中草药

金属有机骨架材料在中药领域的应用进展与挑战

PDF下载

曹曦文, 尹东阁, 李廷杰, 林舒婷, 陈红月, 孙宇菲, 荆霄鸿, 常榕蓉, 冯洋, 邓兮玺, 吴辰瑶, 曲昌海, 董晓旭, 倪健, 尹兴斌

中草药 | 综述 2026,57(10): 3983-3994

收起

中草药 |综述 2026 , 57 (10) : 3983 -3994

金属有机骨架材料在中药领域的应用进展与挑战

全屏

曹曦文, 尹东阁, 李廷杰, 林舒婷, 陈红月, 孙宇菲, 荆霄鸿, 常榕蓉, 冯洋, 邓兮玺, 吴辰瑶, 曲昌海, 董晓旭, 倪健, 尹兴斌

作者信息

通讯作者:

倪健

作者简介:

曹曦文: 曹曦文,女,本科生,研究方向为中药新剂型与新技术。E-mail:cxwy109@163.com

Application progress and challenges of metal-organic framework materials in field of traditional Chinese medicine

CAO Xiwen, YIN Dongge, LI Tingjie, LIN Shuting, CHEN Hongyue, SUN Yufei, JING Xiaohong, CHANG Rongrong, FENG Yang, DENG Xixi, WU Chenyao, QU Changhai, DONG Xiaoxu, NI Jian, YIN Xingbin

Affiliations

doi: 10.7501/j.issn.0253-2670.2026.10.026

文章导航

摘要

收起

金属有机骨架材料（metal organic frameworks，MOFs）是一类由金属离子中心与有机配体通过配位键形成的多孔晶体材料，具有比表面积高、孔径结构可控、生物相容性良好等优异特性，为解决中药研究中活性成分溶解度低、稳定性差、生物利用度不高等关键问题提供了创新技术路径。紧扣2025年诺贝尔化学奖授予MOFs材料这一时代背景，系统综述了类沸石咪唑酯骨架系列材料、锆基三维微孔骨架系列材料、拉瓦希尔骨架系列材料、孔-通道式骨架系列材料、网状金属有机骨架材料5大主流MOFs类型在中药研究中的应用进展。重点从“构效关系”角度出发，阐述了不同骨架材料的应用侧重。在此基础上，深入剖析了研究多聚焦单一成分、体内生物安全性未完全明确、规模化制备成本高昂等现实问题。最后，展望MOFs材料学特性与中药“君臣佐使”配伍理论的深度融合路径，提出构建仿生智能递送系统新范式，助力中药现代化、国际化及临床产业化。

关键词

金属有机骨架材料 / 中药现代化 / 构效关系 / 智能递送系统 / 复方配伍

Abstract

收起

Metal-organic framework materials (MOFs) are porous crystalline materials formed by coordination bonds between metal ion centers and organic ligands, exhibiting superior properties such as high specific surface area, controllable pore size structure, and excellent biocompatibility. They provide an innovative technological approach to address critical challenges in traditional Chinese medicine (TCM) research, including low solubility, poor stability, and suboptimal bioavailability of active components. Aligned with the historical context of the 2025 Nobel Prize in Chemistry being awarded to MOFs, this article systematically reviews the application advancements of five major MOF types—zeolitic imidazolate frameworks, university of oslos, materials of institute lavoisiers, porous coordination networks and isoreticular metal-organic frameworks—in TCM research. The discussion emphasizes the application priorities of different framework materials from the perspective of “structure-activity relationship”. Furthermore, the study delves into practical issues such as excessive focus on individual components, insufficiently established in vivo biosafety profiles, and high costs associated with large-scale production. Finally, it explores pathways for integrating the material properties of MOFs with the TCM “jun-chen-zuo-shi” (sovereign-minister-assistant-guide) compatibility theory, proposing a novel paradigm for biomimetic intelligent delivery systems to facilitate the modernization, internationalization, and clinical commercialization of TCM.

