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五环三萜类化合物全球创新合作网络的图谱构建与演化研究

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中草药 | 数据挖掘与循证医学 2026,57(10): 3912-3925

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中草药 |数据挖掘与循证医学 2026 , 57 (10) : 3912 -3925

五环三萜类化合物全球创新合作网络的图谱构建与演化研究

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高艺¹, 南敏伦², 胥皓为¹, 张凯月², 高原², 赫玉芳¹

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通讯作者:

赫玉芳

作者简介:

高艺: 高艺,硕士研究生,研究方向为社会发展与管理药学。E-mail:19805484600@163.com

Mapping construction and evolution research of global innovation cooperation network of pentacyclic triterpenoids

GAO Yi, NAN Minlun, XU Haowei, ZHANG Kaiyue, GAO Yuan, HE Yufang

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doi: 10.7501/j.issn.0253-2670.2026.10.020

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目的揭示五环三萜类化合物领域全球创新合作网络的动态演化规律，解析网络结构、国家创新策略与主体行为在技术生命周期不同阶段的协同演变机制。方法基于1945—2025年全球专利数据，运用社会网络分析方法，构建并分析该领域的创新合作网络，依据技术生命周期理论划分4个发展阶段进行动态比较。结果合作网络结构呈现阶段性演变，从萌芽期封闭的“核心小世界”经成长期扩张最终收敛为“战略聚焦型”紧密结构；国家创新策略分为“持续开放型”“先升后降型”“低位平稳型”3类路径，国际合作强度随技术成熟呈“倒U型”衰减；微观主体存在显著的“结构性割裂”，产业界形成高密度协作闭环，而关键学术机构多处于网络边缘的“双边孤立”状态，导致“产学脱钩”的生态失衡。结论从网络结构、国家创新策略与主体行为3个层面，系统揭示五环三萜类化合物领域创新合作网络的动态演进机制，深化对技术生命周期中合作竞争关系的理论认识，为构建更具韧性的创新生态系统提供实证依据与政策启示。

关键词

五环三萜类化合物 / 创新合作网络 / 社会网络分析 / 演化机制 / 专利分析 / 技术生命周期

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Objective To reveal the dynamic evolution of the global innovation cooperation network in the field of pentacyclic triterpenoids, and analyze the collaborative evolution mechanism of network structure, national innovation strategies and individual behaviors at different stages of the technology lifecycle. Methods Based on global patent data from 1945 to 2025, social network analysis method is used to construct and analyze the innovation cooperation network in this field. According to the theory of technology lifecycle, four development stages are divided for dynamic comparison. Results The cooperative network structure presents a phased evolution, from a closed “core small world” in its infancy to a long-term expansion, ultimately converging into a “strategic focused” tight structure; The national innovation strategy is divided into three types of paths: “sustained openness”“first rising and then falling”“low-level stability”. The intensity of international cooperation decreases in an “inverted U-shape” as technology matures; There is a significant “structural fragmentation” among micro entities, with the industry forming a high-density collaborative closed loop, while key academic institutions are often in a “bilateral isolation” state at the edge of the network, leading to an ecological imbalance of “industry academia decoupling”. Conclusion This study systematically reveals the dynamic evolution mechanism of innovation cooperation networks in the field of pentacyclic triterpenoids from three levels: network structure, national strategy, and subject behavior. It deepens the theoretical understanding of cooperation and competition relationships in the technology lifecycle and provides empirical evidence and policy implications for building a more resilient innovation ecosystem.

Key words

pentacyclic triterpenoids / innovation cooperation networks / social network analysis / evolutionary mechanisms / patent analysis / technology lifecycle

引用本文

高艺, 南敏伦, 胥皓为, 张凯月, 高原, 赫玉芳. 五环三萜类化合物全球创新合作网络的图谱构建与演化研究. 中草药, 2026 , 57 (10) : 3912 -3925 . DOI: 10.7501/j.issn.0253-2670.2026.10.020

GAO Yi, NAN Minlun, XU Haowei, ZHANG Kaiyue, GAO Yuan, HE Yufang. Mapping construction and evolution research of global innovation cooperation network of pentacyclic triterpenoids[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (10) : 3912 -3925 . DOI: 10.7501/j.issn.0253-2670.2026.10.020

基金

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吉林省科学技术厅资助项目 (20250601031RC)

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2026年第57卷第10期

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doi: 10.7501/j.issn.0253-2670.2026.10.020

接收时间：2026-01-03
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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