Article(id=1304388053259285039, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.10.017, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1767369600000, receivedDateStr=2026-01-03, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788919946255, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788919946255, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788919946255, creator=13701087609, updateTime=1788919946255, updator=13701087609, issue=Issue{id=1304388047747969563, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='10', pageStart='3685', pageEnd='4088', issueExtLink='null', onlineDate='null', pubDate='1779897600000', pubDateStr='2026-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788919944940, creator='13701087609', updateTime=1788923403989, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304402556332037104, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304402556332037105, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3878, endPage=3885, ext={EN=ArticleExt(id=1304388053590635057, articleId=1304388053259285039, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Evaluating clinical value and economic benefits of Liushen Capsules in treatment of acute tonsillitis based on a real-world study, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To evaluate the clinical efficacy, pharmacoeconomic value, and potential for reducing antibiotic use of Liushen Capsules in the treatment of acute tonsillitis. Methods A multicenter, prospective cohort study was conducted, enrolling 875 patients with acute tonsillitis (660 in the exposed group, 215 in the non-exposed group). Comparisons were made between the two groups regarding sore throat Visual Analog Scale (VAS) scores, disease recovery rate, efficacy of traditional Chinese medicine (TCM) syndrome differentiation, as well as antibiotic and antipyretic-analgesic usage rates. Pharmacoeconomic evaluation and multivariate logistic regression analysis were also performed. Results After seven days of treatment, the exposed group showed significantly better outcomes than the non-exposed group in terms of reduction in sore throat VAS score, improvement in TCM syndrome recovery rate, and reduction in antibiotic use rate (P <0.05).. Pharmacoeconomic cost-minimizationt analysis indicated that the exposed group was more cost-effective than the non-exposed group. Conclusion Liushen Capsules can effectively alleviate symptoms, improve clinical efficacy, significantly reduce antibiotic use, and demonstrate favorable pharmacoeconomic value in the treatment of acute tonsillitis., authors=RUAN Yan, ZHOU Huifang, XIAO Quan, YI Qiong, YANG Wei, LIU Lin, GU Xiaochun, MAO Yiping, LU Chunyan, WANG Jing, HAN Wei, authorsList=RUAN Yan, ZHOU Huifang, XIAO Quan, YI Qiong, YANG Wei, LIU Lin, GU Xiaochun, MAO Yiping, LU Chunyan, WANG Jing, HAN Wei, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388053510943280, articleId=1304388053259285039, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于真实世界研究评价六神胶囊治疗急性扁桃体炎的临床价值与药物经济学效益, columnId=1304140191707456168, journalTitle=中草药, columnName=药理与临床, runingTitle=null, highlight=null, articleAbstract=目的 评价六神胶囊治疗急性扁桃体炎的临床疗效、药物经济学价值及其减少抗生素使用的潜力。方法 采用多中心、前瞻性队列研究设计，纳入急性扁桃体炎患者875例[暴露组（使用六神胶囊）660例、非暴露组（不使用六神胶囊）215例]。比较两组咽痛视觉模拟评分（visual analogue scale，VAS）、疾病痊愈率、中医证候疗效、抗生素及解热镇痛药使用率，并进行药物经济学评价与多因素Logistic回归分析。结果 治疗7 d后，暴露组在咽痛VAS评分降低、中医证候痊愈率提高及抗生素使用率减少方面均显著优于非暴露组（P ＜0.05）。药物经济学最小成本分析显示，暴露组在2种疾病中的经济性均优于非暴露组。结论 六神胶囊治疗急性扁桃体炎可有效缓解症状、提高疗效，并显著降低抗生素使用率，具有良好的药物经济学价值。, authors=阮岩1,1,1 , 周慧芳2 , 肖全3 , 易琼4 , 杨威5 , 柳林6 , 顾小春7 , 毛玉萍8 , 陆春燕9 , 王静10 , 韩伟1 , authorsList=阮岩, 周慧芳, 肖全, 易琼, 杨威, 柳林, 顾小春, 毛玉萍, 陆春燕, 王静, 韩伟, authorCompany=1 1. 郑州大学附属郑州中心医院 耳鼻咽喉头颈外科, 河南 郑州 450000;