Key words

metal-organic framework materials / modernization of Chinese medicine / structure-activity relationship / intelligent delivery system / compound compatibility

引用本文

曹曦文, 尹东阁, 李廷杰, 林舒婷, 陈红月, 孙宇菲, 荆霄鸿, 常榕蓉, 冯洋, 邓兮玺, 吴辰瑶, 曲昌海, 董晓旭, 倪健, 尹兴斌. 金属有机骨架材料在中药领域的应用进展与挑战. 中草药, 2026 , 57 (10) : 3983 -3994 . DOI: 10.7501/j.issn.0253-2670.2026.10.026

CAO Xiwen, YIN Dongge, LI Tingjie, LIN Shuting, CHEN Hongyue, SUN Yufei, JING Xiaohong, CHANG Rongrong, FENG Yang, DENG Xixi, WU Chenyao, QU Changhai, DONG Xiaoxu, NI Jian, YIN Xingbin. Application progress and challenges of metal-organic framework materials in field of traditional Chinese medicine[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (10) : 3983 -3994 . DOI: 10.7501/j.issn.0253-2670.2026.10.026

基金

收起

北京市自然科学基金资助项目 (7262198); 北京市自然科学基金资助项目 (7202121); 国家自然科学基金资助项目 (81703715)

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

蔡梦如, 姚宇, 尹东阁, 等. 金属有机骨架材料在中药研究的应用进展[J]. 中草药, 2021, 52(16): 5028-5038.
邓小娟, 郝放, 袁珑, 等. 金属有机骨架纳米材料的细胞毒性研究进展[J]. 环境化学, 2025, 44(10): 3618-3633.
Cai M R, Chen G S, Qin L Y, et al. Metal organic frameworks as drug targeting delivery vehicles in the treatment of cancer [J]. Pharmaceutics, 2020, 12(3): 232.
He S Y, Wu L, Li X, et al. Metal-organic frameworks for advanced drug delivery [J]. Acta Pharm Sin B, 2021, 11(8): 2362-2395.
Perveen R, Bibi S, Saleem M A, et al. Recent progress in ZIF-polymer composites for advanced drug delivery applications [J]. J Mater Chem B, 2025, 13(24): 6949-6989.
Gao W Y, Han X P, Li L, et al. Functionalized ZIF-8 as a versatile platform for drug delivery and cancer therapy: Strategies, challenges and prospects [J]. J Mater Chem B, 2025, 13(12): 3758-3785.
Wang X H, Zhou L, Shi Y Y, et al. Co-embedding of curcumin and gold nanoparticles with ZIF-8 nanoparticles for the treatment of liver cancer and its impact on metabolomics [J]. Eur J Pharm Biopharm, 2025, 214: 114773.
Meng X F, Guan J W, Lai S S, et al. pH-responsive curcumin-based nanoscale ZIF-8 combining chemophotodynamic therapy for excellent antibacterial activity [J]. RSC Adv, 2022, 12(16): 10005-10013.
Tao Q, Yao H, Wang F F, et al. Curcumin-encapsulated co-ZIF-8 for ulcerative colitis therapy: ROS scavenging and macrophage modulation effects [J]. ACS Omega, 2024, 9(28): 30571-30582.
Xu Z J, Zhang Y, Lu D P, et al. Antisenescence ZIF-8/resveratrol nanoformulation with potential for enhancement of bone fracture healing in the elderly [J]. ACS Biomater Sci Eng, 2023, 9(5): 2636-2646.
Sheik A, Rethinasabapathy M, Kodiveri Muthukaliannan G, et al. ZIF-8 nanocarriers synthesized by co-encapsulating resveratrol and cellulase for biomedical applications [J]. Int J Biol Macromol, 2024, 283: 137756.
Kan T Y, Tian Z T, Sun L, et al. Quercetin-loaded zeolitic imidazolate framework-8(ZIF-8) nanoparticles attenuate osteoarthritis by activating autophagy via the PI3K/Akt signaling [J]. ACS Appl Mater Interfaces, 2024, 16(31): 40444-40454.
Wang N, Li Y F, He F, et al. Assembly of celastrol to zeolitic imidazolate framework-8 by coordination as a novel drug delivery strategy for cancer therapy [J]. Pharmaceuticals, 2022, 15(9): 1076.
Rostamkhani N, Salimi M, Adibifar A, et al. Enhanced anti-tumor and anti-metastatic activity of quercetin using pH-sensitive Alginate@ZIF-8 nanocomposites: In vitro and in vivo study [J]. Nanotechnology, 2024, 35(47): 475102.
