercitrin
/
glycosylation modification
/
antioxidant
/
anti-inflammatory
/
anti-allergy
/
cardiovascular protection
/
application value
谭正熙, 袁志, 於洪建.
酶处理异槲皮苷的研究进展.
中草药,
2026
, 57
(10)
: 4080
-4088
.
DOI: 10.7501/j.issn.0253-2670.2026.10.034
TAN Zhengxi, YUAN Zhi, YU Hongjian.
Research progress on enzymatically modified isoquercitrin[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(10)
: 4080
-4088
.
DOI: 10.7501/j.issn.0253-2670.2026.10.034
参考文献
引证文献
杨云. 中药化学[M]. 北京: 化学工业出版社, 2018: 35.et al . α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans [J]. Arch Biochem Biophys , 2010, 501(1): 91-97.L -鼠李糖苷酶的挖掘、酶学性质表征与应用[J]. 微生物学报, 2024, 64(9): 3474-3488.et al . Evaluation of the toxicity of enzymatically decomposed rutin with 13-weeks dietary administration to Wistar rats [J]. Food Chem Toxicol , 2004, 42(3): 439-444.L -鼠李糖苷酶的分子和结构生物学研究进展[J]. 生命科学研究, 2015, 19(1): 68-74.L -鼠李糖苷酶酶学性质及其在异槲皮素制备上应用[J]. 食品工业科技, 2018, 39(1): 107-111.l -Rhamnosidase selective for rutin to isoquercitrin transformation from Penicillium griseoroseum MTCC-9224[J]. Bioorg Chem , 2017, 70: 222-228.Pflugers Arch , 2020, 472(9): 1273-1298.et al . Prevention effect of quercetin and its glycosides on obesity and hyperglycemia through activating AMPKα in high-fat diet-fed ICR mice [J]. J Clin Biochem Nutr , 2020, 67(1): 75-83.et al . Single oral administration of quercetin glycosides prevented acute hyperglycemia by promoting GLUT4 translocation in skeletal muscles through the activation of AMPK in mice [J]. J Clin Biochem Nutr , 2024, 74(1): 37-46.Food Res Int , 2013, 50(2): 469-479.et al . Synergistic effects of heat-treated green tea extract and enzymatically-modified isoquercitrin in preventing obesity [J]. Nutrients , 2023, 15(13): 2931.et al . Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease [J]. Br J Nutr , 2020, 123(2): 182-189.et al . Effect of enzymatically modified isoquercitrin in spontaneously hypertensive rats [J]. J Nutr Sci Vitaminol , 2007, 53(1): 68-74.et al . Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice [J]. Nutrition , 2009, 25(4): 421-427.et al . Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis [J]. Allergol Int , 2009, 58(3): 373-382.et al . Influence of lifestyle and dietary habits on the prevalence of food allergies: A scoping review [J]. Foods , 2023, 12(17): 3290.et al . Cilostazol and enzymatically modified isoquercitrin attenuate experimental colitis and colon cancer in mice by inhibiting cell proliferation and inflammation [J]. Food Chem Toxicol , 2017, 100: 103-114.Int Immunopharmacol , 2021, 97: 107735.et al . Enzymatically modified isoquercitrin supplementation intensifies plantaris muscle fiber hypertrophy in functionally overloaded mice [J]. J Int Soc Phys Nutr , 2017, 14(1): 32.et al . Effects of enzymatically modified isoquercitrin in supplementary protein powder on athlete body composition: A randomized, placebo-controlled, double-blind trial [J]. J Int Soc Phys Nutr , 2019, 16(1): 39.et al . Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats [J]. Arch Toxicol , 2010, 84(2): 143-153.et al . Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by β-naphthoflavone [J]. Toxicology , 2010, 268(3): 213-218.et al . Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats [J]. Arch Toxicol , 2011, 85(11): 1475-1484.et al . Ten-day and four-week toxicity and toxicokinetics studies of alpha-glycosyl isoquercitrin in juvenile Göttingen minipigs [J]. Toxicol Res Appl , 2019, 3: 2397847319855087.et al . 13-Week oral toxicity and 4-week recovery study of enzymatically modified isoquercitrin in F344/DuCrj rats [J]. J Food Chem Safety , 2002,8(3):161-167.et al . Lack of carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats [J]. Food Chem Toxicol , 2004, 42(12): 1949-1969.et al . Embryo-fetal developmental toxicity study of alpha-glycosyl isoquercitrin administered orally to New Zealand White rabbits [J]. Toxicol Res Appl , 2020, 4: 2397847320964908.et al . Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential [J]. Food Chem Toxicol , 2018, 113: 218-227.
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doi: 10.7501/j.issn.0253-2670.2026.10.034
接收时间：2025-12-02
首发时间：2026-09-09
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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