中草药
|药理与临床
2026
, 57
(10) :
3878
-3885
基于真实世界研究评价六神胶囊治疗急性扁桃体炎的临床价值与药物经济学效益
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阮岩, 周慧芳, 肖全, 易琼, 杨威, 柳林, 顾小春, 毛玉萍, 陆春燕, 王静, 韩伟
作者信息
作者简介:
阮岩: 阮岩(1969—),医学博士,教授,博士生导师,研究方向为中药防治耳鼻喉科疾病。E-mail:ruanyan63@163.com
Evaluating clinical value and economic benefits of Liushen Capsules in treatment of acute tonsillitis based on a real-world study
RUAN Yan, ZHOU Huifang, XIAO Quan, YI Qiong, YANG Wei, LIU Lin, GU Xiaochun, MAO Yiping, LU Chunyan, WANG Jing, HAN Wei
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.10.017
文章导航
目的 评价六神胶囊治疗急性扁桃体炎的临床疗效、药物经济学价值及其减少抗生素使用的潜力。方法 采用多中心、前瞻性队列研究设计，纳入急性扁桃体炎患者875例[暴露组（使用六神胶囊）660例、非暴露组（不使用六神胶囊）215例]。比较两组咽痛视觉模拟评分（visual analogue scale，VAS）、疾病痊愈率、中医证候疗效、抗生素及解热镇痛药使用率，并进行药物经济学评价与多因素Logistic回归分析。结果 治疗7 d后，暴露组在咽痛VAS评分降低、中医证候痊愈率提高及抗生素使用率减少方面均显著优于非暴露组（P ＜0.05）。药物经济学最小成本分析显示，暴露组在2种疾病中的经济性均优于非暴露组。结论 六神胶囊治疗急性扁桃体炎可有效缓解症状、提高疗效，并显著降低抗生素使用率，具有良好的药物经济学价值。
六神胶囊
/
急性扁桃体炎
/
咽痛视觉模拟评分
/
药物经济学
/
Logistic回归分析
Objective To evaluate the clinical efficacy, pharmacoeconomic value, and potential for reducing antibiotic use of Liushen Capsules in the treatment of acute tonsillitis. Methods A multicenter, prospective cohort study was conducted, enrolling 875 patients with acute tonsillitis (660 in the exposed group, 215 in the non-exposed group). Comparisons were made between the two groups regarding sore throat Visual Analog Scale (VAS) scores, disease recovery rate, efficacy of traditional Chinese medicine (TCM) syndrome differentiation, as well as antibiotic and antipyretic-analgesic usage rates. Pharmacoeconomic evaluation and multivariate logistic regression analysis were also performed. Results After seven days of treatment, the exposed group showed significantly better outcomes than the non-exposed group in terms of reduction in sore throat VAS score, improvement in TCM syndrome recovery rate, and reduction in antibiotic use rate (P <0.05).. Pharmacoeconomic cost-minimizationt analysis indicated that the exposed group was more cost-effective than the non-exposed group. Conclusion Liushen Capsules can effectively alleviate symptoms, improve clinical efficacy, significantly reduce antibiotic use, and demonstrate favorable pharmacoeconomic value in the treatment of acute tonsillitis.
Liushen Capsules
/
acute tonsillitis
/
visual analogue scale
/
pharmacoeconomics
/
Logistic regression analysis
阮岩, 周慧芳, 肖全, 易琼, 杨威, 柳林, 顾小春, 毛玉萍, 陆春燕, 王静, 韩伟.
基于真实世界研究评价六神胶囊治疗急性扁桃体炎的临床价值与药物经济学效益.
中草药,
2026
, 57
(10)
: 3878
-3885
.
DOI: 10.7501/j.issn.0253-2670.2026.10.017
RUAN Yan, ZHOU Huifang, XIAO Quan, YI Qiong, YANG Wei, LIU Lin, GU Xiaochun, MAO Yiping, LU Chunyan, WANG Jing, HAN Wei.
Evaluating clinical value and economic benefits of Liushen Capsules in treatment of acute tonsillitis based on a real-world study[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(10)
: 3878
-3885
.
DOI: 10.7501/j.issn.0253-2670.2026.10.017
参考文献
引证文献
孙超, 宋梦月, 苏欣. 急性上呼吸道感染患者的临床特征与病原学变化研究[J]. 临床肺科杂志, 2025, 30(10): 1498-1503.
2026年第57卷第10期
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doi: 10.7501/j.issn.0253-2670.2026.10.017
接收时间：2026-01-03
首发时间：2026-09-09
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.10.017
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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