Qiu Y N, Gao J, Chu W H, et al. ZIF-8 as efficient carriers for polysaccharide from Tetrastigma Hemsleyanum Diels et Gilg in acute lung injury induced by lipopolysaccharides [J]. Int J Biol Macromol, 2024, 283: 137966.
徐晓涵, 张慧中, 阮意丹, 等. 负载葫芦素B锌基金属有机骨架ZIF-8纳米粒的制备、表征及抗肝肿瘤药效评价[J]. 中草药, 2025, 56(16): 5739-5748.
Cai M R, Yao Y, Yin D G, et al. Enhanced lysosomal escape of cell penetrating peptide-functionalized metal-organic frameworks for co-delivery of survivin siRNA and oridonin [J]. J Colloid Interface Sci, 2023, 646: 370-380.
Dong K, Zhang Y, Zhang L, et al. Facile preparation of metal-organic frameworks-based hydrophobic anticancer drug delivery nanoplatform for targeted and enhanced cancer treatment [J]. Talanta, 2019, 194: 703-708.
Liu Y, Hong H H, Xue J C, et al. Near-infrared radiation-assisted drug delivery nanoplatform to realize blood-brain barrier crossing and protection for parkinsonian therapy [J]. ACS Appl Mater Interfaces, 2021, 13(31): 37746-37760.
Li D D, Yao Y, Wang K, et al. Targeted delivery of saikosaponin A and doxorubicin via hyaluronic acid-modified ZIF-8 nanoparticles for TNBC treatment: Inhibiting metastasis and reducing cardiotoxicity [J]. Biomater Adv, 2025, 167: 214114.
Wang L Y, Tian M X, Dong B Z, et al. Macrophage-targeted emodin nanomaterials for effective acute pancreatitis treatment via modulation of the JNK pathway [J]. Biomater Sci, 2025, 13(16): 4461-4481.
Lin S, Cui J W, Li X, et al. Modified ZIF-8 nanoparticles for targeted metabolic treatment of acute spinal cord injury [J]. ACS Appl Mater Interfaces, 2024, 16(12): 14503-14509.
Liu Y L, Sun S W, Shang C Y, et al. MOF-derived nanozymes loaded with botanicals as multifunctional nanoantibiotics for synergistic treatment of intracellular antibiotic-resistant bacterial infection [J]. Nanoscale Horiz, 2025, 10(7): 1377-1389.
Chen Z, Zhe M, Wu W T, et al. Injectable photocrosslinked hydrogel dressing encapsulating quercetin-loaded zeolitic imidazolate framework-8 for skin wound healing [J]. Pharmaceutics, 2024, 16(11): 1429.
Yuan T J, Tan M H, Xu Y, et al. All-in-one smart dressing for simultaneous angiogenesis and neural regeneration [J]. J Nanobiotechnol, 2023, 21(1): 38.
Jimo R, Ma J, Edi S, et al. Bletilla striata polysaccharide microneedles with astragaloside IV loaded ZIF-8 nanoparticles for wound healing and anti-scar treatment [J]. J Nanobiotechnol, 2025, 23(1): 644.
Yang Y, Liu R Y, Xin L Y, et al. ZIF-8 selective dispersive solid-phase extraction-LC-MS/MS method for the determination of aconitine alkaloids in rat plasma: Application in pharmacokinetic studies [J]. J Anal Meth Chem, 2025, 2025: 9937519.
Zhang X, Liu R. An ultrasensitive electrochemical sensor for the simultaneous detection of baicalin and baicalein in pharmaceuticals and serum samples [J]. Talanta, 2025, 285: 127414.
Hassanzadeh J, Al Lawati H A J, Al Lawati I. Metal-organic framework loaded by rhodamine B as a novel chemiluminescence system for the paper-based analytical devices and its application for total phenolic content determination in food samples [J]. Anal Chem, 2019, 91(16): 10631-10639.
Rahmani A, Maleki A, Jafari R, et al. A multifunctional curcumin-Fe₃O₄@ZIF-8 nanoformulation as a T₂ MRI contrast agent and pH-responsive theranostic platform for targeted ROS generation, radiosensitization, and triple-negative breast cancer treatment [J]. J Mater Chem B, 2025, 13(42): 13805-13829.
Li Y X, Tuerhan M, Li B, et al. RGD-modified ZIF-8 nanoparticles as a drug carrier for MR imaging and targeted drug delivery in myocardial infarction [J]. Nanomedicine, 2024, 19(18/19/20): 1585-1600.
Zhang Z Q, Wang L, Zeng D, et al. Preparation, identification, and application of PEG/ZIF-8@ Dendrobium huoshanense polysaccharide as an adjuvant to enhance immune responses [J]. Fish Shellfish Immunol, 2023, 143: 109038.
Zong Z A, Tian G H, Wang J L, et al. Recent advances in metal-organic-framework-based nanocarriers for controllable drug delivery and release [J]. Pharmaceutics, 2022, 14(12): 2790.
Li M Y, Ge J M, Yao J W, et al. Multifunctional nanoplatform based on polyethylene glycol-folic acid modified UiO-66(Zr) as drug delivery platform for enhanced therapy of cancer [J]. Biofabrication, 2025, 17(3): 035012.
Wang F Q, Jiang Y F, Wang Y. Resveratrol-loaded metal-organic framework for mitochondria-targeted amplified CO gas therapy [J]. Front Chem, 2025, 13: 1545850.
Chen Y Z, Yan F Y, Yang Y, et al. Quercetin@UiO-66 NPs and chloroquine in combined tumor therapy by dual autophagy-ubiquitination system blockade [J]. Chem Commun, 2024, 60(42): 5514-5517.
Lei H Q, Liu Y P, Li J, et al. Colon-targeted dual-coating MOF nanoparticles for the delivery of curcumin with anti-inflammatory properties in the treatment of ulcerative colitis [J]. Colloids Surf B Biointerfaces, 2025, 250: 114545.
Liu C J, Lin J H, Li M T, et al. Post-therapy via integrated curcumin and doxorubicin modified cerium-based UiO-66 MOFs using an antioxidant and anticancer therapeutic strategy [J]. J Mater Chem B, 2024, 12(46): 11983-11995.
Li C Q, Wang H F, Sun J S, et al. Novel electrochemiluminescence platform utilizing AuNPs@ UiO-66-NH₂ bridged luminescent substrates and aptamers for the detection of pesticide residues in Chinese herbal medicines [J]. Talanta, 2025, 281: 126924.
Yin S J, Chen H, Wang S P, et al. Preparation of core-shell MOF@MOF nanoparticle as matrix for the analysis of rhubarb anthraquinones in plasma by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry [J]. Heliyon, 2023, 9(5): e16245.
Liu W, Wu S, Sun T X, et al. Post-synthetic modified luminescent metal-organic framework for the detection of berberine hydrochloride in a traditional Chinese herb [J]. RSC Adv, 2024, 14(1): 602-607.
Wang Y, Yin S J, Zhao C P, et al. Preparation of a zirconium terephthalate metal-organic framework coated magnetic nanoparticle for the extraction of berberine prior to high-performance liquid chromatography analysis [J]. J Sep Sci, 2021, 44(6): 1220-1230.
Han X Y, Wang S, Cui T T, et al. Sustainable defect-engineered imprinted UiO-66-NH₂ for selective removal of aristolochic acids from medicinal herbs [J]. ACS Sustainable Chem Eng, 2025, 13(28): 11113-11127.
Mansouri A, Farsani N K, Javanmard A, et al. Combating antimicrobial resistance: In vitro and in vivo efficacy of berberine-loaded metal-organic frameworks with hyaluronic acid coating [J]. Int J Biol Macromol, 2025, 308: 142253.
Wang J, Li L, Hu X Y, et al. pH-responsive on-demand release of eugenol from metal-organic frameworks for synergistic bacterial killing [J]. Dalton Trans, 2024, 53(6): 2826-2832.
Huang L L, Yao Y, Ruan Z R, et al. Baicalin nanodelivery system based on functionalized metal-organic framework for targeted therapy of osteoarthritis by modulating macrophage polarization [J]. J Nanobiotechnology, 2024, 22(1): 221.
Li W W, Liu Y, Wei M, et al. Chondrocyte-targeted α-Solanine through HIF-1α regulating glycolysis to reduce the ferroptosis of chondrocyte in osteoarthritis [J]. Int Immunopharmacol, 2025, 159: 114841.
El-Shafey A A M, Hegab M H A, Seliem M M E, et al. Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis [J]. J Mater Sci Mater Med, 2020, 31(11): 90.
Duan H J, Wang F, Xu W Z, et al. Recent advances in the nanoarchitectonics of metal-organic frameworks for light-activated tumor therapy [J]. Dalton Trans, 2023, 52(44): 16085-16102.
Cabrera-García A, Checa-Chavarria E, Rivero-Buceta E, et al. Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin [J]. J Colloid Interface Sci, 2019, 541: 163-174.
Shen J J, Xue S J, Mei Z H, et al. Synthesis, characterization, and efficacy evaluation of a pH-responsive Fe-MOF@GO composite drug delivery system for the treating colorectal cancer [J]. Heliyon, 2024, 10(6): e28066.
Leng X, Dong X, Wang W P, et al. Biocompatible Fe-based micropore metal-organic frameworks as sustained-release anticancer drug carriers [J]. Molecules, 2018, 23(10): 2490.
Zhang Z J, Hou Y K, Chen M W, et al. A pH-responsive metal-organic framework for the co-delivery of HIF-2α siRNA and curcumin for enhanced therapy of osteoarthritis [J]. J Nanobiotechnol, 2023, 21(1): 18.
Dehghani S, Hosseini M, Haghgoo S, et al. Multifunctional MIL-Cur@FC as a theranostic agent for magnetic resonance imaging and targeting drug delivery: in vitro and in vivo study [J]. J Drug Target, 2020, 28(6): 668-680.
Guo H, Liu Y P, Li X, et al. Magnetic metal-organic framework-based nanoplatform with platelet membrane coating as a synergistic programmed cell death protein 1 inhibitor against hepatocellular carcinoma [J]. ACS Nano, 2023, 17(23): 23829-23849.
Yang D D, Li S Y, Xu X W, et al. Using quercetin to construct molecularly imprinting polymer in the preparation and enrichment of flavonol and flavonoid compounds [J]. Am J Chin Med, 2024, 52(4): 1137-1154.
Tang Z T, Han Q R, Yu G, et al. Fe₃O₄@PDA/MIL-101(Cr) as magnetic solid-phase extraction sorbent for mycotoxins in licorice prior to ultrahigh-performance liquid chromatography-tandem mass spectrometry analysis [J]. Food Sci Nutr, 2022, 10(7): 2224-2235.
Cao C, Li Z P, Huang X J, et al. Immobilization of snailase on glutamate modified MIL-88B(Fe) to efficiently convert the rare ginsenoside CK with high enzyme recyclability and stability [J]. Int J Biol Macromol, 2025, 285: 138146.
Wang D D, Zhou J J, Chen R H, et al. Controllable synthesis of dual-MOFs nanostructures for pH-responsive artemisinin delivery, magnetic resonance and optical dual-model imaging-guided chemo/photothermal combinational cancer therapy [J]. Biomaterials, 2016, 100: 27-40.
Zhou C H, Yang Q Y, Zhou X Y, et al. PDA-coated CPT@MIL-53(Fe)-based theranostic nanoplatform for pH-responsive and MRI-guided chemotherapy [J]. J Mater Chem B, 202216, 10(11): 1821-1832.
Gao Q Q, Sheng Q L, Zhang S, et al. Recent trends on MIL-88(Fe) metal-organic frameworks: Synthesis and applications in pollutant removal and detection [J]. RSC Adv, 2025, 15(32): 26184-26200.
Yang Y M, Du K Z, Liu M, et al. A computer-assisted design of poly(deep eutectic solvent)@MIL-101-NH₂(Cr) imprinting strategy: Selective removal of Zearalenone from Coix seeds [J]. Food Chem, 2025, 491: 145219.
Han Q R, Liu F, Wang C J, et al. Polyethylene glycol functionalized Fe₃O₄@MIL-101(Cr) for the efficient removal of heavy metals from Ligusticum chuanxiong Hort [J]. Arab J Chem, 2023, 16(4): 104635.
Leng X, Huang H L, Wang W P, et al. Zirconium-porphyrin PCN-222: pH-responsive controlled anticancer drug oridonin [J]. Evid Based Complementary Altern Med, 2018, 2018(1): 3249023.
Hamidian K, Barani M, Adeli-Sardou M, et al. Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600) [J]. Heliyon, 2023, 9(1): e12634.
Wan X Y, Zhong H, Pan W, et al. Programmed release of dihydroartemisinin for synergistic cancer therapy using a CaCO₃ mineralized metal-organic framework [J]. Angew Chem Int Ed, 2019, 58(40): 14134-14139.
Sakamaki Y, Ozdemir J, Diaz Perez A, et al. Maltotriose conjugated metal-organic frameworks for selective targeting and photodynamic therapy of triple negative breast cancer cells and tumor associated macrophages [J]. Adv Ther, 2020, 3(8): 2000029.
Kong J H, Cai M R, Zhu R Y, et al. CPP10-targeted photoactivatable MOF nanosystem for combined photodynamic therapy-chemotherapy of cancer [J]. J Sci Adv Mater Devices, 2024, 9(3): 100761.
Zhu R Y, Liao S L, Cai M R, et al. Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition [J]. Nano Research, 2025, 18(1): 94906991.
Cai M R, Fu T T, Zhu R Y, et al. An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy [J]. Acta Pharm Sin B, 2024, 14(9): 4073-4086.
Lv F Z, Fang H Q, Huang L, et al. Curcumin equipped nanozyme-like metal-organic framework platform for the targeted atherosclerosis treatment with lipid regulation and enhanced magnetic resonance imaging capability [J]. Adv Sci, 2024, 11(26): 2309062.
彭龙漩. 锆基卟啉金属有机框架纳米复合材料的抗菌及抗生物膜研究[D]. 上海: 上海师范大学, 2024.
Cheng H D. One-pot preparation of HCPT@IRMOF-3 nanoparticles for pH-responsive anticancer drug delivery [J]. Molecules, 2023, 28(23): 7703.
Xu Y H, Shan Y L, Zhang Y X, et al. Multifunctional Fe₃O₄@C-based nanoparticles coupling optical/MRI imaging and pH/photothermal controllable drug release as efficient anti-cancer drug delivery platforms [J]. Nanotechnology, 2019, 30(42): 425102.
Laha D, Pal K, Chowdhuri A R, et al. Fabrication of curcumin-loaded folic acid-tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo systems [J]. New J Chem, 2019, 43(1): 217-229.
Ray Chowdhuri A, Bhattacharya D, Sahu S K. Magnetic nanoscale metal organic frameworks for potential targeted anticancer drug delivery, imaging and as an MRI contrast agent [J]. Dalton Trans, 2016, 45(7): 2963-2973.
Wang K X, Cai M R, Yin D G, et al. Functional metal-organic framework nanoparticles loaded with polyphyllin I for targeted tumor therapy [J]. J Sci Adv Mater Devices, 2023, 8(2): 100548.
Yang C, Ming H, Li B W, et al. A pH and glutathione-responsive carbon monoxide-driven nano-herb delivery system for enhanced immunotherapy in colorectal cancer [J]. J Control Release, 2024, 376: 659-677.
Cai M R, Qin L Y, You L T, et al. Functionalization of MOF-5 with mono-substituents: Effects on drug delivery behavior [J]. RSC Adv, 2020, 10(60): 36862-36872.
Cai M R, Liang W L, Wang K X, et al. Aperture modulation of isoreticular metal organic frameworks for targeted antitumor drug delivery [J]. ACS Appl Mater Interfaces, 2022, 14(32): 36366-36378.
Chen Y K, Zhang C, Wang X S, et al. Self-amplifying cryo-immunotherapy enabled by Ga-MOF nanoplatform for metastatic lung cancer [J]. Chem Eng J, 2025, 525: 170334.
Zeng H R, Xia C, Zhao B, et al. Folic acid-functionalized metal-organic framework nanoparticles as drug carriers improved bufalin antitumor activity against breast cancer [J]. Front Pharmacol, 2022, 12: 747992.
Zhang H W, Zhu W Q, Pan W, et al. Surface-engineered nanoshuttles hijack macrophages in vivo to boost blood-brain barrier penetration and immunomodulation for targeted glioblastoma therapy [J]. ACS Nano, 2025, 19(32): 29737-29749.
Tian Q W, Wang X D, Song S L, et al. Engineering of an endogenous hydrogen sulfide responsive smart agent for photoacoustic imaging-guided combination of photothermal therapy and chemotherapy for colon cancer [J]. J Adv Res, 2022, 41: 159-168.
Wang F M, Zhang Y, Liu Z W, et al. A biocompatible heterogeneous MOF-Cu catalyst for in vivo drug synthesis in targeted subcellular organelles [J]. Angew Chem Int Ed, 2019, 58(21): 6987-6992.
Moussa Z, Hmadeh M, Abiad M G, et al. Encapsulation of curcumin in cyclodextrin-metal organic frameworks: Dissociation of loaded CD-MOFs enhances stability of curcumin [J]. Food Chem, 2016, 212: 485-494.
Wei L Q, Chen Q, Tang L L, et al. A porous metal-organic framework with a unique hendecahedron-shaped cage: Structure and controlled drug release [J]. Dalton Trans, 2016, 45(9): 3694-3697.
Teplensky M H, Fantham M, Li P, et al. Temperature treatment of highly porous zirconium-containing metal-organic frameworks extends drug delivery release [J]. J Am Chem Soc, 2017, 139(22): 7522-7532.
Li S T, Long M, Li J Q, et al. Improved topical delivery of curcumin by hydrogels formed by composite carriers integrated with cyclodextrin metal-organic frameworks and cyclodextrin nanosponges [J]. Int J Pharm X, 2024, 8: 100310.
Li H X, Du K Z, Liu C, et al. Enhancing Verbena officinalis L. antioxidant yield through natural deep eutectic solvents and MOF synergetic application [J]. Green Chem, 2025, 27(31): 9459-9479.
Xiang R Q, Niu Y F, Han J, et al. A neutral Cu-based MOF for effective quercetin extraction and conversion from natural onion juice [J]. RSC Adv, 2019, 9(58): 33716-33721.
Long J, Gao Y, Sheng K J, et al. Transform waste into profit: Extract licorice residue fiber to load Zr-MOF as a promising adsorbent [J]. Bioresour Technol, 2025, 438: 133199.
Xiong J, Yang L, Gao L X, et al. A highly fluorescent lanthanide metal-organic framework as dual-mode visual sensor for berberine hydrochloride and tetracycline [J]. Anal Bioanal Chem, 2019, 411(23): 5963-5973.
Jiang X L, Hou S L, Jiao Z H, et al. Luminescent detection of colchicine by a unique indium-organic framework in water with high sensitivity [J]. Anal Chem, 2019, 91(15): 9754-9759.
Yin K P, Wu S Q, Zheng H, et al. Lanthanide metal-organic framework-based fluorescent sensor arrays to discriminate and quantify ingredients of natural medicine [J]. Langmuir, 2021, 37(17): 5321-5328.
Wang Q Y, Yang J, Dong X, et al. Zirconium metal-organic framework assisted miniaturized solid phase extraction of phenylurea herbicides in natural products by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry [J]. J Pharm Biomed Anal, 2020, 180: 113071.
Zhang J B, Chen Q C, Gao X M, et al. Study on a TCM evaluation method based on an MIP-modified MOF sensor with highly selective electrocatalytic activity: An Artemisia annua L. perspective [J]. Anal Methods, 2025, 17(17): 3436-3445.

2026年第57卷第10期

PDF下载

引用本文

BibTeX

文章信息

doi: 10.7501/j.issn.0253-2670.2026.10.026

接收时间：2025-12-14
首发时间：2026-09-09

补充材料

相关文章

文章信息

作者

出版历史

收稿日期：2025-12-14

基金

作者信息

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.10.026

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT